Building Blocks

Phenylsuccinic anhydride is a reactive, receptor binding, expressed, polycarboxylic acid that has nitrogen atoms. It can be used as an anticancer agent and has shown anticancer activity against α7 nicotinic acetylcholine receptors in the central nervous system. Phenylsuccinic anhydride is also used for the preparation of fluorinated anhydrides for use in nonaqueous solvents.

(3-Methylbutoxy)benzene is a cyclic monomer that can be used in the production of polyester plastics. It has been shown to polymerize with isopentyl by means of an initiator. This reaction system produces a polymerized polymer. The phenyl group in this molecule has been shown to interact with eugenol through transition-state profile and reaction system studies, as well as polymerization reactions with benzene. The fluorescent properties of this compound make it suitable for use in fluorescent labelling of proteins and DNA.

Versatile small molecule scaffold

Versatile small molecule scaffold

Pteridine-2,4-diamine is a peroxide that is found in nature. It has been shown to have an inhibitory effect on mutant enzymes that are involved in the production of hydrogen peroxide. Pteridine-2,4-diamine binds to a ligand and prevents it from reacting with hydrogen peroxide. This compound is used as a surfactant in pharmaceutical preparations. It also has an inhibitory effect on soybean lipoxygenase, which may be due to its ability to bind to the phosphonium salt at the active site and prevent the catalytic reaction with hydrogen peroxide.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Chloro-9-(propan-2-yl)-9H-purine is an intermediate in the synthesis of nucleoside analogues. It is obtained by the catalyzed reaction of acetonitrile and purines, which undergoes regioisomerization to form a mixture of 6-chloro-9-(propyl)- and 6-chloro-9-(butyl)purine. This intermediate can be used for the alkynylation of amino acids or peptides with alkynes. The selective formation of one regioisomer can be achieved by using a chiral catalyst or by reacting with an optically active reagent such as (+)-camphor sulfonic acid.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ip7E is a neuroprotective agent that has been shown to be effective in the treatment of various neurodegenerative diseases, such as Parkinson's and Alzheimer's disease. Ip7E is a small molecule that modulates the metabolism of cells and protects them from death by inducing changes in cell nuclei. It also prevents radiation-induced neuronal cell death. Ip7E has been shown to be effective when administered before or after the onset of disease, suggesting it may be a possible diagnostic for neurodegenerative diseases.
Ip7E binds to cellular membranes and stabilizes them against oxidative damage, thus protecting cells from death by apoptosis, necrosis, or autophagy. It also inhibits fatty acid synthase (FAS) activity and hepatic steatosis.
Ip7E has not yet been tested on humans but is being investigated as a potential drug target for neuroprotection in various neurological disorders.

Versatile small molecule scaffold

Versatile small molecule scaffold