Building Blocks

<p>Applications A sulfonate ester as potential genotoxic impurity in drug substances. It may exert genotoxic effects in bacterial and mammalian cell systems.<br>References Eder, E., et al.: Xenobiotica, 12, 831 (1982), Li, W., et al.: J. Chromatogr., 1046, 297 (2004), Glowienke, S., et al.: Mutat. Res., 581, 23 (2005), Colon, I., et al.: J. Pharm. Biomed. Anal., 39, 477 (2005),<br></p>

<p>Applications 2-(4-methylphenyl)oxirane (cas# 13107-39-6) is a useful research chemical.<br></p>

<p>Applications 3-Bromobenzyl bromide<br></p>

<p>Applications 1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a Solifenacin (S676700) intermediate. 1-Phenyl-1,2,3,4-tetrahydroisoquinoline had been detected in parkinsonian human brain. 1-Phenyl-1,2,3,4-tetrahydroisoquinoline maybe a candidate for endogenous MPTP-like neurotoxin since it is a structural analogue of MPTP which produces parkinsonism in humans.<br>References Kajita, M. et al.: J. Chrom. B Biomed. Appl., 669, 345 (1995);<br></p>

<p>Applications Cyclopentanone-2,2,5,5-d4 (CAS# 3997-89-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labeled D-Ribitol, which is used in the preparation of L-ribose and and arabinose. it is also a diagnostic tool for identifying human bladder cancer (HBC) through noninvasive urinary metabonomics.<br>References Pasikanti, K. et al.: J . Proteo. Res., 9, 2988 (2010); Ahmed, Z. et al.: J. Biosci. Bioeng., 88, 444 (1999);<br></p>

<p>Applications Trans, trans, trans-1,5,9-cyclododecatrene - (CAS# 676-22-2) is a useful research chemical compound.<br></p>

<p>Stability Temperature Sensitive<br>Applications Methyl 2,3,4-Tri-O-isobutyryl-D-glucopyranuronate (cas# 1190403-86-1) is a compound useful in organic synthesis.<br></p>

<p>Applications H-PRO-GLU-OH (cas# 67644-00-2) is a useful research chemical.<br></p>

<p>Applications Cystamine dihydrochloride is the dihydrochloride salt of Cystamine, a neuroprotective drug that works by inhibiting transglutaminase activity in the body. Cystamine has also exhibited suppressive effects against HIV replication in infected human cells.<br>References Bergamini, A., et al.: J. Clin. Invest., 93, 2251 (1994); Fox, J., et al.: J. Neuro., 91, 413 (2004); Jeitner, T., et al.: Biochem. Pharm., 69, 961 (2005)<br></p>

<p>Stability Air Sensitive, Light Sensitive<br>Applications 5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.<br>References Josko, J., et al.: Annal. Acad. Med. Siles., 66, 13, (2012); Carson, R.P., et al.: Human. Molec. Genetics., 22, 140 (2013);<br></p>

<p>Applications 8-Hydroxy-2(1H)-quinolinone is a substituted quinolinone derivative used in the preparation of pharmaceutical compounds.<br>References Li, F. et al.: J. Proteome. Res., 12, 1369 (2013)<br></p>

<p>Applications Cyclopropanecarboxylic Acid is used as a reagent in the synthesis of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. Also used as a reagent in the synthesis of 2-alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014); Keaney, E.P., et al.: Bioorg. Med. Chem. Lett., 24, 3714 (2014)<br></p>