Building Blocks

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

2-Amino-3-phenylpropanamide is a peptide hormone that has been shown to have biological properties in humans. It is the active form of 2-amino-3-phenylpropanoic acid, which is found in the human serum. This compound may be involved in bowel disease and diabetes. The protonated form of this compound binds to the CB2 receptor and inhibits inflammatory responses. 2-Amino-3-phenylpropanamide also has racemase activity and can be used as an amide or sodium salt. It has a ph optimum of 5.5 to 7.5 and exhibits receptor activity when it binds to opioid receptors, such as those that are expressed on peripheral sensory neurons.

Versatile small molecule scaffold

1-[(Oxiran-2-yl)methyl]pyrrolidin-2-one is a chiral compound with two optical isomers. It is an amino acid derivative that can be used as a chiral catalyst for the resolution of racemic mixtures. 1-[(Oxiran-2-yl)methyl]pyrrolidin-2-one is also an ester, which can be hydrolyzed to release an alcohol and carboxylic acid. This product has been shown to have antihistamine properties and is a precursor to branched chain amino acids.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Spiro[2.2]pentane-1-carboxylic acid is an organic compound with the chemical formula C8H14O4. It is a white solid that is soluble in water, alcohols, and ethers. This compound's stereoisomerism can be determined by its ability to rotate plane-polarized light in either the clockwise or counterclockwise direction. Spiro[2.2]pentane-1-carboxylic acid has been used as an acaricide (a chemical agent that kills ticks and mites) against ticks, lice, and fleas. The insecticidal activity of this compound may be due to its ability to disrupt chitin synthesis because it contains carboxylic acid groups that react with amino groups at the chitin chain's end.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

4-Methoxy-2-pyridinecarboxylic acid N-oxide is a ligand that can form complexes with proton, which is an organic solvent. It has been shown to be able to form ternary complex formation with picolinic acid and a variety of acceptors. 4-Methoxy-2-pyridinecarboxylic acid N-oxide has been shown to catalyze the transfer reactions of hydride and catalysis.

2-Phenylpent-4-en-1-amine is an organic compound that is synthesized by the bond cleavage of an amine and a terminal alkyne. It has been used in ligand design, which is the process of creating molecules to bind to a specific biological target. 2-Phenylpent-4-en-1-amine can be used as a chiral catalyst for asymmetric synthesis, making it enantiopure and optically active. The crystal structure of 2-phenylpentaene was determined by X-ray crystallography, which revealed that it has a c–h bond between its two phenyl groups. This bond may have been formed from an interaction with zirconium.

<p>2-Chloro-3,4-dihydronaphthalen-1(2H)-one is a sulfoxide with significant antifungal activity. It has been shown to be effective against Candida albicans and other fungi, including Aspergillus niger and Mucor racemosus. It is commonly used as an electrolyte in electroluminescent devices, such as light emitting diodes (LEDs). The reaction time for the formation of 2-chloro-3,4-dihydronaphthalen-1(2H)-one from potassium sulfate is dependent on the acid catalyst used. Organic chemists have shown that the use of 2-chloro-3,4-dihydronaphthalen-1(2H)-one can inhibit leukotriene synthesis.</p>

<p>1,3-Bis(1-naphthalenyloxy)-2-propanol is a solvated molecule with 1,3-diphenylpropane as the solvent. It has a basicity of 5.4 and an entropy of -10.5 J mol(-1) K(-1). The solubility of 1,3-bis(1-naphthalenyloxy)-2-propanol in organic solvents ranges from 0.03 to 10 g/L. This compound is soluble in acetone, methanol, ethanol and toluene. The experimentally determined enthalpy of vaporization for 1,3-bis(1-naphthalenyloxy)-2-propanol was found to be -12 J mol(-1) K(-1).</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

9H-Carbazol-9-amine is an amine used as a fluorescent probe in the study of Alzheimer's disease. It has been shown to quench fluorescence from other substances, and can be used to detect the presence of chloride ions. 9H-Carbazol-9-amine has been shown to bind to DNA via hydrogen bonding, which may help elucidate the mechanism by which it inhibits the production of amyloid beta peptides and prevents neuronal cell death. 9H-Carbazol-9-amine is also a cholinergic agent that binds to acetylcholine receptors on nerve cells and increases their activity.

N-Methyl-1H-benzo[d]imidazol-2-amine is a drug that has analgesic and antiinflammatory effects. It is used in the treatment of pain, inflammation, or fever. This active form has been shown to inhibit prostaglandin synthesis by oxidizing cyclooxygenase. N-Methyl-1H-benzo[d]imidazol-2-amine also inhibits the synthesis of inflammatory mediators such as leukotrienes and prostaglandins. The compound has significant activity against carrageenan induced paw edema in rats. The oral bioavailability of this compound is high and it can be taken orally with no adverse side effects.

