Reagenti sintetici

<p>Applications 1-(Tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (cas# 903550-26-5) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications A semi-synthetic derivative of Podophyllotoxin. Antineoplastic.<br>References Stahlen, H., Eur. J. Cancer, 6, 303 (1970), Hacker, M., et al.: Cancer Res., 37, 3287 (1977), Clark, P.I., et al.: Clin. Pharmacokinet., 12, 223 (1987),<br></p>

<p>Applications R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.<br>References Semmler, J., et al.: Int. J. Immunopharmacol.: 15, 409 (1993); Sommer, N., et al.: Nat. Med.: 1, 244 (1995); Robichaud, A., et al.: J. Clin. Invest., 110, 1045 (2002); Card, G., et al.: Structure: 12, 2233 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one is involved in the pharmacological inactivation of Skp2 E3 ligase.<br>References Chan, C., et al.: Cell, 154, 556-568 (2013)<br></p>

<p>Applications 5-Chloropent-1-yne is an intermediate in the synthesis of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Applications 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide (cas# 86608-70-0) is a useful research chemical.<br></p>

<p>Applications Alpha-(trifluoromethyl)styrene<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications α-Acetoxyacetic Acid, is a versatile organic building block, used in the synthesis of pharmaceutical compounds, including inhibitors and therapeutic agents. It can be used for the synthesis of analogs of 5-Aminolevulinic Acid, which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Appleton, D., et al.: J. Chem. Soci., Perkin Transactions , 1, 89 (1998);<br></p>

<p>Applications 3,5-Dibromobenzaldehyde is a dibrominated benzaldehyde that is a very useful building block for the preparation of a wide range of biologically active compounds such as a antibacterials<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nielsen, S. et al.: Bioorg. Med, Chem., 12, 3017 (2004); Balderamos, M. et al.: Exp. Biol. Med., 233, 1395 (2008);<br></p>

<p>Applications N-Carbobenzoxy-1,4-diaminobutane HCl is used in the synthetic preparation of pyrazolyl glucopyranoside and galactopyranoside derivative inhibitors of human sodium-glucose cotransporter 1 (SGLT1) for preventives or therapeutics for diseases related to hyperglycemia or galactosemia.<br>References Teranishi, H.; et al.: PCT Int. Appl. 215 pp. Patent 2004 CODEN:PIXXD2<br></p>

<p>Applications GSK 2606414 acts as a potent and selective inhibitor of protein kinase R and similarly endoplasmic reticulum kinase affecting numerous diseases such as cancer.<br>References Axten, J. et al.: J. Med. Chem., 55, 7193 (2012);<br></p>

<p>Applications Methyl Dimethoxyacetate is used as a reagent in the synthesis of benzimidazole derivatives for use as respiratory syncytial virus inhibitors.<br>References Cooymans, Ludwig Paul; D., et al. PCT Int. Appl. WO 2012080446 A1 20120621. Jun 21, 2012<br></p>

<p>Applications (S,S)-2,3-Butanediol is the (S,S)-isomer of 2,3-Butanediol (B690020), a naturally occurring compound found in cocoa butter.<br>References Wang, Yu., et al.: J. Biological. Chem., 289, 6080 (2014); Cheng, C., et al.: J. Org. Chem., 78, 8562 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications PHA-793887 is a potent CDK (cyclin-dependent kinase) inhibitor. Recent studies shows that PHA-793887 has promising therapeutic activity against acute leukemias in vitro and in vivo. PHA-793887 was used to successfully modulate E2F transcriptional factor-dependent cell cycle, DNA replication, mitosis and apoptosis related gene in both tumors and skin biopsy from patients with solid tumors.<br>References Alzani, R. et al.: Exp. Hematol., 38, 259 (2010); Locatelli, G. et al.: Mol. Cancer Ther., 9, 1265 (2010); Brasca, M. et al.: Bioorg. Med. Chem., 18, 1844 (2010);<br></p>

