Reagenti sintetici

<p>Applications Nickel(II) Bromide, is used as a source of bromide ion. It is also an important raw material used in various chemical synthesis and also as a catalyst in cross-coupling reactions.<br>References Pramanik, M. et al.: RSC Adv. 2015, 5 (53), 42762-42767.<br></p>

<p>Stability Very Hygroscopic<br>Applications Gadolinium Trichloride is a calcium-sensing receptor agonist and is known to work by inducing NLRP3 inflammasome activation in bone marrow-derived macrophages.<br>References Toyoda, Y., et al.: Toxicol. Sci., 126, 16 (2012); Ciceri, P., et al.: Biochem. Biophy. Res. Comm., 418, 770 (2012); Dangi.A., et al.: J. Immunol., 188, 3667 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications A lysine analog used in the preparation of selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.<br>References Lau, O.D. et al.: Mol. Cell, 5, 589 (2000);<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Indium(III) trifluoromethanesulfonate is a catalyst that is used for hetero Diels-Alder reactions including intermolecular Diels-Alder reactions. It is also a catalyst for efficient acylation of alcohols, phenols and amines.<br>References Kamlesh, K.C., et al.: Synlett, 1999, 1743 (1999), Ali, T., et al.: Tetrahedron Lett., 40, 5621 (1999)<br></p>

<p>Applications Yoda 1 is a piezo1 channel activator, sensitizes piezo1 to activation by pressure and slows the inactivation phase of transient currents in human embryonic kidney (HEK) cells.<br></p>

<p>Applications (R)-tert-Butyl 2-hydroxypropanoate is an intermediate used in the stereo controlled synthesis of hydroxy carboxylic acids from L-amino acids.<br>References Kunz, H., et al.: Tetrahedron Lett., 28, 1873 (1987)<br></p>

<p>Applications (R,R)-1,2-Cyclohexanedicarboxylic Acid (cas# 46022-05-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors.<br></p>

<p>Applications Savolitinib is a potent and highly selective c-Met inhibitor. Savoltinib demonstrated anti-tumor efficacy in a panel of cMet-dysregulated gastric cancer PDX models. Savolitinib also demonstrated good antitmuor activities.<br>References Gavine, P., et al.: Mol. Oncol., 9, 323 (2015); Jia, H., et al.: J. Med. Chem., 57, 7577 (2014);<br></p>

<p>Applications 5-(Trifluoromethyl)picolinic Acid is an intermediate used in the synthesis of β-secretase (BACE) inhibitors.<br>References Tresadern, G., et al.: Bioorg. Med. Chem. Lett., 21, 7255 (2011); Watanabe, T., et al.: Bioorg. Med. Chem., 20, 5839 (2010);<br></p>

<p>Stability Store in Freezer<br>Applications Benzyl 3-Amino-3-deoxy-α-D-mannopyranoside Hydrochloride can be used for preparation of swainsonine analogs as immunostimulants.<br>References Dime, D., et al.: PCT Int. Appl., 74 pp. (1993),<br></p>

<p>Applications DI-MU-HYDROXO-BIS[(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II)] CHLORIDE (cas# 30698-64-7) is a useful research chemical.<br>Chemical Name: DI-MU-HYDROXO-BIS[(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II)] CHLORIDE (cas# 30698-64-7) is a useful research chemical.<br></p>

<p>Applications Ethyl (2R,4S)-4-Methylpipecolate is an intermediate in the preparation of Argatroban (A769000).<br>References Hilpert, K. et al.: J. Med. Chem., 37, 3889 (1994), Kim, K. et al.: Med. Chem. Res., 6, 377 (1996),<br></p>

<p>Applications 4-Carboxymethylphenylboronic acid<br></p>

<p>Applications (S)-(-)-2-Chloropropionic Acid (cas# 29617-66-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1-(azidomethyl)-3-methoxybenzene (cas# 123767-44-2) is a useful research chemical.<br></p>

