Reagenti sintetici

<p>Applications Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetate with amide ligands bearing positively charged terbium complexes are used for sensitive detection of NADPH-dependent enzyme activities.<br>References Ito, H., et al.: Chem. Commun., 51, 8319-8322 (2015)<br></p>

<p>Applications Indium element is used in the synthesis of therapeutic particles containing metal ions; characterized by the use of unique ligand sets capable of making the metal ion complex soluble in biolgical media to induce selective toxicity in diseased cells.<br>References Dagher, Z., et al.: Toxicology, 225, 12 (2006), Yoshida, T., et al.: Biol. Pharm. Bull., 33, 780 (2010), Danielsen, P., et al.: Chem. Res. Toxico.,l 2011, 24, 168 (2011),<br></p>

<p>Applications 1-Bromo-3-methyl-2-butene is used to prepare xanthine dipeptidyl peptidase inhibitors for treatment of type 2 diabetes. It can also be used to synthesize natural and non-natural prenylated chalcones with antitumor, antioxidant activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eckhardt, M., et al.: J. Med. Chem., 50, 6450 (2007); Vogel, S., et al.: Bioorg. Med. Chem., 16, 4286 (2008)<br></p>

<p>Applications 2-Hydroxypyrimidine Hydrochloride, is used as a reagent in the synthesis of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for potential treatment of chronic hepatitis C virus infection.<br>References Beaulieu, P.L., et al.: J. Med. Chem., 57, 10130 (2014)<br></p>

<p>Applications Precursor to Kifunensine.<br>References Kayakiri, H., et al.: Chem. Pharm. Bull., 39, 1378 (1991),<br></p>

<p>Applications A potent and selective inhibitor of NAE. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. The ubiquitin-proteasome pathway mediates the destruction of unwanted proteins. Potent NAE inhibitor; NEDD8 E1 Activating Enzyme Inhibitor.<br>References Haas, A., et al.: J. Biol. Chem., 257, 10329 (1982), Walden, H., et al.: Nature, 422, 330 (2003), Kane, R., et al.: Clin. Cancer Res., 13, 5291 (2007), Saha, A., et al.: Mol. Cell., 32, 21 (2008),<br></p>

<p>Applications 1,2-Benzisoxazole has therapeutic uses. It could be useful for treating parkinsonism.<br>References Panza, F., et al.: Expert Opin. Pharmacother., (2020)<br></p>

<p>Stability Volatile<br>Applications Allyltrimethylsilane is used in the allylation of aldehydes, imines, allylic and benzylic alcohols, and chiral α-keto-amides that are derived from (S)-proline esters.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yadav, J.S., et al.: Tetrahedron Lett., 43, 3783 (2002); Aggarwal, V.K., et al.: Tetrahedron Lett., 37, 3745 (1996); Wang, D.K., et al.: J. Org. Chem., 64, 4233 (1999); Kaur, G., et al.: Tetrahedron Lett., 38, 2521 (1997); Soai, K., et al.: J. Chem. Soc., Chem. Commun., 15, 1016 (1984)<br></p>

<p>Applications Calcium Sulfate is used in the biofilm prevention and management of gram-negative bacterial pathogens involved in periprosthetic infection by using antibiotic-loaded calcium sulfate beads in vitro. Calcium Sulfate is used in the bioactive calcium sulfate-based formulation “Biocas” for bone filler applications. Calcium Sulfate is also used as an antibiotic impregnated calcium sulphate in combination with internal fixation for the treatment of open fractures of extremities that prevents infections and promotes the healing of fractures.<br>References Howlin, R., et al.: Biomed.l Mater., 12, 1 (2017); Sandhya, S., et al.: Biomedical Materials, 12, 015022 (2017); Liao, H., et al.: Guangxi Yixue, 37, 1491 (2015)<br></p>

