Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Chloro-3-nitropropane is a compound that has been synthesized from ethylene diamine and yields amide, ethylene, and alkali metal. 1-Chloro-3-nitropropane is used as an intermediate in the production of hydrochloride salts of phosphorus pentoxide. This substance reacts with chlorine to produce phosphonitriles, which are intermediates for the synthesis of nitronates. The synthesis of 1-chloro-3-nitropropane was mechanistically studied by refluxing chlorination agents with phosphorus pentoxide.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2',4'-Dimethoxyacetoacetanilide is a disubstituted dicarbonyl compound that is synthesized by acetoxylation of 2,4-dimethoxybenzaldehyde. The equilibrium between the two forms can be shifted to favor one form through the addition of reagents, such as dimethylformamide or dicarbonyl compounds. The oxidation of 2',4'-dimethoxyacetoacetanilide with hydrogen peroxide yields 2,4-dihydroxydiphenylmethane, which can undergo hydrolysis with hydrochloric acid to yield phenol.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl)butanal is an antibacterial agent that belongs to the group of aminoglycosides. It is a synthetic compound that has shown antibacterial activity against gram positive and gram negative bacteria. 2-(1,3-Dioxo-2,3-dihydro-1H-isoindol-2-)butanal binds to the 30S ribosomal subunit of bacteria and inhibits protein synthesis by inhibiting the translocation of tRNA from the A site to the P site on the ribosome. This compound also prevents bacterial cell wall synthesis by binding to peptidoglycan precursors in the cell wall and inhibiting transglycosylation reactions.</p>

<p>1H-2-Benzothiopyran-4(3H)-one 2,2-dioxide belongs to the group of ketones and isomers. It has an electrophilic character and a nucleophilic character. The tautomerization of this molecule was studied by computational methods. The reactivity of 1H-2-Benzothiopyran-4(3H)-one 2,2-dioxide towards nucleophiles was studied experimentally by using reagents such as hydrogen bond donors, hydrogen bond acceptors, oximes and zwitterions. The conformations of the molecule were analyzed with single crystal x-ray diffraction experiments to find out the most stable conformation for each isomer.</p>

<p>3-N-Propoxypropylamine is an alkyl ether that is synthesized from propylamine. The chemical structure of 3-N-Propoxypropylamine has a low molecular weight and contains acidic functional groups. This compound can be used in the synthesis of other drugs, such as alkanolamide derivatives. 3-N-Propoxypropylamine can also be used to deaminate histidine residues, which are found in proteins, and this property makes it useful for culture cell experiments.</p>

<p>Phenoxybutanamine is a pharmaceutical preparation that contains 4-phenoxybutan-1-amine. It is used for the treatment of inflammatory diseases and bowel disease. Phenoxybutanamine may be prescribed as an antiinflammatory or immunosuppressant agent. This substance is also used to treat tumour necrosis factor-α (TNF-α) mediated inflammatory diseases, such as bowel disease. Phenoxybutanamine may be synthesized by reacting phenol with butylamine and hydrochloric acid. It is an aliphatic hydrocarbon with a carboxy group and a fluorine atom on the side chain. Phenoxybutanamine can inhibit the proliferation of cells in vitro, which may be due to its ability to inhibit protein synthesis in these cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methoxypyridine-2-carboxaldehyde (4MPCA) is a chemical with antihistaminergic properties that can be used as a histamine antagonist. 4MPCA is synthesized from the reaction of 4-methoxypyridine, formaldehyde, and chloroacetic acid. The compound has been shown to inhibit the H2 receptor at concentrations of 1 x 10 M. It also has been shown to possess antiproliferative activity in tumor cell lines. This compound is unique because it contains a heterocyclic moiety in its structure and can be used in cross-coupling reactions.</p>

<p>3-Amino-3-phenylpropanenitrile is a monocarboxylic acid derivative. It is synthesized by reacting acrylonitrile with an excess of benzonitrile in the presence of a base, followed by treatment with an oxidizing agent. 3-Amino-3-phenylpropanenitrile has been shown to undergo protonation and form an amide linkage with dimethylformamide, which may be useful for preparative purposes. The compound class includes other compounds such as benzamide, 2-aminoethanol, and 2-aminophenol.</p>

