Antiparassitari
Gli antiparassitari sono composti progettati per trattare e prevenire le infezioni parassitarie inibendo la crescita e la sopravvivenza dei parassiti. Questa categoria include una gamma di agenti antiparassitari destinati esclusivamente all'uso in laboratorio e non per il consumo umano. Questi prodotti sono essenziali per scopi di ricerca, consentendo agli scienziati di studiare i cicli di vita dei parassiti, i meccanismi d'azione e lo sviluppo della resistenza. L'uso di antiparassitari in ambienti di laboratorio aiuta nella scoperta e nell'ottimizzazione di nuovi trattamenti per le malattie parassitarie, contribuendo ai progressi nella parassitologia medica e veterinaria. I ricercatori si affidano a questi prodotti per migliorare la comprensione delle infezioni parassitarie e sviluppare terapie più efficaci.
Trovati 704 prodotti di "Antiparassitari"
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Antimalarial agent 30
CAS:<p>Antimalarial agent 30 has anti-Plasmodium berghei liver stage parasite activity and antimalarial activity for the study of malarial infections.</p>Formula:C18H11F3N2Purezza:99.83% - 99.90%Colore e forma:SolidPeso molecolare:312.29Brotianide
CAS:<p>Brotianide (BAY-VA4059) has anthelmintic activity and is highly potent against liver fluke and gastric fluke infestations and can be used to treat acute,</p>Formula:C15H10Br2ClNO2SPurezza:97.44% - 98.12%Colore e forma:SolidPeso molecolare:463.57JCP174
CAS:<p>JCP174 is a depalmitoylase inhibitor that enhances Toxoplasma host-cell invasion by targeting TgPPT1.</p>Formula:C12H12ClNO3Purezza:97.05%Colore e forma:SolidPeso molecolare:253.68Allopurinol riboside
CAS:<p>Allopurinol riboside, an allopurinol metabolite, inhibits purine nucleoside phosphorylase in parasites with a Ki of 277 μM.</p>Formula:C10H12N4O5Purezza:99.46% - 99.73%Colore e forma:SolidPeso molecolare:268.23UCT943
CAS:<p>UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).</p>Formula:C22H20F3N5OPurezza:99.87%Colore e forma:SolidPeso molecolare:427.42AP-C5
CAS:<p>AP-C5 inhibits cGKII with a Pic50 of 7.2, useful in diarrheal disease research.</p>Formula:C16H13N5Purezza:99.82%Colore e forma:SolidPeso molecolare:275.31DDD85646
CAS:<p>DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.</p>Formula:C21H24Cl2N6O2SPurezza:97.8% - 99.76%Colore e forma:SolidPeso molecolare:495.43Myrrhterpenoid O
CAS:<p>Unfortunately, you did not provide the description of the chemical compound that needs to be rewritten.</p>Formula:C16H20O3Purezza:98%Colore e forma:SolidPeso molecolare:260.33Propamidine
CAS:<p>Propamidine acts as a covalent inhibitor of TMPRSS2 and exhibits antibacterial properties. [1]</p>Formula:C17H20N4O2Purezza:98%Colore e forma:SolidPeso molecolare:312.37UCB7362
CAS:<p>UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.</p>Formula:C25H26ClN5O3Purezza:97.67%Colore e forma:SolidPeso molecolare:479.96Antileishmanial agent-16
CAS:<p>Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and</p>Formula:C27H37N5O4Purezza:98%Colore e forma:SolidPeso molecolare:495.61Antileishmanial agent-17
CAS:<p>Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells.</p>Formula:C27H37N5O5Purezza:98%Colore e forma:SolidPeso molecolare:511.61SID 26681509
