Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Diphenylmethyl)piperidine is a molecule that has been used to study the effects of dimethylsulfate on pancreatic cells. It can also be used to induce diabetes in humans and animals. 4-(Diphenylmethyl)piperidine binds to chloride ions in the cytoplasm and isomers are formed, which may have an effect on cell morphology and cell toxicity. This drug does not have any pharmacologic activity in humans or animals, but it has been shown to be diabetogenic in animal models.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 3-phenyl-DL-alaninate hydrochloride (3PA) is a potent and selective inhibitor of protein synthesis. It has been shown to inhibit the production of pro-inflammatory cytokines, such as tumor necrosis factor α (TNF-α), in vitro. 3PA is an amide that shows no significant toxicity or adverse effects in rats. This drug inhibits the enzyme activity of protein kinase C, which affects the function of several other enzymes, including cyclooxygenase and lipoxygenase. 3PA also has a skeletal effect by inhibiting the metabolism of amino acids and glycosides. The drug can be formulated as an ester hydrochloride salt for oral administration.

2-[(Ethoxycarbonyl)amino]-3-phenylpropanoic acid is an organic compound that is used as a reagent for the synthesis of esters. It has been used in the synthesis of methylene, carbonic, and chiral pentafluorophenol. 2-[(Ethoxycarbonyl)amino]-3-phenylpropanoic acid has also been shown to be analogous to ethyl chloroformate, yielding high yields with less reactive conditions than ethyl chloroformate. 2-[(Ethoxycarbonyl)amino]-3-phenylpropanoic acid can be used to synthesize active esters such as 1-hydroxybenzotriazole by reacting with n-hydroxysuccinimide and chloroformate.

Versatile small molecule scaffold

1-Phenyl-pyrazolidine-3,5-dione is a synthetic compound that has been synthesized as an analog of the natural product pyrazolidine. It is a potential antibacterial agent that has shown in vitro activity against bacteria such as Escherichia coli and Pseudomonas aeruginosa. 1-Phenyl-pyrazolidine-3,5-dione inhibits protein synthesis by inhibiting tyrosine kinase, which is required for the production of proteins vital to cell division. It also exhibits antiinflammatory properties.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

VPC-14228 is a non-steroidal compound that targets the bromodomain, a protein found in cancer cells. Bromodomain inhibition has been shown to disrupt cancer progression by regulating cellular proliferation and death. VPC-14228 has shown anti-cancer properties in vitro and in vivo models. It can also be taken orally, which makes it an attractive candidate for the treatment of cancers.

Stattic is a small molecule that binds to DNA and prevents the polymerase chain reaction (PCR). Stattic has been shown to have synergistic effects with radiation in the treatment of cancer. Stattic also has pro-apoptotic activity, which leads to the activation of caspases, which are enzymes responsible for apoptosis. Stattic inhibits hyperproliferative disease by binding to DNA and preventing transcription, which prevents protein synthesis from occurring. This drug also has anti-cancer properties due to its ability to bind to DNA and inhibit cellular transformation.

Applications 4-Diazobenzenesulfonic acid (cas# 305-80-6) is a useful research chemical.

Applications 1,3,5-Trifluorotrichlorobenzene is a useful reagent.

4-Acetylimidazole is a histidine analogue that has been shown to have anticancer activity in breast cancer cells. It can react with amines and form imidazoles. The hydroxyl group on the 4-position of the imidazole ring is able to undergo dehydration, which leads to the formation of a chloride ion. This reaction mechanism is reversible and can be used in organic synthesis. 4-Acetylimidazole can also act as an h2 receptor antagonist, although it does not bind to the zwitterionic site of the h2 receptor. NMR spectra show that 4-acetylimidazole exists as a zwitterion in water solution, but becomes a monovalent ion when dissolved in an organic solvent such as methanol or acetone. 4-Acetylimidazole is chemically stable and does not react with poloxamer.