<p>Stability Hygroscopic, Unstable in Solution<br>Applications 3-Hydroxymethyl-(1-oxy-2,2,5,5-tetramethylpyrroline) (cas# 55738-75-5) is a compound useful in organic synthesis.<br>References Qin, P.Z., et al.: Biochemistry, 40, 6929 (2001)<br></p>

<p>Applications 5-Ethylpyridine-2-carboxylic Acid (cas# 770-08-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Chloro-3-iodopropane is used as reagent in the synthesis of several organic compounds including that of (-)-Terengganensine A which is a complex heptacyclic monoterpene indole alkaloid. Also used in the synthesis of A-366 which is a potent inhibitor of histone methyltransferase G9a.<br>References Piemontesi, C., et al.: Angew. Chem. Int. Edit., 55, 6556 (2016); Sweis, R., et al.: ACS Med. Chem. Lett., 5, 205 (2014);<br></p>

<p>Applications tert-Butyl N-Tosyloxycarbamate is a sulfhydroxylamine that, when used in combination with Lithium, functions as an efficient electrophile in the amination of chiral amide cuprate compounds. tert-Butyl N-Tosyloxycarbamate is also used as a reagent to synthesize N-Boc protected primary amines (e.g. N-Boc-ethylenediamine [B655000]).<br>References Chiba, S. &amp; Narasaka, K.: Amin. Grou. Chem: Synth. Life Sci., No vol. given (2008); Gallou, I. &amp; Senanayake, C.: Chem. Rev.: 106, 2843 (2006); Genet, J., et al.: Tetrahedron Lett., 32, 2359 (1991); Zheng, N., et al.: ChemInform, 28, No pp. given (1997)<br></p>

<p>Applications Ciliobrevin D is an inhibitor of the AAA+ ATPase motor cytoplasmic dynein.<br>References Firestone, A., et al.: Nature, 484, 125 (2012)<br></p>

<p>Applications 1,1-Cyclopropanedicarboxylic Acid, is an inhibitor of 1-aminocyclopropane-1-carboxylic Acid oxidase in Lycopersicum esculentum (Tomato plant). It can also be used as a building block for the synthesis of a series of cyclopropanecarboxamides, having antifungal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Petritis, K., et al.: Phytochemical Analy., 14, 347 (2003); Liu, X. H., et al.: Euro. J. Med. , 44, 2782 (2009);<br></p>

<p>Applications Lithium hydroxide is a reagent that is used in the synthesis of O-Desmethyl Mebeverine Acid O-β-D-Glucuronide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ethynyltrimethylsilane is used in the production of novel histone deacetylase inhibitors for the treatment of Freidreich’s ataxia. It also aids in the preparation of conjugated polymers with sn anthracene backbone.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, C. et al.: Pharmaceu. 4, 1578 (2011); Kobayashi, E. et al.: J. Polym. Sci. Part A: Polym. Chem., 28, 2641 (1990);<br></p>

<p>Applications 2-Amino-4-methylphenylboronic acid, pinacol ester<br></p>

<p>Applications A useful intermediate in the synthesis of polypeptides.<br></p>

<p>Stability Air Sensitive<br>Applications Can be used as a building block for chiral ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Potassium Iodide is used primarily used in the treatment of radiation poisoning due to environmental contamination by iodine-131.<br>References Wolff, J. et al.: Pharmacol. Rec., 50, 89 (1998);<br></p>

<p>Applications Dibromoacetic Acid is a halogenated disinfection byproduct. Dibromoacetic Acid was found to induce apoptotic changes and hydroxyl radical formation in human peripheral blood mononuclear cells (PBMCs). Dibromoacetic Acid also found to exhibit carcinogenic activity in which mice and rats were exposed to drinking water containing different concentrations of Dibromoacetic Acid that resulted in increased incidences of mononuclear cell leukemia, malignant mesothelioma, hepatocellular neoplasms, and hepatoblastoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Michalowicz, J., et al.: Toxicol. In Vitro 29, 1416 (2015); Natl Toxicol Program Tech Rep Ser. 537, 1 (2007)<br></p>

