Standard farmaceutici

Applications [N,N 0-Disalicylidene-1,2-ethanediaminato-(2-)]manganese(III) Chloride (cas# 53177-12-1) is a useful research chemical.

Applications (±)-Fluoxetine-d5 Oxalate (phenyl-d5) (CAS# 1219804-82-6) is a useful isotopically labeled research compound.

Applications 4,8-Dihydroxycoumarin, is an intermediate for the synthesis of 4'-, 6-, 7-, and 8-hydroxy metabolites of Warfarin(W498500), and Phenprocoumon (P318820), acting as anti-coagulant agents.
References Heimark, L. D., J. Labeled Compd. Radiopharm., 23, 137 (198); Kohl, C. et al.: Drug. Metab. Disp., 28, 161 (2000); Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953)

Applications 2'-O-Butyryladenosine 3',5'-cyclic phosphate DMAP is an intermediate in the synthesis of 2'-O-Monobutyryladenosine-3', 5'-cyclic Monophosphate (M525120), which is an impurity of Bucladesine Sodium Salt (B689320), a cell-permeable cAMP analogue that activates cAMP dependent protein kinase (PKA) or the cAMP/PKA signaling pathway.
References Yamauchi, J., et al.: J. Neurosci., 31, 12579 (2011); Ma, D., et al.: Mol. Pharmacol., 55, 50 (1999)

Applications 2-Chloro-6-amino-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine (cas# 79999-39-6) is a compound useful in organic synthesis.

Applications 2-Acetyl-5-oxo-hexanoic Acid Methyl Ester is an intermediate in the synthesis of Methyl 5-Methyl-1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylate (M338390), which is an impurity of the drug Amphetamine (A634248).

Applications D-Glucosamine-2-N-sulfate sodium salt (cas# 38899-05-7) is a useful research chemical.

Applications (+/-)-Exo-6-hydroxytropinone is a useful reagent for the preparation of racemic scopolamine (tropane alkaloid).
References Nocquet, P. A., et al.: Eur. J. Org. Chem., 2016, 1156 (2016)

Applications Protected Naphthylamine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Barbay, J., et al.: Bioorg. Med. Chem. Lett.,18, 2544 (2008), Konda, S., et al.: J. Chem. Pharm. Res., 2, 187 (2010),

Applications 4-Androsten-11b,17b-diol-3-one-2,2,4,6,6-d5 is a useful isotopically labeled compound of 11β-Hydroxytestosterone (H956785)

Applications rac 4-Hydroxy-7-methoxy-4-(4-benzyloxyphenyl)-1,2,3,4-tetrahydronaphthalene (cas# 1286878-19-0) is a compound useful in organic synthesis.

Applications 9,10-Dibromoanthracene-2-sulfonic Acid (cas# 70942-82-4) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1-BROMOANTHRACENE (cas# 7397-92-4) is a useful research chemical.

Applications A diamino substituted nathalenesulfonic acid derivative.

Applications A volatile lactone found in fruits giving ripe produce their aroma.
References Tavori, H., et al.: Bioorg. Med. Chem., 16, 7504 (2008), Pandit, S., et al.: J. Sci. Food Agric., 89, 2071 (2009), Xiang, D., et al.: Biochem., 48, 2237 (2009), Pandit, S., et al.: Food Chem., 114, 363 (2009),

Applications Testosterone-2,2,4,6,6-d5 Acetate is a useful isotopically labeled compound of Testosterone 17-O-Acetate (T155025)

Applications 3-Bromopropionic-2,2,3,3-d4 Acid is the labeled analog of 3-Bromopropionic acid (B687705). 3-Bromopropionic Acid is used as a reagent in the synthesis of nitrogen containing diselenides which exhibit antioxidant activity. Also used as a reagent in the synthesis of indolin-2-one-based multi-targeted receptor tyrosine kinase inhibitors as potential anticancer agents.
References Nascimento, V., et al.: Eur. J. Med. Chem., 87, 131 (2014); Zhang, L., et al.: Eur. J. Med. Chem., 82, 139 (2014)

