Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Bicyclo[2.2.1]heptan-2-ol is a ternary compound that has been synthesized by the reaction of trifluoroacetic acid with hydrochloric acid and methyl ethyl ketone. This type of polymerization reaction is highly reactive, leading to an increase in kinetic energy and deuterium isotope effects. The steric interactions between the carbonyl group and the olefin double bond are also important in this process.</p>

<p>1,6-Diaminohexane-N,N,N²,N²-tetraacetic acid (DAHA) is a metal chelator that binds to the metal ions of copper and nickel. It has minimal toxicity and is used to prepare biological samples for analysis. DAHA binds to metal ions in the presence of glycol ethers or fatty acids. This complex is then separated by particle size using a centrifuge or liquid chromatography. DAHA can be used as an antimicrobial agent against bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Heptane-4-thiol is a hydroxyethyl crosslinked, cross-linked, expressed, isomer, transition, sulfide. The crystal structure of this molecule has been determined using X-ray diffraction and it was found to be a potent inhibitor of the transferase enzyme. The isomers of heptane-4-thiol are also studied in order to find out how they affect the biological activity of the molecule. Heptane-4-thiol has been shown to inhibit the human enzyme acid lipase and has a heat resistance that allows for it to be used in industrial processes.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Dec-9-ynoic acid is a synthetic fatty acid that is a precursor to several biologically important substances. It is labile and easily oxidized by air, light, or heat. Dec-9-ynoic acid has been shown to be a central metabolic intermediate for the biosynthesis of polyunsaturated fatty acids. It can also be converted into linolenic acid, which is an essential fatty acid that cannot be synthesized by humans. Dec-9-ynoic acid exists in two geometric isomers: cis and trans. The cis form exhibits kinetic properties that are different from the trans form. Dec-9-ynoic acid has been studied as a potential treatment for human diseases such as diabetes mellitus type 2, Parkinson's disease, Alzheimer's disease, schizophrenia, and depression.</p>

<p>2-Amino-4,6-di-tert-butylphenol is a phenolic compound that has antiviral properties. It reacts with nucleophiles to form 2-amino-4,6-di-(tertiary butyl)phenoxide and 2,4,6-triaminophenol. The functional theory for the antiviral activity of 2-amino-4,6-di-(tertiary butyl)phenol is based on its ability to react with nucleophiles and form products that inhibit viral replication. This agent has been shown to be effective against Mycobacterium tuberculosis and Mycobacterium avium complex in cell culture studies. 2AAP inhibits the growth of human cancer cells in vitro by blocking the synthesis of DNA and RNA. It also inhibits protein synthesis by binding to methylamine groups in proteins and inhibiting the release of aminoacyl adenosine triphosphate (ATP</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,2,2-Trifluoro-1-(naphthalen-2-yl)ethan-1-ol is a diastereomerically pure compound that can be synthesized in high yield. It is a precursor to other compounds that are used as pharmaceuticals and pesticides. This compound is not commercially available, but it can be prepared from the corresponding alcohol by desilylation followed by enantioselective sulfinylation or trifluoromethylation with the use of chiral fluorinating reagents such as trifluoromethyltrimethylsilane. The sulfinyl group in this molecule has been shown to have an increased diastereoselectivity compared to related substrates.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl benzo[b]furan-2-carboxylate is a synthetic chemical compound that is not found in nature. It has been shown to have potent anticancer activity against a variety of cancer cell lines, including leukemia, prostate, colon, and breast cancer cells. Methyl benzo[b]furan-2-carboxylate inhibits the growth of these cells by inducing programmed cell death (apoptosis) through a mechanism that is different from other anticancer drugs. This chemical also has significant inhibitory activity against alkene and benzofuran derivatives, which are known to be resistant to chemotherapy. Methyl benzo[b]furan-2-carboxylate has not shown any neurotoxicity in animal models and has a good safety profile.</p>

<p>1-Bromo-2,3,5,6-tetramethylbenzene (1-BTTB) is an organic compound that is used as a model system to study the reactivity of methyl groups. 1-BTTB reacts with potassium t-butoxide in a nonpolar solvent to form a cyclic ether product. The reaction is initiated by the addition of hydrogen peroxide. This reaction can be monitored using vibrational spectroscopy and yields nitro groups and imidazole derivatives when it is carried out in the presence of nitric acid or ammonium nitrate. 1-BTTB also has heat resistant properties that make it useful for use in chemical processes involving carbon tetrachloride or hydrogen fluoride.</p>

