Cannabinoidi
I cannabinoidi sono una classe di composti chimici diversi derivati dagli acidi grassi o dai polichetoidi, che agiscono sui recettori dei cannabinoidi nelle cellule, alterando il rilascio di neurotrasmettitori nel cervello. Presenti principalmente nelle piante di cannabis, cannabinoidi come il THC e il CBD sono ampiamente studiati per i loro effetti terapeutici, tra cui il sollievo dal dolore, le proprietà anti-infiammatorie e il loro potenziale utilizzo nelle malattie neurodegenerative. Da CymitQuimica troverai una vasta gamma di cannabinoidi per la ricerca in farmacologia, neurobiologia e chimica medica.
Trovati 319 prodotti di "Cannabinoidi"
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URB447
CAS:URB447, a peripherally restricted CB1 cannabinoid antagonist with IC50 values of 313 nM for rat CB1 receptor and 41 nM for human CB2 receptor, effectively reduces food intake and body weight gain in mice. It achieves these effects without penetrating the brain or antagonizing central CB1-dependent responses, making it a potential research tool for obesity studies [1].Formula:C25H21ClN2OColore e forma:SolidPeso molecolare:400.9CB-52
CAS:CB-52 acts as a neutral antagonist and ligand for the CB2 cannabinoid receptor [1].Formula:C26H43NO3Colore e forma:SolidPeso molecolare:417.62Isopropyl dodec-11-enylfluorophosphonate
CAS:Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester functioning as a central cannabinoid receptor (CB1) antagonist and exhibitsFormula:C15H30FO2PPurezza:98%Colore e forma:SolidPeso molecolare:292.37O-Arachidonoyl glycidol
CAS:O-Arachidonoyl glycidol (compound 1), a 2-arachidonoylglycerol (2-AG) analog, effectively inhibits the hydrolysis of cytosolic 2-oleoylglycerol (2-OG) with an IC50 value of 4.5 µM, and also blocks 2-OG and anandamide hydrolysis in membrane fractions with IC50 values of 19 µM and 12 µM, respectively [1].Formula:C23H36O3Colore e forma:SolidPeso molecolare:360.53SAD-448
CAS:SAD-448 is a cannabinoid receptor type 1 (CB1) agonist. SAD-448 controls spasticity via action on the peripheral nerve CB1 receptor.Formula:C24H28N4O8SColore e forma:SolidPeso molecolare:532.57CAY10508
CAS:CAY10508 is a potent and selective inverse agonist for the central cannabinoid (CB1) receptor with therapeutic potential for treating obesity and drug dependence, lacking psychotropic effects. It exhibits a Ki value of 243 nM and an EC50 of 195 nM. At a concentration of 10 µM, CAY10508 displaces [3H]-CP-55,940 with 100% efficacy at the CB1 receptor and 35% at the peripheral cannabinoid (CB2) receptor. Its inverse agonist activity at the CB1 receptor was confirmed through a [35S]-GTPγS binding assay.Formula:C21H14Br2N2O2Colore e forma:SolidPeso molecolare:486.2O-2050
CAS:O-2050: strong CB1 antagonist (Ki 2.5 nM), CB2 inhibitor (Ki 0.2 nM); reduces mouse food intake, increases activity.Formula:C23H31NO4SPurezza:98%Colore e forma:SolidPeso molecolare:417.56(R)-Monlunabant
CAS:<p>(R)-Monlunabant ((R)-MRI-1891) serves as a CB1 receptor antagonist utilized in obesity and metabolic disease research [1].</p>Formula:C26H22ClF3N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:591PF 514273
CAS:PF 514273 is a CB1 receptor antagonist.Formula:C21H17Cl2F2N3O2Purezza:98%Colore e forma:SolidPeso molecolare:452.28GSK494581A
CAS:GSK494581A is a GPR55 agonist and glycine transporter subtype 1 inhibitor.Formula:C27H28F2N2O4SPurezza:98%Colore e forma:SolidPeso molecolare:514.58GW405833 hydrochloride
CAS:GW405833 hydrochloride, a potent and selective agonist of the cannabinoid-2 (CB2) receptor (EC 50 = 0.65 nM; maximum inhibition = 44.6%), exhibits significant antihyperalgesic effects in various rodent pain models [1] [2] [3].Formula:C23H25Cl3N2O3Colore e forma:SolidPeso molecolare:483.822-Linoleoyl Glycerol
CAS:2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decrease endocannabinoid levels post-release.Formula:C21H38O4Colore e forma:SolidPeso molecolare:354.531O-2545 hydrochloride
CAS:O-2545 is a potent water-soluble central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor agonist with Ki values of 1.5 and 0.32 nM, respectively. Typically, cannabinoid agonists are highly lipophilic and require solubilization through surfactant agents or binding to water miscible substances like albumin, Tween 80, or Emulphor for use. When dissolved in saline, O-2545 has shown high efficacy in mouse behavioral models, administered either intravenously or intracerebroventricularly.Formula:C26H36N2O2HClColore e forma:SolidPeso molecolare:445CB1 inverse agonist 1
CAS:MRL-650 is an oral, selective CB1 agonist; IC50: CB1=7.5 nM, CB2=4100 nM; anorexigenic effects noted.Formula:C25H18Cl3N3O3Purezza:99.92%Colore e forma:SolidPeso molecolare:514.7911(Z),14(Z)-Eicosadienoic Acid Ethanolamide
CAS:11(Z),14(Z)-Eicosadienoic acid ethanolamide is an ethanolamide derivative of 11(Z),14(Z)-eicosadienoic acid.Formula:C22H41NO2Colore e forma:SolidPeso molecolare:351.57Amauromine
CAS:Amauromine is a peripherally selective and potent cannabinoid receptor type 1 (CB1) receptor antagonist, a novel alkaloid with vasodilatory activity.Formula:C32H36N4O2Colore e forma:SolidPeso molecolare:508.65PSNCBAM-1
CAS:PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo.Formula:C22H21ClN4OPurezza:99.86%Colore e forma:SolidPeso molecolare:392.88Tricosanoyl Ethanolamide
CAS:Tricosanoyl ethanolamide, a fatty N-acyl ethanolamine within the endocannabinoid family, has an ethanolamine metabolite whose significance remains to be established.Formula:C25H51NO2Colore e forma:SolidPeso molecolare:397.688AM841
CAS:AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor.Formula:C26H39NO3SPurezza:98%Colore e forma:SolidPeso molecolare:445.66GP 1a
CAS:<p>GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.</p>Formula:C23H22Cl2N4OPurezza:99.79%Colore e forma:SolidPeso molecolare:441.35
