Building Blocks

Versatile small molecule scaffold

Covid-19 is a drug that has been developed to help prevent and treat pandemics. Covid-19 is a resonance compound, which can be accessed by magnetic resonance. Covid-19 has two chemical shifts, which are related to the coupling constants between the nuclear spins in the molecule. The covid-19 molecule is made up of five different heterocycles and it has a constant magnetic resonance signal at 1H NMR. Covid-19 may be used for prevention and treatment of pandemic influenza A (H5N1) virus infection.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Oxo-indoline-7-carboxylic acid is an antiinflammatory agent that belongs to the class of hydrazines. It has been shown to have antiinflammatory activity in stepwise manner, which starts with a hydrazine group attacking the carbonyl group of a carboxylic acid and forming a new heterocyclic ring. 2-Oxo-indoline-7-carboxylic acid also has esterase inhibitory effect and can be used for the treatment of inflammatory diseases such as rheumatoid arthritis.

N-Propylnaphthalen-1-amine is a heterocycle that has two functional groups, fluorescence and photophysical properties. It can be synthesised in nature or synthetically. N-Propylnaphthalen-1-amine is used as an antifungal agent with a mechanism of action that is not yet fully understood. It interacts with the chlorides on the cell wall, which enhances its ability to kill fungi. The constant for this drug is 1×10^5M and the chloride transfer interaction constant is 2×10^2L/mol.

Versatile small molecule scaffold

3-Methylcyclohexanol is a reactive chemical substance with the chemical formula CH3CH2OH. It is used in the synthesis of covid-19, a pandemic antiviral drug that can be used to treat influenza A virus. 3-Methylcyclohexanol is a sodium salt that is stable in water and has an acylation reaction with an acid chloride. This reaction produces an ester and carboxylic acid as byproducts. 3-Methylcyclohexanol can be hydrogenated using metal catalysts, such as palladium, platinum or nickel, to produce fatty acids. The efficient method for this process involves dehydration of the alcohol to form the corresponding hydroxy compound.

2-Methylpropyl 2-hydroxypropanoate is a hydrocarbon solvent that contains a hydroxyl group and a hydroxy group. It is used as an organic solvent for industrial purposes, such as patterning in semiconductor fabrication. It is also used in the production of polymers, pharmaceuticals, and other chemical products. This compound may be degraded by radiation or hydrolyzed to produce butanol and benzoic acid.

2-Methylcyclohexanone is an organic compound that is a colorless liquid at room temperature. It is classified as an enolate and has the chemical formula of CH3COCHO. The asymmetric synthesis of 2-methylcyclohexanone can be achieved by adding sodium ethoxide to ethyl formate in the presence of anhydrous sodium. This method produces a 1,3-diketone that can be hydrolyzed to give 2-methylcyclohexanone. Hydrogen bonding interactions between the methyl group and the carbonyl group are important for the stability of this molecule. The solubility data for 2-methylcyclohexanone ranges from 0.015 g/mL at 20 °C to 0.05 g/mL at 100 °C. Activation energies for this molecule range from -2.4 kcal/mol to -1.9 kcal/mol, with a viscosity of 8 cP at

1-Benzoyl-2-sulfanylideneimidazolidin-4-one is a chemical.

Versatile small molecule scaffold

2-Bromopropionyl Bromide is a brominating agent that can be used as a chemical intermediate for the synthesis of polymeric materials. The bromine atom on the propionic acid group reacts with hydroxyl groups to form esters, amides, and phenols. It has minimal toxicity in cell culture and is not cytotoxic at concentrations up to 10%. 2-Bromopropionyl Bromide is an effective macroinitiator for cationic polymerization reactions. The acylation reaction with 3-chloroperoxybenzoic acid yields a diazonium salt which reacts further with tetronic acid or other cross-linking agents to form a polymer film. This product can be used for fluorescence techniques because it emits light when excited by ultraviolet radiation.

4-Nitrophenyl Urea (4NPU) is a compound that has antimalarial activity. It is an intramolecular hydrogen transfer agent that forms a reactive intermediate and interacts with anions, such as hydroxide ions, to form covalent bonds. 4NPU inhibits growth factor-mediated cell toxicity and has been shown to have the ability to select for mutant cells in vitro and in vivo. Crystals of 4NPU belong to the monoclinic system with space group P2 1/c. Hydrogen bonding occurs between the nitrogen atom on the urea moiety and water molecules in the crystal lattice, which stabilizes the molecule's structure.

Violuric acid is a chemical compound that is used in biological treatment. It has a hydroxyl group and UV absorption, which makes it reactive. Violuric acid undergoes protonation and deprotonation to form an acid complex with water. The nitrogen atoms in violuric acid can react with the oxygen atoms of water molecules to form nitrous acid, which then reacts with hydrogen peroxide to form an oxidizing agent. Violuric acid is synthesized by chain reactions between organic acids and inorganic acids. Violuric acid has a redox potential of −0.35 volts, making it an excellent reducing agent for organic compounds. In organic chemistry, violuric acid is used as a reducing agent for esters or amides.

