Building Blocks

<p>2-Amino-6-chloropurine is a nucleophilic substituent that is used in the synthesis of 2-amino-6-chloropurine. It reacts with hydroxyl groups to form a palladium-catalyzed coupling reaction solution, which is then treated with hydrochloric acid and trifluoroacetic acid. The product is purified by crystallization and recrystallization. This compound has potent antitumor activity against carcinoma cell lines, but it has not been shown to have any effect against Mycobacterium tuberculosis.</p>

<p>2-Aminoimidazole sulfate is a chemical compound that is used as a transfection reagent. It has been shown to have high transfection efficiency with low cytotoxicity. The diameter of the molecule is in the range of 2 - 3 nm, which allows it to be taken up by cells and thus be active in them. This chemical can be dehydrogenated to form imidazole-2-sulfonic acid, which may interact with other molecules. There have been many advances in this area, including modifications and gaseous forms of the molecule. Research into the interactions of this compound with other chemicals and their effects on cellular uptake are ongoing.</p>

<p>(R)-(-)-3-Amino-3-phenylpropionic acid is a hydrogenated, stereoselective β-amino acid that is involved in the biosynthesis of animal health. The enzyme acylase catalyzes this reaction by binding with chiral pyridoxal phosphate to form an acylation product. The stereospecificity of the reaction is determined by whether the enzyme has a preference for L or D amino acids. Acylases are found in organisms such as mammals and bacteria.</p>

<p>2-Amino-4-hydroxypyridine (2AH) is a synthetic, isomeric compound that has been synthesized in two different forms: 3-bromo-5-hydroxypyridine and hydroxy group. 2AH has been shown to be chemically stable at room temperature and pH levels of less than 7. It also withstands the loss of membrane fluidity induced by amides, such as 3-amino-2-bromopyridine. 2AH can be used to synthesize oxindole derivatives, which are found in natural gas, and piperidines. This chemical can also be used for aminations with pyrrole or 2 amino 4 hydroxypyridine.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>MW 20,000 - 30,000</p>

<p>5-Amino-3-methylisothiazole HCl is a pyridine-5-carboxylic acid that inhibits bacterial growth by binding to the 50S ribosomal subunit. It has been shown to inhibit the growth of both aeruginosa and nalidixic acid resistant strains of S. aureus, P. aeruginosa, and P. mirabilis in vitro. 5-Amino-3-methylisothiazole HCl has also been shown to be active against E. coli, quinolone resistant strains of Proteus mirabilis, and methicillin resistant strains of Staphylococcus aureus in vitro.</p>

<p>3-Bromo-2-nitrobenzaldehyde is an organic chemical compound used in the synthesis of other chemical compounds. It is a colorless liquid that can be easily synthesized using potassium permanganate, tetrahydrofuran, acetone and hydrochloric acid. The chemical reaction is carried out by reacting potassium permanganate with hydrochloric acid to form potassium chloride and manganese dioxide. The manganese dioxide then reacts with acetone to produce 3-bromo-2-nitrobenzaldehyde. This synthetic method for producing 3-bromo-2-nitrobenzaldehyde uses less hazardous chemicals than the traditional method.</p>

<p>Versatile small molecule scaffold</p>

<p>Di(1-adamantyl)chlorophosphine is a bifunctional ligand that can be used for the palladium-catalyzed coupling of aryl chlorides and amines. Di(1-adamantyl)chlorophosphine is synthesized from adamantane, phosphorous pentachloride, and anhydrous ammonia in the presence of catalytic amounts of palladium. Di(1-adamantyl)chlorophosphine is immobilized on silica gel to prevent hydrolysis. This ligand reacts with primary amines to form iminophosphoranes, which can then be reacted with aryl chlorides to form aryl chloroamines.</p>

<p>Versatile small molecule scaffold</p>

<p>Please enquire for more information about (2R,4R)-1-[(2S)-5-Amino-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic a cid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-chloropropan-1-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Versatile small molecule scaffold</p>