<p>Applications Benzenesulfonyl Chloride is used in the synthesis of cecloprotoberberine derivatives as antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, Y. et al.: Eur. J. Med. Chem., 68, 463 (2013);<br></p>

<p>Applications 2,2,2-Triphenylacetophenone is an endocrine disrupter that is medicated through estrogen receptors.<br>References Roncaglioni, A., et al.: SAR. QSAR. Environ. Res., 19, 697 (2008); Kuzmanich, G., et al.: Photochem. Photobiol., 10, 1731 (2011);<br></p>

<p>Applications 2-(Di-tert-butylphosphino)-1,1'-binaphthyl 98% TrixiePhos is a reagent used as ligand in palladium-catalyzed C-O, C-N, and C-C bond forming reactions.<br>References Tsvelikhovsky, D., et al.; J. Am. Chem. Soc., 132, 14048 (2010); Eidamshaus, C., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis, 1 (2014); Tsvelikhovsky, D., et al.: J. Am. Chem. Soc., 134, 16917 (2012)<br></p>

<p>Applications Tocainide Hydrochloride is used as an anti-arrythmic drug as myocardial depressants.<br>References Courtney, K. et al. J. Molec. Cell. Cardiol., 12, 1273 (1980); Kwok, D. et al.: Res. Comm. Chem. Path. Pharm., 67, 395 (1990);<br></p>

<p>Applications Diethyl Diethylmalonate is an intermediate in the synthesis of Barbital (B118500), a prototype of the barbiturate hypnotics.<br>References Kholod, Y., et al.: Environ. Sci. Technol., 43, 9208 (2009); Yu, J., et al.: Pharm. Res., 27, 457 (2010); Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010)<br></p>

<p>Applications A non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. It becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Masahide H. et al.: J Clin Biochem Nutr., 47, 138 (2010); Noguchi, M. et al.: Biolog. Pharmac. Bull., 28, 2075 (2005); Hyun, J. et al.: Arch. Pharm. Res., 24, 541 (2001);<br></p>

<p>Applications tert-Butyl N-Tosyloxycarbamate is a sulfhydroxylamine that, when used in combination with Lithium, functions as an efficient electrophile in the amination of chiral amide cuprate compounds. tert-Butyl N-Tosyloxycarbamate is also used as a reagent to synthesize N-Boc protected primary amines (e.g. N-Boc-ethylenediamine [B655000]).<br>References Chiba, S. &amp; Narasaka, K.: Amin. Grou. Chem: Synth. Life Sci., No vol. given (2008); Gallou, I. &amp; Senanayake, C.: Chem. Rev.: 106, 2843 (2006); Genet, J., et al.: Tetrahedron Lett., 32, 2359 (1991); Zheng, N., et al.: ChemInform, 28, No pp. given (1997)<br></p>

<p>Applications Phosphorothioic Acid Trisodium Salt Hydrate can be involved in reactions of alkali hexafluoroaluminates.<br>References Bukhalova, G. A., et al.: Issled. v Obl. Khim. i Technol. Mineral'n. Solei i Okislov, Akad. Nauk SSSR, Sb. Statei, 124 (1965)<br></p>

<p>Applications 4-​Methoxy-​6-​methyl-​2H-​pyran-​2-​one acts as a potential selective agonist for the ghrelin receptor (GHS-​R1a), a receptor which plays in a role in appetite.<br>References Pastor-Cavada, E., et al.: Sci. Rep., 6, 36456 (2016);<br></p>

<p>Applications 6-Bromohexene is used as a reagent in the synthesis of carbendazim dithioate analogs which can exhibit antibacterial, antifungal, and soil dehydrogenase activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zahran, M.A H., et al.: Res. J. Pharm., Biol. Chem. Sci., 6, 1084 (2015)<br></p>

<p>Applications Aziridine carboxylic acid ester derivative used for the synthetic application of chiral aziridine via esterification.<br>References Minakata, S., et al.: Chem. Commun., 47, 6363 (2008); Li, Y.X., et al.: Tetrahedron. Lett., 49, 1480 (2008);<br></p>

