Reagenti sintetici

<p>Applications Ammonium Vanadium Oxide is used in pharmaceutical composition of metformin decavanadate for prevention and treatment of metabolic syndrome, obesity and diabetes. Chimeric design, synthesis, and biological assays of new nonpeptide insulin-mimetic vanadium compounds to inhibit protein tyrosine phosphatase 1B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Scior, T., et al.: Drug Des. Devel. Ther., 4, 231 (2010); Gonzalez V., et al.: Pat. Appl. (2016), MX 2015003461 A 20160919;<br></p>

<p>Applications GSK 2606414 acts as a potent and selective inhibitor of protein kinase R and similarly endoplasmic reticulum kinase affecting numerous diseases such as cancer.<br>References Axten, J. et al.: J. Med. Chem., 55, 7193 (2012);<br></p>

<p>Applications α-Acetoxyacetic Acid, is a versatile organic building block, used in the synthesis of pharmaceutical compounds, including inhibitors and therapeutic agents. It can be used for the synthesis of analogs of 5-Aminolevulinic Acid, which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Appleton, D., et al.: J. Chem. Soci., Perkin Transactions , 1, 89 (1998);<br></p>

<p>Applications 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide (cas# 86608-70-0) is a useful research chemical.<br></p>

<p>Applications 5-Chloropent-1-yne is an intermediate in the synthesis of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Applications 4-Chlorobenzeneboronic Acid is used as a catalyst for the preparation of 4-hydroxycoumarin derivatives which display antitrypanosomal and antioxidant properties. It is also used as a catalyst for the asymmetric borane reduction of electron-deficient ketones.<br>References Perez-Cruz, F. et al.: Bioorg Med. Chem. Lett., 22, 5569 (2012); Liu, H. et al.: J. Mol. Cata. A. Chem., 244, 68 (2006);<br></p>

<p>Applications An amide analog of Eugenol, and is used therapeutically as an antispasmodic.<br>References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 14, 6502 (2006),<br></p>

<p>Applications Cesium Acetate (cas# 3396-11-0) is a useful research chemical.<br></p>

<p>Applications Ethynyltrimethylsilane is used in the production of novel histone deacetylase inhibitors for the treatment of Freidreich’s ataxia. It also aids in the preparation of conjugated polymers with sn anthracene backbone.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, C. et al.: Pharmaceu. 4, 1578 (2011); Kobayashi, E. et al.: J. Polym. Sci. Part A: Polym. Chem., 28, 2641 (1990);<br></p>

<p>Applications Cyclopropylacetylene is used in a variety of chemical reactions in organic syntheses. Used in the synthesis of BACE1 inhibitors used in the treatment of Alzheimer’s disease. It is also used in cycloaddition reactions and the synthesis of fluoromethylsydnones.<br>References Xu, Y. et al.: Bioorg. Med. Chem. Lett., 23, 3075 (2013); Foster, R. et al.: J. Org. Chem., 78, 4049 (2013);<br></p>

<p>Applications 2-Amino-4-methylphenylboronic acid, pinacol ester<br></p>

<p>Applications A useful intermediate in the synthesis of polypeptides.<br></p>

<p>Applications Aclidinium Bromide is a novel long-acting antimuscarinic bronchodilator in phase II clinical trials for the treatment of chronic obstructive pulmonary disease (1,2).<br>References (1) Gupta, V. and Singh, D.: Expert Rev Respir Med. 6, 581 (2012) (2) De La Motte, S., et al.: Int. J. Clin. Pharmacol. Therap., 50,403 (2012)<br></p>

<p>Applications 1,2-Diaminopropane-N,N,N',N'-tetraacetic Acid is an aminopolycarboxylic acids found at ultra-trace levels in water; Also, it is used in the construction of Eu3+ ion-selective membrane electrode as suitable ionophore.<br>References Nette, D., et al.: Anal. Chim. Acta, 884, 124-132 (2015); Abedi, M. R., et al.: E-J. Chem., 8, S467-S473 (2011)<br></p>

<p>Applications Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).<br>References Green, L.J., et al.: Biochem. Pharmacol., 61, 1393 (2001), Shepard, R.L., et al.: Int. J. Cancer, 103, 121 (2003),<br></p>

<p>Applications Dibromoacetic Acid is a halogenated disinfection byproduct. Dibromoacetic Acid was found to induce apoptotic changes and hydroxyl radical formation in human peripheral blood mononuclear cells (PBMCs). Dibromoacetic Acid also found to exhibit carcinogenic activity in which mice and rats were exposed to drinking water containing different concentrations of Dibromoacetic Acid that resulted in increased incidences of mononuclear cell leukemia, malignant mesothelioma, hepatocellular neoplasms, and hepatoblastoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Michalowicz, J., et al.: Toxicol. In Vitro 29, 1416 (2015); Natl Toxicol Program Tech Rep Ser. 537, 1 (2007)<br></p>

