Building Blocks

<p>Applications N-Fmoc-D-valine is an N-Fmoc-protected form of D-Valine (V094200). D-Valine (an isomer of the essential amino acid L-Valine [V094205])exhibited inhibitory effects on fibroblasts that contaminated mammalian kidney cultures, allowing for selective growth epithelial cells. D-Valine is also known for its presence in the structure of Actinomycin D, an antitumour drug. D-Valine is naturally synthesized by Streptomyces antibioticus.<br>References Chu, W., et al.: J. Am. Chem. Soc., 116, 7971 (1994); Gilbert, S &amp; Migeon, B.: J. Cell. Phys., 92, 161 (1977); Salzman, L., et al.: J. Biol. Chem., 239, 1864 (1964); Sordillo, L., et al.: Cell Biol. Int. Rep., 12, 355 (1988)<br></p>

<p>Applications (4aS,9aS)-2,4a,9-Trimethyl-2,3,4,4a,9,9a-hexahydro-[1,2]oxazino[6,5-b]indol-6-yl methylcarbamate is an important chemical reagent used in biological study and has therapeutic use.<br>References Hedner, Jan., et al.: PCT Int. Appl. (1997), WO 9722339 A1 19970626<br></p>

<p>Applications 2,5-Furandicarboxylic Acid Diethyl Ester (cas# 53662-83-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Furoic Acid, is metabolized by Corynebacterium fascians from soil, limonoid metabolism based on a biological studies.<br>References Hasegawa, S., et al.: J. Arg. Food Chem., 31, 807 (1983)<br></p>

<p>Applications 7-Methylindole is a reactant in the synthesis of α-amino amides that are found in a variety of biological-active compounds.<br>References Box, H.K., et. al.: Tetrahedron, 70, 9709 (2014)<br></p>

<p>Applications 3-Methyl-2-butenal is used in the synthesis of L-Felinine (F231250), which is an amino acid found in the urine of species of the Felidae family; believed to either possess pheromone activity or give rise to compounds with such activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Daniels, D.L. and Richert, C.: Tetrahedron Letters, 40, 4463 (1999)<br></p>

<p>Applications Methyl 2-Bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.<br>References Gangloff, A et al.: Bioorg. Med. Chem. Lett., 23, 4501 (2013); Zhao, G. et al.: Bioorg. Med. Chem. Lett., 23, 3914 (2013);<br></p>

<p>Applications 3-Furanmethanol (cas# 4412-91-3) is a useful research chemical.<br></p>

<p>Applications Glycerol Trivalerate is used a a substrate to determine lipase activity in cheese.<br>References Svensson, I., et al.: Int. Dairy J., 16, 423 (2006);<br></p>

<p>Applications Methyl trans-4-Bromo-2-butenoate is used as a reagent in the synthesis of several organic compounds including that of dimethoxy ketals and ketones via electrochemical oxidative decarboxylation of malonic acids.<br>References Ma, X., et al.: Org. Lett., 17, 4690 (2015);<br></p>