<p>1,4-Dibromo-2,3,5,6-tetramethylbenzene is a five-membered ring molecule with the chemical formula C8H8Br6. It has been shown to react with dichlorocarbene to form a 1:1 adduct, which is stable at room temperature and can be isolated as a crystalline solid. This compound has been used in the synthesis of perfluorinated compounds. The reaction rate of 1,4-dibromo-2,3,5,6-tetramethylbenzene is affected by electron donating or withdrawing groups on the methyl group. The compound has also been found to have inflammatory effects on diseases such as asthma and arthritis.</p>

<p>2-Bromoethylcyclohexane (2BC) is a heterocycle that has shown antituberculosis activity. This compound inhibits the growth of mycobacteria by inhibiting protein synthesis and cell division, which are vital for bacterial growth. 2BC also has an inhibitory effect on the human papillomavirus (HPV). It binds to the virus' receptor, thereby preventing it from binding to a host cell. 2BC has been shown to be effective against skin cancer cells by inhibiting their proliferation. This heterocyclic compound has fluorescence resonance energy transfer properties and can be used as a marker for DNA double strand breaks in cells.</p>

<p>2-Methyl-2-dodecanol is a reactive chemical that can be used as an additive in metal halides. It has been found to be an effective catalyst for the production of ethylene glycol and other chemicals. The reaction is catalyzed by alkali metals, such as sodium and potassium. 2-Methyl-2-dodecanol can also function as a solvent and has viscosity comparable to water.</p>

<p>6-Methylazulene is a trifluoroacetic acid derivative of azulene that has been used in the synthesis of annulenes and fulvenes. It can be synthesized from carbinols or by cross-coupling with a metal halide. 6-Methylazulene is a reactive intermediate for organic synthesis, which can be used to create new molecules with fluorescent properties. It is also used as a precursor for the synthesis of fulvene and annulene. This compound has two functional groups, an acidic methyl group and an amine group. The molecule adopts a five-membered ring structure with three double bonds around the central carbon atom. The reactivity of this compound is influenced by the presence of electron withdrawing groups at positions 3 and 5, which allow it to undergo nucleophilic substitution reactions more readily than other azulenes. These properties make 6-methylazulene useful in synthetic organic chemistry as well as in</p>

<p>2-Cyanoethyl ether is a chemical compound used for the treatment of wastewater. The compound is prepared by reacting ethylene with hydrogen peroxide in the presence of an alkali metal catalyst. 2-Cyanoethyl ether has been shown to be effective in removing cyanides, acrylonitrile, and other organic compounds from wastewater. The activation energy for this reaction is 22.3 kJ/mol. This chemical can also exist as four isomers: cis-, trans-, syn-, and anti-.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Phenylethylenediamine is a molecule that contains hydrogen bonds. Hydrogen bonds are the covalent interactions between hydrogen atoms and electronegative atoms, like oxygen or nitrogen, in molecules. N-phenylethylenediamine has been shown to have antiinflammatory activity, which may be due to its ability to inhibit prostaglandin synthesis. Hydrogen bonding interactions are also present between carbonyl groups and protonated amines in this molecule. This allows for stereoselective reactions with amines that have a hydrogen atom on an asymmetric carbon atom at the alpha position. It has been isolated as a yield of 34%.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,4-dichlorobenzene-1,2-diamine is a high salt compound that binds to sulfatide and has a molecular weight of 3.2 kilodaltons. It is an agonist for the galactose receptor in muscle cells, which causes stimulation of biochemical properties in the cell. The compound has been shown to be synthetic and expressed in E. coli. 3,4-Dichlorobenzene-1,2-diamine is also used as an immunofluorescent probe for studying the function of galactose receptors in muscle cells. This compound can also be immobilized on polyacrylamide gels to study its interactions with sulfatide.</p>

<p>Versatile small molecule scaffold</p>

<p>1H-Indole-6-carboxamide is a pharmaceutical compound that has been shown to bind to serotonin receptors. It has been studied for its potential use in the treatment of cancer, bowel disease, depression, and inflammatory bowel disease. 1H-Indole-6-carboxamide is a polymorphic chemical compound that exists as an equilibrium mixture of two isomers. The bound form of the drug is more potent than the free form and it binds with high affinity to serotonin receptors. 1H-Indole-6-carboxamide hydrochloride salts are more soluble in water than the free form, making them more efficient for use in humans.</p>

