Building Blocks

<p>Tert-butyl (2S)-2-aminohexanoate is an intermediate that is used in the synthesis of glycine by the reaction of benzyl bromide and tert-butyl amine. The stereospecifically incorporated tert-butyl group has a high degree of enantioselectivity, which makes this intermediate useful in the synthesis of glycine. Tert-butyl (2S)-2-aminohexanoate can be synthesized using lithium diisopropylamide and a tertiary amine as an alkylating agent.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Vinylnicotinic acid methyl ester belongs to the group of antimicrobial agents. It is a chemical compound that has been shown to be effective against cervical cancer and may have potential as an anticancer drug. 5-Vinylnicotinic acid methyl ester inhibits the growth of human chorionic gonadotropin (HCG) in women, which is a hormone necessary for ovulation and pregnancy. This compound also inhibits the growth of viruses, such as herpes simplex virus type 1 (HSV-1), and bacteria, such as dittrichia sp., which causes inflammation of the throat. 5-Vinylnicotinic acid methyl ester has also been shown to inhibit protein synthesis in human osteosarcoma cells at low concentrations, but not at high concentrations.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Bromo-6-hydroxypyrimidine-4-carboxylic acid is a homologous organic acid that is used as a pharmaceutical preservative. It is most commonly found in acidic pharmaceutical formulations. 5-Bromo-6-hydroxypyrimidine-4-carboxylic acid inhibits the growth of bacteria and fungi by acting as an enzyme inhibitor. The inhibition of enzymes such as lactamase, which breaks down the lactam ring in penicillin, prevents bacterial and fungal growth by preventing them from breaking down their natural cell walls. 5-Bromo-6-hydroxypyrimidine-4-carboxylic acid has also been shown to have potent anticancer activity in the lab setting, although the clinical significance of this has not yet been determined.</p>

<p>3-Chloro-N-methyl-2-nitroaniline is an antibiotic that belongs to the group of quinolone antibiotics. It has a broad spectrum against Gram-positive and Gram-negative bacteria, including methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. 3-Chloro-N-methyl-2-nitroaniline binds to bacterial DNA gyrase and topoisomerase IV, as well as human DNA gyrase and topoisomerase II, inhibiting their activity. This leads to cell death by interfering with the production of proteins vital for cell division. The optimal parameters for this drug have been found using isothermal titration calorimetry on the enzyme gyrase in the presence of different concentrations of 3CMA. Pharmacological targets for this drug include DNA gyrase and topoisomerase IV.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Quinoline-5-carbonitrile is a cyanide compound that can be used in the synthesis of heterocyclic compounds. The reaction between quinoline and 5-cyanovaleric acid produces 6-nitroquinoline, which is then converted to dimethyl sulfoxide by alcoholysis. This reaction product can then be used to synthesize an amide or nucleophile. Quinoline-5-carbonitrile reacts with potassium in the presence of bifunctional hydrazide to produce a cyanide ion, which can be hydrolyzed by an acid to release hydrogen cyanide gas. This experiment has been shown as a model for reactions involving cyano compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 3-oxohept-6-enoate is a cyclopropane, which is a type of organic compound that contains one or more rings of carbon atoms. This compound can be synthesized by the chemoenzymatic process using hydrogen chloride and activated methylene chloride. The synthesis starts with an acidic condensation process, followed by the hydroalkylation of methyl 3-oxoheptanoate. The resulting product is then isolated through a chiral synthetic process and has an isolated yield of 51%.</p>

<p>2-Ethyl-5-methyl-1H-1,3-benzodiazole is a chemical compound with the molecular formula C10H12N2. It is a white solid that is soluble in organic solvents such as benzene. This substance has shown to be a potent, noncompetitive inhibitor of the enzyme nucleoprotein. 2-Ethyl-5-methyl-1H-1,3-benzodiazole has been shown to have carcinogenic properties and can cause liver tumors in rats. The mechanism of action for this substance may be due to its ability to inhibit the metabolism of vitamin A and other chemicals in the liver by competitive inhibition with enzymes such as cytochrome P450.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Oxaspiro[4.4]nonane-1,3-dione is a heterocycle that has been developed as a lead molecule for the treatment of cancer. It was discovered by researchers at the University of Illinois who were investigating the use of Friedel-Crafts reaction to synthesize triazoles. 2-Oxaspiro[4.4]nonane-1,3-dione has physicochemical parameters that make it ideal for pharmaceutical research and development. This molecule has been shown to have anti-inflammatory properties and can be used to focus on carbon bond synthesis in order to synthesize pyridazines and ketocarboxylic acid derivatives.</p>

<p>Versatile small molecule scaffold</p>

<p>(2R)-2-Hydroxy-1-(2,4,5-trimethoxyphenyl)propan-1-one is an efficient method for the synthesis of adenosine. This method is based on a cyclic reaction with trimethoxybenzene and yields 2 moles of adenosine per mole of trimethoxybenzene. The reaction time is short and the yield is high. This synthetic route has been used to produce large quantities of adenosine for use in pharmacological studies. (2R)-2-Hydroxy-1-(2,4,5-trimethoxyphenyl)propan-1-one can be used as an enantiomer for the synthesis of other compounds. It was also shown that nitrite mediates this reaction</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-(2-Chloroacetyl)-3-methyl-2,3-dihydro-1,3-benzoxazol-2-one is a molecule that has the formula C8H6ClNO. It is an ambident alkylation reagent and can be used to form chloroalkylations with various nucleophiles, such as triethylamine, potassium carbonate and carbonyl compounds. The compound is a benzoxazolinone derivative that can be nitrated. 6-(2-Chloroacetyl)-3-methyl-2,3-dihydro-1,3-benzoxazol-2-one has been used to synthesize a variety of heterocycles.</p>

<p>4,6-Dinitrobenzene-1,3-diamine is an impurity in the manufacture of 4,6-dinitrotoluene. It was first synthesized by heating dinitrotoluene with nitric acid and ammonium hydroxide. The compound crystallizes as a trimorphic mixture of three polymorphs: α (monoclinic), β (orthorhombic), and γ (tetragonal). The α form has a melting point of 114°C, while the β form melts at 107°C. This compound has been used as a solvent for xylene and glycol ethers.</p>

<p>2-{[(Furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid is a water soluble drug that is used as a dietary supplement. It has been shown to be effective in inhibiting the growth of cancer cells and preventing the carcinogenic properties of some chemical compounds. 2-{[(Furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid has been shown to inhibit the growth of cancer cells, with no evidence of toxicity in rats. The compound was found to be safe for use in humans, but its carcinogenic activity could not be ruled out. Studies have shown that 2-[(furan-2-yl)methyl]amino]-5-(sulfamoyl)benzoic acid can inhibit the growth of cancer cells and prevent the carcinogenic properties of chemical compounds. 2-[(furan-2-yl)methyl]am</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>