Alcoli

16-Epiestriol is a natural estrogen that can be found in urine samples. It has been shown to bind to the glucocorticoid receptor, which plays an important role in the regulation of immune responses and metabolism. 16-Epiestriol has also been shown to have immunosuppressive activities and may be used to treat cancer. 16-Epiestriol is metabolized by esterases in the liver, which leads to the production of covalent adducts. These covalent adducts bind to proteins in human liver and other tissues, leading to potential carcinogenicity. 16-Epiestriol binds with high affinity to streptococcus faecalis, which is an opportunistic pathogen associated with urinary tract infections. The optimum pH for this drug is 8.5 and it has been shown that it does not bind well at pH levels below 7 or above 11.

Arotinolol hydrochloride is a beta-blocker that, in contrast to propranolol, has a higher selectivity for the β1 receptor. It is used to treat hypertension and angina pectoris. Arotinolol hydrochloride lowers blood pressure by inhibiting the activity of α-adrenergic receptors, which are found in the heart and vascular smooth muscle. This inhibition reduces the release of norepinephrine and causes vasodilation. Arotinolol hydrochloride also has a positive effect on cardiac function as it decreases myocardial oxygen demand and increases coronary flow. Arotinolol hydrochloride has been shown to lower systolic pressure in anesthetized dogs with an intravenous dose of sodium citrate. The drug also lowers diastolic pressure in conscious dogs at doses of 0.5 mg/kg (0.2 mg/lb) or greater when given intravenously or subcutaneously.

Darunavir is a HIV-1 protease inhibitor used orally in the treatment of patients with multi-drug resistant HIV-1 infection (Ghosh, 2007). It has also been shown to be effective against other infectious diseases such as hepatitis C virus and SARS coronavirus. Metabolized by cytochrome P450 3A (CYP3A) isoenzymes, darunavir is often administered together with ritonavir that prolongs its bioavaiability, giving a terminal elimination half-life (t1/2) of 15 hours (Back, 2008). The effect of darunavir on natural compounds such as matrix proteins and toll-like receptor activity has also been studied via high performance liquid chromatography (HPLC) experiments.

4-Chloro-3-nitrobenzenethiol (4CNBT) is a micropet that is used as a radiotracer to measure the uptake of serotonin in the brain. This compound has been shown to bind to the serotonin transporter, which is responsible for reuptake of serotonin from the synapse. The radiolabeled 4CNBT can be used for positron emission tomography (PET) scanning and postinjection autoradiography. 4CNBT has also been used as a ligand in pharmacological studies on serotonin transporters.

4-(1-Adamantyl)-2-nitrophenol is a versatile building block that can be used to construct complex compounds. It is a research chemical that can be used as a reagent, as well as in the synthesis of pharmaceuticals and other chemicals. 4-(1-Adamantyl)-2-nitrophenol is soluble in water and ethanol, and has an odorless and colorless appearance. This chemical can be found under the CAS number 32599-84-1.

(S)-(-)-Diphenyl-2-pyrrolidinemethanol is a chiral compound that contains a chelate ring. It can be synthesized by the asymmetric synthesis of propargylamine, which is then converted to an amide chloride. The ester hydrochloride can be obtained from the esterification of propargylamine with epoxides, followed by hydrolysis. The stereoselective reaction of (S)-(-)-Diphenyl-2-pyrrolidinemethanol with primary amines at temperatures below -10°C produces secondary amines. This compound has been used in crystallography and in the reaction of β-unsaturated ketones with amines.

Emax (230 nm) = 3113