<p>Versatile small molecule scaffold</p>

<p>6-Chloro-4-hydroxy-1,2-dihydroquinolin-2-one is a diazotized aromatic amine. This compound has absorption spectra and acidic properties. It can be used as a precursor to other compounds, including hydrazones and substituted quinolines. 6-Chloro-4-hydroxy-1,2-dihydroquinolin-2-one can also act as an amine or an aromatic amine in the presence of acids or bases. When treated with acid, this compound forms an ionic salt that has a systematic name of 6-(chlorocarbonyl)-4H-[1,2]diazaquinoline 2,4(1H,3H)-dione. This compound also has two tautomers: the keto form and the enol form.</p>

<p>Versatile small molecule scaffold</p>

<p>Benzenesulfonanilide is a compound that is soluble in water. It has potent antagonists against the chemokine receptor CXCR2 and the chemokine CCL5. The molecular weight of benzenesulfonanilide is 212.2 g/mol, and it has a fluorine atom at the 2-position on the benzene ring, a carbonyl group (-C=O) at the 2-position on the benzene ring, and a nitro group (-NO2) at the 3-position on the benzene ring. The structural formula for benzenesulfonanilide is shown below:</p>

<p>Versatile small molecule scaffold</p>

<p>3-Cyclohexene-1-methanol is a fatty acid that is used as a precursor in the synthesis of pharmaceuticals and other chemicals. It has been shown to have antifungal activity against Trichophyton mentagrophytes and Xylomyces sp. It also has been shown to be effective against Staphylococcus aureus, but not against Escherichia coli. 3-Cyclohexene-1-methanol has been shown to reduce the size of tumors in mice by inhibiting cell proliferation through cationic polymerization with DNA. This chemical also inhibits the growth of MCF-7 cells in vitro and can cause cell death by apoptosis. 3-Cyclohexene-1-methanol is soluble in water and insoluble in organic solvents such as chloroform or ether.<br>3CEMM shows x ray absorption at 807 nm, which corresponds to the</p>

<p>10-Hydroxydecanoic acid is a nonsteroidal anti-inflammatory drug that has the ability to inhibit prostaglandin synthesis. 10-Hydroxydecanoic acid has been shown to be effective in treating inflammatory diseases such as arthritis and psoriasis. It is also used to treat lacrimal gland inflammation, and caco-2 cells have been shown to have a maximal response to this drug. 10-Hydroxydecanoic acid is synthesized from trans-10-hydroxy-2-decenoic acid by an acylation reaction with silver ions in a nonpolar solvent, followed by heating. This compound can be separated from other fatty acids using an analytical technique called thin layer chromatography (TLC).</p>

<p>2-Ethyl-5-methylphenol is a natural product that belongs to the class of phenols. It is biosynthesized by the conversion of 2-methylacetophenone, which is found in styrene and exocrine glands in arachnids. This compound has been shown to be toxic to a number of bacteria, including strains resistant to antibiotics such as methicillin and cephalothin. The toxicity of 2-ethyl-5-methylphenol against bacteria may be due to its ability to inhibit protein synthesis and disrupt cellular membranes. The pathways leading from 2-methylacetophenone to 2-ethyl-5-methylphenol involve two steps: nitration followed by ethylation.<br>2E5MP can be synthesized using acetone and 3- methyl1 -butanol as precursors, which are scalable and inexpensive chemicals.</p>

