Composti deuterati

Applications A labelled analog of a metabolite of Cetirizine and Hydroxyzine.

Applications 1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide-d3 is the isotope labelled analog of 1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide (D453415); a compound that has been shown to be one of the potential novel biomarkers of peroxisome proliferation in the rat.
References Ringeissen, S., Biomarkers, 8, 240 (2003); Shibata, K., et al.: Biosci. Biotech. and Biochem., 77, 2105 (2013)

Applications Labelled Morpholine. Morpholines compounds used as selective inhibitors of cytochrome p450 2a13 in treatment of cancer. Salicylate as analgesic; antipyretic; anti-inflammatory.
E0
References Paladini, D., et al.: Biochem., 48, 5760 (2009), Bard, B., et al.: J. Med. Chem., 52, 3416 (2009),

Applications Bis(2,3-dibromopropyl) Phosphate-d10 is the isotope labelled analog of Bis(2,3-dibromopropyl) Phosphate. Bis(2,3-dibromopropyl) Phosphate is a derivative of Tris(2,3-dibromopropyl) Phosphate, a widely used flame retardant in plastic and textiles.
References Elliott, W.C., et al.: Life. Sci., 7, 1107 (1983);

Applications Labelled Benzotriazole. BT is an anticorrosive agent well known for its use in aircraft deicing and antifreeze fluids but also used in dishwasher detergents. Benzotriazole is antiestrogenic in vitro but not in vivo.Isotopic purity: 97% d4, 3% d3.
References Rollinson, G., et al.: Biotechnol. Lett., 8, 303 (1986), Cancilla, D., et al.: Environ. Toxicol. Chem., 16, 430 (1997), Beresford, N., et al.: Toxicol. Appl. Pharmacol., 162, 22 (2000), Cornell, J., et al.: Environ. Toxicol. Chem., 19, 1465 (2000), Giger, W., et al.: Environ. Sci. Technol., 40, 7186 (2006),

Applications Labelled Tolazamide, an antidiabetic.
References Welling, et al.: J. Pharmac. Sci., 71, 1259 (1982);

Applications Dimethyl phthalate-3,4,5,6-d4

Applications Labelled 1,2-Bis(2,4,6-tribromophenoxy)ethane (B585425). One of the major "novel" brominated flame retardants (NBFRs) from varous polymer materials. An environmental pollutant.
References Zhu, L., et al.: Environ. Sci. Technol., 40, 3711 (2006), Qui, X., et al.: Environ. Sci. Technol., 42, 31 (2008), Stone, R., et al.: Science, 325, 1055 (2009),

Applications Pinoxaden-d3 is a deuterized labeled form of Pinoxaden (P469505), which is derived from Diethylene Glycol Dimethanesulfonate (D444275), an intermediate in the production of alkylating agents.
References Wong, I., et al.: J. Med. Chem., 52, 5311 (2009); Muehlebach, M., et al.: Bioorg. Med. Chem., 17, 4241 (2009)

Applications Labelled analogue of Acrolein 2,4-Dinitrophenylhydrazone, a dinitrophenylhydrazone (DNPH) derivative of an aliphatic alldehyde found in mainstream cigarette smoke.
References Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010);

Applications Carbamazepine-D10 is used to study occurrence of emerging trace organic chemicals in wastewater effluents in Saudi Arabia.
References Alidina, M., et al.: Sci. Total Environ., 478, 152 (2014);

Stability Hygroscopic
Applications Isotope labelled analogue of Guanosine (G837900), a constituent of nucleic acids.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Miles, et al.: Science, 142, 1458 (1963), Bugg, et al.: Biochem. Biophys. Res. Commun., 3, 436 (1968),

Applications Cyclopentanone-2,2,5,5-d4 (CAS# 3997-89-5) is a useful isotopically labeled research compound.

Applications Pyruvic Acid-13C2 is an intermediate in synthesizing L-Lactic Acid-d3 Sodium Salt (L113503), a labelled sodium salt of L-Lactic Acid (L113500). L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-(+)-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and other organs and body fluids.
References Wenzel, A., et al.: J. Neurosci., 21, 53 (2001); Martinez., et al.: Development, 6, 851 (2002); Nakayama, K., et al.: J. Biochem., 146, 757 (2009); Tanaka, T., et al.: J. Pharmacol. Sci., 109, 24 (2009)

Stability Unstable in Solution, Hygroscopic
Applications Used in nucleophilic substitution.
References Genicot, C., et al.: Bioorg. Med. Chem. Lett., 13, 437 (2003),

Stability Hygroscopic
Applications Guaiacol-beta-D-gentiobioside-d3, is the labeled analogue of Guaiacol-beta-D-gentiobioside (G245570), a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.
References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);

Applications Labelled N-Nitrosopiperidine (N545370). A carcinogenic nitrosocompound.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bos, J., et al.: Cancer Res., 49, 4682 (1989), Wong, H., et al.: Carcinogenesis, 24, 291 (2003), Gonzalez-Mancebo, S., et al.: Mutat. Res., 558, 45 (2004), Gonzalez, M., et al.: Bioorg. Med. Chem., 13, 601 (2005),

Applications Ethylbenzene-13C6 is the labeled form of Ethylbenzene (E899745), which is used in the industrial production of stryrene trough various organic processes.
References Weiss, W. et al.: Prog. Surf. Sci., 70, 1 (2002); Cavani, F. et al.: App. Catal. A., 133, 219 (1995);

Applications Labelled 2,3-Butanedione (B690030). 2,3-Butanedione (Diacetyl), the molecule implicated in the disease known as popcorn lung, has now been implicated in amyloid-β peptide toxicity associated with Alzheimer’s disease. Diacetyl accelerates amyloid-β aggregation-a hallmark of Alzheimer’s disease. These preliminary finding raise the possibility of long-term neurological toxicity mediated by DA.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, J., et al.: Exp. Neurol., 158, 328 (1999); Brown, M., et al.: Cell, 100, 391 (2000); Heinitz, K., et al.: J. Neurochem., 98, 1930 (2006); Brody, D., et al.: Science, 321, 1221 (2008); More, S., et al.: J. Med. Chem., 52, 4650 (2009);