<p>Applications 2-Methoxybenzoyl Chloride is an aromatic acyl chloride derived from anisic acid. 2-Methoxybenzoyl Chloride is used in the preparation of a wide range of compounds such as anti-virals, anti-bacterials and antitumor agents.<br>References Li, Z. et al.: Chem. Biol. Drug Des., 79, 1018 (2012); Liu, W. et al.: Huax. Tong., 74, 665 (2011); Sousa, E. et al.: Eur. J. Med. Chem., 44, 3830 (2009);<br></p>

<p>Applications 1-Bromo-3,5-difluorobenzene is used in the synthesis of selective antagonists of GluN2C/GluN2D is used in the synthesis of COX-2 inhibitors as anti-inflammatory agents and anti-cancer agents.<br>References Khanna, I. et al.: J. Med. Chem., 40, 1634 (1997); Pommery, N. et al.: J. Med. Chem., 47, 6195 (2004);<br></p>

<p>Applications (S,S)-(-)-Hydrobenzoin is a chral auxiliary with versatile applications. It is also used as a building block.<br>References Marshall, J., et al.: J. Org. Chem. 60, 7230 (1995); Stolle, A., et al. Tetrahedron Lett. 35, 3521 (1994); Burk, M., et al.: J. Am. Chem. Soc. 115, 10125 (1993); Burk, M., et al.: Tetrahedron Asymmetry 2, 569 (1991); Pichon, M., et al: Tetrahedron Asymmetry 7, 927 (1996)<br></p>

<p>Applications Silver Carbonate is used in organic synthesis in the Koenigs-knorr glycosylation reaction. It is also known as Fetizon's reagent acting as an oxidising agent on celite forming lactones form diols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fetizon, M., et al.: J. Chem. Soc. Chem. Comm., 19, 1118 (1969);<br></p>

<p>Applications Intermediate for the synthesis of enantiopure substituted 1,4-Dioxanes. Extremely valuable and versatile alcohol used as a chiral building block in organic synthesis.<br>References Bagnoli, L., et al.: Chem. Eur. J., 17, 993 (2011)<br></p>

<p>Applications VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.<br>References Bridges, et al.: Bioorg. Med. Chem. Lett., 20, 1972 (2010); Lebois, et al.: ACS Chem. Neurosci., 1, 104 (2010),<br></p>

<p>Applications Benzyl Isocyanate is a general reagent used in the synthesis of complex bisindolylmethanes. Also used in the preparation of urea derivatives of thiazol-2-ethylamines for their anti-trypanosomal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patrick, D. et al.: Bioorg. Med. Chem., 24, 2451 (2016);<br></p>

<p>Applications 2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liau, B. et al.: J. Am. Chem. Soc., 134, 16765 (2012); Tatsuta, K. et al.: Tetrahedron Lett., 53, 422 (2012);<br></p>

<p>Applications Niobium Pentachloride is a reagent used in the synthesis of mixed chloro-aryloxide compounds and dyes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ilin, A. et al.: J. Alloy. Comp., 748, 543 (2018); Yuan, L. et al.: Inorg. Chem., 57, 4226 (2018);<br></p>

<p>Applications WAY-100635 Maleate Salt is a selective SR-2B antagonist. It can be used in biological study of drug effects viewed from a signal transduction network perspective.<br>References Fliri, A., et al.: J Med Chem, 52, 8038 (2009)<br></p>

<p>Applications Magnesium tert-Butoxide is a reagent used in deprotonation reactions in organic synthesis. A mild alkaline earth metal alkoxide base that also functions as a Lewis acid and Bronsted base in chemical transformations.<br>References Ponikiewski, L., et al.: Z. Anorg. Allg. Chem., 634, 1770 (2008); Roman, D. S., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis, 1 (2013)<br></p>

<p>Applications Used in the preparation of antibacterial oxazolidinones.<br>References Kim, J. et al.: 19, 550 (2009); Michael R. et al.: J. Med. Chem., 50, 5886 (2007)<br></p>

<p>Applications LY2157299 is a TGF-β type I receptor kinase inhibitor. LY2157299 has been used to inhance chemotherapy action against triple negative breast cancer (TNBC).<br>References Bhola, N.E., et. al.: J. Clin. Invest., 123, 1348 (2013)<br></p>

