Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

N-Aminomorpholine-4-carbothioamide is a ligand that binds to the carboxylates of chloroform. It is produced by the enzyme subtilisin from the amino acid L-alanine and the compound 2-acetylpyridine. This ligand has been found in microorganisms such as Escherichia coli, Staphylococcus aureus, and Saccharomyces cerevisiae. N-Aminomorpholine-4-carbothioamide has been shown to be an effective inhibitor of yeast growth but not bacterial growth. The molecular weight of this ligand is 226.2 g mol−1 and it is a dimer at room temperature with two molecules linked together by hydrogen bonds.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Methylquinazoline-4-thiol is a heterocyclic compound with a thione group. Its amide groups are similar to those found in peptides, which play an important role in the coordination chemistry of the molecule. The 2-methylquinazoline-4-thiol skeleton is tetracyclic and can be used for synthetic purposes. This compound has been shown to have hepatoprotective properties, but also has cytotoxic effects on cells.

Versatile small molecule scaffold

3-Phenylumbelliferone is a coumarin derivative that is used as an antidiabetic drug. It is a competitive inhibitor of the enzyme phosphatase, which inactivates tyrosine kinase, and inhibits the formation of DOPA from L-tyrosine, resulting in inhibition of glucose uptake by cells. 3-Phenylumbelliferone also fluoresces at wavelengths of 340 nm when excited with ultraviolet light. This property has been shown to be helpful in the detection of phenylurea herbicides, polycyclic aromatic hydrocarbons, and other compounds.

Versatile small molecule scaffold

1-(o-Methoxyphenoxy)-2-propanone is a guaifenesin precursor that is used as a supercritical solvent. It has been shown to liquefy benzyl groups, which are difficult to dissolve in other solvents. The 1-(o-methoxyphenoxy)-2-propanone molecule contains methoxy groups and benzyl groups, which are both susceptible to irradiation. The optimum irradiation time for the 1-(o-methoxyphenoxy)-2-propanone molecule was found to be about 15 hours at room temperature. This compound has high affinity values for gas chromatography/mass spectrometry parameters and can be reused up to ten times without significant change in its properties.

2-Phenoxypropanenitrile is a hydrogen chloride derivate of an amide. It reacts with ethylene diamine to form 2-aminoethanol. This compound can be further reacted with sulfide to form the sulfide derivative, cysteamine. The reaction time for this process is between 10 and 20 hours at room temperature. 2-Phenoxypropanenitrile has been shown to inhibit tyrosine kinase and other enzymes that are important for cancer cell growth. This substance also has anti-inflammatory properties, which may be due to its ability to scavenge hydroxyl radicals and react with ROS (reactive oxygen species) such as hydrogen peroxide and superoxide anion radicals.

Versatile small molecule scaffold

2-(4-Aminophenoxy)ethanol is a drug that has been studied for the treatment of cancer. It has been shown to inhibit the growth of cancer cells in animals by inhibiting their ability to synthesize DNA, RNA, and proteins. 2-(4-Aminophenoxy)ethanol also inhibits the production of a number of inflammatory mediators, such as TNF-α and IL-1β, which are involved in carcinogenesis. This drug is an acyltransferase inhibitor that prevents the formation of N-acetylated prodrugs from acetaminophen and other drugs. 2-(4-Aminophenoxy)ethanol also inhibits sulfation, which is required for the synthesis of glucuronide conjugates with amines and catechols. This inhibition may be responsible for its antiinflammatory effects.

Versatile small molecule scaffold

Versatile small molecule scaffold