<p>Applications BDP 37 is a AMPA modulator that may exhibit therapeutic properties for treating Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI) (1,2,3,4). It is also an ampakine drug that facilitates activation of glutamatergic AMPA receptors.<br>References (1) Arai, A., et al.: J. Pharmacol. Exp. Ther., 278, 627 (1996)(2) Marini, A., et al.: J. Biol. Chem., 273, 29394 (1998)(3) Balkowiec, A., et al.: J. Neurosci., 22, 10399 (2002) (4) Dicou, E., et al.: Brain Res., 970, 221 (2003)<br></p>

<p>Applications Volasertib (BI 6727) is a highly potent Polo-like kinase (PLK) inhibitor.<br>References Rudolph, D., et al.: Clin. Cancer Res., 15, 3094 (2009); Grinshtein, N., et al.: 71, 1385 (2011)<br></p>

<p>Applications 4-benzylmorpholine-2-carbonitrile (cas# 126645-52-1) is a useful research chemical.<br></p>

<p>Applications 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid, is one of the glucokinase activator derivatives. GKAs activate GK via binding to an allosteric site of the enzyme. They increase glucose-stimulated insulin secretion and decrease blood glucose levels. Also, glucokinase activator GKA50 is shown to be able to promote proliferation by increasing the cell volume and thus, preventing apoptosis in rat pancreatic insulinoma-1 beta cell.<br>References Wei, P., et al.: Diabetologia, 52, 2142 (2009); McGlasson, L., et al.: Mol. Cell. Endo., 342, 48, (2011);<br></p>

<p>Applications Vitamin D3 (V676045) analog.<br>References Roy, A., et al.: Steroids, 60, 530 (1995);<br></p>

<p>Applications (1,​5-​Cyclooctadiene)​(hexafluoroacetylace​tonato)​iridium(I) is a catalyst used in hydrogenation reactions in organic synthesis.<br>References Maj, A. et al.: Tetrahedron, 72, 1375 (2016);<br></p>

<p>Applications Methyl 4-Acetylbenzoate is used in the preparation of trisubstituted pyrazoles as novel hepatitis C virus entry inhibitors.<br>References Hwang, J.Y., et al.: Bioorg. Med. Chem. Lett., 23, 6467 (2013); Simmonds, P., et al.: Hepatology, 42, 962 (2005)<br></p>

<p>Applications The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3ß inhibitor (IC50=23nM).<br>References Zaharevitz, D.W., et al.: Cancer Res., 59, 2566 (1999), Leclerc, S., et al.: J. Biol. Chem., 276, 251 (2001), Bain, J., et al.: Biochem. J., in press.<br></p>

<p>Applications Drug used in the treatment of Parkinson’s disease and psychosis.<br>References Snigdha, S., et al.: J. Pharmacol. Exper. Ther., 332, 622 (2010), Meltzer, H., et al.: Neuropsychopharmacol., 35, 881 (2010),<br></p>

<p>Applications 2-Methoxybenzenemethanol is used in the synthesis of antimycobacterial and antibacterial derivatives. Also used in the synthesis of phthalazines and analogues as benzodiazepine receptor ligands with specific activity.<br>References Wei, Z. et al.: Molecules., 18, 3872 (2013); Carling, R. et al.: J. Med. Chem., 47, 1807 (2004);<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Phenylbis(trifluoromethanesulfonamide) is used in the enantioselective synthesis of β-amino acids via the Mannich reaction. Used in the synthesis of sphingosine 1-phosphate-1 receptor agonists useful in pharmaceutical application.<br>References Asano, M. et al.: Tetra. Asymm., 24, 449 (2013);<br></p>

<p>Applications ent-Ticagrelor is the enantiomer of Ticagrelor (T437700); the first reversible oral P2Y12 receptor antagonist that provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004); Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications 4,4’,(5’)-Di-(tert-butylcyclohexano)-18-crown-6 is a crown ether-based sorbent used in the analysis and separation of minerals.<br>References Yankovskaya, V. et al: J. Radioanal. Nucl. Chem., 314, 119 (2017);<br></p>

<p>Stability Unstable in Solution<br>Applications 2-Pyrimidineacetic acid is a reagent that is used in the preparation of pyrimidine derivatives for treating and or preventing sexual dysfunction.<br>References Huang, Z., Faming Zhuanli Shenqing, 2012:400114<br></p>

