Building Blocks

<p>Applications (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) (cas# 19249-03-7) is a useful research chemical.<br></p>

<p>Applications N-(Benzyloxycarbonyl)-4-piperidone<br></p>

<p>Applications Diethyl Phosphite, is an phosphorous precursor used for the synthesis of various organophosphorus compounds, acting as insecticide, and pesticides.<br>References Kjoelholt, J., et al.: Chemosphere, 14, 1763 (1985); Zhou, Q., et al.: Atmospheric Environ., 43, 4163 (2009);<br></p>

<p>Applications 4-Benzyloxybenzoic Acid is a chemical reagent in the preparation of anticancer leads such as quinolin-4-one derivatives.<br>References Cheng, Y. et al.: Bioorg. Med. Chem. Lett., 23, 5223 (2013);<br></p>

<p>Applications Methyl chlorodifluoroacetate<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Dimethyl Malonate-d2 is an intermediate in the synthesis of Prasugrel Thiolactone-d5 (Mixture of Diastereomers). A labelled inactive metabolite of Prasugrel (P701150).<br>References Sugidachi, A., et al.: Br. J. Pharmacol., 129, 1439 (2000); Takahashi, S., et al.: J. Pharm. Sci., 97, 5434 (2008); Williams, E., et al.: Drug Metab. Dispos., 36, 1227 (2008); Hagihara, K., et al.: Xenobiotica, 39, 218 (2009);<br></p>

<p>Applications (1R,2S)-rel-1,2-Cyclopentanedicarboxylic Acid is a Possible inhibitor of prolidase.<br>References Mock, W. et al.; J. Biol. Chem. 265, 19606 (1990)<br></p>

<p>Applications 1,1-dimethylguanidine Sulfate (cas# 598-65-2) is a useful research chemical.<br></p>

<p>Applications Ethyl Cyano(ethoxymethylene)acetate is an intermediate in the synthesis of anti-inflammatory agents with gastroprotective effect in rats.<br>References Karoui, A., et al.: Med. Chem. Res., 23, 1591 (2014);<br></p>

<p>Applications m-Toluoyl Chloride is used as a reagent in the synthesis of glycine benzamides as oral GPR139 receptor agonists. m-Toluoyl Chloride is also used in the preparation of colchicine derivatives which have potent anticancer activity and reduced P-glycoprotein induction liability.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dvorak, C.A., et al.: ACS Med. Chem. Lett., 6, 1015 (2015); Singh, B., et al.: Org. Biomol. Chem., 13, 5674 (2015)<br></p>

<p>Applications 3,3,5,5-Tetramethylcyclohexanone (cas# 14376-79-5) is a useful research chemical and a pharmaceutical intermediate.<br>References Ebrahimi, H. P., et al.: Spectrochim. Acta A: Mol. Biomol. Spectrosc., 137, 1067 (2015); Bishop, A. C., et al.: Bioorg. Med. Chem. Lett., 16, 4002 (2006)<br></p>

<p>Applications 2-Hydroxy-1-phenylpentane is an impurity of Prolintane (P756100) synthesis.<br>References Hucker, H.B. et al.: Experientia, 28, 430 (1972); Hollister, L.E. et al.: J. Clin. Pharmacol. J. New Drugs, 10, 103 (1970); Kuitunen, T. et al.: Meth. Find. Exp. Clin. Pharmacol., 6, 265 (1984):<br></p>

<p>Applications Triisopropyl Borate is a borate ester used in Suzuki couplings.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wolfe, J. et al.: J. Am. Chem. Soc., 121, 9550 (1999); Darses, S. et al.: Eur. j. Org. Chem., 8, 1875<br></p>

<p>Applications 4-Nitrobenzonitrile-d4 (CAS# 1219798-46-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Diethyl Phenylmalonate is a reagent used in the synthesis of antituberculosis agents.<br>References Ng, P. S., et al.: J. Med. Chem., 106, 144-156 (2015)<br></p>

<p>Applications An intermediate in the formation of L-egothioneine, a natural amino acid ubiquitously present in cells and tissues of most plants and mammalian species. In humans, L-ergothioneine is found in red blood cells, liver, kidney, brain, seminal fluid, and cataract-free lenses at concentrations ranging from 100 uM to 2 mM. L-ergothioneine is exclusively biosynthesized in fungi and mycobacteria. Hence, humans assimilate it through dietary intake.L-ergothioneine has been proven to act as an antioxidant in vivo and to afford protection from g and UV radiation as well as from singlet oxygen in vivo. Recently, it has been shown that L-ergothioneine protects isolated perfused heart against the deleterious effect of post-ischemic reperfusion.The intermediate, 2-mercaptohistine has been used for the<br>References Makinen, K.K., et al.: Eur. J. Biochem., 123, 171 (1982), Howard, R.J., et al.: Biochem. Pharmacol., 35, 1589 (1986),<br></p>

<p>Stability Moisture Sensitive<br>Applications 10-Bromodecanol can be used to synthesize rotaxane dendrimers. It can also be used to synthesize J2326, a molecule that induces neurite outgrowth in neuronal cells.<br>References Wei, W., et al.: Proc. Natl. Acad. Sci. USA 112, 5597 (2015); Chang, P., et al.: Neuropharmacology 92, 146 (2015)<br></p>