Building Blocks

Versatile small molecule scaffold

2-p-Tolyloxazole is a soluble drug, which is a benzyl derivative of p-tolyloxazole. It has an acidic character and can be dissolved in solvents such as dimethyl sulfoxide, dimethylformamide, and acetone. 2-p-Tolyloxazole has been shown to be effective against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. 2-p-Tolyloxazole is also active against Gram negative bacteria such as Escherichia coli and Pseudomonas aeruginosa. The mechanism of action of this compound is not well understood but it is hypothesized that the drug interacts with the ribosome to inhibit protein synthesis.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

4-Azidophenylacetic acid is a glutamate receptor antagonist that has been shown to be selective for the AMPA receptor. It has been shown to inhibit the production of inflammatory mediators, such as prostaglandin E2, from cells by inhibiting COX-2. 4-Azidophenylacetic acid also inhibits the binding of glutamate to its receptors and blocks NMDA receptors. The compound has been shown to be biodegradable, due to its reversible binding with proteins and nucleic acids. This drug has shown inhibitory potency against COX-2 and is being developed as an anti-inflammatory drug.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

1-(Ethanesulfonyl)piperazine is an oxidation product of ethylsulfonyl. It is used to inhibit the synthesis of chemokines and proteins, which are involved in inflammation. 1-(Ethanesulfonyl)piperazine has been shown to cause the release of chemokines from human serum albumin and inhibit protein synthesis in gram-negative bacteria. The absorption spectra show that this compound is able to bind to albumin at the N-terminal site and S-site, which may account for its ability to inhibit protein synthesis. 1-(Ethanesulfonyl)piperazine is also able to interact with methoxy groups on s. aureus cells, preventing them from introducing themselves into human cells by binding to the surface of these cells and blocking their adhesion sites.

1-Carboxymethylcyclopentane-1,1-dicarboxylic acid is a crosslinker that can be used for the production of polymers. It is biodegradable and can be hydrolyzed under alkaline conditions. 1-Carboxymethylcyclopentane-1,1-dicarboxylic acid reacts with an alkynyl group to form a polycarboxylic acid. This reaction product may be a monocarboxylic or dicarboxylic acid. 1-Carboxymethylcyclopentane-1,1-dicarboxylic acid has been used as a viscosity enhancer and crosslinking agent for various polymers. This compound is also an effective polymerization initiator for the production of silicone elastomers.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Methyl 2-[3-(benzyloxy)phenyl]acetate (MBPCA) is a patent-pending lead compound with potential pharmacological applications as an inhibitor of acetyl-coa carboxylase. MBPCA has been shown to reduce plasma triglyceride levels in subchronic studies and is being developed as a potential treatment for hypertriglyceridemia. MBPCA has been shown to be effective against high fat diet-induced obesity, increasing the level of fat oxidation and reducing body weight gain. The pharmacokinetic properties of MBPCA are currently being optimized, including parameters such as bioavailability, volume of distribution, and clearance.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>3H-Benzotriazole-4-carboxylic acid is a copper chelator that has been used to study the reactivity of copper and its complexes. It is known to be reactive with hydroxyl groups, fatty acids, glycol ethers, and amines. 3H-Benzotriazole-4-carboxylic acid inhibits the growth of bacteria by binding to enzymes such as fatty acid synthase and acyl coenzyme A:cholesterol acyltransferase. This chemical binds to copper ions in enzyme active sites and prevents them from catalyzing biological reactions. 3H-Benzotriazole-4-carboxylic acid is also able to inhibit hydrogen fluoride production through its ability to bind hydrogen atoms.</p>

5-Bromo-2-deoxyuridine (5BrdUrd) is a nucleoside analog that is used for labeling DNA in the laboratory. It is a potent inhibitor of DNA synthesis and has been shown to be effective against cancer cells. 5BrdUrd is synthesized by coupling 5-bromouracil with an alcohol, typically bovine serum albumin, in the presence of glutathione. The product can then be isolated as its sodium salt. 5BrdUrd can also be prepared from cisplatin, which has been shown to have anticancer properties. Cisplatin binds to DNA and inhibits replication and transcription by inhibiting polymerase activity and causing crosslinking of DNA strands. This inhibition causes cell death through necrosis or apoptosis. 5BrdUrd is a better choice for labelling because it does not cause cellular toxicity in tissues or animals, as cisplatin does.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N'-Methyl-N'-oxobenzenecarboximidamide is an isoenzyme that is a synthetic molecule. It's main function is to catalyze reactions, which are computationally scalable and can be titrated. The benzamidine catalysed reaction mechanism of N'-Methyl-N'-oxobenzenecarboximidamide has been studied in detail and found to be fossil-based. The methylated form of this molecule has been expressed in research and emissions have been shown to be a potential energy source.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-3-oxobutanal is a reactive chemical intermediate which is used as a reagent in organic synthesis. It can be used to synthesize amines, amides, or imines. 2-Bromo-3-oxobutanal is also used as an industrial solvent and as an intermediate in the production of pharmaceuticals. This compound has been shown to react with DNA and RNA, altering their conformation and inducing conformational changes.</p>

Versatile small molecule scaffold