Eterocicli con azoto (N)

<p>Applications 5-phenyl-1H-1,2,3-triazole-4-carboxylic acid (cas# 830-78-4) is a useful research chemical.<br></p>

<p>Applications 4,6-Dichloropyrazolo[3,4-d]pyrimidine (cas# 42754-96-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 6-Chloro-3-Fluoro-2-Iodopyridine (cas# 1211590-36-1) is a useful research chemical.<br></p>

<p>Applications 5-(4-Bromo-2-methylphenyl)-1H-tetrazole (cas# 1007128-19-9) is a useful research chemical.<br></p>

<p>Applications β-Chlorophenethylamine derivatives and their conversion into halogen-free compounds.<br>References Bretschneider, H., et al.: Monatshefte fuer Chemie, 78, 82 (1948),<br></p>

<p>Stability Hygroscopic<br>Applications 5-(4-methylpiperazin-1-yl)pyridin-2-amine (cas# 571189-49-6) is a useful research chemical.<br></p>

<p>Applications 2-propylpiperidine (cas# 3238-60-6) is a useful research chemical.<br></p>

<p>Applications 4-Nitro-1,2,3-triazole is a highly impact sensitive and explosive material.<br>References Politzer, P. et al.: Int. J. Quant. Chem., 61, 389 (1997);<br></p>

<p>Applications 2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrolo-3-acetic Acid (cas# 76194-00-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.<br>References Li, X., et al.: PCT Int. Appl., WO 2014183520 A1 20141120 (2014)<br></p>

<p>Applications 6-Methylpyridine-3-amine, is a heterocyclic building block used in the manufacture of various pharmaceutical compounds. It can be used for the synthesis of 2-aminoquinazoline derivatives, as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators (mGluR5), leading toward a drug candidate for the treatment of l-DOPA induced dyskinesia.<br>References Kubas, H., et al.: Bioorg. Med. Chem. Lett., 23 (16), 4493 (2013);<br></p>

<p>Applications Urazole derivative.<br></p>

<p>Applications 4-Chloro-6-ethylthieno[2,3-d]pyrimidine is a useful intermediate for organic synthesis.<br>References Ostrynska, O. V., et al.: Eur. J. Med. Chem., 115, 148 (2016); Ram, V. J., et al.: J. Heterocycl. Chem., 1277 (1981); Sharma, C., et al.: E-J. Chem., 7, 655 (2010)<br></p>

<p>Applications 3-Hydroxypiperidine is used as a reagent to synthesize trisubstituted ureas, compounds that act as thrombin receptor (PAR-1) antagonists. 3-Hydroxypiperidine is also a metabolite of Piperidine (P479985), Piperidine is an organic heterocyclic amine widely used as building block and reagent in the synthesis of organic compounds including pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Barrow, J., et al.: Bioorg. Med. Chem. Lett., 11, 2691 (2001); Reshmi, S.K., et al.: J. Med. Plant. Res., 4, 1535 (2010); Wiles, J.A., et al.: J. Med. Chem., 54, 3418 (2011);<br></p>

<p>Applications Intermediate in the preparation of various biological inhibitors.<br>References Chonan, T., et al.: Bioorg. Med. Chem. Lett., 19, 6645 (2009), Bunnage, M., et al.: J. Med. Chem., 50, 6095 (2007),<br></p>

<p>Applications 5-Benzyl-4H-1,2,4-triazol-3-amine can be used as positive modulators of GABAA1 receptor with potent anticonvulsant activity and low toxicity.<br>References Huang, L., et.al.: Eur. J. Med. Chem., 185, 111824, (2020);<br></p>

<p>Applications tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate (cas# 371775-73-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-ethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid (cas# 80709-74-6) is a useful research chemical.<br></p>

<p>Applications 1,2-benzisoxazol-3-amine (cas# 36216-80-5) is a useful research chemical.<br></p>

<p>Applications 3-tert-Butylthio-2-cyanopyridine (cas# 178811-40-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-{[5-(trifluoromethyl)pyridin-2-yl]amino}butanoic acid (cas# 923121-46-4) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-4-(trifluoromethyl)pyrimidine (cas# 33034-67-2) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Moisture Sensitive, Hygroscopic<br>Applications 1,2-dimethyl-1H-imidazole-4-sulfonyl chloride (cas# 137049-02-6) is a useful research chemical.<br></p>

