Eterocicli con azoto (N)

<p>Applications 3,4-Dihydro-4-hydroxy-1(2H)-pyridinecarboxylic Acid Ethyl Ester is a synthetic intermediate/reactant in the synthesis of streptazolin.<br>References Kozikowski, A., Park, P.: J. Org. Chem., 55, 4668 (1990);<br></p>

<p>Applications 4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine is an important intermediate in the preparation of the janus kinase inhibitor INCB018424.<br>References Lin, Q. et al.: Org. Lett., 11, 1999 (2009);<br></p>

<p>Applications 1-Benzoyl-4-(2,3-dichlorophenyl)piperazine is an intermediate in the synthesis of Aripiprazole (A771000) related compound.<br>References Satyanarayana, Bollikonda. et al., Heterocyclic. Commun., 11, 485 (2005);<br></p>

<p>Applications Piperazine-d10 (CAS# 362049-61-4) is a useful isotopically labeled research compound.<br></p>

<p>Stability Light Sensitive<br>Applications 5-Amino-3-methylpyrazole (cas# 31230-17-8) is a compound useful in organic synthesis.<br></p>

<p>Applications tert-butyl 6-chloropyridazine-3-carboxylate (cas# 1340506-55-9) is a useful research chemical.<br></p>

<p>Applications (2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile-d1 is the deuterated form of (2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile (C363780), which is a key intermediate for dipeptidyl peptidase IV inhibitor Vildagliptin (V305000).<br>References Singh, S.K., et al.: Beil. J. Org. Chem., 4, 20 (2008);<br></p>

<p>Applications 3-{5,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl}propanoic Acid (cas# 832135-73-6) is a useful research chemical.<br></p>

<p>Applications 2-PHENYLPIPERAZINE 2HCL (cas# 872139-22-5) is a useful research chemical.<br></p>

<p>Applications 1-(2,4-Difluorophenyl)-2-(4H-1,2,4-triazol-4-yl)-ethanone is an intermediate in the synthesis of so Fluconazole (Fluconazole EP Impurity A) is an impurity of Fluconazole (F421000). Fluconazole USP impurity A.<br>References Rogers, T., et al.: Antimicrob. Agents Chemother., 30, 418 (1986), Itoh, H., et al.: Chem. Pharmaceut. Bull., 48, 1148 (2000),<br></p>

<p>Applications N-(2-Chloroethyl)-N'-(4-pyridinyl)urea (cas# 62491-96-7) is a useful research chemical.<br></p>

<p>Applications 4-(3-Pyridinyl)-3-buten-1-amine is a useful synthetic intermediate.<br></p>

<p>Applications 5-Methyl Tetrazole is used in the preparation of novel antifungal agents based derived from N-iodopropargylazoles and N-triiodoallylazoles. 5-Methyl Tetrazole also in the preparation of novel quinoline derivatives against mycobacterium tuberculosis.<br>References Koyama, M. et al.: J. Med. Chem., 30, 552 (1987); Upadhayaya, R. et al.: Bioorg. Med. Chem., 17, 2830 (2009);<br></p>

<p>Applications Octahydro-1H-pyrrolo[3,4-b]pyridine-d2 Di-trifluoroacetate is an intermediate in the synthesis ofhybrid antibacterial agents that exhibits inhibitory activities towards DNA Polymerase-Topoisomerase.<br>References Zhi, C.X., et al.: J. Med. Chem., 49, 1455 (2006);<br></p>

<p>Applications 2-Dimethylamino-4-hydroxy-6-aminopyrimidine (cas# 76750-84-0) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide -d4 is labelled N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide (C988880) which was shown to exhibit regulatory effects towards the expression of pH sensing G protein-coupled receptor-68 and is now a new drug target for ischemic heart disease.<br>References Russell, J.L., et al.: ACS. Chem. Biol., 7, 1077 (2012); Schneider, J.W., et al.: ACS. Chem. Neurosci., 3, 557 (2012);<br></p>

<p>Applications 1-Ethyl-3-piperidinamine is an intermediate of 4-Amino-N-(1-ethyl-3-piperidinyl)-5-(ethylsulfonyl)-2-methoxybenzamide (A609495).<br>References Elslager, E.F., et al.: J. Med. Chem., 24, 127 (1981),<br></p>

<p>Applications 4-Bromo-2-(trifluoromethyl)pyridine is used in the synthesis of a potent and selective Class IIa histone deacetylase inhibitors as a potential therapy for Huntington’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Burli, R.W., et al.: J. Med. Chem., 56, 9934 (2013)<br></p>

<p>Applications 2,2,6,6-tetramethylpiperidin-4-one hydrochloride (cas# 33973-59-0) is a useful research chemical.<br></p>

<p>Applications 2-(DIMETHYLAMINOMETHYL)-PYRIDINE (cas# 43071-19-8) is a useful research chemical.<br></p>

<p>Applications N-[1-(6-Benzothiazolyl)-2-methyl-1H-benzimidazol-5-yl]acetamideis used in the synthesis of 6-N-aryl and heteroaryl benzthiazoles as potential anthelmintics.<br></p>

<p>Stability Hygroscopic<br>Applications 1,3-Dibenzyl-1H-benzo[d]imidazol-3-ium Chloride is a useful reagent in the preparation of the antimicrobial benzimidazolium compounds via N-alkylation of benzimidazoles with benzyl chloride.<br>References Meng, J. P., et al.: Adv. Mat. Res., 554, 1686 (2012)<br></p>

<p>Applications An intermediate for the preparation of isotope Labelled Haloperidol.<br></p>

<p>Applications 4-Amino-3,5-bis(4-pyridyl)-1,2,4-triazole can be used to prepare cadmium aminoisophthalate pyridinyltriazolamine metal-organic frameworks for detection applications. It has also been utilized to synthesize a linear trinuclear Cu(II) complex with magnetic properties.<br>References Wang, H., et al.: RSC Adv. 5, 48881 (2015); Zhang, Q., et al.: J. Coord. Chem. 64, 2110 (2011)<br></p>

<p>Applications 3-Hydroxypyrrolidine, HCl<br></p>

<p>Applications 3-Bromopyridine N-Oxide (cas# 2402-97-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,3-Dimethyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine is used in the preparation of a pluripotent stem cell inhibitor.<br>References Furukawa, Yusuke. et al., Jichi Medical University(2019);<br></p>

<p>Applications 1H-1,2,4-triazol-5-ol (cas# 930-33-6) is a useful research chemical.<br></p>

<p>Applications bis(4-(2-Methoxyphenyl)piperazine-1-carboximidamide) Sulfuric Acid is an aminopyrimidines derivatives that are used as glycogen synthase kinase 3 inhibitors<br>References Nuss, John M. et al., U.S. Pat. Appl. Publ. (2002)<br></p>

<p>Applications An intermediate in the preparation of Candesartan. Also used in the synthesis of novel biphenyltetrazole derivatives.<br>References Chao, S. et al.: J. Chin. Chem. Soc., 52, 539 (235);<br></p>

<p>Applications Sulfosuccinimidyl Palmitate Sodium is an analog of Sulfosuccinimidyl Oleate Sodium (S689200).<br></p>

<p>Applications 3-(1H-imidazol-4-yl)propanoic acid (cas# 1074-59-5) is a useful research chemical.<br></p>

<p>Applications N1,N4-Bis[2-(phenylthio)phenyl]-1,4-piperazine-d8-dicarboxamide is the labeled analog of N1,N4-Bis[2-(phenylthio)phenyl]-1,4-piperazinedicarboxamide (B522635), an impurity of Quetiapine (Q510000), a benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties; used as an antipsychotic.<br>References Stolarczyk, E.U., et. al.: Pharm. Develp. Tech., 14, 27 (2009); Wetzel, H., et al.: Psychopharmacology, 119, 231 (1995)<br></p>

<p>Applications 4-(1-Piperazinyl)-1H-indole Dihydrochloride (cas# 84807-09-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(3-(5-Oxo-2-(trifluoromethyl)-2,5-dihydrooxazol-4-yl)propyl)guanidine is an intermediate in the synthesis of δ-Guanido-α-ketovaleric Acid (G412100), a useful flavouring ingredient and a component of Cheddar cheese flavour.<br>References Van den Ouweland, G., et. al: PCT Int. Appl. WO 9610927 A1, 19960418 (1996); Ney, K., et, al.: Eur. Food Res. Technol., 146, 337 (1971)<br></p>

<p>Applications Ethyl 1-(4-(aminosulfonyl)phenyl)-3-(trifluoromethyl)-5-p-tolyl-1h-pyrazole-4-carboxylate<br></p>

<p>Applications 2-Pivaloylamino-3-(α-hydroxybenzyl)pyridine (cas# 86847-67-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Phenyl-3-pyrrolidinone-d5 is the isotope labelled analog of 1-Phenyl-3-pyrrolidinone (P336730); a reagent used in the synthesis of a series of non-classical antifolates which were evaluated for their in vitro cytotoxicity. Also used in the preparation of azetidine- and pyrrolidine-containing alkynes as mGluR5 regulators.<br>References Huang, Y., et al.: Bioorg. Med. Chem., 11, 145 (2003); Chen, L., et al.: PCT Int. Appl. WO 2014124560 A1 20140821. Aug 21, 2014<br></p>

<p>Applications 3-Bromo-6-ethynylpyridazine (cas# 1797130-79-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrolo-3-acetic Acid (cas# 76194-00-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Isoxazolo[5,4-b]pyridin-3-amine<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Pyrazinecarbonyl Chloride is an intermediate used in the synthesis of (S)-N-[1-(3-Hydroxy-3-methylbutanamido)-1-oxo-3-phenylpropan-2yl]pyrazine-2-carboxamide (H805105), which is an impurity of bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.<br></p>

<p>Applications 6-Bromopiperonal is a disubstituted 1,3-benzodioxole that displayed synergistic activity with carbaryl on houseflies. 6-Bromopiperonal is used as an intermediate in the preparation of GPR30-selective agonist G-1.<br>References Wilkinson, C.F. et al.: J. Agric. Food Chem., 15, 139 (1967): Hewlett, P.S. et al.: J. Sci. Food Agric., 18, 279 (1967); Burai, R. et al.: Org. Biomol. Chem., 8, 2252 (2010);<br></p>

<p>Applications 6-Nitropyrido[2,3-d]pyrimidin-4(3H)-one is a useful research chemical for organic synthesis and other chemical processes.<br></p>

<p>Applications 4-(3-Fluorophenyl)pyrimidin-2-amine (cas# 56875-59-3) is a useful research chemical.<br></p>

<p>Applications 2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride (cas# 169905-10-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(3-Aminophenyl)pyridine Dihydrochloride<br></p>

<p>Applications 5-(4-Bromophenyl)-4,6-dichloropyrimidine is a reactant used in the synthesis of Macitentan, an orally active dual endothelin receptor antagonist.<br>References Bolli, M. et al.: J. Med. Chem., 55, 7849 (2012);<br></p>

<p>Applications 6-Fluoro-4-methyl-2-pyridinamine can be synthesized from 2,6-Dichloro-4-methylpyridine (39621-00-6).<br></p>