Building Blocks Chirali

<p>Applications Hydroxymethyl Ivacaftor is an impurity of Ivacaftor (I940600); a drug used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012)<br></p>

<p>Applications An impurity of the anti-convulsant (S)-Pregabalin (P704790).<br>References Lin, S. et al.: J. Liq. Chrom. Rel. Technol., 19, 2699 (1996); Sripathi, S. et al.: ARKIVOC, 10, 266 (2010);<br></p>

<p>Impurity Terbinafine BP Impurity A; Terbinafine USP Related Compound A<br>Applications N-Methyl-1-naphthalenemethanamine hydrochloride (Terbinafine BP Impurity A; Terbinafine USP Related Compound A) is an intermediate used in the synthesis of various pharmaceuticals such as Terbinafine hydrochloride (T107500) and Butenafine hydrochloride (B690195).<br>References Petranyi, G., et al.: Science, 224, 1239 (1984); Ryder, N.S., et al.: Antimicrob. Agents Chemother., 27, 252 (1985); Evans, E.G.V., et al.: Br. Med. J., 318, 1031 (1999); Kokjohn, K., et al.: Int. J. Dermatol., 42, 11 (2003); Sumikawa, M., et al.: J. Dermatol., 34, 456 (2007)<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Methylbutyl Chloroformate is an ester of chloroformic acid and is used as an intermediate in the synthetic preparation of pharmaceutical goods and inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dupuy, W.E., et al.: J. Chem. Soc. Phy. Org. Chem., 1, 74 (1973);<br></p>

<p>Applications 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol (cas# 26021-57-8) is a useful research chemical.<br></p>

<p>Applications 5,6-Dehydropregabalin is an impurity of the anticonvulsant, Pregabalin (P704800).<br>References Dousa, M, et al.: J. Pharmac. Biomed. Anal., 53, 717 (2010);<br></p>

<p>Applications 3-Oxohexanedioic Acid is a degradation product of catechol in the presence of hydrogen peroxide; Also, it is derived from 3-Oxohexanedioic Acid Diethyl Ester (O856830), which is an intermediate used to prepare CMPF (C595000) which is a drug-binding inhibitor which is also a constituent of urine. CMPF can inhibit specific T4 binding in serum by increasing the free concentration of direct competitors.<br>References Gogoi, A., et al.: Chem. Eng. J., 311, 153-162 (2017); Mabuchi, H., Nakahashi, H.: Nephron, 44, 277 (1986); Lim, C.F., et. al.: Metabolism Clin. Exp., 42, 1468 (1993)<br></p>

<p>Applications trans-β-Farnesene is a sesquiterpene natural product made my different plants to repel pest aphid species.<br>References Bruce, T., et al.: Pest Manag. Sci., 61, 1115 (2005);<br></p>

<p>Applications 1,1-Bis(4-hydroxyphenyl)-2-phenyl-1-butene (cas# 91221-46-4) is a compound useful in organic synthesis.<br></p>

<p>Applications α-Copaene is a tricyclic sesquiterpenes and can be extracted from the oil of S. aethiopis. It also exhibit anti-plasmodial activity against P. falciparum in culture.<br>References Boyom, F. F., et al.: Phytochemistry 64, 1269 (2003); Rustaiyan, A., et al.: Flavour Frag. J 14, 276 (1999)<br></p>