CAS:<p>SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).</p>Formula:C27H33N5O5SPurezza:98.16%Colore e forma:SolidPeso molecolare:539.65FIKK9.1-IN-1
CAS:<p>FIKK9.1-IN-1 (Compound 1), an antimalarial agent (IC50: 2.68 μg/mL), serves as a FIKK9.1 inhibitor by interacting with the ATP-binding residues within FIKK9.1,</p>Formula:C22H22N2SePurezza:98%Colore e forma:SolidPeso molecolare:393.38ELQ-596
CAS:<p>ELQ-596, a quinolone derivative, exhibits antimicrobial activity against several protozoan parasites, including the intraerythrocytic parasites Plasmodium and Babesia. ELQ-596 attenuates babesiosis in immunosuppressed mice [1].</p>Formula:C24H17ClF3NO3Colore e forma:SolidPeso molecolare:459.84Fervenulin
CAS:<p>Fervenulin, from Streptomyces sp. CMU-MH021, halts egg hatch (MIC: 30 μg/mL) and kills J2 larvae (MIC: 120 μg/mL) of M. incognita.</p>Formula:C7H7N5O2Purezza:99.75%Colore e forma:SolidPeso molecolare:193.16Z-Pro-Pro-CHO
CAS:<p>Z-Pro-Pro-CHO acts as a prolyl oligopeptidase inhibitor with half-maximal inhibitory concentrations (IC50) of 0.16 μM for human prolyl oligopeptidase and 0.01</p>Formula:C18H22N2O4Purezza:98%Colore e forma:SolidPeso molecolare:330.38BTG 502
CAS:<p>BTG 502 is an alkylamide insecticide that binds to voltage-gated sodium channels, antagonising the activation of sodium channels by Batrachotoxin (BTX).</p>Formula:C21H24BrNOPurezza:99.30%Colore e forma:SolidPeso molecolare:386.33EDI048
CAS:<p>EDI048, also known as compound 1.16, is an orally active inhibitor of Cryptosporidium PI4K, utilized in the study of cryptosporidiosis [1].</p>Formula:C25H21ClN4O4Purezza:98%Colore e forma:SolidPeso molecolare:476.91OfChi-h-IN-2
CAS:<p>OfChi-h-IN-2 (compound TQ19) is a potent inhibitor of OfChi-h, exhibiting a K i of 0.33 μM, and significantly impairs the growth and development of Ostrinia</p>Formula:C25H28ClN5O3Purezza:98%Colore e forma:SolidPeso molecolare:481.98Eugenitin
CAS:<p>Eugenitin, a polyketide from Mycoleptodiscus indicus, exhibits inhibitory activity against Leishmania major with an LD50 of 39.9 μM and demonstrates low</p>Formula:C12H12O4Purezza:98%Colore e forma:SolidPeso molecolare:220.22Antileishmanial agent-23
CAS:<p>Antileishmanial agent-23 (compound G1/9), a potent and selective trypanothione reductase (TR) inhibitor, exhibits an IC50 of 2.24 ± 0.52 μM.</p>Formula:C20H17N3O4S2Purezza:98%Colore e forma:SolidPeso molecolare:427.5Phylloflavan
CAS:<p>Phylloflavan, an antileishmanial compound, exhibits an intracellular half maximal effective concentration (EC50) of 3.2 nM in RAW 264.7 cells and inhibits the</p>Formula:C26H26O10Purezza:98%Colore e forma:SolidPeso molecolare:498.48MMV688533
CAS:<p>MMV688533 has antimalarial activity.</p>Formula:C24H15F6N5O2Purezza:99.12%Colore e forma:SoildPeso molecolare:519.4Dehydroemetine
CAS:<p>Dehydroemetine, a synthetic emetine, treats amoebic infections and leishmaniasis, and resists metronidazole amoebiosis.</p>Formula:C29H38N2O4Purezza:98.68% - 99.68%Colore e forma:SolidPeso molecolare:478.62ZY-19489
CAS:<p>ZY-19489: Antimalarial, potential single-dose cure, FDA orphan drug status.</p>Formula:C24H32FN9Purezza:>99.99%Colore e forma:SoildPeso molecolare:465.57GSK3186899
CAS:<p>GSK3186899 is an inhibitor of Cdc2-related kinase 12 with an EC50 of 1.4 μM for L. donovani.</p>Formula:C19H28F3N7O3SPurezza:98.35% - 99.61%Colore e forma:SolidPeso molecolare:491.53CWHM-1552