Applications An intermediate in the production of Guanidinoacetic Acid
References Kennelly, P., et al.: J. Mol. Biol., 145, 583 (1981),

Applications 2-(2-((6-(2-Cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-2-oxoacetic Acid Methyl Ester is an intermediate in the synthesis of (Z)-Azoxystrobin (A965155), a fungicide that inhibits mitochondrial respiration by blocking electron transfer between cytochromes b and c1
References Smalling, K., et al.: Environ. Toxicol. Chem., 29, 2593 (2010), Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),

Applications 3'-Hydroxy[1,2'-binaphthalene]-1',3,4,4'-tetrone is prepared by the oxidation reaction of 3,4-dihydro-1(2H)-naphthalenone with selenium dioxide.
References Weygand, F., et al.: Chem. Ber., 84, 591 (1951);

Applications N-(4,4’-Dinitro-biphenyl-2-yl)benzamide (cas# 84682-33-7) is a compound useful in organic synthesis.

Applications Testosterone-2,2,4,6,6-d5 Benzoate is a useful isotopically labeled compound of Testosterone Benzoate (T155015)

Applications 7-Methoxy-2-naphthol is used as a reactant in the preparation of 9-hydroxy benzopyrene (H829410). It is also used in the preparation of (pyridyl)naphthalenes as highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.
References Pinto-Bazurco Mendieta, M.A.E., et al.: J. Med. Chem. 56, 6101 (2013)

Applications 6-(Trifluoromethoxy)-3,4-dihydronaphthalen-1(2H)-one is used in the preparation of pyridine or pyridazine derivatives as histone demethylase inhibitors.
References Chen, Y.K., et. al.: PCT Int. Appl., WO 2014100818 A1 20140626 (2014)

Applications 3-Nitrophenylhydrazine Hydrochloride acts as a reagent in the preparation of isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents, preparation of pyrazolobenzothiazines as inhibitors of hepatitis C virus replication.
References Zhu, S., et al.: Eur. J. Med. Chem., 65, 70 (2013); Barreca, M. L., et al.: J. Med. Chem., 56, 2270 (2013);

Applications p-Salicylic Acid 4-Sulfate is a urine metabolite of Methylated paraben (B693600), an antimicrobial agent used in cosmetic products.
References Tsukamoto, H., et al: Chem. Pharma. Bull., 10, 86 (1962); Desai, N.B., et al.: J. Sci. Indust. Res., 14, 330 (1955);

Applications Di(α-tocopherol) Phosphate-d12 is labelled Di(α-tocopherol) Phosphate (T526190) which is used as a vitamin E supplement.
References Libinaki, R., et al.: Food Chem. Toxicol., 44, 916 (2006)

Applications A potential metabolite of Exemestane (E957000).
References Buzzetti, F., et al.: Steroids, 58, 527 (1993),

Applications 5-Nitropyridin-2(1H)-one can be used for molecular crystal optical materials.
References Uemya, T., et.al., Jpn. Kokai Tokkyo Koho, 22, (1995);

Applications Cholesterol-3-d1 (CAS# 51467-57-3) is a useful isotopically labeled research compound.

Stability Unstable in Solution
Applications β-Ketoglutaric Acid is used in the synthesis of benzodiazepine derivatives. Also used in the synthesis of orally available hepatitis C virus polymerase inhibitors.
References Jung, D. et al.: Synth. Comm., 29, 1941 (1999); Li, H. et al.: J. Med. Chem., 52, 1255 (2009);

Applications N-BENZYL-3,3'-IMINODIPROPIONIC ACID (cas# 6405-28-3) is a useful research chemical.

Applications 9-Methylanthracene-d12 (CAS# 6406-97-9) is a useful isotopically labeled research compound.

Applications B-1-Naphthalenyl-boronic Acid is a useful synthetic intermediate. It is a reagent used to synthesize potassium aryltrifluoroborates which is a convenient precursor of arylboron difluoride lewis acids. It can also be used to prepare high yields of biaryls via Suzuki coupling.
References Vedejs, E., et al.: J. Org. Chem., 60, 3020 (1995); Larhed, M., et al.: Tetrahedron Lett., 37, 8219 (1996); Singh, R., et al.: 7, 1829 (2005)

Applications Tetramethylthiourea (cas# 2782-91-4) is a useful research chemical.

Applications 1,3-Dicyclohexyl-2-phenyl-pseudourea is an intermediate in the synthesis of [R-(R*,R*)]-(1,2-Dihydroxypropyl)phosphonic Acid (D454455) which is a Fosfomycin (F727500) impurity. Fosfomycin is an antibiotic that exerts a broad spectrum of antibacterial activity. P-[(1R,2R)-1,2-Dihydroxypropyl]-phosphonic Acid is an intermediate in the synthesis of [2-[2-Amino-3-hydroxy-2-(hydroxymethyl)propoxy]-1-hydroxypropyl]phosphonic Acid (A611565), another Fosfomycin (F727500) impurity.
References McGrath, J.W., et al.: Org. Biomolec. Chem., 7, 9 (1944); Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981);

Stability Moisture Sensitive
Applications 2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.
References D’Amato, R., et al.: Proc. Nat. Acad. Sci., 91, 4082 (1994); Ehrenpreis, E., et al.: Gastroenterology, 117, 1271 (1999); Parma, T., et al.: Nat. Med., 5, 582 (1999); Singhal, S., et al.: New Engl. J. Med., 341, 1565 (1999)

Applications A metabolite of Nabumetone.
References Nobilis, M., et al.: J., Pharm., Biomed., Anal., 32, 641 (2003),

Applications 4,5,6,7-Tetrahydro-7-oxo-benzo[b]thiophene-4-carboxylic Acid methyl Ester is a useful synthetic intermediate.

Applications Labelled analogue of Crotonobetaine Hydrochloride, a trimethylammonium compound that can be converted into L-Carnitine by Escherichia coli via stereoselective hydration.
References Seim, H. et al.: Eur. Congr. Biotechnol., 1, 481 (1984); Seim, H. et al.: Appl. Microbiol. Biotechnol., 27, 538 (1988);

Applications (S)-2-(tert-Butoxycarbonylamino)-4-(3-methyl-3H-diazirin-3-yl)butanoic acid is a novel photo-cross linker for live-cell imaging.
References Pan, S., et al.: Angewandte Chemie Int. Ed., 56, 11816(2017)

Applications β-Cyclogeraniol (cas# 472-20-8) is a compound useful in organic synthesis.

Applications Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.
References Demetriou, A., et al.: Science, 233, 1190 (1986); Aebischer, P., et al.: Nat. Med., 2, 696(1996); Prakash, S., et al.: Biotechnol. Bioeng., 46, 621(1995);

Applications L-Methionine methyl ester is a protected form of L-Methionine (M260440). L-Methionine is an essential amino acid that is obtained from our diet. L-Methionine can be found in grain legumes (such as lentils), and poultry. L-Methionine’s main function is to act as the primary “Start” sequence on mRNA so that the ribosomes can start translating the mRNA into proteins.
References Forbes, J. & Shariatmadari, F.: World. Poul. Sci. J., 50, 7 (24); Kozak, M.: J. Cell. Biol., 108, 229 (1989); Müntz, K., et al.: Food/Nahrung, 42, 125 (1998); Wright, L., et al.: Amer. J. Physiol., 149, 130 (1947)

Applications α-Naphthyl-d7 Glycidyl Ether is an intermediate in the synthesis of rac-Propranolol-d7 (P831803) which is the labeled analogue of Propranolol (P831800), a β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),