<p>2,2',4,4'-tetrahydroxybenzophenone is a hydroxylated benzophenone that has immunomodulatory effects. It binds to the receptor in the immune system and can cause an increase in cytokine production. 2,2',4,4'-tetrahydroxybenzophenone is cytotoxic and has significant toxicity in vitro. The molecule has been shown to disrupt mitochondrial membrane potential. This may be due to its ability to form hydrogen bonds with molecules on the mitochondrial membrane. 2,2',4,4'-tetrahydroxybenzophenone also modulates transcriptional regulation of genes involved in cell proliferation and apoptosis. The drug is detectable at low levels by mass spectrometry and is not known to have any toxicological effects.END&gt;&gt;</p>

<p>Triglycol dichloride is a synthetic, water-soluble solid that is prepared by the reaction of 3-chloroperoxybenzoic acid with a hydroxide solution. It has been used in a variety of applications such as the preparation of hemicyanine, the synthesis of polymers, and the degradation of chlorinated hydrocarbons. Triglycol dichloride also has synergistic effects with other photocatalysts, increasing their activity and reducing their cost. Triglycol dichloride can be used to synthesize polymer films or coatings that are biodegradable, have low environmental impact, and are structurally stable. This compound is also unaffected by water or neutral pH and can be used in the production of semiconductors.</p>

<p>Please enquire for more information about 1,1',1''-(1,3,5-Triazinane-1,3,5-triyl)tris(2-bromoethan-1-one) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about DL-Tropic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Tert-butyl N-(8-bromooctyl)carbamate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1,2,3,4-Tetrahydropyridin-4-one is an organic compound that can be synthesized by a cross-coupling reaction between a pyridine and chloroformate. The reaction mechanism involves nucleophilic addition of the amine to the electrophile followed by reductive elimination. This process leads to the formation of a tetrahydroquinoline skeleton with stereoselectivity. Tetrahydropyridin-4-one can also be synthesized from an iminium ion or an activated pyridinium salt. The resulting product will have a different skeleton because it was synthesized through different mechanisms.</p>

<p>JMJD2 is an enzyme that catalyzes the methylation of histone H3 at lysine 27. JMJD2 inhibitors are compounds that inhibit JMJD2 activity, which may be used to treat cancer. This class of drugs inhibits the activity of JMJD2 by binding to the active site and blocking the substrate from entering. The most potent compound in this class, 5-carboxy-8HQ, has been shown to have antibacterial efficacy in a squamous cell carcinoma model system and up-regulated expression in wild-type cells. Additionally, this compound has been shown to significantly inhibit tumor growth in a mouse model of atherosclerotic lesion.</p>

<p>Please enquire for more information about N-Me-D-Ala-OMe·HCl including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>6-Maleimidocaproic acid N-hydroxysuccinimide ester (6MCA-NHS) is a fluorescent probe that reacts with the hydroxyl group of fatty acids in human serum and other biological samples. 6MCA-NHS binds to the carboxylic acid group at the end of a fatty acid molecule, forming a covalent bond. This process generates light emission that can be detected by a fluorescence probe to measure changes in pH or other chemical properties within the solution. 6MCA-NHS has been used as a tumor treatment, where laser ablation is used to break up tumor cells and release 6MCA-NHS into the cytoplasm. The drug can then bind to DNA molecules and inhibit protein synthesis, which results in cell death.</p>

<p>Please enquire for more information about MCPA 2-ethylhexyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 10-Oxooctadecanoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-Hydroxy-5-methylpyridine (3HMP) is a chemical substance that has been classified as an amine. It is a product of the metabolism of purines, which are nitrogenous bases found in DNA and RNA. 3HMP is produced by aerogenic bacteria (such as Enterobacter), and can be used to estimate the number of these bacteria present in water samples. 3HMP has been shown to have antiviral properties against influenza virus, and can be used as a biomarker for the presence of other viruses in animals. 3HMP also has mineralization properties, which have been studied extensively, particularly with regards to pancreatic disease.</p>

<p>Fmoc-Dap(Ac)-OH is a fine chemical that is used as a building block in the synthesis of complex compounds. It reacts with various nucleophiles to form an amide bond, and has been shown to be useful for both research and industrial applications. Fmoc-Dap(Ac)-OH can also be used as a reagent to synthesize peptides, which are biologically active compounds that form the basis of many drugs. This versatile intermediate is also used as a scaffold in the construction of more complex molecules. Fmoc-Dap(Ac)-OH has CAS No. 181952-29-4 and is classified as a speciality chemical by the International Union of Pure and Applied Chemistry (IUPAC).</p>

<p>Please enquire for more information about Fmoc-α-methyl-L-phenylalanine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Versatile small molecule scaffold</p>

<p>Please enquire for more information about 4-Chloro-N-[2-(1,2-dihydro-2-oxo-4-quinolinyl)ethyl]benzamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2,4-Dichloro-3-nitropyridine is a halogenated pyridinium salt that has been shown to inhibit the influenza virus in vitro. This compound is also reactive with nucleophilic groups such as amines, alcohols, and thiols. 2,4-Dichloro-3-nitropyridine has been used for the synthesis of quinoline derivatives that have potential applications in autoimmune diseases or cancer. 2,4-Dichloro-3-nitropyridine has also been found to be an inhibitor of tumor necrosis factor alpha (TNFα) production by LPS stimulated human monocytes.</p>

<p>2,4-Dinitrophenylacetic acid is a chemical substance with the potential to inhibit acetylation. It can be used as an antigen and has been detected in environmental chemistry. 2,4-Dinitrophenylacetic acid is produced by the reaction of chemicals that are found in the environment and it can be detected at low concentrations. This compound is able to react with proteins in cells, leading to high cytotoxicity. 2,4-Dinitrophenylacetic acid can also stabilize optical systems.</p>

<p>Please enquire for more information about (αR)-α-(2-Chlorophenyl)-2H-tetrazole-2-ethanol  including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Disodium 8-amino-1,3,6-naphthalenetrisulfonate is a fluorescent sensor that can detect albumin in human serum. Disodium 8-amino-1,3,6-naphthalenetrisulfonate selectively detects the molecule albumin in blood with a sensitivity of approximately 1.5 nmol/L and a selectivity of nearly 100%. The fluorescent sensor consists of an immobilized nanometer sized molecule of 8-aminonaphthalene trisulfonic acid on hydrotalcite. The sensor has been shown to be selective for albumin and does not react with other serum proteins such as immunoglobulins or fibrinogen.</p>

<p>3,5-Dihydroxybenzaldehyde (DHBA) is a plant metabolite that is classified as a phenolic compound. It is found in many plants and has important biological functions such as the production of carotenoids or the cleavage of carotenoid to form other compounds. DHBA can be extracted from plant tissue with hydrochloric acid or carbon sources. It has been shown that DHBA inhibits the growth of soil bacteria by binding to amines and thus preventing them from reacting with substrates. This may be due to its ability to act as an electron donor, which could also explain its inhibitory activity on carotenoid cleavage.</p>

<p>3,5-Dihydroxy-4-methylbenzoic acid is an efficient synthesis of the natural product lucidin. It is a quinone that is found in citrifolia and morindone, compounds which are used as analgesics and antipyretics. This compound has been shown to inhibit the growth of fungi by inhibition of protein synthesis. 3,5-Dihydroxy-4-methylbenzoic acid also inhibits the production of citric acid cycle intermediates such as succinic acid and fumaric acid.</p>