<p>2-Amino-2-phenylacetonitrile is a chiral compound that has been shown to be effective in the treatment of inflammation in the bowel. It has been shown to be effective against inflammatory bowel disease, which is a chronic inflammatory condition of unknown origin that affects the large intestine. 2-Amino-2-phenylacetonitrile inhibits neutrophil migration and reduces proinflammatory cytokines, such as tumor necrosis factor (TNF)-α and interferon (IFN)-γ. The drug may also have an effect on apoptosis protein expression. The drug is well tolerated with minimal side effects and can be used in patients with diabetes suffering from diabetic neuropathy. 2-Amino-2-phenylacetonitrile has pharmacokinetic properties that make it suitable for oral administration, while its hydrochloric acid solubility makes it well suited for use in the bladder. The drug's redox potentials are low</p>

<p>4-Amino-2-isopropylphenol is a phenolic compound that is used in the synthesis of esters. It reacts with carboxylic acids to form an acylation product, which is selective for hydroxy groups. 4-Amino-2-isopropylphenol can be used as a solvent for phenolic compounds such as resorcinols and hydroquinones. This reagent also selectively reacts with organic solvents preferentially to hydroxy groups on the same molecule. The regioselective reaction of 4-amino-2-isopropylphenol is due to its steric hindrance by the substituent on the isopropyl group.</p>

<p>4-Amino-2-bromophenol is a homolytic, alkaline, nitrate, oxidative, evolution, pyridinecarboxylic, alkylation, chloroplasts, aminophenols, oxidative decarboxylation, acyl chlorides and catalyzed by photosynthesis. 4-Amino-2-bromophenol is used in the preparation of acyl chlorides and catalyzed by photosynthesis. It is also used in the synthesis of azo dyes. 4-Amino-2-bromophenol hydrolyzes in an alkaline solution to form 4-aminobenzoic acid and bromine water. This reaction can be reversed by adding acid to the solution.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Chloro-1,2-dimethoxybenzene is a ligand that binds to the active site of acetylcholinesterase. It is used in synthetic chemistry as a precursor for acridone and dimethoxyacridone. 4-Chloro-1,2-dimethoxybenzene has been found to have antioxidant properties and may be used as an antioxidant. This substance may also act as a potential antioxidant by protecting lipids against oxidation.</p>

<p>3-(Phenylcarbamoyl)benzoic acid (PCBA) is a molecule that is used in different fields of research, including mass spectrometry and diagnostic medicine. It has been shown to have properties that can be used for the diagnosis of Parkinson’s disease. The chemical structure of PCBA includes a carboxylic acid group and an aromatic ring with three hydroxyl groups. PCBA can be synthesized from phenylacetic acid by decarboxylation, elimination, or ortho-elimination reactions. This molecule has two possible isomers: 4-hydroxy-3-(phenylcarbamoyl)benzoic acid and 3-hydroxy-4-(phenylcarbamoyl)benzoic acid. PCBA may be used as a diagnostic agent for Parkinson’s disease because it can form molecular ions with m/z values of 302, 268, and 204, which are diagnostic for this</p>

