Nucleotidi

<p>5,6-Dihydrothymidine is a hydroxylated thymidine analogue. It binds to the leukocyte antigen, which is found on many different types of cells. 5,6-Dihydrothymidine inhibits the replication of herpes simplex virus and can be used for diagnostic purposes. 5,6-Dihydrothymidine has been shown to have conformational properties that are similar to those of thymine, which allows it to bind to the template strand in DNA. This binding prevents the synthesis of messenger RNA from DNA. 5,6-Dihydrothymidine is also able to inhibit cell growth in culture and can be used as a cell culture medium supplement.</p>

<p>2-Deoxycytidine 3',5'-diphosphate is an additive that is used in the production of DNA. It is a single-stranded nucleotide with a guanine base. 2-Deoxycytidine 3',5'-diphosphate has been shown to inhibit bacterial growth by reacting with hydrogen peroxide, which is produced during the process of oxidative phosphorylation. This reaction leads to the formation of reactive oxygen species, which damage DNA and cause cell death. The compound also binds to metal ions and prevents them from interacting with cellular components. 2-Deoxycytidine 3',5'-diphosphate can be used as a chromatographic agent for separating DNA fragments according to their size.</p>

<p>2'-O-Methylcytidine 5'-triphosphate lithium is a synthetic nucleotide</p>

<p>2',3',5'-Triacetyl-azacytidine is a transcription factor that has dose-dependent effects on the production of melanin. It inhibits the synthesis of melanin by binding to two specific transcription factors, the microphthalmia-associated transcription factor and the histone methyltransferases. This drug also inhibits tyrosinase, which is an enzyme involved in the production of melanin. 2',3',5'-Triacetyl-azacytidine has been shown to inhibit the growth of murine melanoma cells and may be useful for treating skin cancer.</p>

S-Adenosyl-L-methionine (SAM-e) is a co-substrate involved in methyl group transfer to nucleic acids, proteins and lipids. SAM-e is produced in the liver from adenosine triphosphate (ATP) and methionine by action of the enzyme methionine adenosyltransferase. Therapeutic use of S-adenosyl-L-methionine includes osteoarthritis, liver disease and major depressive disorder. S-Adenosyl-L-methionine is available as a dietary supplement.

<p>6-Chloro-2-iodo-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine is a protected purine nucleoside</p>

<p>5-Isopropyl-2'-deoxyuridine is a nucleoside analog that is used in the treatment of inflammatory bowel disease. It has been shown to be effective in the treatment of Crohn's disease, ulcerative colitis, and indeterminate colitis. 5-Isopropyl-2'-deoxyuridine inhibits bacterial growth by inhibiting RNA synthesis, which leads to cell death. This drug also inhibits the production of inflammatory mediators such as prostaglandins and leukotrienes that are released from cells infected with bacteria. 5-Isopropyl-2'-deoxyuridine is converted into an active form by hydrolysis or oxidation followed by phosphorylation. This drug binds to the 5' end of bacterial DNA and prevents the formation of hydrogen bonds between adjacent bases, causing strand breakage.</p>

7-TFA-ap-7-Deaza-2',3'-dideoxyadenosine is a diphosphate nucleoside analogue that can be activated by phosphoramidites. It is a novel, synthetic, and high quality nucleotide with antiviral and anticancer properties. This drug has been shown to inhibit the synthesis of DNA and RNA at the transcriptional level. 7-TFA-ap-7-Deaza-2',3'-dideoxyadenosine is a monophosphate nucleoside analogue that can be used in ribonucleotide synthesis for the treatment of cancer.

<p>9-(2'-Deoxy-2'-fluoro-b-D-ribofuranosyl)-2-fluoroadenine is a modified nucleoside that is used as an antiviral and anticancer agent. It acts as an activator for the synthesis of DNA, RNA, and protein. 9-(2'-Deoxy-2'-fluoro-b-D-ribofuranosyl)-2-fluoroadenine also inhibits the growth of cancer cells by interfering with the division process. This drug is synthesized from 9-(5'-deoxy-5'-iodo-b-D-ribofuranosyl) -2,6 difluoro adenine (diFdA). The Ribonucleosides are then prepared in a similar manner to other nucleosides by using phosphoramidites. The product is then purified using HPLC.</p>

