Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide is an environmental and industrial chemical that is used as a formate, benzoate, and methyl benzoate intermediate. It reacts with nitric acid to form N-(4-aminophenyl)-N-methyl-2-(4-nitrophenoxy)acetamide (NPA). NPA has been shown to have antiangiogenic properties. NPA inhibits the proliferation of endothelial cells by interfering with the cell cycle and inducing apoptosis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Chloromethyl)-4-methoxy-3-methylpyridine hydrochloride is a lead compound that belongs to the family of pyridine derivatives. It has been shown to be a potent inhibitor of bacterial RNA synthesis, with an IC50 value of 1.2 μM for Escherichia coli and 8 μM for Bacillus subtilis. 2-(Chloromethyl)-4-methoxy-3-methylpyridine hydrochloride also inhibits the growth of Gram negative bacteria such as Pseudomonas aeruginosa and Enterobacter cloacae. The compound binds to the nucleophilic site on ribosomes, which prevents the formation of peptide bonds between amino acids in protein synthesis. This leads to cell death by inhibiting protein synthesis, leading to cell division.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Benzyl N,N,N',N'-tetraisopropylphosphorodiamidite is a reagent that reacts with hydroxybenzyl amine to form an ester. This product is used for the synthesis of phosphoramidites and benzyl esters. It is also used as a catalyst for the synthesis of diesters.</p>

<p>7-Bromo-1-methylnaphthalene is a fluorescent dye that can be used to measure the concentration of DNA, RNA, and proteins. This compound is an intercalator, which means that it can bind to double stranded DNA or RNA near the center of the molecule where there is a space for binding. It has been used in the study of the thymic gland because it binds to DNA and RNA in cells from this organ. 7-Bromo-1-methylnaphthalene has also been used as a skeleton for organic compounds, such as dimethylammonium. The bromine atom in this compound can be replaced with other atoms like iodine or chlorine to make different colored dyes.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,6-Dimethoxyisonicotinic acid is a cytotoxic agent that is structurally related to colchicine and combretastatin A-4. It has been shown to induce apoptosis in cancer cells by inhibiting the polymerization of tubulin. This drug also inhibits the proliferation of cancer cells by binding to DNA and disrupting the synthesis of proteins necessary for cell division. The inhibitory effect on protein synthesis may be due to its ability to inhibit the activity of RNA polymerase II and III, which are essential for transcription. 2,6-Dimethoxyisonicotinic acid also induces an anticancer effect through its ability to bind to phenolic moieties and inhibit the growth of cancer cells.</p>

<p>Triglycol dichloride is a synthetic, water-soluble solid that is prepared by the reaction of 3-chloroperoxybenzoic acid with a hydroxide solution. It has been used in a variety of applications such as the preparation of hemicyanine, the synthesis of polymers, and the degradation of chlorinated hydrocarbons. Triglycol dichloride also has synergistic effects with other photocatalysts, increasing their activity and reducing their cost. Triglycol dichloride can be used to synthesize polymer films or coatings that are biodegradable, have low environmental impact, and are structurally stable. This compound is also unaffected by water or neutral pH and can be used in the production of semiconductors.</p>

<p>Prop-1-en-2-ylboronic acid is a chemical compound that belongs to the group of aromatic hydrocarbons. It is used in pharmaceutical preparations as a monomer and as a chiral building block for the synthesis of oxazolidinones, which are used in medicinal chemistry as protein inhibitors against cancers. Prop-1-en-2-ylboronic acid is also used as a reagent in preparative high performance liquid chromatography. This chemical has shown maximal response against colorectal carcinoma cells and has been shown to be an inhibitor of cholesterol ester transfer.</p>