<p>Applications A reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br>References Palomo, J.M. et al.: Tetrahedron Asymm., 16, 869 (2005); Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981); Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984);<br></p>

<p>Applications rac-Clopidogrel Hydrogen Sulfate is used in the synthesis of Clopidogrel derivatives as platelet aggregation inhibitors.<br>References Chen, J., et. al.: Hecheng Huaxue, 18, 586 (2010); Defreyn, G. et al.: Thromb. Haemo., 65, 186 (1991);<br></p>

<p>Applications NE-100 is a potent and selective σ1 receptor antagonist.<br>References Sabino, V., et al.: Psychopharmacology, 205, 327 (2009); Kunitachi, S., et al.: Brain Res., 1279, 189 (2009)<br></p>

<p>Applications Tetramethylammonium Bromide (cas# 64-20-0) is a useful research chemical.<br></p>

<p>Applications BAY 57-1293 Methanesulfonate Salt is used in biological studies as an antiviral agents for treating and preventing shingles and a method of treating zoster(herpes) associated pain as it is a potent helicase primase inhibitor.<br>References Kleyman, G., et al.: Nat. Med., 8, 392 (2002); Wozniak, M.A., et al.: Antiviral Res., 99, 401 (2013);<br></p>

<p>Stability No Data available<br>Applications An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. GW 501516 has been found to enhance endurance in mice without any training.<br>References Oliver, W.R., et al.: Proc. Natl. Acad. Sci., USA, 98, 5306 (2001), Sznaidman, M.L., et al.: Bioorg. Med. Chem. Lett., 13, 1517 (2003), Wang, Y.X., et al.: Cell, 113, 159 (2003); Chem. and Eng. News, p. 9, May 8, 2017<br></p>

<p>Applications An indole derivative used in synthesis of matrix metalloprotease inhibitors.<br>References Somei, M., et al.: Nat. Prod. Rep., 22, 73 (2005),<br></p>

<p>Stability Very Hygroscopic<br>Applications Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>

<p>Applications 3-Amino-2-Naphthol (cas# 5417-63-0) is a useful research chemical.<br></p>

<p>Applications Nickel boride, (cas# 12007-01-1) is a useful research chemical.<br></p>

<p>Applications GI 254023X is an ADAM10 metaloproteinase inhibitor.<br>References Hoettecke, N., et. al.: Neurodegeneration Diseases, 7, 232 (2010)<br></p>

<p>Applications An intermediate of synergistic pesticide Boscalid. Also, used in the preparation of thieno[2.3-b]pyrrole derivatives as cannabinoid receptor agonists useful in mono- and combination therapy of diseases.<br>References Granger, D., et al.: Arthritis Rheum., 37, 1053 (1994), Robinson, R., et al.: J. Med. Chem., 39, 10 (1996),<br></p>

<p>Applications 3,5-Di-t-butyl-2-hydroxybenzaldehyde is a salicylaldehyde derivative with antibacterial activity used in the preparation nickel complexes. 3,5-Di-t-butyl-2-hydroxybenzaldehyde is structurally related to 3,5-di-t-butylcatechol (DTCAT) but is not as potent an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).<br>References Tuerkkan, B. et al.: Trans. Met. Chem., 36, 679 (2011); Fusi, F. et al.: Biochem. Biopharmacol., 69, 485 (2005);<br></p>

<p>Applications 1-Methyl-2-indolone is a reactant for preparation of fluorescent analogues of strigolactones as affectors of parasitic weed germination and fungal branching, irreversible Nek2 Kinase Inhibitors and anticancer agents.<br>References Prandi, C., et al.: Eur. J. Org. Chem., 3781, Henise, J., et al.: J. Med. Chem., 54, 4133 (2011); Kamal, A., et al.: Eur. J. Med. Chem., 46, 2427 (2011)<br></p>

<p>Applications Chiral ligand for metal mediated asymmetric catalysis.<br>References Inui, Y., et al.: Chem. Pharm. Bull., 57, 1158 (2009), Lam, K., et al.: Eur. J. Med. Chem., 45, 5527 (2010),<br></p>

<p>Applications (R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors.<br>References Biswas, S., et al.: J. Med. Chem., 51, 101 (2008); Prasad, C., et al.: Bioorg. Med. Chem. Lett., 14, 1917 (2004)<br></p>