<p>8-(p-Chlorophenylthio)-cGMP is a modified nucleoside that has anticancer activity. It inhibits DNA synthesis and the activation of protein kinases, which are enzymes that transmit signals from the cell surface to the nucleus. 8-(p-Chlorophenylthio)-cGMP can also inhibit viral replication by inhibiting the production of new virus particles and by inhibiting the action of reverse transcriptase, an enzyme that converts RNA into DNA.</p>

<p>N6-Propargyladenosine is an alkyne functionalised nucleoside.</p>

<p>5-Methylcytidine is a methyltransferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to 5-methylcytosine. This reaction is essential for DNA replication and repair. 5-Methylcytidine has been shown to be an important factor in the regulation of mitochondrial functions, as well as other cellular processes such as protein synthesis, nuclear DNA replication, and tumor suppression. It also has been shown to inhibit the replication of murine sarcoma virus and Toll-like receptor. 5-Methylcytidine can be used in chemotherapy treatment against mouse tumors and murine sarcoma virus by preventing viral RNA synthesis with monoclonal antibodies.</p>

5-Carboxymethylaminomethyl- 2'-O-methyluridine (5CmAMU) is a modified nucleobase that is categorized as a modified base. It is an analog of uridine, which has been shown to be effective against tuberculosis in mice. 5CmAMU inhibits the methylation of rRNA and DNA by binding to the enzyme RNA methyltransferase, thereby inhibiting transcription and replication. This modification has also been shown to inhibit cellular proliferation and promote apoptosis. 5CmAMU binds to guanine with a stoichiometry of 1:1, which provides evidence for its role in DNA synthesis and repair. The structural modifications on this molecule may lead to diagnostic applications or treatments for diseases such as tuberculosis.

<p>2',3'-Dideoxyadenosine-5'-triphosphate lithium salt is a nucleoside for use in research applications</p>

<p>8-Aminoguanosine is a synthetic purine nucleoside that inhibits DNA synthesis. It has been shown to inhibit the proliferation of HL-60 cells, which are a model for human monocytes and neutrophils. 8-Aminoguanosine has been shown to bind to the template strand of DNA and inhibit the incorporation of deoxyribonucleotide triphosphates into the newly synthesized strand. This binding prevents DNA replication by preventing access to the template strand of DNA. 8-Aminoguanosine inhibits cyclin D2, an enzyme required for cell division, at concentrations as low as 0.1 mM, and it also inhibits microtubule assembly. 8-Aminoguanosine has shown in vitro activity against various tumor cell lines including Molt-4 and MCF7 cells, and in vivo activity in a mouse model against C3H/HeJ mice transplanted with Lewis lung carcinoma cells.</p>

<p>2-Methylthio-N6-methyladenosine is an adenosine nucleoside that is found in the DNA of eukaryotes. It is similar to 2-methylthio-n6-isopentenyladenosine, which is a modified form of n6-methyladenosine. The chemical structures of both molecules are related to the thermodynamic properties of the molecule and their ability to be postsynthetically modified. These modifications can lead to changes in their translation, which can have implications for the development and progression of disease. 2-Methylthio-N6-methyladenosine has a role in epigenetics, which is defined as changes in gene expression without any alterations in DNA sequence. In this case, it may modify the chloride ion concentration by changing its chemical structure, leading to epigenetic changes that can affect how genes are expressed or translated into proteins.</p>

<p>2'-Deoxy-2'-fluoro-2'-C-methylcytidine is a nucleoside analog with modifications on both the sugar and the nucleobase. It is a derivative of cytidine, with fluorine attached to the 2' carbon of the sugar (deoxyribose) and a methyl group at the 2' carbon of the sugar as well. These modifications provide the compound with unique properties, such as potnetial increased resistance to enzymatic degradation, which can make it useful in antiviral and anticancer applications.</p>

<p>2'-O-Methylguanosine 5'-triphosphate lithium salt is a synthetic nucleotide</p>

<p>Please enquire for more information about 2′-O-Succinyladenosine 3′,5′-monophosphate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>6-(Benzylamino)-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (BMPT) is a synthetic cytokinin that belongs to the group of 6-benzylaminopurines. BMPT is an inhibitor of cytokinin receptor kinases, as it is a benzyl uracil derivative. BMPT can be used as a building block for the synthesis of other compounds and has been used as an inhibitor of cell growth in various organisms.</p>

<p>7-Deaza-7-iodoadenosine is a nucleotide that has been used in experiments to assess the levels of adenosine, a dinucleotide phosphate that is involved in many cellular functions. 7-deaza-7-iodoadenosine has been shown to inhibit locomotor activity in rats and cyclase activity in 3T3-L1 preadipocytes. It also inhibits the release of inflammatory proteins from polymorphonuclear leucocytes and angiogenesis (formation of new blood vessels) in liver cells. Although this nucleotide has not been extensively studied, it has been proposed as an antiinflammatory agent because it inhibits protein synthesis and downregulates proinflammatory proteins.</p>

<p>5′-O-DMT-LNA N-dmf guanosine is a modified nucleoside that has anticancer, antiviral, and anti-inflammatory activities. It binds to the ribonucleotide reductase enzyme, which is an enzyme required for the production of new DNA and RNA. This binding prevents the synthesis of new DNA and RNA in cells, leading to cell death. 5′-O-DMT-LNA N-dmf guanosine has been shown to be active against cancer cells in vitro and in vivo. In addition, it also inhibits replication of human immunodeficiency virus type 1 (HIV) by binding to reverse transcriptase (RT), which is an enzyme critical for HIV replication.</p>

5'-O-DMT-thymidine-3'-lcaa-CPG is a nucleoside, ribonucleoside, and diphosphate that inhibits viral DNA synthesis. It is a novel compound with antiviral properties that has been shown to inhibit the replication of human cytomegalovirus (HCMV) and herpes simplex type 1 virus. 5'-O-DMT-thymidine-3'-lcaa-CPG also functions as an anticancer agent by inhibiting DNA synthesis in tumor cells. This nucleoside analog is phosphoramidite, which can be used for the preparation of modified oligonucleotides. 5'-O-DMT-thymidine-3'-lcaa-CPG has high purity and high quality.

<p>Cytidine 5’-phosphoromorpholidate N,N’-dicyclohexyl-4-morpholinecarboximidamide is a novel cytidine phosphoramidate monophosphate that has been shown to have anticancer and antiviral properties. It can be used as a DNA nucleoside phosphoramidite in the synthesis of oligonucleotides or as an antiviral agent by inhibiting viral RNA replication. Cytidine 5’-phosphoromorpholidate N,N’-dicyclohexyl-4-morpholinecarboximidamide is chemically synthesized in high purity and quality for use in research in the field of DNA, nucleosides, and antiviral agents.</p>

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Kinetin riboside-5'-monophosphate sodium salt is a synthetic nucleotide that has been modified to include a phosphate group at the 5' position. Kinetin riboside-5'-monophosphate sodium salt is an activator of DNA synthesis and can be used for the treatment of viral infections. It also shows anticancer activity and is effective against cancer cells that are resistant to other cancer drugs.

3'-Deoxyadenosine-5'-triphosphate sodium salt is a nucleotide that has been shown to be effective in chemotherapy. It is a substrate for the synthesis of DNA, RNA, and ATP. 3'-Deoxyadenosine-5'-triphosphate sodium salt is also a building block for DNA polymerase, which is an enzyme that synthesizes DNA from a template. It has been shown to have anticancer activity in drug-resistant cells and can be used as an alternative to purine analogs such as 6-mercaptopurine or cladribine. 3'-Deoxyadenosine-5'-triphosphate sodium salt has been shown to inhibit the production of nucleotides by blocking their conversion into triphosphates, which are necessary for DNA replication and repair. This inhibition leads to apoptosis in cells with high levels of nucleotide turnover such as cardiac and myeloid cells. The drug interactions may depend on the

1-b-D-Arabinofuranosyluracil 5'-monophosphate is a pyrimidine nucleotide analog. Because of its structural similarity to natural nucleotides, it can interact with enzymes involved in nucleic acid synthesis. It is also a metabolite of Ara-U (arabinosyluracil), which is itself a compound studied for its biological activity. Scientists could potentially use this molecule in research to study how cells process and use nucleotides, and to understand how changes in nucleotide structure can affect biological processes.