<p>Applications meso-Tetra (N-methyl-4-pyridyl) porphine tetrachloride is a synthetic porphyrin for research use.<br></p>

<p>Applications Sodium Thiocyanate is used widely in chemical synthesis as source of thiocyanate anion such as in the conversion of alkyl halides to alkylthiocyanates.<br>References Shriner, R., et al.: Org. Synth., 2, 11 (1931);<br></p>

<p>Applications Mirin is an MRN-ATM pathway inhibitor blocking 3’ and 5’ exonuclease activity associated with Mre11, inducing G2 cell cycle arrest.<br>References Shibata, A. et al.: Mol Cell., 53, 7 (2014);<br></p>

<p>Applications Bromomethyl Methyl Ether acts as a reagent in the synthesis and evaluation of hydroxymethyl-aminocyclitols as glycosidase inhibitors, preparation of pyridine derivatives for minimizing CYP2C9 inhibition for cancer therapy. Also a reagent in the discovery of GBT 440, an orally bioavailable R state stabilizer of sickle cell Hb.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trapero, A., et al.: J. Org. Chem., 80, 3512 (2015); Zak, M., et al.: J. Med. Chem., 59, 8345 (2016); Metcalf, B.; et al.: ACS Med. Chem. Lett., 8, 321 (2017)<br></p>

<p>Applications β-Naphthylcarbinol is an intermediate in the synthesis of 2-Naphthylcarbapenem derivatives with broad spectrum antibiotics with enhanced potency against MRSA.<br>References Martikainen, L.E., et al.: Euro. J. Pharma. Sci., 47, 996 (2012);<br></p>

<p>Applications 4-Tolylhydrazine Monohydrochloride has shown tumorigenic potential through studies. In addition, due to its hydrazine moiety, it has anti-cancer potential and is a compound from which derivatives are made in the search of novel anticancer drugs.<br>References Gohil, V. et al.: Ind. J. Exp. Biol., 48, 265 (2010); Toth, B. et al.: J. Toxicol. Environ. Health, 8, 1 (1981);<br></p>

<p>Applications 4,6-Di-tert-butyl-1,2-benzoquinone is a Ortho-Quinone derivative is know to possess a number of biological properties such as antitumoral, antimicrobacterial and anti-cardiovascular disease.<br>References Singh, R., et al.: Res. J. Med. Plant., 6, 123 (2012); Sygmund. C., et al.: Microbiol., 157, 3203 (2011); Vidal, J.C., et al.: Electroanal., 20, 865 (2008); Kaizer, J., et al.: Food. Chem., 93, 425 (2005);<br></p>

<p>Applications 2,6-Di-tert-butyl-4-nitrophenol is a potentially powerful uncoupler of ATP-generating oxidative phosphorylation that has been reported to be a contaminant in submarines and indoor spaces, causing a number of objects to turn yellow (even human skin).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ball, J., et al.: Science, 272, 101 (1996); Rivera-Nevares, J., et al.: Env. Toxicol. Chem., 14, 251 (1995); Rothweiler, H., et al.: Atm. Env. B: Urb. Atm., 25, 231 (1991)<br></p>

<p>Applications 1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression<br>References Qian, F., et al.: Cancer Immunology Immunothrapy, 61, 2013 (2012)<br></p>

<p>Applications 1,2-Dibromo-4,5-dimethylbenzene is used as a reagent in the synthesis of Thalidomide (T338850); an inhibitor of FGF-induced angiogenesis and replication of human immunodeficiency virus type 1. Also a teratogenic sedative and immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma.<br>References Chen, J., et al.: Org. Biomol. Chem., 12, 5578 (2014); D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994); Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993); Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)<br></p>

<p>Stability Hygroscopic<br>Applications Rhodium (II) Acetate Dimer is used in the preparation of molybdenum triisopropylbenzoate isonicotinate which maintains ambivalent properties.<br>References Chisholm, M. et al: Inorg. Chem., 47, 9248 (2008);<br></p>