<p>Applications BDP 37 is a AMPA modulator that may exhibit therapeutic properties for treating Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI) (1,2,3,4). It is also an ampakine drug that facilitates activation of glutamatergic AMPA receptors.<br>References (1) Arai, A., et al.: J. Pharmacol. Exp. Ther., 278, 627 (1996)(2) Marini, A., et al.: J. Biol. Chem., 273, 29394 (1998)(3) Balkowiec, A., et al.: J. Neurosci., 22, 10399 (2002) (4) Dicou, E., et al.: Brain Res., 970, 221 (2003)<br></p>

<p>Applications Reagent commonly used in organic chemistry for the introduction of the BOC protecting group.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-{[2-(Dimethylamino)ethyl]methylamino}ethanol is a reagent in the preparation of diamino(aminoalkoxy)quinazolines.<br>References Liu, F., et al.: J. Med. Chem., 53, 5844 (2010);<br></p>

<p>Applications Sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, also known as the BARF anion, is a compound used in catalytic cycles due to its inability to coordinate to metal centres.<br>References Brookhart, M.; et al.: J. Am. Chem. Soc., 114, 5894 (1992).<br></p>

<p>Applications 5-Methylsalicylamide (cas# 39506-61-1) is a useful research chemical.<br></p>

<p>Applications A MEK inhibitor with antitumor activity.<br>References Lee, W., et al.: Bioorg. Med. Chem. Lett., 15, 3573 (2005), Normanno, N., et al.: J. Cell. Physiology, 207, 420 (2006), Narlawar, R., et al.: J. Med. Chem., 49, 7588 (2006),<br></p>

<p>Stability Volatile<br>Applications Cyclobutanone is a member of cycloketone compounds that have potential genotoxic and cytotoxic effects and are most commonly found in irradiated food.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anandon, A., et al.: EFSA Journal, 9, 1930 (2011); Delincee, H., et al.: Radiat. Phys. Chem., 63, 431 (2002); Obana, H. ,et al.: J. Health Sci., 52, 375 (2006)<br></p>

<p>Applications tert-Butyl (S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate, is a building block used foe the synthesis of novel nicotinic acetylcholine receptor ligands with cognition-enhancing properties. It can also be used in the synthesis of chiral β-amino sulfides and β-amino thiols.<br>References Elliiot, R. L., et al.: Bioorg. Med. Chem. Lett., 6, 2283 (1996); Abreo, M. A., et al.: J. Med. Chem., 39(4), 817 (1996);<br></p>

<p>Applications Methyl 4-(Chloroformyl)butyrate is used in the synthesis of Leukotriene B4, a proinflammatory agent produced from leukocytes.<br>References Crooks, S. et al.: Int. J. Biochem. Cell. Biol., 30, 173 (1998); Wenkert, E. et al.: J. Org. Chem., 55, 6203 (1990);<br></p>

<p>Applications It is used in the synthesis of nickel-chelating fluorinated lipids for protein monolayer crystallizations.<br>References Vince, R., et al.: J. Med. Chem., 14, 402 (1971), Melander, W., et al.: Arch. Biochem. Biophys., 183, 200 (1977),<br></p>

<p>Applications Piperonylamine is a metabolite of dopamine analogs.<br>References Goodwin, B.L., et al.: Xenobiotica, 24, 129 (1994),<br></p>

<p>Applications Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.<br>References Pargellis, C. et al.: Nat. Struct. Biol., 9, 268 (2002,); Kuma, Y. et al.: J. Biol. CHem., 280, 19472 (2005); Yasui, H. et al.: Br. J. Haematol., 136, 414 (2007);<br></p>

<p>Applications NE-100 is a potent and selective σ1 receptor antagonist.<br>References Sabino, V., et al.: Psychopharmacology, 205, 327 (2009); Kunitachi, S., et al.: Brain Res., 1279, 189 (2009)<br></p>

<p>Applications Tetramethylammonium Bromide (cas# 64-20-0) is a useful research chemical.<br></p>

<p>Applications Aluminum Bromide, is used as a catalyst for the Friedel-Crafts alkylation reaction, and also for bromination and isomerization in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Encyclopedia of Reagents for Organic Synthesis. (2001); Renfew, M. M., et al.: J. Chem. Educate. 68 (9, (1991);<br></p>

<p>Applications BAY 57-1293 Methanesulfonate Salt is used in biological studies as an antiviral agents for treating and preventing shingles and a method of treating zoster(herpes) associated pain as it is a potent helicase primase inhibitor.<br>References Kleyman, G., et al.: Nat. Med., 8, 392 (2002); Wozniak, M.A., et al.: Antiviral Res., 99, 401 (2013);<br></p>

<p>Applications An indole derivative used in synthesis of matrix metalloprotease inhibitors.<br>References Somei, M., et al.: Nat. Prod. Rep., 22, 73 (2005),<br></p>

<p>Applications The (R)-enantiomer intermediate in the preparation of Oxiracetam (O846905).<br>References Kondepudi, D., et al.: Science, 250 975 (1990), Di Silvestro, G., et al.: J. Pharm. Sci., 82, 758 (1993),<br></p>

<p>Applications MDL 29951 is an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase.<br>References Wright, S., et. al.: Bioorg. Med. Chem. Lett., 13, 2055 (2003)<br></p>

<p>Applications 11-Bromo-1-undecene acts as a reagent used in the chemoenzymatic synthesis of macrolide antibiotics for the treatment of common bacteria infection.<br>References Chatterjee, S., et al.: RSC Adv., 4, 42697 (2014)<br></p>

<p>Applications Calcium Sulfate is used in the biofilm prevention and management of gram-negative bacterial pathogens involved in periprosthetic infection by using antibiotic-loaded calcium sulfate beads in vitro. Calcium Sulfate is used in the bioactive calcium sulfate-based formulation “Biocas” for bone filler applications. Calcium Sulfate is also used as an antibiotic impregnated calcium sulphate in combination with internal fixation for the treatment of open fractures of extremities that prevents infections and promotes the healing of fractures.<br>References Howlin, R., et al.: Biomed.l Mater., 12, 1 (2017); Sandhya, S., et al.: Biomedical Materials, 12, 015022 (2017); Liao, H., et al.: Guangxi Yixue, 37, 1491 (2015)<br></p>

<p>Applications An intermediate for polycyclic indazole derivatives that are ERK inhibitors.<br>References Orjales, A., et al.: J. Med. Chem., 46, 5512 (2003), Mariappan, P., et al.: J. Eur. Urology., 51, 67 (2007), Hughes, J., et al.: Bioorg. Med. Chem. Lett., 18, 4872 (2008), Kielbasa, W., et al.: Drug Metab. Dispos., 37, 137 (2009),<br></p>

<p>Applications [4,​4'-​Bis(tert-butyl)​-​2,​2'-​bipyridine]​bis[3,​5-​difluoro-​2-​[5-​(trifluoromethyl)​-​2-​pyridinyl]​phenyl]​iridium(III) hexafluorophosphate is commonly used as a catalyst in the synthesis of various compounds such as saturated N-​heterocycles from aldehydes, fosmidomycin analogue, and many more.<br>References Jindakun, C., et al.: Org. Lett. 20, 2071-75 (2018); Guo, T., et al.: Adv. Synth. Catal., 360, 1352-57 (2018); Abbas, S.Y., et al.: Org. Lett., 20, 868-71 (2018)<br></p>

<p>Applications [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene] Dichloro(o-isopropoxyphenylmethylene)ruthenium is a cross-metathesis catalyst used for installation of S-allylcysteine in proteins for enabling olefin metathesis on proteins.<br>References Lin, Y.A., et al.: J. Am. Chem. Soc., 132, 16805 (2010); Chalker, J.M., et al.: Chem. Comm., no vol., 3714 (2009)<br></p>

