Amidi

Adamantyl-2-chloroacetamide is an analog of adamantyl acetamide and has been shown to be a potent inhibitor of Mycobacterium tuberculosis. Adamantyl-2-chloroacetamide inhibits the growth of Mycobacterium tuberculosis by inhibiting the synthesis of DNA, RNA, and protein. This compound also shows selectivity for Mycobacterium tuberculosis over other bacteria such as Escherichia coli. Adamantyl-2-chloroacetamide may have a role in the treatment of tuberculosis because it can inhibit the synthesis of DNA, RNA, and protein in Mycobacterium tuberculosis while leaving these functions intact in other bacteria.

Sulfamide is a pharmacological agent that inhibits the growth of bacteria. Sulfamide has been shown to be reactive with hydrogen fluoride, which may result in the formation of sulfamoyl chloride. This reactive form of sulfamide may react with other compounds and cause unwanted side-effects.
Sulfamides are used for the treatment of infectious diseases such as pneumonia and urinary tract infections, as well as for the treatment of other conditions like congestive heart failure and rheumatoid arthritis. They work by inhibiting enzymes necessary for bacterial growth, including target enzymes such as dihydropteroate synthase, which is involved in folate synthesis. Sulfamides also have inhibitory properties on human osteosarcoma cell proliferation.

1-Methyl-nicotinamide iodide is a drug that has been used in clinical trials for the treatment of type 2 diabetes mellitus. It is thought to work by increasing the sensitivity of cells to insulin, which may be related to its ability to bind to protein amide groups and form hydrogen bonds with the amino acid side chains. The compound also has been shown to increase the activity of the enzyme glycogen synthase in rats. 1-Methyl-nicotinamide iodide is soluble in water and human serum, and shows low solubility in ethanol. It has not been studied in humans, but animal studies have shown that it can be absorbed orally and metabolized into hippuric acid, which is excreted as a metabolic product through urine. Animal studies also showed that 1-methyl-nicotinamide iodide inhibits glucose production by pancreatic beta cells, which may lead to an increased insulin response after eating.

2-Chloro-N-(hydroxymethyl)acetamide (2CHAA) is an inhibitor that has been shown to be effective against a number of infectious diseases. 2CHAA inhibits the growth of bacteria by inhibiting the synthesis of proteins from RNA. This drug is also active against viruses, including herpes simplex virus and human immunodeficiency virus type 1, as well as fungi, such as Aspergillus niger. 2CHAA has no genotoxic effects in humans, but it does have carcinogenic potential and can cause allergic reactions. It also reacts with strong acids to form toxic compounds.

N,N'-Ethylenebis(iodoacetamide) is a molecule that binds to peptides and is used in cancer research. It has been shown to inhibit the growth of leukemia cells by inhibiting the synthesis of DNA. N,N'-Ethylenebis(iodoacetamide) has been shown to be an active analog for artemisinin, a drug used for malaria prophylaxis, and podophyllotoxin, a natural product used for the treatment of cancer. The molecule also inhibits cancer cell proliferation through its effects on protein synthesis.