Building Blocks

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>3-Chloro-4-nitrobenzene-1-sulfonamide is a potent antiproliferative agent that binds to the bcl-xl protein and inhibits cancer cell growth. It has been shown to induce apoptosis in cancer cells, and has been found to inhibit the expression of the mcl-1 protein. 3-Chloro-4-nitrobenzene-1-sulfonamide binds directly to the bcl2 family proteins Bax and Bak, which are involved in regulating apoptosis, leading to cell death. This drug also causes dose dependent inhibition of proliferation in cancer cells at low concentrations while not affecting healthy cells.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

3,5-Dimethyldodecanoic acid is a fatty acid with high densities that has potential use in pest control. It is synthesized by the enantioselective addition of malonic acid to oleic acid and it has been shown to be a potent attractant for the target pest. The stereoisomers of 3,5-dimethyldodecanoic acid are active against different pests, which may be due to their ability to bind to specific receptors on the insect's antennae. This compound could also be used as a chromatographic stationary phase for separating stereoisomers.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-[(1S)-1-Hydroxyethyl]phenol is a compound that is metabolized to 4-hydroxymandelic acid and 4-hydroxyphenylglycine by microbial metabolism. This chemical has been shown to be a substrate for the enzyme dehydrogenase, which may be flavoprotein or polyacrylamide gel. The regiospecificity of the reaction was determined through enantiomer analysis of vanillyl alcohol as the product. Enantiomers were separated using a short-chain alkyl ester, although other solvents such as acetone may be used. The eugenol isomers are present in the reaction products and they can be determined by gas chromatography or liquid chromatography with a mass spectrometer detector. 4-[(1S)-1-Hydroxyethyl]phenol has an optimum pH of 7 and its reactivity increases at pH values below 6.5 or above 8.5.

5-Chloro-7-methyl-1,3-benzoxazole-2-thiol is a benzoxazole that has been shown to have high binding affinity for the 5HT3 receptor in the distal colon. It has been proposed as a potential therapeutic agent for irritable bowel syndrome (IBS). This compound may be useful for treating IBS because it has been shown to act as an antagonist of the 5HT3 receptor, which is involved in the regulation of visceral pain. 5Chloro-7-methyl-1,3-benzoxazole-2-thiol does not bind to other receptors and does not show any agonist activity.