<p>Applications Methyl 11-bromoundecanoate is a brominated fatty acid building block, used in the synthesis of Emmyguyacins A and B, which are proposed inhibitors of the influenza virus.<br>References Jana, S.; et al.: Org. Lett., 20, 6938 (2018).<br></p>

<p>Applications Antineoplastic adjunct (chemosensitizer).<br>References Boesch, D., et al.: exp. Cell Res., 196, 26 (1991), Lush, R.M., et al.: J. Clin. Pharmacol., 37, 123 (1997), Scott, M.G., et al.: Clin. Chem., 43, 505 (1997), Advani, R., et al.: Blood, 93, 787 (1999),<br></p>

<p>Applications 3'-Bromo-4'-methylacetophenone is used as a starting material in the synthesis of mansonone E which is used to make mansonone E dervivatives. These derivatives are potent inhibitors of topoisomerase II (Topo II) and topoisomerase I (Topo I) and are also potent antitumor agents. 3'-Bromo-4'-methylacetophenone is also used as a reagent in the synthesis of BAF312, Siponimod which has been tested in the treatment of patients suffering from relapsing-remitting multiple sclerosis.<br>References Fang, X., et al.: J. Chem. Res., 38, 137 (2014); Huang, Z., et al.: Eur. J. Med. Chem., 68, 58 (2013); Pan, S., et al.: ACS Med. Chem. Lett., 4, 333 (2013)<br></p>

<p>Applications 5-Amino-2-methylene-1,3,3-trimethylindoline (cas# 6872-05-5) is a compound useful in organic synthesis.<br></p>

<p>Stability Unstable in solution. Small amounts of precipitate should have no effect on use.<br>Applications 1-Chloro-N,N-2-trimethylpropenylamine acts as a reagent in the synthesis and antitumor activity of (-)-bassianolide in human cancer cells through cell cycle arrest. Enantioselective total synthesis of nannocystins A and A0 as elongation factor 1 inhibitors. Total synthesis of (-)-caprazamycin A with antibacterial activity against Mycobacterium tuberculosis (TB) via diastereoselective aldol reaction.<br>References Mun, B., et al.: Bioorg. Chem., 69, 64 (2016); Huang, J., et al.: Org. Lett., 18, 4702 (2016); Nakamura, H., et al.: Angew. Chem., Int. Ed., 54, 3136 (2015)<br></p>

<p>Applications 5-METHYLPYRROLIDIN-3-OL (cas# 94134-94-8) is a useful research chemical.<br></p>

<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>

<p>Applications (S,S)-(-)-Hydrobenzoin is a chral auxiliary with versatile applications. It is also used as a building block.<br>References Marshall, J., et al.: J. Org. Chem. 60, 7230 (1995); Stolle, A., et al. Tetrahedron Lett. 35, 3521 (1994); Burk, M., et al.: J. Am. Chem. Soc. 115, 10125 (1993); Burk, M., et al.: Tetrahedron Asymmetry 2, 569 (1991); Pichon, M., et al: Tetrahedron Asymmetry 7, 927 (1996)<br></p>

<p>Applications (S)​-​(+)​-​Pantolactone is a versatile cyclic ester reactant used in the preparation of tunable ligands carbohydrate-derived diarylphosphinites for asymetric catalysis hydrovinylation of styrene derivatives.<br>References Park, H., RajanBabu, T.: J. Am. Chem. Soc., 124, 734 (2002);<br></p>

<p>Applications A Wittig reagent.<br></p>

<p>Applications Triphenylsilylamine is used as a reagent to produce 2-Amino-3-hydroxy-indoles with potent in vivo antimalarial activity. Triphenylsilylamine is also used to modify Mo/HZSM-5 catalysts and is predicted to have effects on selectivity in the methane-to-benzene (MTB) reaction.<br>References Kikuchi, S., et al.: J. Catal., 242, 349 (2006); Urgaonkar, S., et al.: Org. Lett., 12, 3998 (2010);<br></p>

<p>Applications BL 918 is a potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.<br>References Ouyang, Liang., et al.: J. Med. Chem., 61, 2776 (2018),<br></p>