<p>Applications 1-(Formamidomethyl)-1H-benzotriazole is a useful reagent for the synthesis 1-​isocyanomethyl azoles and related compounds.<br>References Saikachi, H., et al.: Chem. Pharm. Bull., 31, 723 (1983)<br></p>

<p>Applications 6-bromo-5-iodopyridine-3-carboxylic acid (cas# 1200130-82-0) is a useful research chemical.<br></p>

<p>Applications 2-(3,5-Dichlorophenyl)-imidazo[1,2-a]pyridine is derived from Ethyl Bromoacetate (E900140), which is used in the synthesis of metabolites of carcinogenic PAHs. Also it is used in the preparation of steroidal antiestrogens through cyclic condensation. A reactant in the preparation of antimicrobial and antioxidant coumarinyloxymethyl-thiadiazolone.<br>References Wu, A. et al.: Tetrahedron, 68, 7217 (2012); Clark, E. et al.: J. Med. Chem., 20, 1096 (1977); Al-Amiery, A. et al.: Chem. Nat. Comp., 48, 950 (2013);<br></p>

<p>Impurity Flecainide EP Impurity B<br>Applications 2-Piperidinemethanamine is used in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. It also is used in the synthesis of potent antibacterial.<br>References Reddy, G. et al.: Hetero. Chem., 23, 247 (2012); Fujita, M. et al.: Chem. Pharm. Bull., 46, 787 (1998);<br></p>

<p>Applications 4-Bromo-2-(trifluoromethyl)pyridine is used in the synthesis of a potent and selective Class IIa histone deacetylase inhibitors as a potential therapy for Huntington’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Burli, R.W., et al.: J. Med. Chem., 56, 9934 (2013)<br></p>

<p>Applications An intermediate of Rosuvastatin (R700500).<br></p>

<p>Applications Diethyl Pyridine-2,3-dicarboxylate is a useful reagent in preparation of herbicides.<br>References Doehner, R.: Eur. Pat. Appl. (1988), EP 254951 A2 19880203.<br></p>

<p>Applications 3-Bromopicolinic Acid Sodium Salt (cas# 1189933-55-8) is a compound useful in organic synthesis.<br>References See mercaptopicolinic acid file<br></p>

<p>Applications (2,3-Dimethylpyridin-4-yl)boronic Acid is used to prepare substituted azaanthracene derivatives as GLP-1 receptor modulators useful in the treatment of GLP-1 receptor-mediated diseases<br>References Mjalli, A., et al.: PCT Int. Appl. (2010), WO 2010114824 A1 20101007<br></p>

<p>Applications 2-Oxo-2-(1-phenyl-1H-pyrazol-4-yl)acetic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.<br>References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)<br></p>

<p>Stability Light Sensitive<br>Applications 5-Amino-3-methylpyrazole (cas# 31230-17-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Amino-1,5-dimethylpyrazole is used in the preparation of pyridine compounds as focal adhesion kinase inhibitors.<br></p>

<p>Stability Light Sensitive<br>Applications 4-(1-Naphthylvinyl)pyridine (cas# 16375-56-7) is a useful research chemical.<br></p>

<p>Applications 4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzenamine is one of the key reactants with N-[1-(4-Aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide used in the synthesis of a pyrrolo[3,2-c]pyridine derivative [N-[1-[4-[[[[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide (I)], an anticancer diarylurea derivative with multiple-kinase inhibitory effect; Also, it is an intermediate used in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References El-Gamal, M. I., et al.: Bull. Korean Chem. Soc., 33, 1571-1576 (2012); Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications A reagent in the preparation of 4-phenyl-tetrahydrophenyl substituted oxazolidinone derivatives with potent central nervous depressant, analgetic, and antiinflammatory activities as well as α1A adrenergic receptor antagonists.<br>References Welstead, W.J. et al.: J. Med. Chem., 16, 1129 (1973); Lagu, B. et al.: J. Med. Chem., 43, 2775 (2000);<br></p>

<p>Applications 5-Chloro-6-(2,3-dichlorophenoxy)-1,3-dihydro-2H-Benzimidazole-2-thione is used in the preparation of triclabendazoles which are drugs used to treat liver fluke.<br>References Iddon, B., et al.:Journal of the Chemical Society 22, 3129 (1992);<br></p>