Versatile small molecule scaffold

Mephenytoin is a drug that inhibits the activity of CYP2C19, which is an enzyme in the cytochrome P450 system. It has been shown to be effective in treating chronic viral hepatitis and autoimmune diseases such as psoriasis. The minimal toxicity of mephenytoin makes it a desirable candidate for use in chronic oral therapy. This drug also interacts with many other drugs, including nonsteroidal anti-inflammatory drugs, which may cause an increase or decrease in their effectiveness. Mephenytoin has been shown to inhibit the activities of the polymerase chain reaction (PCR) and reverse transcriptase in humans, making it useful for analytical purposes.

2-Ethyl-5-methylphenol is a natural product that belongs to the class of phenols. It is biosynthesized by the conversion of 2-methylacetophenone, which is found in styrene and exocrine glands in arachnids. This compound has been shown to be toxic to a number of bacteria, including strains resistant to antibiotics such as methicillin and cephalothin. The toxicity of 2-ethyl-5-methylphenol against bacteria may be due to its ability to inhibit protein synthesis and disrupt cellular membranes. The pathways leading from 2-methylacetophenone to 2-ethyl-5-methylphenol involve two steps: nitration followed by ethylation.
2E5MP can be synthesized using acetone and 3- methyl1 -butanol as precursors, which are scalable and inexpensive chemicals.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

PB-22 is a synthetic cannabinoid, which can be classified as a CB1 receptor agonist. It is one of the many cannabinoids that have been created in an attempt to circumvent drug laws by creating compounds that are similar to those found in cannabis but have different chemical structures. PB-22 has shown to increase locomotor activity and stimulate the cb1 receptor in mice. Magnetic resonance spectroscopy (MRS) and assays were used to determine the binding affinity of PB-22 for the CB1 receptor. The MRS data showed that PB-22 bound with high affinity to the CB1 receptor and had a lower affinity for CB2 receptors. This suggests that PB-22 may be more potent than other synthetic cannabinoids, such as JWH-018 and CP 55,940, which bind better with CB2 receptors than CB1 receptors.
PB-22 is an analog of JWH-073 and has been shown to have a stronger effect on locomotor activity than JWH

Ethyl 3-aminopent-2-enoate is an enantioselective and efficient ligand that is used in asymmetric synthesis. It reacts with a variety of acceptors such as 2-bromo-3-methylpyridine to form the corresponding β-unsaturated ester. The reaction with cuprate leads to the formation of an α,β-unsaturated carbonyl compound. Ethyl 3-aminopent-2-enoate can be used to synthesize crotonates and esters by hydrolysis and alkylation respectively. The crotonate formed can be converted into its corresponding acid or ester using an enolate formed from ethyl malonate.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(2-Furyl)-DL-alanine is a chiral amino acid that is used as a building block in the synthesis of peptides and proteins. The enantiomers of 3-(2-furyl)alanine have been shown to have different properties. One enantiomer has been shown to be more soluble in cyclohexane and 2-propanol, while the other has been shown to be more soluble in water. This difference can be optimized by using an appropriate solvent or by adding a complexing agent such as sodium chloride. It also has been found that one enantiomer is more reactive than the other with metal ions such as copper(II).

Versatile small molecule scaffold

2-{[(Furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid is a water soluble drug that is used as a dietary supplement. It has been shown to be effective in inhibiting the growth of cancer cells and preventing the carcinogenic properties of some chemical compounds. 2-{[(Furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid has been shown to inhibit the growth of cancer cells, with no evidence of toxicity in rats. The compound was found to be safe for use in humans, but its carcinogenic activity could not be ruled out. Studies have shown that 2-[(furan-2-yl)methyl]amino]-5-(sulfamoyl)benzoic acid can inhibit the growth of cancer cells and prevent the carcinogenic properties of chemical compounds. 2-[(furan-2-yl)methyl]am

4,6-Dinitrobenzene-1,3-diamine is an impurity in the manufacture of 4,6-dinitrotoluene. It was first synthesized by heating dinitrotoluene with nitric acid and ammonium hydroxide. The compound crystallizes as a trimorphic mixture of three polymorphs: α (monoclinic), β (orthorhombic), and γ (tetragonal). The α form has a melting point of 114°C, while the β form melts at 107°C. This compound has been used as a solvent for xylene and glycol ethers.

6-(2-Chloroacetyl)-3-methyl-2,3-dihydro-1,3-benzoxazol-2-one is a molecule that has the formula C8H6ClNO. It is an ambident alkylation reagent and can be used to form chloroalkylations with various nucleophiles, such as triethylamine, potassium carbonate and carbonyl compounds. The compound is a benzoxazolinone derivative that can be nitrated. 6-(2-Chloroacetyl)-3-methyl-2,3-dihydro-1,3-benzoxazol-2-one has been used to synthesize a variety of heterocycles.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(2-Aminoethyl)-1H-indol-6-ol (3-OH-6) is a compound that is structurally related to the neurotransmitter acetylcholine. It has been shown to have an inhibitory effect on amines and blood pressure in cell culture. 3-OH-6 also has the ability to bind to model proteins such as tyrosinase. This binding inhibits the uptake of 3-OH-6, which leads to its accumulation in cells where it can cause damage by acting on adrenergic receptors. 3-(2 Aminoethyl)-1H-indol-6-ol’s ability to act on dopamine receptors may be due to its hydroxyl group.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold