Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Quinoline-5-carbonitrile is a cyanide compound that can be used in the synthesis of heterocyclic compounds. The reaction between quinoline and 5-cyanovaleric acid produces 6-nitroquinoline, which is then converted to dimethyl sulfoxide by alcoholysis. This reaction product can then be used to synthesize an amide or nucleophile. Quinoline-5-carbonitrile reacts with potassium in the presence of bifunctional hydrazide to produce a cyanide ion, which can be hydrolyzed by an acid to release hydrogen cyanide gas. This experiment has been shown as a model for reactions involving cyano compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Benzothiophene-6-carboxaldehyde (BTA) is a heterocyclic compound that contains sulfur. It is a colorless liquid with a sweet odor. BTA is used in the manufacture of pesticides, pharmaceuticals, and other organic chemicals. It is also used as a building block in the synthesis of other compounds and has been shown to have anti-inflammatory properties.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Flindersia laevicarpa is a small tree native to Australia. The leaves of the tree are used for medicinal purposes and contain 1,5-diphenylpentan-3-ol. Flindersia laevicarpa has been shown to have anti-inflammatory and antioxidant properties, as well as an ability to inhibit platelet aggregation.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-[(2-Methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole is a recombinant protein that binds to the ribosomal protein L11. It has been shown to inhibit the biosynthesis of the bacterial cell wall and therefore inhibit replication of the bacterial genome. 3-[(2-Methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole also inhibits the synthesis of proteins essential for cell division. This compound has been shown to bind to ribosomes in both prokaryotic and eukaryotic cells. It may have potential as an inhibitor of cancerous cells because it inhibits protein synthesis in mammalian cells.</p>

<p>Versatile small molecule scaffold</p>

<p>1,4-Dimethyl 2-hydroxy-2-methylbutanedioate is an allylating agent that modifies the amino acid lysine residues in proteins. It has been shown to be effective in the treatment of skin lesions caused by Staphylococcus aureus and other bacteria because it inhibits bacterial growth through an antimicrobial effect. 1,4-Dimethyl 2-hydroxy-2-methylbutanedioate also has been used as a precursor for the synthesis of vitamin D3. This compound is metabolized in mammalian cells to form cysteamine, which is further converted to S-(1,4-dimethylpentadienoyl)cysteamine (DMPE). The resulting product can be used as a functional group on collagen or malic acid. 1,4-Dimethyl 2-hydroxy-2-methylbutanedioate also is used for modifications of mucocutaneous tissues such as skin and oral muc</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>The synthesis of (2-bromophenyl)(phenyl)methanol is accomplished by the reaction of an aldehyde with bromine followed by an alkylation with magnesium. The product is obtained as a racemic mixture of enantiomers with a chiral center, which can be resolved by fractional crystallization or other separation methods. This method has been shown to be efficient for the synthesis of alcohols and carbinols, and stereogenic reactions.</p>

<p>2-Amino-4H,5H-naphtho[2,1-b]thiophene-1-carbonitrile is a dihydronaphthalene compound that has been shown to be active against influenza viruses. It inhibits the virus by binding to the pyrimidine ring of the virus's RNA polymerase. This inhibits viral replication and reduces plaque formation. 2-Amino-4H,5H-naphtho[2,1-b]thiophene-1-carbonitrile has antiviral activity against influenza A and is effective in inhibiting h5n1 virus replication.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>3,5-dimethoxyphenyl isothiocyanate (3,5-DMPIC) is a benzimidazole derivative that has been shown to be a potent and selective antagonist of the gonadotropin-releasing hormone (GnRH). 3,5-DMPIC has been shown to desensitize GnRH receptors on the pituitary gland and may have applications in the treatment of prostate cancer. It also inhibits the release of luteinizing hormone and follicle stimulating hormone from the pituitary gland.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-3,3,3-trifluoro-1-propene is a chemical compound that has been synthesized in an asymmetric reaction. The reactant is bromopropane and the product is 2,2,2-trifluoropropene. The methylene group on the propene molecule is activated by the nucleophilic attack of a fluoride ion from hydrogen fluoride to form a cavity with a highly strained bond. The kinetic study of this reaction revealed that the activation energy for the reaction is 42 kJ/mol. Palladium-catalyzed coupling reactions are catalyzed by palladium and require nonpolar solvents such as toluene or dichloromethane. This type of reaction has been shown to be exothermic with an isolated yield of 1%.</p>