<p>2',3'-Dideoxy-2',3'-didehydro-2'-fluorocytidine (ddC) is a nucleoside with antiviral activity. The mechanism of action is not well understood, but ddC has been shown to inhibit the proliferation of human immunodeficiency virus (HIV). It is also active against isolates of herpes simplex virus and vesicular stomatitis virus. The elimination half-life of ddC in humans is about 8 hours. In humans, this drug is eliminated by methylation and glucuronidation reactions. The pharmacokinetics of ddC have been studied in animals, including rats and rabbits, with preliminary indications that the elimination half-life may be longer than in humans.</p>

2'-Amino-2'-deoxycytidine is a modified nucleoside, based on cytidine. In this compound 2'-hydroxyl group has been replaced by an amino group, which can change hydrogen bonding patterns potentially affecting how it interacts with biomolecules.

3'-O-Propargyladenosine is a modified nucleoside that has antiviral and anti-inflammatory properties. It is a synthetic compound that is chemically related to adenosine. 3'-O-Propargyladenosine is an activator of the immune system and it inhibits viral DNA synthesis. The compound also has been shown to reduce inflammation in mice by inhibiting the production of prostaglandin E2 (PGE2). 3'-O-Propargyladenosine has been shown to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV).

<p>2'-Deoxyuridine-5'-monophosphate disodium salt (2DUMP) is a nucleoside analog that inhibits the synthesis of DNA and RNA by inhibiting the enzyme thymidylate synthase. 2DUMP is a covalent inhibitor of thymidylate synthase, which prevents the formation of dTMP from deoxyuridine 5'-triphosphate. This compound has been shown to be effective in treating squamous cell cancer and hyperproliferative diseases such as chronic myelogenous leukemia. 2DUMP is also used as an antiviral agent against HIV, herpes simplex virus, and varicella zoster virus. It has been shown to bind to benzalkonium chloride (BAK) in biological samples such as serum or plasma.<br>2DUMP binds to BAK through a covalent linkage between the 3' hydroxyl group on BAK and the phosphate group on 2DUMP</p>

<p>Uridine-3',5'-cyclic monophosphate sodium salt is a phosphotriester that is an intermediate in the biosynthesis of nucleosides. It is also a phosphodiesterase inhibitor, which means it inhibits the breakdown of cyclic nucleotides and allows them to accumulate. This drug has been shown to increase platelet production and has anti-inflammatory effects. Uridine-3',5'-cyclic monophosphate sodium salt is a human metabolite that can be synthesized from uridine, which is present in DNA, RNA, and food sources such as meat, eggs, and milk. The synthesis of uridine-3',5'-cyclic monophosphate sodium salt requires phosphoramidite as a precursor.</p>

<p>Inhibitor of adenylyl and guanylyl cyclase</p>

<p>2'-O-Propargyladenosine is a modified nucleoside that belongs to the group of deoxyribonucleosides. It is an activator of viral DNA polymerases, which causes the synthesis of viral DNA to stop. This compound has antiviral and anticancer activities. 2'-O-Propargyladenosine has been shown to be effective against various human cancer cell lines in vitro and in vivo. It is a synthetic nucleoside with high purity, showing no detectable impurities by HPLC analysis.</p>

<p>3'-Adenylyl-5'-guanosine ammonium salt is a dinucleoside that competes with guanosine for binding to the enzyme adenylate cyclase. This reaction leads to increased levels of cyclic AMP, which causes an increase in the rate of viral replication. 3'-Adenylyl-5'-guanosine ammonium salt has been shown to inhibit the growth of pyogenic bacteria such as Streptococcus pyogenes and has also been used to treat influenza infections. 3'-Adenylyl-5'-guanosine ammonium salt is an inorganic compound that is found in tobacco. It can be synthesized from uridine and p-nitrophenyl phosphate by the reaction: 3'--O--(CH2)4--COOH + H2N--PO4--&gt; 3'--O--(CH2)4--CONH2 + H3PO4</p>

2'-Deoxyadenosine is a nucleoside that is found in DNA. It has been shown to have potent anticancer activity against carcinoma cell lines and to bind to the adenosine receptor A3. 2'-Deoxyadenosine has also been shown to inhibit the production of inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6, from nuclear extracts of mouse tumor cells. This nucleoside may be a potential drug target for the treatment of cancer and inflammation.