<p>Stability No Data available<br>Applications An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. GW 501516 has been found to enhance endurance in mice without any training.<br>References Oliver, W.R., et al.: Proc. Natl. Acad. Sci., USA, 98, 5306 (2001), Sznaidman, M.L., et al.: Bioorg. Med. Chem. Lett., 13, 1517 (2003), Wang, Y.X., et al.: Cell, 113, 159 (2003); Chem. and Eng. News, p. 9, May 8, 2017<br></p>

<p>Applications Hypotaurine is a metabolite of taurine and affects the regulation of the inflammatory aspects of the immune response. It is also converted into taurine in the body.<br>References Grove, R. et al.: Free Radical. Biol. med., 108, 575 (2017);<br></p>

<p>Stability Hygroscopic<br>Applications Lodoxamide is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.<br>References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)<br></p>

<p>Applications Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.<br>References Fagervall, I. et al.: Biochem. Pharmacol., 35, 1381 (1986); Horita, A.: Princ. Psychopharmacol., 279 (1970); O'Donnell, J.M. et al.: Psychopharmacology, 78, 214 (1982);<br></p>

<p>Applications Silver benzoate is an aromatic salt that is used as a catalyst to prepare β-amino acids (such as N-Acetyl-β-alanine [A168070]) from α-amino acids (such as D-Alanine [A480995]). Silver benzoate is also used as a catalyst in Wolff rearrangement reactions.<br>References Barnes, R. &amp; Prochaska, R.: J. Am. Chem. Soc., 72, 3188 (1950); Ogilvie, W., et al.: Bioorg. Med. Chem., 7, 1521 (1999); Podlech, J. &amp; Seebach, D.: Lieb. Ann., 1995, 1217 (1995)<br></p>

<p>Applications 2,5-Dihydrofuran is used in the synthesis of Sch 38516 aglycon (fluvirucin B1) an influenza A antibiotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tomita, K. et al.: J. Antibiot., 44, 940 (1991); Houri, A. et al.: J. Am. Chem. Soc., 117, 2943 (1995);<br></p>

<p>Applications 2-Acetamido-4-(trifluoromethyl)phenylboronic acid, pinacol ester<br></p>

<p>Impurity Eletriptan Impurity 13<br>Applications Tris(2-methylphenyl)phosphine (Eletriptan Impurity 13) is a phosphine catalyst. It can be used in the rhodium-catalyzed hydrogenation, Suzuki-Miyaura cross-coupling reactions and Heck reactions.<br>References Hoen, R., et al.: Org. Biomol. Chem., 5, 267 (2007); Haug, B., et al.: Bioorg. Med. Chem. Lett., 17, 2361 (2007); Cacchi, S., et al.: Org. Biomol. Chem., 9, 1727 (2011)<br></p>

<p>Applications Iodoethane, is used in a variety of organic chemical reactions including the synthesis if disubstituted α-amino acids through alkylation reaction. Also used in electrochemical reduction reactions in the preparation of carbamates.<br>References Feroci, M. et al.: J. Org. Chem., 72, 200 (2007); Xu, P. et al.: J. Org. Chem., 71, 4364 (2006);<br></p>

<p>Applications IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. IWP-2 is useful in the treatment diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.<br>References Poss, K., et al.: Dev. Biol., 222, 347 (2000), Tanaka, K., et al.: Eur. J. Biochem., 267, 4300 (2000), Clevers, H., et al.: Cell, 2006, 127, 469 (2006),<br></p>

<p>Applications Tributylhexadecylphosphonium Bromide (CAS# 14937-45-2) is a dynamic compound used as a surface modifier for thermal properties of palygorskite, an additive in water to improve resistance of epoxy-anhydride matrices, and as a modifier of phenolic resin to improve thermal degradation.<br>References Cisneros-Rosado, D. E.; et al.: Polym. Compos., 39, E1531 (2018).; Capiel, G.; et al.: Polym. Adv. Technol., 28, 886 (2017); Asaro, L.; J. Therm. Anal. Calorim., 128, 1463 (2017).<br></p>

