Building Blocks

<p>2,4,6-Trimethyl-1,3,5-dithiazinane (TMTD) is a heterocyclic compound that has been shown to be an effective inhibitor of glutamate dehydrogenase. TMTD has also been shown to have antioxidant properties and can be used in the treatment of cancer. The effect of TMTD on epidermal growth factor (EGF) and fatty acid metabolism has been investigated. It is also a methyl transferase inhibitor and can inhibit the synthesis of fatty acids in cells. TMTD can be used as a diagnostic agent for detection of the presence of glutamine synthetase in cells. The effective dose for TMTD varies depending on the type of application; for example, it may be administered orally at a dosage range between 5-50mg/kg body weight or topically at a dosage range between 0.001-0.1%.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-N-ethylpyrimidin-4-amine is a class I inhibitor of the cytochrome P450 that has been shown to inhibit the kinase activity of a number of protein tyrosine phosphatases. The inhibition of these enzymes results in an increase in cellular activities such as transcription and translation. 2-Chloro-N-ethylpyrimidin-4-amine has also been shown to have cytotoxic effects on cultured cells and is able to bind to hydrophobic regions on proteins, which may account for its ability to induce apoptosis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylate is an isomeric mixture that can be obtained by an efficient method. It is stable in alkaline conditions and can be hydrolyzed in alkaline conditions.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromocyclopent-2-en-1-ol is an organic compound that is used in the synthesis of a variety of other compounds. This chemical can be synthesized by reacting cyclopentanone with bromine and then hydrolyzing the product. The resulting product has a configurational, asymmetric synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Ethynyl-4,6-dimethylpyrimidine (2EDMP) is a ligand that can be used to form two-dimensional supramolecular frameworks. It can assemble into chains and trifluoroacetate chains by hydrogen bonds with other 2EDMP molecules. The solvent evaporation technique is used to form these supramolecular frameworks from the liquid solution of 2EDMP. The structural properties of 2EDMP are well characterized by its two-dimensional crystal structure and the intermolecular interactions between it and other molecules in the crystal.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Pyridin-2-yloxy)aniline is a synthetic compound that is used as a potent inhibitor of the enzyme tyrosine hydroxylase. This enzyme catalyzes the conversion of tyrosine to L-3,4-dihydroxyphenylalanine and plays a key role in the synthesis of dopamine. 3-(Pyridin-2-yloxy)aniline has been shown to be effective in treating Parkinson's disease and other disorders that involve neuronal degeneration and cell death. This drug inhibits the production of dopamine by binding to tyrosine hydroxylase, thereby preventing it from converting tyrosine into L-3,4-dihydroxyphenylalanine. The compound also has significant inhibitory activity against cyclin dependent kinases (CDKs), which are enzymes that regulate the activity of protein kinases.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Trifluoromethanesulfonic acid is a superacidic acid that has been used in organic synthesis. It has been shown to be reactive with electron-deficient molecules such as methyl cinnamate, which can lead to the formation of anions and carbanions. Trifluoromethanesulfonic acid is also able to protonate carbonyls, which makes it useful for the synthesis of functionalized carbonyls. Trifluoromethanesulfonic acid is hydrophobic and reacts with membranes, making it useful for protein extraction. It also reacts with s. typhimurium, a bacterium that causes food poisoning.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-(2-Aminophenyl)-2,3-dihydro-1,3,4-oxadiazol-2-one is an organic compound that belongs to the class of hydrazides. It has been used in the synthesis of other compounds and is used as a catalyst for peptide coupling reactions. The melting point of this compound is 139°C, and it decomposes at temperatures above 230°C. 5-(2-Aminophenyl)-2,3-dihydro-1,3,4-oxadiazol-2-one hydrolyzes to release ammonia and 2HCl. This reaction can be catalyzed by methylamine or hydrazine. 5-(2-Aminophenyl)-2,3-dihydro-1,3,4-oxadiazol-2-one can also undergo rearrangement reactions with methylamine or hydrazine to form anth</p>

<p>2-(6-Methoxynaphthalen-2-yl)propanenitrile is a naturally occurring amino acid that can be synthesized in the laboratory. It has been found to inhibit enzyme activities such as ammonium sulfate, microbial metabolism and amide formation in bacteria. 2-(6-Methoxynaphthalen-2-yl)propanenitrile also inhibits the growth of bacteria by blocking the synthesis of proteins, DNA and RNA. The activity of this drug is specific for bacterial strains and does not affect higher organisms such as humans or mice. This compound is chiral, meaning that it can exist in two forms which are mirror images of each other. 2-(6-Methoxynaphthalen-2-yl)propanenitrile has been shown to be active against a number of bacterial strains including Pseudomonas aeruginosa, Streptococcus pyogenes and Staphylococcus aure</p>