Applications 3'-O-Levulinoyl-N-benzoyl-2'-deoxythymidine is a protected nucleotide derivative/building block.
References Kiuru, E., et al.: Helvetica Chimica Acta, 96, 1997-2008 (2013);

Applications 2-[1-(2-Naphthyl)ethyl]benzoic Acid (cas# 904236-46-0) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Stability Hygroscopic
Applications Phosphinothricin metabolite.
References Komossa, D. et al.: Pestic. Biochem. Phys. 43, 95 (1992)

Applications N1,O2'-Dimethyladenosine Monohydriodide-d3, is the labeled a analogue of N1,O2'-Dimethyladenosine Monohydriodide (D447411), is an intermediate useful in the synthesis of N6,O2'-Dimethyladenosine (D447415), which is naturally occurring modified nucleoside in RNA. It was reported in the preparation of alkylated adenosines as antihypertensive agents.
References Yamada, T., Kageyama, K.: Eur. Pat. Appl. (1988), EP 269574 A2 19880601; Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007);

Applications Testosterone Hexanoate-d11 is the isotopic analog of Testosterone Hexanoate. Testosterone Hexanoate is a metabolite of testosterone(T155000), which is used in analytical studies to determine the use of anabolic steroid esters and related compounds in equine hair sample though ultra high performance liquid chromatography-tandem mass spectrometry.
References Gray, B.P., et al.: Analtica Chemica Acta, 787, 163 (2013); McKinney, A., et al.: Bioanalysis 1, 785 (2009)

Applications 2'-Hydroxyflavone (cas# 35244-11-2) is a useful research chemical.

S-(+)-1-Aminotetrahydronaphthalene is an amido derivative that is the enantiomer of S-(-)-1-amino-N,N'-diphenylformamide. It has been shown to have anti-obesity effects in mice by increasing energy expenditure and reducing food intake. S-(+)-1-Aminotetrahydronaphthalene also inhibits the release of fatty acids from adipose tissue, which may be due to its ability to suppress lipolysis. The molecular mechanism for these effects is not yet known, but it is thought that the amide group on this compound interacts with certain protein surfaces and steric interactions are involved in its activity.

Salbutamol sulphate impurity B is a substance that is an impurity in salbutamol sulfate. It is a white crystalline powder and is soluble in organic solvents. Salbutamol sulfate impurity B can be detected by liquid chromatography, which separates the substances based on their solubility in different phases. The substances are detected at a specific wavelength, and it is possible to identify peaks of the substances on the chromatogram synchronously. Salbutamol sulfate impurity B can be found as a part of other medicines or substances by using this detection method.

Prednisolone is a synthetic corticosteroid that is used in the treatment of a number of lung diseases, including asthma. Prednisolone is used to decrease the inflammation and swelling around the airways and lungs. Prednisolone is used to treat certain skin conditions, such as eczema and dermatitis. This drug also decreases the activity of the immune system by inhibiting production of substances that cause inflammation. The onset of action for prednisolone is typically one day with a duration of up to two weeks. It has been shown to be more effective when taken orally than when applied topically. It may be taken with or without food and can be given as an oral or an intravenous dose. Prednisolone tablets must be dissolved in water before they are placed under the tongue (sublingual). The tablets will dissolve quickly under the tongue, releasing prednisolone into your bloodstream. Enteric-coated tablets should not be crushed or chewed

Cefradine impurity F is a hydrolysis product of cefradine, which is an antibiotic. It is catalysed by β-lactamase enzymes and undergoes nucleophilic attack on the carbon atom adjacent to the carbonyl group. Cefradine impurity F has been shown to be effective against enterobacter, which is a type of bacteria that can cause urinary tract infections. The uptake of cefradine impurity F into bacteria can occur through passive diffusion or active transport mechanisms. This drug was also found to be hydrolyzed by buffers such as phosphate and acetate in vitro, but not by other substances such as EDTA and citrate. Cefradine impurity F has been shown to be hydrolyzed in vivo, with the most likely mechanism being spontaneous hydrolysis.