<p>4-(Phenylcarbamoyl)benzoic acid is a metabolite of all-trans-retinoic acid that has been shown to induce promyelocytic leukemia in human cells. It binds to cellular retinobenzoic acid receptors, which are proteins that regulate cellular differentiation and apoptosis. The binding of 4-(phenylcarbamoyl)benzoic acid to these receptors leads to the inhibition of cellular proliferation and the induction of apoptosis in promyelocytic leukemia cells. 4-(Phenylcarbamoyl)benzoic Acid also inhibits the metabolism of retinoids by inhibiting the enzyme retinol dehydrogenase, thereby increasing the levels of all-trans-retinoic acid. This leads to an increased activity of retinoic acid on its receptor.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-4,5-dimethoxyaniline is a chemical compound that is used to optimize the synthesis of antimalarial agents. It has been shown that 2-bromo-4,5-dimethoxyaniline can be used as an efficient and selective synthetic intermediate for the preparation of benzene derivatives with biological properties. This chemical compound has been shown to be a mediation agent in biological systems and is also responsible for cross-coupling reactions between carbazoles and acridinium. The method for preparing this chemical compound involves a two step process involving alkylation and hydrolysis. The first step involves the preparation of dimethylformamide by reacting methyl iodide with formaldehyde in methanol. In the second step, acetyl chloride reacts with 2-bromoethanol in DMF to produce 2-bromo-4,5-dimethoxyaniline.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Chlorobenzoyl isothiocyanate (4CBI) is an antibacterial agent that inhibits the growth of bacteria by binding to a molecule in the bacterial cell wall. 4CBI has been shown to inhibit the synthesis of a phytoalexin, which is a chemical compound that plants produce in response to infection or other injury. 4CBI's mode of action involves hydrogen bonding with the pyrazole ring and trisubstituted center of the molecule. This inhibition prevents formation of a reactive intermediate, which would otherwise lead to bacterial death.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Chlorophenethyl bromide is a linker that binds to viral proteins in the dimer interface and inhibits viral replication. It has been shown to be an inhibitor of HIV-1 reverse transcriptase and human immunodeficiency virus type 1 protease. 3-Chlorophenethyl bromide has also been found to inhibit the binding of HIV-1 integrase, which leads to inhibition of HIV-1 DNA integration into host cell chromosomes. 3-Chlorophenethyl bromide can be used for the treatment of AIDS and is being investigated for its use as a prophylactic agent for HIV infection.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methoxy-2-cyclohexen-1-one is a stereoisomer of cyclohexanone. It is the product of an asymmetric synthesis by irradiation. The reaction requires methoxyphenol and acetyl chloride, with isomers being separated by gel chromatography. The stereoselectivity of the reaction has been shown to be high, with the desired product being oriented in a chiral environment. A hydrochloric acid solution is used to convert 3-methoxy-2-cyclohexen-1-one into 2,3-dimethoxybenzoic acid.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methoxy-1-naphthalenemethanol is an isoenzyme of a dehydrogenase. It is found in the pancreas, tissues and human serum. 4-Methoxy-1-naphthalenemethanol has been shown to catalyze the conversion of acetaldehyde to acetate and reduces fatty acids to their corresponding hydroxy acid. This enzyme also converts ethyl esters and aldehydes into their corresponding alcohols or carboxylic acids. The reduction products are carbocations, which can be reduced by other enzymes such as thioredoxin reductase.</p>

<p>The condensation of 6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol with a diaryl or chlorotrimethylsilane in the presence of a catalyst such as pyridine or triethylamine leads to the formation of a carbinol. The reaction is often used for the synthesis of phenols.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Cyclohexyl 2-sulfanylacetate is an organic compound that belongs to the class of polycarboxylic acids. It is soluble in glycol ether and insoluble in water. Cyclohexyl 2-sulfanylacetate has a high melting point, which makes it a good conditioning agent. It also has functional groups that make it suitable for use as a modifier or colorant. This chemical can be used as a functional ingredient in hair care products, such as shampoos and conditioners, because of its cationic surfactant properties.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methoxy-5-methyl-1,2-oxazole-4-carboxylic acid hydrobromide is an excitatory drug that belongs to the group of carboxylic acids. It has been shown to increase the firing rate of neurons in the cerebral cortex. 3-Methoxy-5-methyl-1,2-oxazole-4-carboxylic acid hydrobromide is used as a research tool for studying nervous system function and as a diagnostic agent for epilepsy.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-4,6-dimethylpyrimidine (2-BDMP) is a chemical compound that is synthesised by reacting acetonitrile with methylene bromide in the presence of copper. The 2-BDMP has a molecular weight of 136.22, melting point of 117°C and boiling point of 165°F. It has an ambident nature with respect to anions, which means it is soluble in water and organic solvents such as acetonitrile and tetrahydrofuran. 2-BDMP can be used as a building block for synthesising other compounds such as amidines or dioxanes. This chemical can also be used to produce yields of bromoalkyls in the presence of alkylating agents such as chloromethyl methyl ether or methanol.</p>