<p>Applications Chiral ligand for metal mediated asymmetric catalysis.<br>References Inui, Y., et al.: Chem. Pharm. Bull., 57, 1158 (2009), Lam, K., et al.: Eur. J. Med. Chem., 45, 5527 (2010),<br></p>

<p>Applications 3,5-Di-t-butyl-2-hydroxybenzaldehyde is a salicylaldehyde derivative with antibacterial activity used in the preparation nickel complexes. 3,5-Di-t-butyl-2-hydroxybenzaldehyde is structurally related to 3,5-di-t-butylcatechol (DTCAT) but is not as potent an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).<br>References Tuerkkan, B. et al.: Trans. Met. Chem., 36, 679 (2011); Fusi, F. et al.: Biochem. Biopharmacol., 69, 485 (2005);<br></p>

<p>Applications An intermediate of synergistic pesticide Boscalid. Also, used in the preparation of thieno[2.3-b]pyrrole derivatives as cannabinoid receptor agonists useful in mono- and combination therapy of diseases.<br>References Granger, D., et al.: Arthritis Rheum., 37, 1053 (1994), Robinson, R., et al.: J. Med. Chem., 39, 10 (1996),<br></p>

<p>Applications Nickel boride, (cas# 12007-01-1) is a useful research chemical.<br></p>

<p>Applications 3-Amino-2-Naphthol (cas# 5417-63-0) is a useful research chemical.<br></p>

<p>Stability Very Hygroscopic<br>Applications Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>

<p>Stability Unstable in Solution<br>Applications 2-Pyrimidineacetic acid is a reagent that is used in the preparation of pyrimidine derivatives for treating and or preventing sexual dysfunction.<br>References Huang, Z., Faming Zhuanli Shenqing, 2012:400114<br></p>

<p>Stability Volatile<br>Applications rac 1,2-Diaminopropane is used as model precursor in the electron induced deposition of amorphous carbon nitride films. It is also used to synthesize cage peroxide, 1,6-diaza-3,4,8,9-tetraoxa-11-methylbicyclo[4.4.2]dodecane.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wnuk, J., et al.: J. Phys. Chem., 113, 12345 (2009); Edward, J., et al.: Can. J. Chem., 77, 1057 (1999)<br></p>

<p>Applications Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).<br>References Green, L.J., et al.: Biochem. Pharmacol., 61, 1393 (2001), Shepard, R.L., et al.: Int. J. Cancer, 103, 121 (2003),<br></p>

<p>Applications (S)-4-(prop-1-En-2-yl)cyclohex-1-enecarbaldehyde (cas# 18031-40-8) is a useful research chemical. A possible biomarker of Parkinson’s disease.<br>References Drupad, K. T., et al.: ACS Central Science, (2019)<br></p>

<p>Applications Dichlorobis(triphenylphosphine) Palladium (II) is used primarily in organometallic catalytic reactions due to the palladium content of the compound. It is also involved in crystalized structures of metallacyclic complexes which show antiinflammatory and antifungal properties.<br>References Paul, P. et al.: J. Organometal. Chem., 724, 281 (2013); Pandiarajan, D. et al.: J. Organometal. Chem., 708-709, 18, (2012); Shhaheen, F. et al.: J. Organometal. Chem., 693, 315 (2010);<br></p>

<p>Applications 4-Formyl-2-nitrophenol is an Intermediate used in synthesis of novel amodiaquine analogs as potential antimalarial and antifilarial compounds.<br>References Jiang, D.X., et al.: Int. J. Environ. Res., 5, 923 (2011); Al-Zereini, W., et al.: J. Antibiotic., 63, 297 (2010);<br></p>

