Reagenti sintetici

<p>Applications 5-Methylisoxazole-3-carboxylic Acid is a metabolite of UTL-5b, a structural analog of the anti-arthritic drug, Leflunomide (L322750).<br>References Shaw, J. et al.: Eur. J. Drug. Metab. Ph., 37, 83 (2012)<br></p>

<p>Applications trans-2-[3-(4-tert-Butylphenyl)-2-methyl-2-propenylidene]malononitrile (cas# 300364-84-5) is a useful research chemical.<br></p>

<p>Applications Lithium Chloride is primarily used in the synthesis of lithium metal by electrolysis. Also acts as a prescribed drug for bipolar mood disorder, it may also exhibit anti-inflammatory properties. Anti-cancer agent.<br>References Tsao, N. et al.: Antimicrob. Agents Chemother., 59, 1525 (2015); Cockle, J. et al.: 112, 693 (2015);<br></p>

<p>Applications Silver Carbonate is used in organic synthesis in the Koenigs-knorr glycosylation reaction. It is also known as Fetizon's reagent acting as an oxidising agent on celite forming lactones form diols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fetizon, M., et al.: J. Chem. Soc. Chem. Comm., 19, 1118 (1969);<br></p>

<p>Applications Phosphorothioic Acid Trisodium Salt Hydrate can be involved in reactions of alkali hexafluoroaluminates.<br>References Bukhalova, G. A., et al.: Issled. v Obl. Khim. i Technol. Mineral'n. Solei i Okislov, Akad. Nauk SSSR, Sb. Statei, 124 (1965)<br></p>

<p>Applications 4-​Methoxy-​6-​methyl-​2H-​pyran-​2-​one acts as a potential selective agonist for the ghrelin receptor (GHS-​R1a), a receptor which plays in a role in appetite.<br>References Pastor-Cavada, E., et al.: Sci. Rep., 6, 36456 (2016);<br></p>

<p>Applications Sodium Thiosulfate is used primarily as a medicament against cyanide poisoning, able to convert cyanide into thiocyanate, a reaction which is catalyzed by the enzyme Rhodanese. Antioxidant.<br>References Emuebie, O. et al: Aus. J. Basic App. Sci., 5, 507 (2011); Cambal, L. et al.: Chem. Res. Toxicol., 24, 1104 (2011); Lam, X. et al.: J. Pharm. Sci., 86, 1250 (1997);<br></p>

<p>Applications 4-(t-Boc-amino)-1-butyl Bromide (cas# 164365-88-2) is a compound useful in organic synthesis.<br>References Bendale, P., et al.: J. Med. Chem., 50, 4585 (2007), Lansdell, M., et al.: Bioorg. Med. Chem. Lett., 18, 4944 (2008), Imaeda, Y., et al.: Bioorg. Med. Chem., 16, 2243 (2008),<br></p>

<p>Applications Aziridine carboxylic acid ester derivative used for the synthetic application of chiral aziridine via esterification.<br>References Minakata, S., et al.: Chem. Commun., 47, 6363 (2008); Li, Y.X., et al.: Tetrahedron. Lett., 49, 1480 (2008);<br></p>

<p>Applications Hypotaurine is a metabolite of taurine and affects the regulation of the inflammatory aspects of the immune response. It is also converted into taurine in the body.<br>References Grove, R. et al.: Free Radical. Biol. med., 108, 575 (2017);<br></p>

<p>Applications D-Glyceraldehyde is the simplest of all aldoses and have been shown to be the one of the carbonyl metabolite of dietary fructose.<br>References Yang, K., et al.: Chem-Biol. Interact., 191, 315 (2011); Zheng, X.H., et al.: Chem. Med. Chem., 7, 1921 (2012);<br></p>

<p>Applications A phopshine ligand used in transition-metal mediated organic synthesis, in particular in wittig reactions to improved (Z) selectivity.<br>References Andersen N.G. et al.: Chem. Rev., 101, 997 (2001); Appel M. et al.: Eur. J. Org. Chem., 1143, (2002);<br></p>

<p>Applications MK-886 is a potent and selective inhibitor of FLAP and Cox-1.<br>References Gillard, J., et al.: Can. J. Physiol. Pharmacol., 67, 456-464 (1989);<br></p>

<p>Stability Hygroscopic<br>Applications Lodoxamide is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.<br>References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)<br></p>

<p>Applications tert-Butyl 2-(diethylphosphono)acetate is a chemical reagent used in the synthesis of pharmaceuticals such as Clopidogrel (C587250), s prodrug anticoagulant.<br>References Shaw, S. et al.: J. Org. Chem., 80, 7019 (2015);<br></p>

<p>Stability Air and Moisture Sensitive<br>Applications Diethyl Chlorophosphite is used in the synthesis of organophosphates and are considered anticholinesterase agents through observation in studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Segall, Y. et al.: Chem. Res. Toxicol., 16, 350 (2003);<br></p>

<p>Stability Hygroscopic<br>Applications An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).<br>References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);<br></p>

<p>Applications Di-O-glycinoylcurcumin Dihydrochloride is a metabolite of curcumin (C838500), which is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disea<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)<br></p>

<p>Applications 2-Acrylamide-2-methylpropanesulfonic Acid is used in preparation of PAMPS/PHEMA/PEDOT Hydrogel Polyelectrolyte for activated carbon electrode.<br>References Zhang, X., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications SU11652 is a cell-permeable pyrrole-indolinone that acts as a tyrosine kinase receptor &amp; angiogenic inhibitor.<br></p>

<p>Applications 4-(Bromomethyl)benzoic Acid Methyl Ester is an ester derivative of a bromoalkylated benzoic acid. 4-(Bromomethyl)benzoic Acid Methyl Ester is used in the preparation of potential anti-HIV agents. It is also used as a catalyst for rearrangement of benzylthiothiazoline derivatives in the preparation aldose reductase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cushman, M. et al.: Bioorg. Med. Chem. Lett., 8, 833 (1998); Nagao, Y. et al.: Chem. Pharmac. Bull., 36, 509 (1988);<br></p>

<p>Applications Procinolol is a beta adrenergic receptor antagonist. It is also an intermediate in synthesizing (±)-Procinolol Hydrochloride (P755815).<br>References Singh, K.: Indian J. Phsiol. Pharmacol., 27, 311 (1983)<br></p>

<p>Stability Hygroscopic<br>Applications Indium(III) chloride tetrahydrate (cas# 22519-64-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive<br>Applications Belinostat is a novel histone deacetylase 3 selective inhibitor, which protects the β cells from cytokine-induced apoptosis.<br>References Chou, D.H., et al.: Chem. Biol., 19, 669 (2012); Hwang, J.J., et al.: Inves. New. Drugs., 30, 1434 (2012); Dizon, D.S., et al.: Gynecol. Oncol., 125, 367 (2012);<br></p>

<p>Applications 2-(Dicyclohexylphosphino)biphenyl is used as a catalyst for Suzuki coupling reactions.<br>References Wolfe, J., et al.: J. Am. Chem. Soc., 121, 9550 (1999);<br></p>

<p>Applications Acetylhistamine, is a histamine metabolite, and can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions.<br>References Xu Y, et al. Asian Pac J Allergy Immunol. 2017 Dec;35(4):224-232.;<br></p>

<p>Applications Protected Propargyl. A possible genotoxic compound that can affect the bacterial and mammalian cell systems.<br>References Glowienke, S. et al., Mutat. Res. Genet. Tox., 581, 23 (2005)<br></p>

<p>Applications N-Carbobenzoxy-1,4-diaminobutane HCl is used in the synthetic preparation of pyrazolyl glucopyranoside and galactopyranoside derivative inhibitors of human sodium-glucose cotransporter 1 (SGLT1) for preventives or therapeutics for diseases related to hyperglycemia or galactosemia.<br>References Teranishi, H.; et al.: PCT Int. Appl. 215 pp. Patent 2004 CODEN:PIXXD2<br></p>

<p>Applications 2-Bromobenzyl Alcohol acts as a reagent for the synthesis of alkoxy tetrasubstituted chiral amino acids via three-component reaction of (diazo)oxindoles, alcohols and benzhydrylimino ester involving enantioselective trapping of oxonium ylides by benzhydrylimino ester. Also acts as a reagent for the preparation of orally active and liver-targeted prodrug of 5-fluoro-2'-deoxyuridine for treatment of hepatocellular carcinoma.<br>References Jia, S., et al.: Chin. Chem. Lett., PagesAhead of Print (2016); Peng, Y., et al.: J. Med. Chem., 59, 3661 (2016)<br></p>

<p>Stability Moisture Sensitive<br>Applications Fluorescein Isothiocyanate is a fluorescent reagent with incompletely defined position of the NCS. Fluorescein Isothiocyanate is used in multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance, fluorescence imaging. and drug delivery. Dyes and metabolites.<br>References Kim, J., et al.: Angew. Chem. Int. Ed., 47, 8438 (2008);<br></p>

<p>Applications Mdivi-1 is an inhibitor of mitochondrial division DRP1 and Dynamin I.<br></p>

<p>Applications 2-Acetamido-5-fluorophenylboronic acid, pinacol ester<br></p>

<p>Applications Ethyl (2R,4S)-4-Methylpipecolate is an intermediate in the preparation of Argatroban (A769000).<br>References Hilpert, K. et al.: J. Med. Chem., 37, 3889 (1994), Kim, K. et al.: Med. Chem. Res., 6, 377 (1996),<br></p>

<p>Applications Precursor to Kifunensine.<br>References Kayakiri, H., et al.: Chem. Pharm. Bull., 39, 1378 (1991),<br></p>

<p>Applications Sodium Metasilicate is an antibacterial pharmaceutical compound containing Sodium Hydrogen Carbonate.<br>References Karaagac, M., et al.: Turk. Pat. Appl., (2017);<br></p>

<p>Applications N-Carbobenzyloxy-D-serine-beta-lactone (cas# 98632-91-8) is a useful research chemical.<br></p>

<p>Applications 2-Isobutyrylcyclohexanone (cas# 39207-65-3) is a useful research chemical.<br></p>

<p>Applications (1S)-[1,1'-Binaphthalene]-2,2'-diol is used in the stereoselective synthesis of Peloruside A. Also used in the synthesis of BINAP-based aminophosphines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Raghavan, S. et al.: Tetrahedron, 69, 4835 (2013); Anstiss, C. et al.: Mol., 18, 2788 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Ethoxyamine Hydrochloride acts as a reagent in the preparation of biflorin derivatives (hydrazones, oximes, terpene ketones) and determination of their activity as antibacterial and anticancer agents.<br>References Souza, L. G., et al.: Bioorg. Med. Chem. Lett., 26, 435 (2016)<br></p>

<p>Stability No Data available<br>Applications An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. GW 501516 has been found to enhance endurance in mice without any training.<br>References Oliver, W.R., et al.: Proc. Natl. Acad. Sci., USA, 98, 5306 (2001), Sznaidman, M.L., et al.: Bioorg. Med. Chem. Lett., 13, 1517 (2003), Wang, Y.X., et al.: Cell, 113, 159 (2003); Chem. and Eng. News, p. 9, May 8, 2017<br></p>

<p>Applications Benzenesulfonyl Chloride is used in the synthesis of cecloprotoberberine derivatives as antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, Y. et al.: Eur. J. Med. Chem., 68, 463 (2013);<br></p>

<p>Applications Nimustine Hydrochloride is a DNA alkylator and cross-linking agent. It is used in chemotherapy in a part of anti-cancer cocktail used to treat malignant melanoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matsumoto, T. et al.: J. Eur. Acad. Dermatol. Venereol., 27, 1514 (2013);<br></p>

<p>Applications Bismuth Citrate is a reagent used in the preparation of nano-array wires and nanotubes. Also used in the preparation of collidal bismuth subcitrate with ulcer healing properties.<br>References Chen, R. et al.: Chem. Commun (Camb)., 21, 2265 (2006); Asato, E. et al.: Inorg. Chem., 34, 2447 (1995);<br></p>

<p>Applications (-)-B-Methoxydiisopinocampheylborane hydrate is an intermediate used in the synthesis of homoallylic alcohol's and several complex natural products.<br>References Mishra, V. K., et al.: J. Org. Chem., 81, 9728 (2016); Jonnalagadda, S. C., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis 1, (2009); Bailey, A. M., et al.: Angew. Chem. Int. Ed., 55, 639 (2016)<br></p>

<p>Stability Hygroscopic<br>Applications A semi-synthetic derivative of Podophyllotoxin. Antineoplastic.<br>References Stahlen, H., Eur. J. Cancer, 6, 303 (1970), Hacker, M., et al.: Cancer Res., 37, 3287 (1977), Clark, P.I., et al.: Clin. Pharmacokinet., 12, 223 (1987),<br></p>

<p>Applications R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.<br>References Semmler, J., et al.: Int. J. Immunopharmacol.: 15, 409 (1993); Sommer, N., et al.: Nat. Med.: 1, 244 (1995); Robichaud, A., et al.: J. Clin. Invest., 110, 1045 (2002); Card, G., et al.: Structure: 12, 2233 (2004);<br></p>

<p>Applications (S)-(-)-2-Chloropropionic Acid (cas# 29617-66-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1-Butenylboronic Acid is a reagent used in the synthesis of polyene natural products.<br>References Lee, S. J., et al.: J. Am. Chem. Soc., 130, 466-468 (2008)<br></p>

<p>Applications 5-Chloro-2-nitroaniline is a useful synthetic intermediate. It can be used as a reagent to synthesize benzamide derivatives as histone deacetylase inhibitors. It is an intermediate used to synthesize 1-Nitro Febantel (M264880), a Febantel (F227000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Suzuki, T., et al.: J. Med. Chem., 42, 3001 (1999); Wollweber, H., et al.: Arzneim.-Forsch., 34, 531 (1984),<br></p>

<p>Applications Di-p-toluoyl-d-tartaric Acid Monohydrate is a useful intermediate in the preparation of chiral rivastigmine hydrogen tartrate.<br>References Feng, J., et al.; Nanfang Yike Daxue Xuebao, 27, 177 (2007)<br></p>

<p>Applications (R)-1,2-Propylene Carbonate (cas# 16606-55-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl Dimethoxyacetate is used as a reagent in the synthesis of benzimidazole derivatives for use as respiratory syncytial virus inhibitors.<br>References Cooymans, Ludwig Paul; D., et al. PCT Int. Appl. WO 2012080446 A1 20120621. Jun 21, 2012<br></p>

<p>Applications Tocainide Hydrochloride is used as an anti-arrythmic drug as myocardial depressants.<br>References Courtney, K. et al. J. Molec. Cell. Cardiol., 12, 1273 (1980); Kwok, D. et al.: Res. Comm. Chem. Path. Pharm., 67, 395 (1990);<br></p>

<p>Applications JNJ 17203212 is a high affinity TRPV1 receptor antagonist.<br></p>

<p>Applications 4-Bromobutyric Acid is used in the preparation of analgesic and anti-inflammatory agents as nitroalkyl ethers. It is also used in the synthesis of Autotaxin (ENPP2) inhibitors, used in tissue fibrosis regulation, cancer cell invasion and metastasis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anzini, M. et al.: J. Med. Chem., 56, 4821 (2013); Kawaguchi, M. et al.: ACS Chem. Biol. et al.: 8, 1713 (2013);<br></p>

<p>Applications γ-Butyrobetaine is a synthetic carnitine related compound used as a transporter substrate in the cloning and sequencing of human carnitine transporter 2 (CT2).<br>References Enomoto, A. et al.: J. Biol. Chem., 277, 36262 (2002);<br></p>

<p>Applications 1-(azidomethyl)-3-methoxybenzene (cas# 123767-44-2) is a useful research chemical.<br></p>

<p>Stability Hygroscopic, Unstable in Solution<br>Applications 3-Hydroxymethyl-(1-oxy-2,2,5,5-tetramethylpyrroline) (cas# 55738-75-5) is a compound useful in organic synthesis.<br>References Qin, P.Z., et al.: Biochemistry, 40, 6929 (2001)<br></p>

<p>Applications 5-Ethylpyridine-2-carboxylic Acid (cas# 770-08-1) is a compound useful in organic synthesis.<br></p>

<p>Applications (2-Bromoethyl)trimethylammonium Bromide (cas# 2758-06-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Paetzel, M., et al.: J. Biol. Chem., 272, 9994 (1997), Francavilla, C., et al.: Bioorg. Med. Chem. Lett., 19, 2731 (2009),<br></p>

<p>Applications Darodipine, is a calcium channel antagonist.<br>References Matucci, R., et al.: British J. Pharmacol., 122, 1353 (1997);<br></p>

<p>Applications Silver Acetate is used as a reagent in chemical synthesis in reaction such as carbonylation of primary and secondary amines as well as in woodward cis-hydroxylation converting alkenes into cis-diols. Also used in gum, lonzenges and sprays that are targeted to assist people in quitting the habit of smoking since it produces a bad taste when combined with cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wright, L., et al.: J. Phys. Chem., 59, 1060 (1955); Woodward, R., et al.: J. Am. Chem. Soc., 80, 209 (1958); Lancaster, T., et al.: Cochrane DB Syst. Rev., 2, 191 (2000);<br></p>

<p>Applications tert-Butyl N-Tosyloxycarbamate is a sulfhydroxylamine that, when used in combination with Lithium, functions as an efficient electrophile in the amination of chiral amide cuprate compounds. tert-Butyl N-Tosyloxycarbamate is also used as a reagent to synthesize N-Boc protected primary amines (e.g. N-Boc-ethylenediamine [B655000]).<br>References Chiba, S. &amp; Narasaka, K.: Amin. Grou. Chem: Synth. Life Sci., No vol. given (2008); Gallou, I. &amp; Senanayake, C.: Chem. Rev.: 106, 2843 (2006); Genet, J., et al.: Tetrahedron Lett., 32, 2359 (1991); Zheng, N., et al.: ChemInform, 28, No pp. given (1997)<br></p>