<p>Applications 1,3-Dimethyl-1H-pyrazole-4-carboxylic acid<br></p>

<p>Applications 3-Cyano-4-oxo-piperidine-1-carboxylic Acid tert-Butyl Ester is a useful research reagent for organic synthesis and other chemical processes.<br>References Guo, X., et al.: Molecules, 16, 2626 (2011); Chai, Y., et al.: Bioorg. Med. Chem. Lett., 20, 5195 (2010); Chai, Y., et al.: Bioorg. Med. Chem. Lett., 21, 3377 (2011)<br></p>

<p>Applications 5-Amino-1-tert-butyl-3-(3-methylbenzyl)-4-cyanopyrazole (cas# 1185162-28-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Used in the preparation of heterocyclic compounds of pharamaceutical interest.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Di Fabio, R., et al.: J. Med. Chem., 51, 7370 (2008), Vaccaro, W., et al.: Bioorg. Med. Chem. Lett., 18, 6381 (2008),<br></p>

<p>Applications 4-[4-[(5R)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride is an intermediate in the synthesis of ent-Rivaroxaban (R538005), the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent.<br>References Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>

<p>Applications 1-Ethyl-2-piperazinone is used in the synthesis of piperidine and piperazine derivatives as cognition enhancers.<br>References Bioorg, Med. Chem., 16, 1431 (2008);<br></p>

<p>Applications 1,3-Dimethyl-2-imidazolidone, is a solvent used in various synthetic organic transformations. Studied in the formation of functionally stabilized hydrosilanediyl-transition metal complexes produced photochemically from arylsilanes.<br>References Mukaiyama, T., et al.: Chem. Lett., 1507 (1980); Seebach, D., et al.: Chem. Ber., 115, 1705 (1982);<br></p>

<p>Applications 4-Aminothieno[3,2-d]pyrimidine is a useful research intermediate<br>References Robba, M., et al.: Tetrahedron, 27, 487 (1971); Park, J. H., et al.: Heterocycles, 91, 835 (2015)<br></p>

<p>Applications 1-(Oxazol-2-yl)ethanone is a benzimidazole derivatives which is used as regulators of steroid receptor coactivators<br>References O'Malley, Bert W. et al.,PCT Int. Appl. (2017);<br></p>

<p>Applications 3-Hydroxymethyl-(1-oxy-2,2,5,5-tetramethylpyrroline)-15N is an isotope labelled spin-labelling compound.<br></p>

<p>Applications 2-Acetyl-6-bromopyridine is used in the synthesis of some embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors.<br>References Kantevari, S. et al.: Bioorg. Med. CHem., 19, 4772 (2011);<br></p>

<p>Applications Ethyl 4-Methyl-1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylate is an intermediate used in the synthesis of 4-Methyl-1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylic Acid (M339120), which is an impurity of the drug Amphetamine (A634248).<br></p>

<p>Applications 3-(2,6-Dimethylphenyl)-2-oxazolidinone is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications 3-Chloro-2,5-difluoropyridine is an intermediate used to prepare selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseases.<br>References Jimenez, J., et al.: J. Med. Chem., 56, 1799 (2013)<br></p>

<p>Applications 2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liau, B. et al.: J. Am. Chem. Soc., 134, 16765 (2012); Tatsuta, K. et al.: Tetrahedron Lett., 53, 422 (2012);<br></p>

<p>Applications 3-Aminopicolinic Acid (cas# 1462-86-8) is a compound useful in organic synthesis.<br>References Dominguez, C., et al.: Bioorg. Med. Chem. Lett., 17, 6003 (2007), Stukenbrock, H., et al.: J. Med. Chem., 51, 2196 (2008),<br></p>

<p>Applications Intermediate in the preparation of Losartan derivatives.<br></p>

<p>Applications 3-Bromo-5-hydroxypyridine (cas# 74115-13-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Isotope labelled B-[1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]boronic Acid is used in the preparation of ALK receptor mediators.<br></p>

<p>Applications 7-(3-Bromophenyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (cas# 933054-30-9) is a compound useful in organic synthesis.<br></p>