Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Fluoro-8-methylquinoline is a catalytic agent that participates in the formation of 8-methylquinoline. It is prepared by reacting benzyl chloride with ethanolamine in the presence of phosphine, chlorine and catalytic amounts of iodine. The reaction product is purified by fractional distillation to yield 5-fluoro-8-methylquinoline. This compound can also be synthesized from chlorination of cyclic or carbonyl compounds with phosphine and chlorine, as well as from iodides and sulfate.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(3-Methylfuran-2-yl)ethan-1-one is a heterocyclic compound that can be found in the leaves and tubercles of Bignoniaceae plants. It is structurally related to an oxygen heterocycle, which is a class of organic compounds with oxygen in their molecular structures. 1-(3-Methylfuran-2-yl)ethan-1-one has been isolated from the leaves of Blechnum pennaefolium and the tubers of Tuberculosa leontopodioides by alkaline hydrolysis. It has shown antimicrobial activity against Gram positive bacteria. The diacetate form was isolated from the leaves of Bignonia colemanii and shown to have antiviral properties. Formylation reactions are also possible with this compound, as it has been shown to react with sodium methoxide or dimethyl sulfoxide to produce formaldehyde and methanal respectively.

2-Ethylbut-2-enedioic acid is an aliphatic hydrocarbon that has a particle size of about 1 micron. It is a monocarboxylic acid that is commonly used as a precursor to the synthesis of polycarboxylic acids. 2-Ethylbut-2-enedioic acid can be activated by reacting with tertiary amines or phosphines and subsequently reacting with alcohols or thiols. The latter reaction will produce esters or ethers, respectively. This compound has been shown to have antiinflammatory effects in models of autoimmune diseases, such as arthritis and colitis, which are due to its ability to inhibit the production of proinflammatory cytokines.

Versatile small molecule scaffold

2-Hydroxyethane-1-sulfonamide is a potent antiviral agent that inhibits the virus from entering cells by binding to the fatty acid component of the viral envelope. It also has potent antitumor activity and has been shown to be effective against HIV infection. 2-Hydroxyethane-1-sulfonamide binds to mitochondrial matrix proteins, inhibiting fatty acid oxidation and glycogen synthase kinase 3 (GSK3) activation. This inhibition leads to the depletion of cellular energy stores, which eventually results in cell death. 2-Hydroxyethane-1-sulfonamide also inhibits ammonolysis reactions, which converts ammonium into ammonia, a process that is necessary for nitrogen fixation in plants and bacteria.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold