Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Thiazol-5-yl)acetic acid is an antimicrobial that is used as a fungicide. It has been shown to inhibit the growth of Fusarium and Curvularia. 2-(Thiazol-5-yl)acetic acid also has fungicidal activity against Refluxing, butanoic acid, and Oxysporum. This compound has been found to be effective against fungi in a number of different studies. 2-(Thiazol-5-yl)acetic acid inhibits the synthesis of ribosomes by inhibiting mRNA translation, leading to cell death by inhibition of protein synthesis.

Versatile small molecule scaffold

N-Methylquinolin-2-amine is a quinoline derivative that binds to the fatty acid ester of amides, which are found on the surface of cells. It has high specificity for hydroxy groups and is operational in aqueous solutions. N-Methylquinolin-2-amine has been shown to have activity against Alzheimer's disease by binding to the fatty acid ester of amide and blocking the function of ligands. The reaction time can be reduced by adding hydroxy group and alkyl group to the molecule. A molecular orbital diagram shows how this compound reacts with an amide substrate. This drug can be used as a diagnostic or postoperative treatment for Alzheimer's disease.

Versatile small molecule scaffold

2-bromo-1-cyclopentylethan-1-one is a racemic mixture of two enantiomers, 2-bromo-1-(2-methylpropyl)ethanone and 1-(2-methylpropyl)-2-(phenyl)ethanone. The compound has been shown to inhibit cell proliferation in vitro and has been used in the treatment of allergies without any observed side effects. This drug may act by inhibition of the synthesis of L-amino acids or vitamin B6, which are required for cell division. It may also have an effect on alkylating DNA, leading to inhibition of protein synthesis.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Benzyl Methyl Malnonate (BMM) is a polycarboxylic acid that has an inhibitory effect on the receptor binding of inorganic acids. It is used as a solid catalyst for the oxidative carbonylation of olefins and dienes. BMM can also be used to prepare heterocycles by the reaction of an active methylene with malonic acid and fluorine. The hydroxyl group on the benzyl methyl malonate molecule can undergo thermally induced oxidative carbonylation, which produces benzoic acid and formaldehyde.

1-Hydroxy-3-methylanthraquinone is a quinone compound that has been shown to have binding constants for the fungal filamentous fungus, Vulgare L. (strain pachybasin), and bacterial strains. This chemical has also been shown to have biological properties such as antimicrobial activity against Acetobacter aceti, inhibition of growth of the human pathogen Streptococcus pyogenes, and induction of locomotor activity in mice. 1-Hydroxy-3-methylanthraquinone binds to fatty acids in the cell membrane and alters the permeability of this membrane. 1HMR spectroscopy data suggests that this compound is regiospecific with respect to its two hydroxyl groups.

Versatile small molecule scaffold

3-Propylbenzenamine is an attractant for tsetse flies. 3-Propylbenzenamine has been shown to be a potent carbonate catalyst and can also be used as a carbamate pesticide.

Versatile small molecule scaffold