<p>Applications 4-Bromobenzotrifluoride is an aromatic compound that is used as a reagent to synthesize Bergenin (B318650), a compound that originates in Mallotus japonicus that exhibits hepatoprotective and antioxidant effects. 4-Bromobenzotrifluoride is also used as a reagent to prepare (±)-Preclamol, a partial dopamine D2 agonist that is used to treat Parkinson’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lim, H., et al.: Pharmacology, 63, 71 (2001); Parkan, K., et al.: Chem. Eur. J., 20, 4414 (2014); Pirtosek, Z., et al.: Clin. Neuro., 16, 550 (1993); Takahashi, H., et al.: Bioorg. Med. Chem., 11, 1781 (2003); Vasdev, N., et al.: Synapse, 60, 314 (2006)<br></p>

<p>Applications SKF 81297C is a dopamine D1 agonist (1).<br>References (1) Bergman, J., et. al.: J. Pharmacol. Exp. Ther., 273, 40 (1995)<br></p>

<p>Applications Sildenafil (S435000) derivative.<br></p>

<p>Applications 5-Methylisoxazole-3-carboxylic Acid is a metabolite of UTL-5b, a structural analog of the anti-arthritic drug, Leflunomide (L322750).<br>References Shaw, J. et al.: Eur. J. Drug. Metab. Ph., 37, 83 (2012)<br></p>

<p>Applications trans-2-[3-(4-tert-Butylphenyl)-2-methyl-2-propenylidene]malononitrile (cas# 300364-84-5) is a useful research chemical.<br></p>

<p>Applications WAY-100135 is a selective and potent 5-HT1A receptor antagonist.<br></p>

<p>Applications D-Glyceraldehyde is the simplest of all aldoses and have been shown to be the one of the carbonyl metabolite of dietary fructose.<br>References Yang, K., et al.: Chem-Biol. Interact., 191, 315 (2011); Zheng, X.H., et al.: Chem. Med. Chem., 7, 1921 (2012);<br></p>

<p>Applications A phopshine ligand used in transition-metal mediated organic synthesis, in particular in wittig reactions to improved (Z) selectivity.<br>References Andersen N.G. et al.: Chem. Rev., 101, 997 (2001); Appel M. et al.: Eur. J. Org. Chem., 1143, (2002);<br></p>

<p>Stability Hygroscopic<br>Applications An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).<br>References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);<br></p>

<p>Applications Di-O-glycinoylcurcumin Dihydrochloride is a metabolite of curcumin (C838500), which is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disea<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications Indium(III) chloride tetrahydrate (cas# 22519-64-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Bromobutyric Acid is used in the preparation of analgesic and anti-inflammatory agents as nitroalkyl ethers. It is also used in the synthesis of Autotaxin (ENPP2) inhibitors, used in tissue fibrosis regulation, cancer cell invasion and metastasis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anzini, M. et al.: J. Med. Chem., 56, 4821 (2013); Kawaguchi, M. et al.: ACS Chem. Biol. et al.: 8, 1713 (2013);<br></p>

<p>Applications Darodipine, is a calcium channel antagonist.<br>References Matucci, R., et al.: British J. Pharmacol., 122, 1353 (1997);<br></p>

<p>Applications Silver Acetate is used as a reagent in chemical synthesis in reaction such as carbonylation of primary and secondary amines as well as in woodward cis-hydroxylation converting alkenes into cis-diols. Also used in gum, lonzenges and sprays that are targeted to assist people in quitting the habit of smoking since it produces a bad taste when combined with cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wright, L., et al.: J. Phys. Chem., 59, 1060 (1955); Woodward, R., et al.: J. Am. Chem. Soc., 80, 209 (1958); Lancaster, T., et al.: Cochrane DB Syst. Rev., 2, 191 (2000);<br></p>

<p>Applications NU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors<br>References Arris, C.E., et. al.: J. Med. Che., 43, 2797 (2000); Peasland, A., et. al.: Brit. J. Cancer, 105, 372 (2011)<br></p>