Antimicrobici

BIOSAFE® Quaternary Siloxane Powder
BIOSAFE® Antimicrobial is a non-leaching silicon-based antimicrobial that imparts bacteriostatic, fungistatic, and algistatic properties
to coatings and resins for manufactured goods.
3-(Trihydroxysilyl)propyldimethyloctadecyl ammonium chloride; Octadecyldimethyl(3-trihydroxysilylpropyl)ammonium chloride, 84% active condensed; Silsesquioxanes, 3-(dimethyloctadecylammonio)propyl, hydroxy-terminated, chlorides
EPA Registration Number: 83019-1FDA Approved for Food ContactNSF 51 approvedNo VOCsUsed in resin blending, compounding, and coatingsMicrobiostatic agent that protects articles from deterioration and discolorationLeach resistantActive against forms of fungi, algae, and bacteriaHigh antimicrobial performance in ISO and ASTM testingDoes not promote development of resistant microorganismsRecommended process temperature: <170 °CTypical use concentrations of 0.25-0.5 wt% active relative to the substrate being treatedIncompatible with anionic surfactantsAvailable in aqueous solutions HM4005 and HM4001
Resin Compatibility
TPU - Thermoplastic PolyurethaneUrethane FoamPolyether bock amide (PEBAX®)Silicone (not post-cured)Polyamide 6 (PA6 or nylon 6)Acrylic (cast and thermoplastic)Acrylic AdhesivesSpun FiberFiberglass Gel Coat
Used in Certainty® SmartBoost™ Laundry Additive
For more information on BIOSAFE® products, please contact Customer Service at 888.734.8344.

BIOSAFE® Antimicrobial 72% in methanol
BIOSAFE® Antimicrobial is a non-leaching silicon-based antimicrobial that imparts bacteriostatic, fungistatic, and algistatic properties
to coatings and resins for manufactured goods.
Octadecyldimethyl(3-trimethoxy silylpropyl)ammonium chloride, 72% in methanol; (Trimethoxysilylpropyl)octadecyldimethylammonium chloride; Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride
EPA Registration Number: 83019-4Microbiostatic agent that protects articles from deterioration and discolorationActive against forms of fungi, algae, and bacteriaLeach resistantUsed in water based surface treatments and coatings,High antimicrobial performance in ISO and ASTM testingDoes not promote development of resistant microorganismsTypical use concentrations of 0.25-0.5 wt% active relative to the substrate being treatedIncompatible with anionic surfactantsAvailable as a no VOC powder HM4100
Water Based Surface Treatments
CarpetNon-wovensRoll goodsBuilding materialsShoesIndoor environment surfaces

Applications 6R,10R-Dimethyl-2-pentadecanone is a byproduct in the synthesis of (+)-Phytone (P398050), which is an constituent of leaf essential oil of Lawsonia Inermis growing in Nepal with potential anti-microbial activities.
References Satyal, P., et al.: Pharmacol., 1, 31 (2012);

Applications (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-(4-hydroxyphenyl)propanoic Acid Methyl Ester is an intermediate in the synthesis of Aureusimine A (A794560), a metabolite of non-ribosomal origin produced by Staphylococcus aureusan, formed by the fusion of two amino acids. Aureusimine A was shown to exert control over the virulence cascade responsible for Golden Staph infection.
References Archer, G., et al.: Clin. Infect. Dis., 26, 1179 (1998); Novick, R., et al.: Mol. Microbiol., 48, 1429 (2003); Liang, X., et al.: Infect. Immun., 74, 4655 (2006); Geiger, T., et al.: J. Bacteriol., 190, 3419 (2008);

Applications (5Z,​8Z,​11Z,​14Z)​-5,​8,​11,​14-​Eicosatetraenoic Acid 2-​[[(1,​1-​Dimethylethoxy)​carbonyl]​amino]​ethyl Ester is an intermediate used in synthesizing O-Arachidonoyl ethanolamine hydrochloride (A765130), a partial agonist at CB1 receptor and a full agonist at CB2 receptor. O-Arachidonoyl ethanolamine hydrochloride can be isolated from constituent of human and rat brain. It can be used to prepare antimicrobial arachidonic acid derivative.
References Kvasenkov, O. I. RU 2171610 C2 20010810 (2001); Sharir, H., et al.: J Neuroimmune Pharmacol. 7, 856 (2012)

Applications ​[5-​[(3aS,​4S,​6aR)​-​Hexahydro-​2-​oxo-​1H-​thieno[3,​4-​d]​imidazol-​4-​yl]​-​1-​oxopentyl]​-​3-​(2-​pyridinyldithio)​-L-alanine is an intermediate in the synthesis of Biotinyl Pyridinyldithio N-Hydroxysuccinimide Alanine Ester (B397300), which is an antimicrobial bisulfide prodrug.
References Ponpipom, et al.: J. Med. Chem., 24, 1388 (1981), Hausch, F., et al.: Bioconjug. Chem., 8, 885 (1997), Seelig, B., et al.: Chem. Biol., 6, 167 (1999),

Applications 2,7-Dibromonapthalene acts as a reagent for the expedient synthesis of aminopropoxy-functionalized bis(aryltriazoly) arylenes via click chemistry and their antimicrobial and hemolytic activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fu, T., et al.: ACS Med. Chem. Lett., 4, 841 (2013)

Applications 2,2'-Methylenebis(4-bromophenol) can be derived from bromophenols from the red alga Odonthalia corymbifera and display potential antimicrobial activity. It is used as an intermediate in the synthesis of Albuterol Dimer (A514515) which is an impurity of the drug Albuterol used to treat asthma.
References Oh, K., et al.: Bioorg. Med. Chem. Lett., 18, 104 (2008); Haddad, N., et al.: Tetrahedron Lett., 43, 1135 (2002);

Stability moisture sensitive
Applications 4,7-Difluoro-1,3-isobenzofurandione is used in the synthesis of phthalic compounds, phthalazines, and quinones with antimicrobial activity.
References Cardia, M. et al.: J. Hetero. Chem., 40, 1011 (2003); Krohn, K.. et al.: Sci. Synth., 28, 367 (2006); Vina, D. et al.: Tetrahedron, 65, 1574 (2009);

Ceftiofur is a third-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating bacterial infections in veterinary medicine.

Kitasamycin is a macrolide antibiotic with a mode of action that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It is used for treating bacterial infections in veterinary medicine.

Gentamicin C2a is an aminoglycoside antibiotic, which is a complex of compounds derived from the fermentation of the bacterium *Micromonospora purpurea*. Its mode of action involves binding to the bacterial 30S ribosomal subunit, thereby inhibiting protein synthesis and resulting in the bactericidal effect on susceptible strains. The disruption of protein synthesis prevents the growth and replication of bacteria, effectively killing them.