Composti deuterati

<p>Applications Labelled Mecoprop (M203052). Herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gagne, F., et al.: Environ. Res., 103, 238 (2007), LaChapelle, A., et al.: Reprod. Toxicol., 23, 20 (2007),<br></p>

<p>Applications (±)-Mianserin-d3 HCl (methyl-d3) (CAS# 1219804-97-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,2′,4,4′-Tetrahydroxybenzophenone-d4 is an isotopic analog of 2,2′,4,4′-Tetrahydroxybenzophenone (T295900), a benzophenone-type UV filter with known or suspected endocrine disrupting properties detected in surface waters, sunscreens, personal care products, clothing and food packaging. It is used to protect the skin and materials from the adverse effects of UV-radiation.<br>References Wu, M., et al.: Ecotoxicol. Environ. Saf., 141, 235-241 (2017); Krause, M., et al.: Environ. Int., 99, 177-184 (2017); Jimenez-Diaz, I., et al.: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 1035, 57-66 (2016)<br></p>

<p>Applications Diphenyl-2,2',4,4',6,6'-d6-amine (CAS# 99234-91-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Acts on certain olfactory receptor cell types to reduce the activating or attracting effect of odor sources.Insect repellent.<br>References Boeckh, J., et al.: Pestic. Sci., 48, 359 (1996), Yap, H.H., et al.: J. Vector Ecol., 23, 62 (1998),<br></p>

<p>Applications Medetomidine-d5 (d5-Major) is an intermediate in the synthesis of Dexmedetomidine-d4 L-Tartrate (d4-Major) (D299006). Dexmedetomidine-d4 L-Tartrate is the labeled salt analogue of Dexmedetomidine (D299000), an α2-Adrenergic agonist; (+)-isomer of Medetomidine; sedative; analgesic.<br>References Rajala, R., et al.: Eur. J. Pharm. Sci., 1, 219 (1994); Jalonen, J., et al.: Anesthesiology, 86, 331 (1997); Talke, P., et al.: Anesth. Analg., 85, 1136 (1997); Bhana, N., et al.: Drugs, 59, 263 (2000)<br></p>

<p>Applications Isotope labelled β-Alanine is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of dihydrouracil (D449990) and carnosine. β-Alanine is also the rate-limiting precursor of carnosine, as a result supplementation with β-alanine increases the concentration of carnosine in muscles.<br></p>

<p>Applications 4-Ethylphenol-2,3,5,6-d4,OD (CAS# 340256-40-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Octadecanoic-17,17,18,18,18-d5 Acid (CAS# 211443-83-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Butoxyethanol-d4 is the isotope labelled analog of 2-Butoxyethanol; a reagent in the synthesis of 4-butoxyethoxy-N-octadecyl-1,8-naphthalimide as a new fluorescent probe for the determination of proteins. Also used as a reagent in the synthesis of 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors.<br>References Sun, Y., et al.: Bioorg. Med. Chem. Lett., 21, 3798 (2011); Yi, W., et al.: Eur. J. Med. Chem., 45, 639 (2010)<br></p>

<p>Applications Isotope labelled Urethane (U82500), which is a naturally occurring contaminant in fermented foods, particularly wine, stone-fruit brandies, and bread. This substance is reasonably anticipated to be a human carcinogen (1) despite being an additive in some alcoholic beverages and foods (2). It binds covalently with DNA however due to its low unavoidable daily intake, it is considered of negligible concern (3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mirvish, S. et al.: Adv. Cancer Res. 1968;11:1-42.2. Battaglia R. et al.: Food Addit Contam. 1990 Jul-Aug;7(4):477-96.3. Zimmerli B. et al.: Mutat Res. 1991 Mar-Apr;259(3-4):325-50.<br></p>

<p>Applications N-Methyl-d3-formamide (CAS# 87955-92-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled D-Glucitol is a sugar alcohol obtained from the reduction of glucose and is naturally found in various fruits such as apples, pears and peaches. D-Glucitol has been widely used as a sweetener, laxative, various medical applications and in cosmetic products.<br>References Wang, Z.J., et al.: Anal. BIoanal. Chem., 405, 3899 (2013); Vinarta, S.C., et al.: Carb. Poly., 92, 1107 (2013); Kaumanu, M.L., et al.: Soil. Biol. Biochem., 57, 644 (2013); Hailu, T., et al.: Anal. Biochem., 434, 181 (2013);<br></p>

<p>Applications 2-Naphthol-d7 has been used as a reactant for the preparation of stable isotope-labeled internal standards of PAH metabolites from urine of smokers and nonsmokers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jacob, P. III, et. al.: Anal. Chem., 79, 587 (2007)<br></p>

<p>Applications Labelled analog of a restricted use pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bradford, D., et al.: Environ. Sci. Technol., 44, 4609 (2010), Trtic-Petrovic, T., et al.: Anal. Bioanal. Chem., 397, 2233 (2010), Stewart, C., et al.: Weed Biol. Man., 10, 40 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled analog of α-D-Galactose 1-Phosphate, the phosphate conjugate of α-D-Galactose (G155260), a natural aldohexose which is ubiquitous in bacteria, plants, and animals, including human brains.<br>References Sang, J.L., et al.: J. Bacteriol., 190, 7932 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications 4,4'-Dipyridyl-d8 as a solid-solution approach to control the dynamics of molecular rotors in crystal solids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Inukai, M., et al.: J. Amer. Chem. Soc., 137, 12183-12186 (2015)<br></p>