<p>Versatile small molecule scaffold</p>

<p>3,3-Dimethyl-2-benzofuran-1(3H)-one is a benzene derivative with a nitro group. It is an organic compound with the formula C8H8NO2 and can be considered as an aromatic nitro compound. The molecule contains a benzene ring with two methyl substituents at the 3 and 3' positions. The nitro group is located at the 1 position on the benzene ring and it has an electron withdrawing effect on this ring. This molecule also has three nitro groups which are located at the 1, 2, and 4 positions on the benzene ring. These groups have electron donating effects to this ring. <br>The uptake of 3,3-dimethyl-2-benzofuran-1(3H)-one by alkali metal ions has been observed to be catalysed by chloride ions due to its electrophilic nature. The chloride ion is able to stabilize a negative charge that forms on</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Acetylmorpholine is a recycled amide that is synthesized from an alkanolamine and an acylation reaction. It has been used in the dehydrating of organic compounds, such as reaction solution, and for the preparation of acrylamide. 4-Acetylmorpholine is also used as a viscosity control agent in the extraction of aromatic hydrocarbons. Its chemical structure consists of a carbonyl group and an aromatic hydrocarbon. 4-Acetylmorpholine can be synthesized by reacting acetaldehyde with ammonia or thiourea with methyl chloride or ethylene oxide.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(Pyridin-4-yl)propan-1-one is a catalytic, asymmetric, deuterated solvent that is used in the synthesis of various pyridine alkaloids. Its chemical properties are similar to those of other carbonyl compounds, but it can be differentiated by its catalytic properties. This compound has been shown to be effective at low temperatures and is soluble in a variety of solvents. It also has the ability to bind to metal ions such as chloride or potassium. 1-(Pyridin-4-yl)propan-1-one has been shown to promote growth at temperatures below 37°C and can be used in porcine cells.</p>

<p>1-(Pyridin-3-yl)butan-1-one (1PYB) is a naturally occurring compound that has inhibitory effects on the population of acid molecules. It prevents the formation and release of nitrosamines in alkoxycarbonyl, which are carcinogenic compounds. 1PYB has been shown to be an antioxidant marker in human leukoplakia tissue and is also involved in the production of conjugates. 1PYB can bind to liver S9 enzymes, which may inhibit their activity. This drug is used as a sunscreen agent and is also used for its anti-inflammatory properties.</p>

<p>N-Methyl-3-indoleglyoxylic acid 97 is a potent and selective inhibitor of protein kinases, including the mitogen activated protein kinase (MAPK) family. It has been shown to inhibit proliferation of cells in vitro. In addition, N-Methyl-3-indoleglyoxylic acid 97 inhibits the activation of MAPK in response to stress or cytokine stimulation. This agent has been shown to be selective for different isotypes of protein kinases and displays good selectivity for inhibition of the enzyme activity.</p>

<p>2,5-Dichloro-3,4-dinitrothiophene is a crystalline solid with a tetragonal crystal system. It has been shown to form with yields of up to 45%, depending on the solvent. The crystal structure has been determined by X-ray crystallography and it was found to be monoclinic with nitro groups interacting in a manner analogous to nitro groups. Nitration of 2,5-dichloro-3,4-dinitrothiophene has been shown to produce 2,5-dichloro-3,4-dinitrobenzene and 2,5-dichloro-3,4-dinitrophenylhydrazine.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(4-Fluorophenyl)prop-2-en-1-one is a chalcone that has been shown to have anticancer activity. It has been shown to stabilize the response elements of the transcriptional regulatory protein NF-κB and induce apoptosis in colorectal adenocarcinoma cells. This compound is also able to inhibit cancer growth by inhibiting tumor angiogenesis and metastasis. 1-(4-Fluorophenyl)prop-2-en-1-one binds to DNA, preventing transcription and replication, which leads to cell death. 1-(4-Fluorophenyl)prop-2-en-1-one has also been found to bind withaferin A, a molecule that has been shown to have anticancer activity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Isothiourea is an imidazole derivative that acts as a competitive antagonist of histamine H2 receptors. It has been used in the synthesis of cimetidine and other histamine H2 receptor antagonists. Isothiourea inhibits the action of histamine on the H2 receptor by binding to it, thereby preventing its activation. This drug is a synthetic compound that can be made from chloroform and thionyl chloride. It may be synthesized in a two-step process starting with chloromethyl methyl (methylchloro)imidazole, which is reacted with hydrochloric acid to produce 5-(chloromethyl)-4-methyl-1H-imidazole hydrochloride.</p>

<p>2-Bromo-4-isopropylaniline is a spiroindoline that was synthesized by modification of the natural product, bryostatin. The compound has shown experimental activity against encephalomyelitis in mice. However, the mechanism of action is not known. 2-Bromo-4-isopropylaniline has been found to be an activator for ethylene and can catalyze reactions involving diphosphines and ligands. It binds to phenyl substituents on the molecule and forms x-ray crystallographic structures with high resolution. Optimization of the structure may lead to more potent analogs.</p>

