Building Blocks Contenenti Azoto (N)

<p>Applications 6S-Nalfurafine is a stereoisomer of Nalfurafine (N255600), a on-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test. Nalfurafine is a new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients.<br>References Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004); Mori, T., et al.: Life Sci., 75, 2433 (2004); Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006); Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010)<br></p>

<p>Applications 2,3-Piperazinedione is a metabolite of Ketoconazole (K186000), a broad-spectrum antifungal drug that inhibits steroid synthetic pathways and is used to treat patients with seborrheic dermatitis.<br>References Brown, M., et al.: Clin. Pharm. Ther., 37, 290 (1985); Edlund, P. &amp; Baranczewski, P.: J. Pharm. Biomed. Anal., 34, 1079 (2004); Skinner Jr., R., et al.: J. Am. Acad. Derm., 12, 852 (1985); Trachtenberg, J., et al.: J. Urology, 130, 152 (1983)<br></p>

<p>Applications 2-​Aminoindan-​2-​carboxylic Acid can be used as a potential tyrosine hydroxylase inhibitor.<br>References Pinder, R., et al.: J. Med. Chem., 14, 892 (1971)<br></p>

<p>Applications (±)-1-Hydroxy Mephedrone Hydrochloride is a metabolite of Mephedrone Hydrochloride (M224200), a stimulant drug related to cathinone and methcathinone. The effects of Mephedrone are reportedly comparable to those of similar drugs such as MDMA and methylone.<br></p>

<p>Applications 4,4'-METHYLENEBIS(2,6-DIISOPROPYLANILINE) (cas# 19900-69-7) is a useful research chemical.<br></p>

<p>Applications 2-Hydroxyimino-3-pentanone is an intermediate in the preparation of indole derivatives.<br>References Goya, P., et al.: J. Med. Chem., 35, 3977 (1992), Masaguer, C., et al.: Chem. Pharm. Bull., 47, 621 (1999), Wu, S., et al.: Bioorg. Med. Chem. Lett., 16, 5859 (2006),<br></p>

<p>Applications N-Methylacetoacetamide is a starting material in the synthesis of 1-Carbamoyl-2-oxopropyl acetate with the aid (diacetoxyiodo)benzene (DIB) as the oxidant. Also, it is a reagent used in the synthesis of 10H-Phenothiazines, which possesses for their biological activity against the regulatory enzymes involved in inflammatory diseases.<br>References Liu, W., et al.: Beilstein J. Org. Chem., 7, 1436-1440 (2011); Sadanandam, Y. S., et al.: Eur. J. Med. Chem., 44, 197-202 (2009)<br></p>

<p>Applications Reagent used for asymmetric syntheses.<br>References Schlessinger, R., et al.: J. Org. Chem., 28, 3070 (1986)<br></p>