<p>Applications Labelled Isoferulic Acid 3-O-β-D-Glucuronide, the glucuronide conjugate of Isoferulic Acid (H946180). Isoferulic Acid 3-O-β-D-Glucuronide is one of the circulating metabolites in human plasma after coffee consumption.<br>References Fumeaux, R. et al.: Org. Biomol. Chem., 8, 5199 (2010); Redeuil, K. et al.: J. Chrom. A, 1218, 4678 (2011);<br></p>

<p>Applications Vardenafil oxopiperazine-D6 is a labelled analogue of Vardenafil oxopiperazine (V098030)<br></p>

<p>Applications 1-Pyren-2,3,4,5,6,7,8,9,10-d9-amine is derived from Pyrene-d10 (P849002), which is labelled Pyrene. Occurs in coal tar. Also obtained by the destructive hydrogenation of hard coal.<br>References Winterstein, et al.: Z. Physiol. Chem., 230, 162 (1934)<br></p>

<p>Applications 4-n-Propylphenol-d12 (CAS# 352431-21-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 16alpha-Hydroxy-17beta-estradiol-2,4-d2 (CAS# 53866-32-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzonitrile-D5 is a labelled analogue of benzonitrile, commonly used as a precursor to synthesize a wide range of aromatic compounds and also forms stable coordination complexes with transition metals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anderson, G., et al.: Inorg. Syn., 28, 60 (1990); Cui, D., et al.: Angew. Chem. Int. Edit., 117 981 (2005)<br></p>

<p>Applications Propoxyphenyl-​thiohydroxyhomosilde​nafil-d4 is labelled Propoxyphenyl-thiohydroxyhomosildenafil (P831630), an analogue of Hydroxythiohomo Sildenafil (H963150).<br>References Balayssac, S., et. al.: J. Pharmaceut. Biomed., 63, 135 (2012)<br></p>

<p>Applications Griseofulvin-d3 is the labeled analogue of Griseofulvin (G787500), an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum.Environmental contaminants; Food contaminants<br>References Oxford, et al.: Biochem. J., 33, 240 (1939); Townley, E.R., et al.: Anal. Profiles Drug Subs., 8, 219 (1979)<br></p>

<p>Applications 2,3,4-Trihydroxybenzophenone-2’,3’,4’,5’,6’-d5 is the isotope labelled analog of 2,3,4-Trihydroxybenzophenone; a trihydroxy derivative of Benzophenone (B204980) which is a compound used in the manufacturing of antihistamines, hypnotics, and insecticides.<br>References Wallace, W., et al.: Environ. Toxicol. Chem., 19, 962 (2000); Hayashi, T., et al.: Toxicol. Lett., 167, 1 (2006); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008)<br></p>

<p>Stability Air sensitive<br>Applications Reagent used in the preparation of labelled non-steroidal anti-inflammatory drugs, dyes and pesticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cauchon, D., et al.: J. Appl. Toxicol., 17, 397 (1997),<br></p>

<p>Stability Light Sensitive<br>Applications A labelled derivatized of 3-amino-2-oxazolidone (AOZ, A618570), a metabolite of Furazolidone and Nitrofuran.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Vroomen, L., et al.: Drug Metab. Rev., 22, 663 (1990), Hoogenboom, L., et al.: Food Chem. Toxicol., 29, 185 (1991), McCracken, R., et al.: Food Addit. Contam., 17, 75 (2000),<br></p>

<p>Stability Volatile<br>Applications Assignments of far-IR (FIR) laser lines have been found for optically pumped Methanol-13C.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moraes, J.C.S., et. al.: J. Mol. Spec., 177, 302 (1996)<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications 13C-labelled Phenol (P318000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Irbesartan-d6 is deuterium labelled Irbesartan (I751000) which is an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998),<br></p>

<p>Applications Glutaric Acid-1,5-13C2 (cas# 1185108-16-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Isotope Labelled 2,4,6-Trichloroanisole (T774085), which is considered the main compound responsible for the cork taint, a wine flavor defect usually perceived as a moldy off-flavor. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Chatonnet P. et al.: J Agric Food Chem. 2004 Mar 10;52(5):1255-62. 2. Cserjesi, A. et al.: Can J Microbiol. 1972 Jan;18(1):45-9.<br></p>

<p>Applications Isotope labelled Methiocarb Sulfoxide acts as a pesticide which is used in the protection of crops from insects and fungus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wong, J. et al.: J. Agri,. Food. Chem., 58, 5897 (2010); Ghini, S. et al.: Arch. Env. Cont. Toxicol., 47, 479 (2004);<br></p>

<p>Applications Labelled analogue of Procaine, a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kania, B.H. et al.: Pol. J. Vet. Sci., 6, 279 (2003); Jussi, L. et al.: Cont. Derm., 60, 150 (2009); Gangarosa, L.P. Sr.: J. Dent. Res., 60, 1471 (1981);<br></p>

<p>Applications Bis(4-hydroxyphenyl) Sulfone is commonly used as a reactant in epoxy reactions and is also used as a latent thermal catalyst for epoxy resin.<br>References Fu, J.W., et al.: Adv. Mat. Rsch., 266, 1022 (2011); Li, J.X., et al.: Polymers. Adv. Tech., 23, 803 (2012);<br></p>

<p>Applications Betaine-d3 Hydrochloride is a useful gastric acidifier.<br>References Wilcken, D.E., et al.: N. Engl. J. Med., 309, 448 (1983),<br></p>

<p>Applications Pentadecanoic-d29 Acid (CAS# 130348-95-7) is a useful isotopically labeled research compound.<br></p>