Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Amino-4-bromobenzene-1-thiol is a semiconducting polymer that can be used in devices such as solar cells, transistors, and sensors. It has electron deficient properties and is therefore able to form the backbone of a polymer. 2-Amino-4-bromobenzene-1-thiol is an electron donor that can be used for polymerization reactions with electron acceptors such as indigoid compounds. This compound has been shown to have optical absorption bands in the near infrared region, which are suitable for solar energy conversion applications.</p>

<p>4-(Methoxymethyl)benzaldehyde is an organic chemical compound that has the molecular formula CHO. It can be obtained by catalytic cleavage of 4-hydroxybenzaldehyde with hydrogen chloride in the presence of a nickel catalyst, followed by chlorination and reduction. This chemical is used in pharmaceuticals as a catalyst for reductive cleavage and cyclization reactions. The acidity of 4-(methoxymethyl)benzaldehyde is due to its nitrogen substituents, which are capable of deprotonating the carbon atom adjacent to the carbonyl group. This allows for selective synthesis at the benzylic position.<br>4-(Methoxymethyl)benzaldehyde is also able to catalyze lithiation reactions because it contains a reactive chlorine atom.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>BI6015 is a fatty acid that inhibits the transcriptional regulation of genes involved in tumorigenesis, cell survival, and drug resistance. It has been shown to inhibit the uptake of glucose and fatty acids by cells. BI6015 also blocks the binding of growth factor-β1 to its receptor, thereby inhibiting signal transduction pathways that regulate cell proliferation and differentiation. BI6015 has been shown to inhibit the activity of enzymes involved in lipid synthesis, which may contribute to its ability to prevent congenital heart disease. This drug has been tested in animal models with promising results but it is not yet known how it will affect human subjects.<br>BI6015 is rapidly absorbed after oral administration and excreted unchanged in urine. The pharmacokinetic properties of this compound have not yet been evaluated in humans.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Tetrabenazine is a drug that is used to treat hyperkinesia, a neurological disorder. It decreases the release of dopamine in the brain by binding to and blocking the activity of vesicular monoamine transporter 2 (VMAT2) and inhibits the reuptake of dopamine into synaptic vesicles. Tetrabenazine has been shown to decrease locomotor activity in rats. The clinical relevance of tetrabenazine is not known, but it may have adverse effects on the liver, for example, if taken with anhydrous sodium. Tetrabenazine is not recommended for use in patients with hepatic impairment or with symptoms of liver disease.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>The synthesis of 2-{Cyclopentyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino}acetic acid is accomplished through an asymmetric, stereoselective, catalytic route. The first step in the synthesis is conversion of glycine to the corresponding N-protected glycine methyl ester by reaction with benzyl chloroformate followed by protection of both carboxylic acid groups as FMOC derivatives. The key steps are a diastereoselective hydrogenation of the cyclopentane ring system and an efficient alkylation reaction of the resulting alcohol with 9H-fluoren-9-ol. <br>2-[Cyclopentyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]acetic acid has been shown to be a potent inhibitor against bacterial growth. It binds to bacterial topoisomerase IV enzyme, which</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>