<p>3,4-Diaminobenzophenone is an unsymmetrical compound and a derivative of benzophenone. It is used in the synthesis of other organic compounds, such as pharmaceuticals. 3,4-Diaminobenzophenone is also used as a solubilizing agent for drugs that are insoluble in water. The molecular weight of 3,4-Diaminobenzophenone can be determined by gravimetric analysis or FTIR methods. 3,4-Diaminobenzophenone has been shown to have antioxidative properties. This molecule can bind to hydroxyl groups on biomolecules and protect them from oxidation by reactive oxygen species (ROS).</p>

<p>2,6-Diaminopyridine is a heterocyclic compound that is used in analytical chemistry as an indicator for the presence of protonated amines. It is prepared by coupling 2,6-diamino-pyridine with 1,3-benzodioxole-5-carboxylic acid. The nitrogen atoms are electron withdrawing groups and form hydrogen bonding interactions with the protonated amine. This type of interaction leads to a phase transition temperature of about 115°C and a high value for electrochemical impedance spectroscopy (EIS) measurements. The reaction mechanism involves the formation of a protonated amine from 2,6-diaminopyridine and 1,3-benzodioxole-5-carboxylic acid followed by proton transfer to yield the corresponding pyridinium salt.</p>

<p>Please enquire for more information about N-[2-[(2S)-2-Cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-6-[methyl[3-(1-piperazinyl)propyl]amino]-4-quinolinecarboxamide trifluor oacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about D-Carnosine trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>tert-Butyl 2-(hydroxymethyl)azetidine-1-carboxylate is a versatile compound that has various applications across different industries. It is commonly used as a building block in the synthesis of shikimic acid, which is a key intermediate in the production of inhibitors and herbicides. Additionally, this compound can be utilized in electrode fabrication and is often sought after by researchers for their chemical studies. Another notable application of tert-Butyl 2-(hydroxymethyl)azetidine-1-carboxylate is its use in the pharmaceutical industry. It serves as an important starting material for the synthesis of cetirizine, an antihistamine medication used to alleviate allergy symptoms. Furthermore, it has been studied for its potential therapeutic effects on conditions such as psoriasis and photocatalytic reactions. In addition to its pharmaceutical applications, tert-Butyl 2-(hydroxymethyl)azetidine-1-carboxylate</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Chromane-2-carboxylic acid is an amide with a hydroxy group that has inhibitory effects on alkoxyphenols. It has been shown to have the ability to inhibit the growth of cancer cells in mammalian tissue and has been used in synthesizing nitro compounds. Chromane-2-carboxylic acid also inhibits matrix metalloproteinases, which are enzymes that break down proteins in the extracellular matrix and are associated with tumor invasion and metastasis. This compound also has radical scavenging activities, which may be due to its ability to form hydrogen bonds or intramolecular hydrogen bonds with aromatic hydrocarbons or fatty acids.</p>

<p>(1R,2S)-2-Phenylcyclopropane-1-carboxylic acid is a dicarboxylic acid that is produced from the decarboxylation of benzyne. This compound has been shown to be a precursor of benzene and ozonolysis. The stereospecifically of (1R,2S)-2-Phenylcyclopropane-1-carboxylic acid has been determined using lead tetraacetate as the substrate. (1R,2S)-2-Phenylcyclopropane-1-carboxylic acid is an asymmetric molecule.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>tert-Butyl 2-bromo-2-methylpropanoate is a versatile compound with various applications. It is commonly used as a cytotoxic agent in the pharmaceutical industry and as an amide intermediate in organic synthesis. This compound has also been studied for its potential therapeutic effects, such as its ability to inhibit the growth of cancer cells. tert-Butyl 2-bromo-2-methylpropanoate is often utilized in research settings to study the efficacy of drugs like rabeprazole and tripterygium. Additionally, it finds applications in the production of polymers, catalysts, and hydrogen atom transfer reactions. With its wide range of uses, tert-Butyl 2-bromo-2-methylpropanoate is a valuable compound for researchers and industries alike.</p>

<p>2,3-Dihydro-1H-pyrrolo[3,2-c]pyridine is an alkaloid compound that has various applications in research and chemical studies. It has been found to interact with dopamine receptors and exhibit photothermal properties. This compound has been studied in the context of G. lucidum (also known as Reishi mushroom) and its potential therapeutic effects. Additionally, it has shown interactions with quinpirole, lithium, ergovaline, efrotomycin, and other compounds. The photocatalytic and fatty acid properties of 2,3-Dihydro-1H-pyrrolo[3,2-c]pyridine make it a versatile compound for various research purposes.</p>

<p>Please enquire for more information about Dibromoethane-d4 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(2S,6S)-2,6-Dimethylmorpholine is an optically pure compound that can be used to optimize the epoxidase reaction. It belongs to the class of morpholines and has two enantiomers. The (2R,6R)-enantiomer is more active than the (2S,6S)-enantiomer in catalyzing the epoxidase reaction. The temperature optima for both enantiomers are different with the (2R,6R)-enantiomer having a higher optimal temperature than the (2S,6S) enantiomer. This compound can be used as a chiral auxiliary to separate racemic mixtures by focusing on one enantiomer at a time. It can also be used as an analytical method for determining plate number and plate height.</p>

<p>4-Hydroxy-5-methoxy-2-nitrobenzaldehyde (4HMN) is a proton donor that can be used as a crosslinking agent. It is an acidic compound that binds to the substrate, usually via hydrogen bonds. 4HMN has been shown to have good binding affinity for tumour cell lines and can be used as a crosslinking agent in bioconjugation reactions. It is also a reversible chemical reaction, which means it can be hydrolyzed under certain conditions. 4HMN has been shown to be capable of enhancing the rate of enzymatic reactions by acting as a cofactor or coenzyme, such as degradable enzymes and enzymes with low turnover rates. The kinetic process of these reactions are measured by fluorescence techniques and gel permeation chromatography.</p>

<p>2,6-Dimethylphenylacetic acid is a hydrogen phosphate that is soluble in solvents such as acetonitrile. It has been used in the synthesis of lidocaine with high sensitivity and specificity. It can be used to detect phosphoric compounds, which are often present in pharmaceuticals and food supplements. This compound has also been shown to have a solvent effect on the conditions of the reaction, making it a useful additive for optimizing processes. The main impurities of this compound are 2-methylbenzoic acid and benzoic acid.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Ethyl-4-methylpyrrole-2,5-dione is a chlorophyll analog. It has been found to be an electron donor in photosystem II of the chlorobium reaction center. The compound was prepared by evaporation of a solution of chlorobenzene and ethyl acetoacetate in carbon tetrachloride with the aid of a vacuum pump. 3-Ethyl-4-methylpyrrole-2,5-dione has also been used as a reagent for the preparation of phycocyanin from Spirulina platensis, which is an important component of blue algae. The compound reacts with phenoxy and furyl groups under acidic conditions to produce carboxylate and calcium carbonate, respectively. Oxidation products are formed in reactions with ethyl group and other organic compounds under alkaline conditions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Oxohexanoic acid (2-OHBA) is a fatty acid that is synthesized from the amino acids lysine and methionine. It is involved in mitochondrial metabolism and has been found to be necessary for spermatozoa motility. 2-OHBA has been shown to inhibit the activity of glutamate dehydrogenase, an enzyme that catalyzes the conversion of glutamate to α-ketoglutarate, which is required for energy production. This inhibition leads to a decrease in ATP levels, which may cause a variety of symptoms, including fatigue and weight loss. Furthermore, 2-OHBA inhibits protein synthesis by blocking the incorporation of amino acids into proteins. The inhibition of this process can lead to high ammonia levels in the blood and accumulation of other nitrogenous wastes in tissues such as liver or muscle tissue. Analysis of urine samples has shown that 2-OHBA is excreted unchanged in urine.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Pentanimidamide hydrochloride is a drug that belongs to the group of aromatic hydrocarbon drugs. It is a potent antihypertensive agent with a rapid onset and long duration of action. Pentanimidamide hydrochloride has been shown to inhibit the production of reactive oxygen species, which are generated by the respiratory chain in mitochondria, and to prevent the formation of pyrazinoic acid, an inhibitor of blood vessel relaxation. This drug also has been shown to reduce blood pressure in animal models by binding to specific receptors on cells in the cardiovascular system. The active form is bound to plasma proteins such as albumin and alpha-1-acid glycoprotein, which are found in high concentrations in erythrocytes. Pentanimidamide hydrochloride also binds to alkynyl groups and phenyl groups, which may be due to its ability to form covalent bonds with these functional groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,3²-Dithiobis(propionitrile) is a molecule that includes sodium hydroxide solution and acrylonitrile. It reacts with 3-mercaptopropionic acid to form sodium hydrogen ester compounds. This reaction takes place in a sealed container and is catalyzed by carbonic and hydrochloric acids. The product of this reaction is 3-thiocyanatoacrylic acid.</p>

<p>4-(2-Bromoethyl)morpholine hydrobromide is a solvent that is used as an agent in the production of other chemicals. It is a colorless, crystalline solid with a constant melting point of 130 to 131 degrees Celsius. 4-(2-Bromoethyl)morpholine hydrobromide is soluble in acetone, ethanol, ether, and water. This chemical has been shown to be toxic and should be handled with care.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Acetylbenzoic acid is a functional molecule that contains an acetyl group. It can form hydrogen bonds with other molecules and has been shown to induce apoptosis in cells. The reaction products of 2-acetylbenzoic acid are malonic acid, acetylsalicylic acid, and 2-benzoylbenzoic acid. These three compounds are made by the addition of hydrogen or hydroxide to the molecule 2-acetylbenzoic acid. The molecule has two functional groups: a carbonyl group and an acetyl group. The chemical structure of this molecule can be seen in the figure below.<br>2-Acetylbenzoic Acid</p>

<p>1-Adamantane carboxylic acid is a hydrophobic molecule that can form a complex with metal hydroxides. It is used in the process optimization of the synthesis of sodium salts. 1-Adamantane carboxylic acid binds to metals, such as magnesium and calcium, in a coordination geometry that is similar to that observed for water molecules. The complexation of 1-Adamantane carboxylic acid with metal ions results in an acidic environment, which is important for bowel disease. This acid complex also has anti-inflammatory properties. The hydroxyl group on the 1-adamantane carboxylic acid reacts with oxygen to form an alcohol group and this reaction mechanism may be involved in physiological functions.</p>

<p>1-(But-3-yn-1-yl)piperidine is a chiral compound that inhibits the reuptake of serotonin. It has been shown to be an effective inhibitor of the serotonin transporter and to cause an increase in extracellular serotonin levels. 1-(But-3-yn-1-yl)piperidine also has affinity for the dopamine transporter, which may account for its antidepressant effects.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Amino-4-bromopyridine is a potent, selective antagonist of the nicotinic acetylcholine receptor (nAChR) that has been shown to inhibit the proliferation of cancer cells in vitro. 2-Amino-4-bromopyridine binds to the nAChR and stabilizes it by binding to an allosteric site on the receptor. 2-Amino-4-bromopyridine is synthesized from 4,5-dibromobenzene and 2,6-diaminopyridine in two steps with a yield of 47%. The synthesis of 2-amino-4-bromopyridine proceeds via reaction mechanism involving electrophilic substitution at the bromine atom followed by nucleophilic addition at the nitrogen atom.</p>

<p>N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide is an environmental and industrial chemical that is used as a formate, benzoate, and methyl benzoate intermediate. It reacts with nitric acid to form N-(4-aminophenyl)-N-methyl-2-(4-nitrophenoxy)acetamide (NPA). NPA has been shown to have antiangiogenic properties. NPA inhibits the proliferation of endothelial cells by interfering with the cell cycle and inducing apoptosis.</p>