<p>Chloro[(chlorocarbonyl)disulfanyl]methanone is a chemical compound that is used in the synthesis of new organic compounds. It is a substrate for cross-coupling reactions with organometallic reagents. Chloro[(chlorocarbonyl)disulfanyl]methanone reacts to form a chloroalkyl sulfide and an alkene, which can be converted into an amide or amine. The reaction mechanism involves nucleophilic attack at the sulfur atom by the metal halide, followed by elimination of chloride ion from the intermediate sulfonium salt to form the desired product. Chloro[(chlorocarbonyl)disulfanyl]methanone has been used in the synthesis of enantiopure compounds that are difficult to obtain through other methods.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Phenylethynyl)aniline is a chemical compound that is insoluble in water and has a reactive crosslink. It is reactive with long-term exposure and has a gel permeation chromatography isolated yield. 3-(Phenylethynyl)aniline can be thermally decomposed to phenylethanethiol, which is an exothermic reaction. The technique of nmr spectroscopy can be used to study the reactivity of this compound. 3-(Phenylethynyl)aniline exhibits specific spectral features that can be used to identify it by nmr spectroscopy.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Azabicyclo[2.2.2]octane-3-carbonitrile (1ABOC) is a hydrolyzing antihistamine that is used to treat allergies in the eye. This drug binds to histamine H1 receptors and blocks the release of histamine from mast cells, thereby preventing allergic symptoms. 1ABOC also has anti-inflammatory properties and may be useful for treating inflammatory disorders.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-ylhydrosulfide is a compound that is used in the synthesis of fonamide. It is a sugar with nitrification and nitrogen metabolism activity. 5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-ylhydrosulfide can be converted to ammonium hydroxide by reaction with hydroxide or carbon disulfide. The resulting product can be further converted to amides by an amine or ethanol. The structure of this compound is similar to that of fonamide and may have antiinflammatory properties.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Benzoyl-3-phenylaziridine is a heterocyclic compound that is obtained by the condensation of benzoyl chloride and phenylamine. It is used in the synthesis of azomethine dyes, which are mainly used as textile dyes. The ammonium salt of 2-benzoyl-3-phenylaziridine can be obtained on refluxing the hydrate with thiocyanate and acetonitrile. This transformation has been shown to be dependent on pH with an optimum at pH 8.5.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Bromo-2-chloronaphthalen-1-amine is a chemical compound that can be synthesized from acetone and chlorides. The reaction proceeds via a nucleophilic substitution reaction in which one of the chlorine atoms is replaced by an electron pair from acetone. This process occurs when the substituent on the naphthalene ring is not sterically hindered, and it is therefore necessary to use substituents that are electron donors, such as methyl or ethyl groups. 4-Bromo-2-chloronaphthalen-1-amine has been synthesized in Japan by reacting acetone with sodium chloride and bromine at high temperature and pressure. The solvent used was benzene, which was removed after the reaction was complete.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methylbenzene-1,3-dicarbaldehyde is a divalent hydrocarbon that has an oxidation catalyst. This compound is used as an intermediate in the production of drugs and pharmaceuticals. It has been shown to have cardiovascular disorders, such as vasodilatation and hypotension. The mechanism of action is not fully understood but may be related to its ability to act as a nitrovasodilator by increasing nitric oxide (NO) release. 2-Methylbenzene-1,3-dicarbaldehyde also produces psychotic disorders when long term exposure occurs. This compound has been shown to have neurotoxic effects in animal models with long term exposure.</p>

<p>4-Methyl-3-phenylpentanoic acid is a chiral, enantioselective catalyst. It is catalyzed by rhodium and used in the asymmetric synthesis of β-unsaturated amides. This reaction is an example of an esterification that is catalyzed by a chiral, enantioselective reagent. 4-Methyl-3-phenylpentanoic acid has also been shown to be effective for the synthesis of chiral esters.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Chloro-2-methylbutanoyl Chloride is a thiolactone that is used in the synthesis of dl-homocysteine. It is an environmental pollutant and can be found in the distillate from chlorinated solvents. 4-Chloro-2-methylbutanoyl Chloride reacts with chloride to form an environmentally hazardous reaction product. This chemical has been used as a medicine, but it has not been approved by the FDA for use in humans.</p>

<p>Versatile small molecule scaffold</p>