Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Chloro-4-nitrobenzene-1-sulfonamide is a potent antiproliferative agent that binds to the bcl-xl protein and inhibits cancer cell growth. It has been shown to induce apoptosis in cancer cells, and has been found to inhibit the expression of the mcl-1 protein. 3-Chloro-4-nitrobenzene-1-sulfonamide binds directly to the bcl2 family proteins Bax and Bak, which are involved in regulating apoptosis, leading to cell death. This drug also causes dose dependent inhibition of proliferation in cancer cells at low concentrations while not affecting healthy cells.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3,5-Dimethyldodecanoic acid is a fatty acid with high densities that has potential use in pest control. It is synthesized by the enantioselective addition of malonic acid to oleic acid and it has been shown to be a potent attractant for the target pest. The stereoisomers of 3,5-dimethyldodecanoic acid are active against different pests, which may be due to their ability to bind to specific receptors on the insect's antennae. This compound could also be used as a chromatographic stationary phase for separating stereoisomers.

Versatile small molecule scaffold

2,3-Dihydroxypropyl 4-hydroxybenzoate is a hydrolysis product of the parabens and is an intermediate in the synthesis of 4-hydroxybenzoic acid. The transesterification reaction involved in this process requires glycerol as a byproduct. The chemical stability of 2,3-Dihydroxypropyl 4-hydroxybenzoate has been evaluated using spectroscopy to determine if it can be used as a medicinal preparation. The hydrolysis of this compound occurs at pH values between 6 and 8, with a half-life of 1.2 hours at pH 7.5 and 50°C. This compound is stable when heated to 100°C for 10 minutes or when subjected to light for 3 hours. It also shows no mutagenicity under conditions that induce gene mutation in bacteria (Ames test).

4-[(1S)-1-Hydroxyethyl]phenol is a compound that is metabolized to 4-hydroxymandelic acid and 4-hydroxyphenylglycine by microbial metabolism. This chemical has been shown to be a substrate for the enzyme dehydrogenase, which may be flavoprotein or polyacrylamide gel. The regiospecificity of the reaction was determined through enantiomer analysis of vanillyl alcohol as the product. Enantiomers were separated using a short-chain alkyl ester, although other solvents such as acetone may be used. The eugenol isomers are present in the reaction products and they can be determined by gas chromatography or liquid chromatography with a mass spectrometer detector. 4-[(1S)-1-Hydroxyethyl]phenol has an optimum pH of 7 and its reactivity increases at pH values below 6.5 or above 8.5.

5-Chloro-7-methyl-1,3-benzoxazole-2-thiol is a benzoxazole that has been shown to have high binding affinity for the 5HT3 receptor in the distal colon. It has been proposed as a potential therapeutic agent for irritable bowel syndrome (IBS). This compound may be useful for treating IBS because it has been shown to act as an antagonist of the 5HT3 receptor, which is involved in the regulation of visceral pain. 5Chloro-7-methyl-1,3-benzoxazole-2-thiol does not bind to other receptors and does not show any agonist activity.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Amino-4-bromobenzene-1-thiol is a semiconducting polymer that can be used in devices such as solar cells, transistors, and sensors. It has electron deficient properties and is therefore able to form the backbone of a polymer. 2-Amino-4-bromobenzene-1-thiol is an electron donor that can be used for polymerization reactions with electron acceptors such as indigoid compounds. This compound has been shown to have optical absorption bands in the near infrared region, which are suitable for solar energy conversion applications.

4-(Methoxymethyl)benzaldehyde is an organic chemical compound that has the molecular formula CHO. It can be obtained by catalytic cleavage of 4-hydroxybenzaldehyde with hydrogen chloride in the presence of a nickel catalyst, followed by chlorination and reduction. This chemical is used in pharmaceuticals as a catalyst for reductive cleavage and cyclization reactions. The acidity of 4-(methoxymethyl)benzaldehyde is due to its nitrogen substituents, which are capable of deprotonating the carbon atom adjacent to the carbonyl group. This allows for selective synthesis at the benzylic position. 4-(Methoxymethyl)benzaldehyde is also able to catalyze lithiation reactions because it contains a reactive chlorine atom.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

BI6015 is a fatty acid that inhibits the transcriptional regulation of genes involved in tumorigenesis, cell survival, and drug resistance. It has been shown to inhibit the uptake of glucose and fatty acids by cells. BI6015 also blocks the binding of growth factor-β1 to its receptor, thereby inhibiting signal transduction pathways that regulate cell proliferation and differentiation. BI6015 has been shown to inhibit the activity of enzymes involved in lipid synthesis, which may contribute to its ability to prevent congenital heart disease. This drug has been tested in animal models with promising results but it is not yet known how it will affect human subjects. BI6015 is rapidly absorbed after oral administration and excreted unchanged in urine. The pharmacokinetic properties of this compound have not yet been evaluated in humans.

Versatile small molecule scaffold

Versatile small molecule scaffold

Tetrabenazine is a drug that is used to treat hyperkinesia, a neurological disorder. It decreases the release of dopamine in the brain by binding to and blocking the activity of vesicular monoamine transporter 2 (VMAT2) and inhibits the reuptake of dopamine into synaptic vesicles. Tetrabenazine has been shown to decrease locomotor activity in rats. The clinical relevance of tetrabenazine is not known, but it may have adverse effects on the liver, for example, if taken with anhydrous sodium. Tetrabenazine is not recommended for use in patients with hepatic impairment or with symptoms of liver disease.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

The synthesis of 2-{Cyclopentyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino}acetic acid is accomplished through an asymmetric, stereoselective, catalytic route. The first step in the synthesis is conversion of glycine to the corresponding N-protected glycine methyl ester by reaction with benzyl chloroformate followed by protection of both carboxylic acid groups as FMOC derivatives. The key steps are a diastereoselective hydrogenation of the cyclopentane ring system and an efficient alkylation reaction of the resulting alcohol with 9H-fluoren-9-ol. 2-[Cyclopentyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]acetic acid has been shown to be a potent inhibitor against bacterial growth. It binds to bacterial topoisomerase IV enzyme, which

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold