Building Blocks

Applications An efficient carbonylating agent for liquid and solid-phase aza-peptide synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ferrari, B., et al.: Bioorg. Med. Chem. Lett., 4, 45 (1994),

Applications (RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGluR1 and mGluR5. It has been shown that (RS)-3,5-DHPG can modulate Kir4.1 protein and mRNA in cultured rat retinal Müller cells.(RS)-3,5-DHPG acts as a potential target in treatment of parkinson's disease.
References (1) Gao, F., et al.: Neurosci Lett. 588, 12 (2015)

Applications α,2,4-Trichloroacetophenone is a reagent used in the synthesis of isoconazole, a potent antifungal agent.
References Dulcevscaia, G. et al.: Polyhed., 52, 106 (2013); Wang, Y. et al.: Bioorg. Med. Chem. Lett., 22, 5363 (2012);

Applications Thymol O-β-D-Glucuronide is a glucuronide derivative of Thymol (T413000); an antimicrobial compound which can increase the efficacy of antibiotics involving drug resistant bacteria. It inhibits growth and lactate production as well as reduces cellular glucose uptake within the bacteria.
References Palaniappan, K. et al.: Int. J. Food Microbiol., 140, 164 (2010); Evans, J. et al.: Curr. Microbiol., 41, 336 (2000)

Applications 5-Hydroxypentanoic acid sodium salt

Applications 2,4-Thioxylenol is a building block that has been used as a reactant for the preparation of Dibenzothiophene derivatives via palladium catalyzed aryl(alkyl)thiolation of unactivated arenes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Saravanan, P., Anbarasan, P.: Org. Lett., 16, 848 (2014)

Applications Phthalate ester metabolite used to study the role of peroxisome proliferator-activated receptor (PPAR) in the mediating effects of phthalates and metabolites in the liver. Studies suggest that it may possess testicular toxicity.
References Lapinskas, P.J. et al.: Toxicology, 207, 149 (2005); Watanabe, N. et al.: J. Health Sci., 48, 527 (2002);

Applications 2,2-Difluoropropionic acid (cas# 373-96-6) is a useful research chemical.

Stability Hygroscopic
Applications p-Hydroxyphenylacetylglycine is derived from the metabolism of L-DOPA (D533751), a dopamine precursor that induces dyskinesia in Parkinson’s disease patients. p-Hydroxyphenylacetylglycine is also used as a reagent to synthesize novel piperazine salts that have antimicrobial activity against Escherichia coli and Bacillus subtilis.
References Abha, B., et al.: Pharma Chemica, 2, 446 (2010); Picconi, B., et al.: Nat. Neurosci., 6, 501 (2003)

Applications 2,3-dihydroxypropyl 4-hydroxybenzoate (cas# 93778-15-5) is a useful research chemical.

Applications 4-Thiouracil is a derivative of Uracil (U801000), which is a nitrogenous base in RNA nucleic acid. 4-Thiouracil is used for tagging in cell type-specific RNA isolation from intact complex tissues.
References Miller, M., et al.: Nat. Methods, 6, 439 (2009); Seth, P., et al.: J. Med. Chem., 53, 8309 (2010); Cui, H., et al.: Eur. J. Med. Chem., 45, 5140 (2010);

Impurity Fluorouracil EP Impurity D
Applications 5-Methoxyuracil (Fluorouracil EP Impurity D) is methoxylated uracil, a component of nucleid acid. 5-Methoxyuracil is used in the preparation of nucleosides.
References Vorbrueggen, H. et al.: Chem. Ber., 114, 1279 (1981); Novacek, A. et al.: Coll. Czech. Chem. Comm., 32, 1045 (1967);

Applications Trans, trans, trans-1,5,9-cyclododecatrene - (CAS# 676-22-2) is a useful research chemical compound.

Applications Centrally acting myorelaxant; formerly used as an antispasmodic and uricosuric. Used as a tool for assessing hepatic cytochrome P-450 activity in rodents.
References Tomaszeski, J.E., et al.: Arch. Biochem. Biophys., 176, 788 (1976), M van der Graaff, et al.: Drug Metab. Dispos., 14, 331 (1986),

Applications Byproduct produced in the preparation of Atropine.

Applications Dimethyl Tetradecanedioate (cas# 5024-21-5) is a useful research chemical.

Applications p-Methoxytoluene is a building block that has been used as a reactant for the preparation of electrophilic fluorinating agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Baudoux, J., Cahard, D.: Org. Reactions, 69, 347 (2007)

Stability Hygroscopic
Applications A metabolite of Catecholamines.
References Kopin, I.J., et al.: J. Biol. Chem., 236, 2109 (1961), Short, F.W., et al.: J. Med. Pharm. Chem., 5, 642 (1962)