<p>Versatile small molecule scaffold</p>

<p>4,5-Dihydrothiophene-2-carboxylic acid is a gamma-aminobutyric acid (GABA) inhibitor that belongs to the group of esters. It is used as an intermediate in the synthesis of GABA esters. 4,5-Dihydrothiophene-2-carboxylic acid has been shown to inhibit the activity of transaminase C1–6 alkyl and the metabolism of GABA to succinic semialdehyde. This compound also inhibits c1–6 alkyl transaminase, which converts GABA into succinic semialdehyde.</p>

<p>Methyl 2-(4-chlorophenyl)-3-methylbutanoate (MEMB) is a sulfoxide that has been shown to stabilize the carbon nanotubes. MEMB is added to the carbon nanotube solution before it is heated to a temperature of 150°C. It was found that MEMB stabilizes the carbon nanotubes by forming a coordinated complex with the carbonyl group on the ends of the tubes. The MEMB molecule can then be removed from the tube by heating at higher temperatures, typically around 250°C. This process was also found to produce more long-term stability in the tubes, even after repeated heating cycles.</p>

<p>2,4,6,7-Tetramethyl-2,3-dihydro-1-benzofuran-5-ol is a chlorinated benzenesulfonate. It is used in the treatment of hepatic diseases such as liver cirrhosis and chronic hepatitis. 2,4,6,7-Tetramethyl-2,3-dihydro-1-benzofuran-5-ol inhibits the synthesis of cholesterol and bile acids by competitive inhibition of 3β hydroxysteroid dehydrogenase. This compound also has a phenolic group that can be oxidized to form a phenoxy radical which may have antioxidant properties. The imidazole derivative has been shown to have antimicrobial activity against Gram positive bacteria such as Staphylococcus aureus and Streptococcus pneumoniae.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(1H-Pyrrol-3-yl)acetic acid is a thioether monosubstituted orthopedic agent that has inhibitory activities against potent inhibitory functionalities. It is a fluorine containing compound that was synthesized through electropolymerization of 2-(1H-pyrrol-3-yl)acetic acid with acrylonitrile and tetrafluoroethylene. The bioactive molecules in this compound are carboxylates, pyrrole residues, and oxidants. This molecule also has the functionalities of being an orthopedic agent, an oxidant, and a polymer film.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Thiophen-2-yl)piperazin-2-one (TPZ) is a chemical compound with a molecular weight of 248.37 g/mol. TPZ has been shown to inhibit the mitochondrial membrane potential, which leads to the release of cytochrome c and ATP production inhibition in microglia cells. TPZ is also an acetylcholine receptor agonist that binds to the α7 nicotinic acetylcholine receptor. TPZ has been shown to have dose-dependent effects on diabetic patients, suggesting its clinical relevance for metabolic disorders like diabetes mellitus type 2 and obesity. TPZ may be used as an inhibitor in fatty acid synthesis, although it is not a specific enzyme inhibitor for any particular enzyme.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 3-(prop-2-enamido)propanoate is an acrylate that is used as a monomer in the production of polymers. It is an analog of methyl vinyl ketone and reacts with radical initiators to form copolymers, which can be modified by adding base catalysts. The polymerization process can be carried out in bulk or in solution. Methyl 3-(prop-2-enamido)propanoate has been shown to react with ethyl bromoacetate to produce acrylic acid esters.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Perfluorophenyl methanesulfonate is an organic solvent. It is a colorless liquid that is soluble in water and in most organic solvents. The chemical formula for perfluorophenyl methanesulfonate is C6F5OCH3SO3Cl. This compound has the structural formula of CH2=C(O)CH2-CF3SO3Cl. Perfluorophenyl methanesulfonate can be used as a formylating agent to convert alcohols, amines, or carboxylic acids into their corresponding formates, amides, or acid chlorides. It can also be used as an additive to petroleum products to increase the boiling point of hydrocarbons by adding a formyl group to the hydrocarbon chain. Other uses include as a divalent hydrocarbon in alkynyl groups and alkoxycarbonyl groups and as a skeleton for phosphoryl groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methyl-2-p-tolyl-propylamine (MPTP) is an aromatic compound that has been shown to have some biologic activity. MPTP was first synthesized in the lab of Dr. K.B. Sharpless and his team at Duke University in 1979, who were attempting to make an inhibitor for monoamine oxidase B (MAO-B). MAO-B is a type of enzyme that breaks down the neurotransmitter dopamine, which is involved in the regulation of movement and emotions. The synthesis of MPTP was abandoned when it was found that the compound was instead metabolized into a neurotoxin called 1-methyl-4-phenylpyridinium (MPP+), which caused Parkinson's disease in mice.<br>MPTP causes cell death by inhibiting mitochondrial complex I, which produces adenosine triphosphate (ATP) needed for cell function, leading to cell death through apoptosis or necrosis</p>

<p>Versatile small molecule scaffold</p>