<p>2-Phenylpyrimidine-4-carboxylic acid is a luminescent copper complex that has been synthesized as a ligand in coordination complexes. It is soluble in dilute solutions and can be used to prepare the complexes of other metals. 2-Phenylpyrimidine-4-carboxylic acid has been shown to have an affinity for lanthanide metal ions and can be used as a sensitizer for lanthanides. The magnetic properties of this compound were determined using x-ray diffraction on single crystals. It was found that the compound is paramagnetic and has a weak antiferromagnetic interaction with dysprosium, which was confirmed by elemental analysis and diffraction measurements.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Propan-2-yl)-1H-indole is a zeolite that has been shown to catalyze the conversion of 2-propanol to butyl acetate. It is used in catalytic alkylation reactions, which are used to produce chemicals such as octane and styrene. 3-(Propan-2-yl)-1H-indole is able to increase the velocity of this reaction by lowering the reaction parameters. The zeolite can be used in industrial settings or in laboratory experiments.</p>

<p>Versatile small molecule scaffold</p>

<p>Azapropazone is a non-steroidal anti-inflammatory drug that has been used for the treatment of chronic inflammatory conditions such as rheumatoid arthritis and osteoarthritis. Azapropazone has also been shown to be effective in the treatment of gastric ulcers. Azapropazone binds to the H2 receptor, which is the histamine receptor found on parietal cells in the stomach lining. This binding inhibits gastric acid secretion and reduces the release of histamine from these cells, thereby reducing inflammation and ulceration. Azapropazone is metabolized by cytochrome P450 enzymes, which are found in many tissues including liver, kidney, and lung tissue. The drug's major metabolite is N-desmethyl azapropazone (NDAZ), which has similar anti-inflammatory effects to azapropazone but with less risk of gastric upset and ulceration.</p>

<p>8-Thiabicyclo[3.2.1]octan-3-one is a chiral tropane alkaloid that is used as an analog for pseudotropine and hyoscyamine. It is metabolized by oxidation, hydroxylation, or amide hydrolysis to form compounds with similar structures to tropane and hyoscyamine. 8-Thiabicyclo[3.2.1]octan-3-one has been shown to inhibit the biosynthesis of dopamine, norepinephrine, and serotonin in rat brain cells; therefore it may have therapeutic potential as a treatment for Parkinson's disease as well as other neurological disorders such as depression and anxiety.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 2-(2-iodophenyl)acetate is an alkylating agent that inhibits the growth of cancer cells by binding to their estrogen receptors. It has been shown that this drug binds to the estrogen receptor and blocks its interaction with estradiol in MCF-7 cells. Methyl 2-(2-iodophenyl)acetate also inhibits cell cycle progression, leading to cancer cell death. The stereoselective nature of this drug may be due to a specific interaction with the estrogen receptor, as well as other interactions with proteins in the target cell. In addition, this compound can be used to treat breast cancer by inhibiting tumor growth and stimulating apoptosis in MDA-MB-231 cells.</p>

<p>2-Hydrazino-4-methylpyrimidine-5-carboxylic acid ethyl ester is a heterocyclic compound that is used in organic synthesis. It is obtained by the reaction of ethylene with chloroacetic acid and 2,6-dichloropyrimidine. This product can be used as a cocatalyst to promote the polymerization of ethylene. The molecular structure of this heterocyclic ring consists of three carbon atoms, five nitrogen atoms, and two oxygen atoms. The nomenclature for this product can be found in IUPAC Gold Book 1985. Triisobutylaluminium (TIBA) is a typical catalyst for the reaction. In addition, 2-hydrazino-4-methylpyrimidine-5-carboxylic acid ethyl ester chelates with copper or zinc compounds to form catalysts for reactions with other substrates.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>