Building Blocks

<p>Ethyl (2-methoxybenzoyl)acetate is a furan derivative that has two dihedral angles. It has a crystal structure with a benzene ring and a furan ring. Ethyl (2-methoxybenzoyl)acetate is soluble in most organic solvents and water but not in ether or hexane. It has a boiling point of 180 degrees Celsius and the molecular weight is 170.3 g/mol.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Methoxyhexanoic acid is a carboxylic acid that functions as a metabolic intermediate in the biosynthesis of phenoxy compounds. The synthesis of 6-methoxyhexanoic acid can be achieved by reacting phenol with formaldehyde, followed by hydrolysis and decarboxylation. It is also used as an intermediate in the production of biodegradable polymers. The functional group is hydrophobic and exists in both the alpha- and beta-positions on the carbon chain. 6-Methoxyhexanoic acid has been shown to have anti-inflammatory properties, which are related to its inhibition of prostaglandin synthesis.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

4-(Diaminomethylidene)amino-N-methylbenzoic acid (DABA) is a potent histone deacetylase inhibitor that has been shown to inhibit the growth of cancer cells in vitro. DABA binds to the hydrophobic pocket of the acetyltransferase domain of the HDAC enzyme and prevents its interaction with the substrate lysine, inhibiting histone acetylation. In addition, DABA also inhibits platelet aggregation by reducing ATP production in platelets, which may be due to its ability to inhibit protein kinase A activity. The molecular modeling study demonstrated that DABA fits well into the hydrophobic pocket of HDAC2, with potential for binding to other HDACs.

<p>Ethyl 3-sulfanylbenzoate is a potent inhibitor of cytosolic phospholipase A2 (cPLA2). This enzyme is involved in the production of arachidonic acid, which is a precursor for prostaglandins and leukotrienes. Inhibition of cPLA2 prevents the release of arachidonic acid, reducing the production of inflammatory molecules. Ethyl 3-sulfanylbenzoate has been shown to inhibit platelet aggregation and reduce thrombus formation in vitro. The activity of this drug can be attributed to its substitution with electron-donating groups at the ortho position on the phenyl ring.</p>

<p>Methyl 2-hydroxy-3-methylpentanoate is a volatile chemical compound that is found in the essential oil of guajava fruit. It is an ester of a hydroxycarboxylic acid and an alcohol. This chemical has been identified by magnetic resonance spectroscopy and was found to be present in the headspace of guava fruit. Methyl 2-hydroxy-3-methylpentanoate interacts with the hydroxyl group of benzoic acid to form methyl benzoate, which is used as a food preservative. This compound can also be found in other plants such as psidium guajava, which is native to South America and has been used for centuries as a natural remedy for various ailments.</p>

<p>Ethyl 3-bromoprop-2-ynoate is a synthetic chemical that can be used as an ethynylation reagent in cross-coupling reactions. This compound has been shown to efficiently catalyze both Pd(0)- and Cu(I)-catalyzed cross-couples with good yields of the desired products. The stereochemistry of this reaction is not affected by the nature of the substrate, and it does not require any protecting groups. Ethyl 3-bromoprop-2-ynoate is useful for the synthesis of natural products such as amino acids, amides, and carbohydrates.</p>

<p>Versatile small molecule scaffold</p>

<p>1-((Pyridin-2-yl)methyl)piperidin-4-one is an organic compound that can be synthesized from piperidine and malonic acid. It is an antipsychotic agent that binds to the dopamine D4 receptor, which may be responsible for its antiangiogenic properties. 1-(Pyridin-2-yl)methyl)piperidin-4-one has been shown to inhibit the growth of human umbilical vein endothelial cells in culture and to block the formation of new blood vessels, as well as to reduce the volume of existing blood vessels. This drug also has a high yield in crystallization and is easy to synthesize from commercially available starting materials.</p>

Versatile small molecule scaffold

5-Chloro-1,3-thiazol-2(3H)-imine (CTA) is a mutagen with the ability to induce point mutations in DNA. It binds to sulfur, which can be found in proteins and nucleotides. CTA has been shown to cause substitutions in Salmonella typhimurium TA100 and E. coli strains TA98 and TA1535. This compound has also been shown to have mutagenic activity against the organisms Escherichia coli and Pneumoniae, although it is not active against Ta10 or Ta1537.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

The chemical structure of N-(4-ethoxybenzyl)-n-methylamine is C(O)NHCH3. It is a colorless liquid with a boiling point of 176°C and a melting point of -5°C. N-(4-ethoxybenzyl)-n-methylamine is soluble in water, ethanol, ether, acetone and benzene. The molecule contains carboxylic acid groups that can interact with nonpolar environments. Hydrogen bonds are also possible between the molecule and water molecules. This product has been used experimentally as a screening tool for interactions with other molecules. The chemical formula of this product is C8H14N2O2 and it has an empirical formula weight of 174.22 g/mol.

2-Methyl-6-methylideneocta-1,7-dien-3-one is a chemical substance that has been found to act as an attractant for insects. In assays, it was found to have significant chemotactic activity and also to be able to damage the wings of flies in both damaged and undamaged states. It has been shown that 2-methyl-6-methylideneocta-1,7-dien-3-one interacts with solid phase microextraction (SPME) fibers, which can be used for extracting the compound from samples. The chemical has been found to be active against Diptera and Lepidoptera species. 2MEMO can be used in treatments for controlling insects in agriculture or industry by attracting them and damaging their wings or preventing them from flying.

<p>Versatile small molecule scaffold</p>

4-Hydroxy-2,3-dihydro-1H-isoindole-1,3-dione is a nonpolymeric compound that has been shown to be an inhibitor of tumor growth. It inhibits the proliferation of tumor cells by binding to the hydroxyl group on the cell surface and inducing apoptosis. 4-Hydroxy-2,3-dihydro-1H-isoindole-1,3-dione also prevents the formation of inflammatory bowel disease in mice. This drug also absorbs infrared light and can be used as an absorber for infrared radiation.

<p>1H-Indene-2-carboxylic acid is a 6-carboxylic acid that has been found to inhibit the growth of cancer cells in vitro. It has been shown to competitively inhibit the activation of peroxisome proliferator-activated receptor gamma (PPARγ), which is involved in controlling cell growth and differentiation. 1H-Indene-2-carboxylic acid also inhibits the activity of cytochrome P450 and induces apoptotic cell death, which may be due to its ability to activate caspase 3. This drug was also shown to increase levels of growth factors by upregulating expression of insulin like growth factor II (IGFII).</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 4-amino-3,5-dichlorobenzoate is a reactive intermediate that is obtained by chlorination of 4-hydroxybenzoic acid. It is used in the synthesis of various esters and salts, such as 4-amino-3,5-dichlorobenzoic acid and methyl 3,5-dichlorobenzoyl chloride. This compound can be synthesized by saponifying the ester with stannous chloride or by hydrolyzing the ester with hydrochloric acid. The spectra of Methyl 4-amino-3,5-dichlorobenzoate are consistent with those reported for other compounds of this type. The chlorine atoms in Methyl 4-amino-3,5-dichlorobenzoate have a Cl to C ratio of 1:1.

<p>3,5-Dichloro-4-methoxybenzaldehyde is a white crystalline solid that is soluble in water. It has been shown to inhibit the activity of oxidase enzymes, which are involved in the degradation of chlorinated hydrocarbons and other toxic substances. The compound also exhibits potent cytotoxicity against various cancer cells, including melanoma cells. 3,5-Dichloro-4-methoxybenzaldehyde is used as an intermediate for the production of vanillyl alcohol (VAN) and 4-methoxybenzaldehyde (MMB). It reacts with chlorine to produce chlorohydroxyl compounds that are used as pesticides or disinfectants. 3,5-Dichloro-4-methoxybenzaldehyde has been shown to be effective against plant diseases such as powdery mildew and black spot on roses. The compound is also used in the production of methyl cinnamate (MC) by reaction</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

2-[(1-Bromo-2-naphthyl)oxy]acetic acid is a fluorescent probe that is used in fluorescence data assays. It has a low molecular weight of 216.3 and fluoresces when excited with UV light. 2-[(1-Bromo-2-naphthyl)oxy]acetic acid has been shown to inhibit the production of oxidase enzymes in vitro, which are found in many bacteria and fungi. 2-[(1-Bromo-2-naphthyl)oxy]acetic acid is also a substrate for the enzyme assembly, which catalyzes the formation of peptide bonds between amino acids. The probe can be used as a marker for protein synthesis and has been shown to have anti-diabetic effects in vivo.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

5-Amino-1,2,3,4-tetrahydronaphthalen-1-one is an organic compound that belongs to the class of heterocyclic compounds. It has been shown to act as a superacid and has been used in the synthesis of multidrug resistant cancer cells. 5-Amino-1,2,3,4-tetrahydronaphthalen-1-one also binds to topoisomerase II and III and inhibits DNA replication. The drug can also inhibit the function of p-glycoprotein and other multidrug resistant transporters at the cellular level.

Versatile small molecule scaffold

3-{[2-(Morpholin-4-yl)ethyl]amino}propanenitrile is a prodrug that is metabolized to the active drug, 2-morpholinoethanol. It is used for the treatment of breast cancer and mastitis (inflammation of the breast). 3-{[2-(Morpholin-4-yl)ethyl]amino}propanenitrile has a high water solubility and high stability, which makes it an ideal candidate for injection as a sustained release drug. This drug can be injected into solid tumors that are difficult to treat with other drugs and may also be used in conjunction with chemotherapy. 3-{[2-(Morpholin-4-yl)ethyl]amino}propanenitrile inhibits the production of estrogen, which plays a role in the growth of some types of breast cancer cells.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

6-Hydroxy-2-methylnicotinonitrile is a reagent that is used for the condensation of aldehydes and amines. It can also be used to form enamines from primary amines with carbonyl compounds. Dimethyl acetal, dimethyl, methyl methacrylate, cyclized, methacrylate, acetal are some of the products that are made using 6-Hydroxy-2-methylnicotinonitrile.

<p>Versatile small molecule scaffold</p>