Versatile small molecule scaffold

2-(4-Methylphenyl)-1,3-thiazole-4-carboxylic acid is a chlorinated compound that has been shown to have anticancer activity. It is structurally modified to increase its potency and has been shown to inhibit cancer cell proliferation in vitro. 2-(4-Methylphenyl)-1,3-thiazole-4-carboxylic acid has been used in the treatment for breast cancer and prostate cancer. This drug also has anticancer effects on the mcf7 cell line, which is an immortalized human mammary epithelial cell line. The mechanism of action of this drug is very similar to that of other anticancer agents: inhibiting DNA synthesis by interfering with DNA replication or by inducing apoptosis.

Versatile small molecule scaffold

3,5-Dichlorothiophenol is a potent inhibitor of the enzyme acetylcholinesterase. As an inhibitor of the enzyme, it blocks the breakdown of acetylcholine and leads to accumulation of acetylcholine at nerve endings. This can lead to death by asphyxiation. Acetylcholinesterase inhibitors such as 3,5-dichlorothiophenol are used in insecticides and chemical warfare agents. 3,5-Dichlorothiophenol has been shown to inhibit the enzyme acetycholinesterase in a dose-dependent manner in vitro with an IC50 of 8 μM. It has also been shown that 3,5-dichlorothiophenol can be used in surface-enhanced Raman spectroscopy (SERS) for detection of metal ions on surfaces.

<p>2,3-Dichlorobenzenethiol is an organic compound that is used as a reagent in the synthesis of polymers. It inhibits HIV infection by inhibiting viral replication through the inhibition of reverse transcriptase and protease enzymes. This chemical has been used as a standard in analytical methods for estimating the inhibitory effect of substances on these enzymes. 2,3-Dichlorobenzenethiol also has an inhibitory effect on cyclohexane ring formation and polymerization initiation. It is also an important intermediate for the synthesis of naphthalene.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>2,​3-​Dihydro-3-​thiopheneacetic acid 1,​1-​dioxide is a nucleophilic reagent that can be used to synthesize amides. It reacts with amines to form 2,​3-​dihydro-3-​thiophenecarboxylic acid 1,​1-diamide. Reactions of this compound with heterocycles such as pyridine and quinoline result in the formation of heterocyclic amines.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>3,4-Dichlorothiophene is a quinonoid compound that is synthesized from 3,4-dichlorobenzene and hydrogen sulphide. The reaction of the two compounds with persulphate, followed by hydrolysis and silver nitrate, yields 3,4-dichlorothiophene as a yellow liquid. This product can be treated with alkanoic acid or alkylated with an alkyl halide to produce homologues. 3,4-Dichlorothiophene reacts with ammonia in the presence of sodium amide to produce a mixture of amides. The reaction can also be carried out in the presence of diazotisation and nitration to form heterocycles.</p>

Versatile small molecule scaffold

<p>5-Amino-4-chloro-2-methyl-2,3-dihydropyridazin-3-one is a metabolite of carbamazepine and caffeine. It is not an active compound, but it has been found to be a potent inhibitor of the enzyme aromatase. This inhibition prevents the conversion of androstenedione to estrone and testosterone to estradiol, which are hormones that regulate sex characteristics in humans. It is possible that this inhibition may be responsible for some of the side effects associated with high doses of these medications. 5-Amino-4-chloro-2 methyl 2,3 dihydropyridazine has also been shown to inhibit the growth of bacteria in vitro.</p>

<p>3-Chloro-4,6-dimethylpyridazine is a chlorinated derivative of the pyridine family of compounds. It has been synthesized by the reaction of azides with sulfur and aminopyridazines with cinnolines. 3-Chloro-4,6-dimethylpyridazine can be used in research as a medicinal agent for treating bacterial infections. It also has anti-inflammatory properties that are related to its ability to inhibit prostaglandin synthesis. The compound was found to have potent antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) and Clostridium perfringens.</p>

<p>Versatile small molecule scaffold</p>

1-Cyclohexyl-1-propanol is an organic compound that is a colorless liquid with a sweet, etherial odor. It has been used in pharmaceutical preparations as a solvent and as an intermediate for the production of other compounds. 1-Cyclohexyl-1-propanol has been shown to have effects on the bladder muscle and detrusor muscle, which may be due to its ability to inhibit the activity of amines. The compound also forms enantiomers, which are stereoselective and react differently in multiphase reactions.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Butyl-2-methylphenol is a phenolic compound that is found in the essential oils of plants such as rosemary. It has been shown to inhibit the growth of animal cells, and this effect may be due to its ability to induce apoptosis. 4-Butyl-2-methylphenol also inhibits the production of basic fibroblast growth factor and epidermal growth factor by inhibiting protein synthesis and DNA synthesis. This chemical is an analog of platelet derived growth factor and has been shown to stimulate angiogenesis in vitro. 4-Butyl-2-methylphenol has been found to increase vessel density in animals when applied topically.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>