CAS:<p>CWHM-1552 is an effective Plasmodium falciparum inhibitor. For the 3D7 and Dd2 strains, the IC50s are 51 nM and 53 nM.</p>Formula:C22H27F2N3OPurezza:99.56%Colore e forma:SolidPeso molecolare:387.47Ac-Atovaquone
CAS:<p>Ac-Atovaquone, an ester-acetylated derivative of atovaquone, acts as a potent inhibitor of cytochrome bc1 (cytochrome bc1). This compound shows potential for use in malaria research.</p>Formula:C24H21ClO4Colore e forma:SolidPeso molecolare:408.87WR-27653
CAS:<p>WR-27653 (RC-12), a derivative of Catechol, demonstrates significant activity against hypnozoites in the Plasmodium cynomolgi-Rhesus monkey (Macaca mulatta) model, which is considered the gold standard. Additionally, WR-27653 exhibits antimalarial properties.</p>Formula:C20H36BrN3O2Colore e forma:SolidPeso molecolare:430.423PFK-IN-1
CAS:<p>PFK-IN-1 (compound 1) is an inhibitor of 6-phosphofructo-1-kinase (PFK), demonstrating IC50 values of 0.41 and 0.23 μM against T. brucei and T. cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T. brucei. The compound has a half-life of 9.7 minutes in rat liver microsomes and 408 minutes in mouse liver microsomes.</p>Formula:C18H15Cl2N3O4SColore e forma:SolidPeso molecolare:440.3Ipronidazole
CAS:<p>Ipronidazole (RO-71554) is an orally effective antiprotozoal agent used to prevent and ameliorate histomoniasis in turkeys, commonly referred to as blackhead disease.</p>Formula:C7H11N3O2Colore e forma:SolidPeso molecolare:169.18Arohynapene B
CAS:<p>Arohynapene B is an anticoccidial compound that inhibits the growth of Eimeria parasites.</p>Formula:C18H22O3Colore e forma:SolidPeso molecolare:286.366NEU-1017
CAS:<p>NEU-1017 serves as a broad-spectrum antiparasitic compound, effectively inhibiting T. brucei, L. major, and P. falciparum with EC50 values of 210 nM, 240 nM, and 3 nM, respectively.</p>Formula:C33H31ClFN5O3SColore e forma:SolidPeso molecolare:632.147SLU-10906
CAS:<p>SLU-10906 (Compound 63) is an orally active inhibitor of Cryptosporidium. It demonstrates activity against the parasite in cell-based infection models with an EC50 of 0.19 μM and exhibits no cytotoxicity. SLU-10906 is a promising candidate for research in cryptosporidiosis.</p>Formula:C22H21BFN5O2Colore e forma:SolidPeso molecolare:417.244SPB07935
CAS:<p>SPB07935 inhibits plasmepsin II in the malaria-causing parasite Plasmodium falciparum and serves as an antimalarial agent. It affects the life cycle of P. falciparum, hindering the growth of the parasite's FcB1 and 3D7 strains, with IC50 values of 8 μM and 4.7 μM, respectively.</p>Formula:C22H15N5O4S2Colore e forma:SolidPeso molecolare:477.516Menoctone
CAS:<p>Menoctone is an orally effective antimalarial agent that inhibits blood-induced rodent malaria. It enhances the antimalarial effects of chloroquine or quinine, making it useful for malaria research.</p>Formula:C24H32O3Colore e forma:SolidPeso molecolare:368.51Insecticidal agent 16
CAS:<p>Insecticidal agent 16 (compound A21) exhibits insecticidal activity against Plutella xylostella, with LC50 values of 1.2 and 13.2 µg/mL respectively.</p>Formula:C21H13Cl2F6N5O2SColore e forma:SolidPeso molecolare:584.32Antimalarial agent 48