<p>Applications Tributylhexadecylphosphonium Bromide (CAS# 14937-45-2) is a dynamic compound used as a surface modifier for thermal properties of palygorskite, an additive in water to improve resistance of epoxy-anhydride matrices, and as a modifier of phenolic resin to improve thermal degradation.<br>References Cisneros-Rosado, D. E.; et al.: Polym. Compos., 39, E1531 (2018).; Capiel, G.; et al.: Polym. Adv. Technol., 28, 886 (2017); Asaro, L.; J. Therm. Anal. Calorim., 128, 1463 (2017).<br></p>

<p>Applications IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. IWP-2 is useful in the treatment diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.<br>References Poss, K., et al.: Dev. Biol., 222, 347 (2000), Tanaka, K., et al.: Eur. J. Biochem., 267, 4300 (2000), Clevers, H., et al.: Cell, 2006, 127, 469 (2006),<br></p>

<p>Applications Methyl 11-bromoundecanoate is a brominated fatty acid building block, used in the synthesis of Emmyguyacins A and B, which are proposed inhibitors of the influenza virus.<br>References Jana, S.; et al.: Org. Lett., 20, 6938 (2018).<br></p>

<p>Applications Antineoplastic adjunct (chemosensitizer).<br>References Boesch, D., et al.: exp. Cell Res., 196, 26 (1991), Lush, R.M., et al.: J. Clin. Pharmacol., 37, 123 (1997), Scott, M.G., et al.: Clin. Chem., 43, 505 (1997), Advani, R., et al.: Blood, 93, 787 (1999),<br></p>

<p>Applications 3'-Bromo-4'-methylacetophenone is used as a starting material in the synthesis of mansonone E which is used to make mansonone E dervivatives. These derivatives are potent inhibitors of topoisomerase II (Topo II) and topoisomerase I (Topo I) and are also potent antitumor agents. 3'-Bromo-4'-methylacetophenone is also used as a reagent in the synthesis of BAF312, Siponimod which has been tested in the treatment of patients suffering from relapsing-remitting multiple sclerosis.<br>References Fang, X., et al.: J. Chem. Res., 38, 137 (2014); Huang, Z., et al.: Eur. J. Med. Chem., 68, 58 (2013); Pan, S., et al.: ACS Med. Chem. Lett., 4, 333 (2013)<br></p>

<p>Applications (+)-Biotinyl 3,6,9-Trioxaundecanediamine is a biotin derivative and is used as a reagent in the synthesis of a potent, covalent BTK inhibitor for B-cell lymphoma.<br>References Wu, H., et al.: ACS Chem. Biol., 9, 1086 (2014)<br></p>

<p>Applications (Ethoxycarbonylmethyl)triphenylphosphonium-13C2 bromide is an intermediate in the synthesis of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-13C5, which is an isotope labelled Mutagen X (MX) is a chlorinated furanone that accounts for more of the mutagenic activity of drinking water than any other disinfection byproduct. DNA damages provoked by the six mutagens (furylframide, MX, 4-nitroquinoline N-oxide, sodium azide, 1-nitropyrene, and captan) used in the present study have been known to subject to the nucleotide excision repair system.<br>References Hakulinen, P., et al.: Toxicol. Lett., 151, 439 (2004), Richardson, S., et al.: Mutat. Res., 636, 178 (2007), Kim, J., et al.: Environ. Toxicol., 23, 319 (2008),<br></p>

<p>Applications Sodium Carbonate, has wide rang of applications. It can be used as a food additive acting as an acidity regulator, anti-caking agent, raising agent, and stabilizer. It is also used widely in the manufacture of glass. Sodium carbonate is also used as a relatively strong base in various settings.<br>References Karaca, H. et al.: Int. J. Food Microbio., 58, 1230 (2014); Merten, G. et al.: J. Am. Med. Addoc., 291, 2328 (2004); Robey, I. et al.: Canc. Res., 69, 2260 (2009);<br></p>

<p>Applications Iodoethane, is used in a variety of organic chemical reactions including the synthesis if disubstituted α-amino acids through alkylation reaction. Also used in electrochemical reduction reactions in the preparation of carbamates.<br>References Feroci, M. et al.: J. Org. Chem., 72, 200 (2007); Xu, P. et al.: J. Org. Chem., 71, 4364 (2006);<br></p>

<p>Applications N-Methoxy-N-methylbenzamide is used to prepare orally bioavailable tetrasubstituted imidazoles as inhibitors of p38 mitogen-activated protein kinase. It is used to synthesize benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.<br>References Liverton, N., et al.: J. Med. Chem., 42, 2180 (1999); Malamas, M., et al.: J. Med. Chem., 43, 1293 (2000)<br></p>