Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Nitro-1H-benzo[d]imidazole is an analog of benzimidazole compounds. It is used in the preparation of antibodies. 2-Nitro-1H-benzo[d]imidazole reacts with hydrochloric acid to form a trifluoroacetic acid, which can be purified by trichloroacetic acid and recrystallized from methanol. The purity of the product can be checked using a UV spectrophotometer, and it has a melting point of 141°C.

4-Allyl-3-thiosemicarbazide is a copper complex that inhibits the growth of cancer cells. Copper chloride is an important catalyst for this reaction. The coordination geometry of the copper ion and the structure of the product are key factors in determining its cytotoxicity. This compound has been shown to have significant cytotoxicity against a variety of cancer cell lines, including leukemia, lymphoma, breast, prostate, lung, pancreatic and colon cancer cells. 4-Allyl-3-thiosemicarbazide is also able to inhibit kinesin by binding to its ATPase site and preventing it from transporting cargo along microtubules.

Versatile small molecule scaffold

5-(Benzyloxy)pentanal is a quinoline derivative that inhibits the enzyme reverse transcriptase, which is an extracellular enzyme that synthesizes DNA from RNA. It also inhibits nucleotide synthesis and interacts with other enzymes such as DNA polymerase. 5-(Benzyloxy)pentanal has been shown to inhibit tumor growth by inhibiting the production of cancer-related proteins. The compound was synthesized in a stereoselective manner by reacting piperidine with allyl bromide followed by oxidation to form the corresponding aldehyde. This method was used to produce an enantiomerically pure compound, which exhibits inhibitory activity against HIV-1 integrase.

Versatile small molecule scaffold

3-Phenylpent-4-enoic acid is a natural product that is obtained from the lipophilic fraction of various plant species. It can be synthesized using chemoenzymatic reactions. 3-Phenylpent-4-enoic acid can be used as a chiral chemical intermediate in the synthesis of other compounds, such as olefinic compounds and alkene derivatives. This compound has been shown to have promiscuous reactivity, which is characterized by its ability to catalyze metathesis reactions with high enantiomeric excess. The isolated yield for this reaction was high at 96%.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(2-Methylpropyl)butanedioic acid is an uncatalyzed chemical reaction that is used for the treatment of wastewater. It is a chiral compound, which means it has a non-superimposable mirror image. 2-(2-Methylpropyl)butanedioic acid can be synthesized by homochiral reactions, which are reactions that uses only one type of chiral molecule to produce a chiral product. The rate of this reaction is controlled by the concentration of reactants and the temperature at which it occurs. This reaction mechanism involves the formation of an enolate ion from 2-(2-methylpropyl) butanedioic acid, followed by deprotonation to form the conjugated enolate. Leukocyte elastase is an enzyme that breaks down elastin in cells, and this enzyme may be inhibited by gabapentin.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Bromo-2-methylpropan-2-yl)benzene is an organic solvent that has a hydrogen bond. It is used in the synthesis of malonic acid and kinetic studies. This solvent has been shown to react with chloride to form 1,2-dibromochloromethane. The reaction rate for this reaction is affected by the presence of other halides, such as iodine and bromine. 1-Bromo-2-methylpropan-2-yl)benzene can also be used as a polymerization inhibitor.

Versatile small molecule scaffold