CAS:<p>Antimalarial agent 48 (Compound 15a) is a triazine compound with antimalarial activity, showing effectiveness against Plasmodium falciparum K1 and Plasmodium falciparum FCR3 with IC50 values of 280 and 290 nM, respectively. It holds promise for research in the field of anti-infective treatments.</p>Formula:C19H14F3N11Colore e forma:SolidPeso molecolare:453.383MMV03
CAS:<p>MMV03 is an antimalarial compound effective against Plasmodium falciparum, with an EC50 of 0.6 μM.</p>Formula:C19H14N4OSColore e forma:SolidPeso molecolare:346.406Antimalarial agent 44
<p>Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.</p>Formula:C37H37N5O7Colore e forma:SolidPeso molecolare:663.72MED6-189
CAS:<p>MED6-189, an analog of kalihinol, disrupts the apicoplast functions and vesicular transport in the malignant malaria parasite (P. falciparum, IC50 < 50 nM). The compound specifically targets the apicoplast, which is a non-photosynthetic plastid essential for isoprenoid synthesis, found in most apicomplexan parasites.</p>Formula:C17H26N2OColore e forma:SolidPeso molecolare:274.40Isazofos
CAS:<p>Isazofos is a broad-spectrum organophosphate insecticide and nematicide effective in controlling a variety of lawn pests, such as nematodes (Radopholus similis). It also demonstrates efficacy in managing rice gall midge.</p>Formula:C9H17ClN3O3PSColore e forma:SolidPeso molecolare:313.74PfCLK3-IN-1
<p>PfCLK3-IN-1 (Compound 4) serves as a covalent inhibitor of the malaria parasite CLK3 (Pf CLK3) under alkaline conditions, with a pEC50 of 7.1. It inhibits the maturation of gametocytes during the sexual stage of the parasite, thereby hindering transmission. Additionally, PfCLK3-IN-1 effectively suppresses the Dd2-B2 clone of the malaria parasite, exhibiting an IC50 of 239.5 nM.</p>Formula:C28H27ClN4O4Colore e forma:SolidPeso molecolare:518.99PIQ-2
CAS:PIQ-2 (compound 54) serves as an antiprotozoal agent, displaying potent activity against IP. falciparum 3D7 and B. divergens Rouen, with IC50 values of 9.4 nM and 1.6 nM, respectively.Formula:C23H21F3N4O3Colore e forma:SolidPeso molecolare:458.43Ferrocene
CAS:<p>Ferrocene, a crucial structural core in bioorganometallic chemistry, is renowned for its intrinsic stability, excellent oxygen reduction capabilities, and low toxicity. It also exhibits antimalarial and anticancer properties.</p>Formula:C10H10FeColore e forma:SolidPeso molecolare:186.03Erythromycin B
CAS:<p>Erythromycin B exhibits antimalarial activity by effectively inhibiting the asexual growth of Plasmodium falciparum.</p>Formula:C37H67NO12Colore e forma:SolidPeso molecolare:717.93SAL-0010042
CAS:<p>SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.</p>Formula:C15H15FN4OColore e forma:SolidPeso molecolare:286.304DNA crosslinker 6
CAS:<p>DNA crosslinker 6 (compound 1) is an anti-mitotic agent known for its strong binding affinity to AT-DNA and inhibition of AT-hook 1 binding to DNA (IC50=0.03 µM). Additionally, it exhibits anti-protozoal activity, effectively inhibiting T. brucei with an EC50 of 0.83 µM.</p>Formula:C19H21N7OColore e forma:SolidPeso molecolare:363.42Etofamide
CAS:<p>Etofamide, an antimicrobial agent, exhibits an IC50 of 5.96 mg/L against amoebae.</p>Formula:C19H20Cl2N2O5Colore e forma:SolidPeso molecolare:427.28