<p>3'-Deoxy-5-methyluridine (3'-DMAU) is a synthetic nucleoside that is used in the treatment of viral infections. 3'-DMAU has antiviral and anticancer activity, and it has been used to synthesize DNA for genetic engineering. It has shown promising results in the treatment of HIV as well as in the prevention of cancer metastasis. 3'-DMAU inhibits DNA synthesis by binding to the enzyme RNA polymerase, which blocks its interaction with ribonucleosides, thus inhibiting RNA synthesis. In addition, 3'-DMAU causes cell death by inhibiting protein synthesis. The drug is activated by phosphorylation to form 5'-triphosphate and 5'-diphosphate derivatives, which inhibit DNA and RNA synthesis at multiple sites within the cell.</p>

<p>Adenosine 3'-monophosphate sodium is a nucleotide that is used as a substrate for enzymes. It has been shown to increase the enzymatic activity of papaverine, litoralis, subtilis, and histidine phosphatase. Adenosine 3'-monophosphate sodium also has protease activity, which can be activated by adding an enzyme preparation containing subtilisin and trypsin. This compound also has a pH optimum of 8.0-9.5 and is active at an alkaline pH of 9.5-10.5. The specific strain of bacteria will determine the optimal pH range for activity, with enterobacter bacterial strains having a maximum range of 6-7 and brevibacterium bacteria strains having a range of 4-6.</p>

<p>2'-Deoxy-4'-ethynyl-2-fluoroadenosine (EFdA) is an analog of adenosine. EFdA is a potent inhibitor of HIV replication, and has been shown to be effective against other viruses such as influenza virus, herpes simplex virus, and vesicular stomatitis virus. EFdA was the first nucleoside analog to show antiviral activity in tissue culture against these viruses. This drug also inhibits the synthesis of mitochondrial rRNA and reduces the formation of mitochondrial DNA in human cells by inhibiting mitochondrial DNA polymerase γ. EFdA also prevents the binding of monoclonal antibodies to human B lymphocytes, which may be due to its steric interactions with plasma RNA. This drug is metabolized by cytochrome P450 2C8 and 2C9 into a variety of metabolites that are excreted in urine as glucuronides or sulfates. EFdA has a long</p>

<p>3-Methyl-8-(2-deoxy-b-D-ribofuranosyl)isoxanthopterin is a nucleoside analog that is used as an activator of phosphoramidite. It can be used as a building block in the synthesis of modified phosphoramidites and it has antiviral, anticancer, and antiinflammatory properties. 3-Methyl-8-(2-deoxy-b-D-ribofuranosyl)isoxanthopterin is a novel nucleoside analog that can be used to synthesize DNA or RNA. It is also an inhibitor of deoxyribonucleoside kinase, preventing the conversion of deoxyribonucleosides into diphosphate monophosphates.</p>

<p>5'-O-Tosylthymidine is a bifunctional reagent that is used in the synthesis of DNA. It is a nucleophilic, inorganic compound that reacts with the electrophilic acrylonitrile group on 5'-hydroxythymidine to form a stable thiophosphate linkage. The reaction takes place stepwise and is catalyzed by an enzyme called DNA polymerase. This product has been used as an antimetabolite in medicine, mainly for treating leukemia.</p>

<p>Ribavirin triphosphate is the biologically active metabolite of antiviral nucleoside analog ribavirin. In cells, the prodrug ribavirin gets triphosphorylated and in it inhibits viral RNA polymerases, interfering with the synthesis of newly formed RNA.</p>

<p>Methyluridine is a derivative of uridine that is used in the synthesis of pyrimidine nucleotides. This drug is also an inhibitor of orotidine 5′-monophosphate decarboxylase, which converts orotic acid to uracil. The conformational properties of methyluridine have been studied and found to be similar to those of other purine derivatives, such as adenine and guanine. In addition, methyluridine has been shown to inhibit the growth of typhimurium and increase the production of uracil in human lymphocytes. Methyluridine is metabolized by hydroxylation in liver microsomes, yielding 6-carboxylic acid.</p>

<p>5′-O-DMT-LNA N-Bz 5-Me cytidine is a protected LNA cytidine nucleoside.</p>

<p>N6-Benzyladenosine 5'-diphosphate sodium salt is a modified nucleoside that has a high purity, which is suitable for synthesis of DNA or RNA. It can be used in the modification of deoxyribonucleosides, ribonucleosides, and phosphoramidites. N6-Benzyladenosine 5'-diphosphate sodium salt has been shown to have anticancer effects and antiviral effects. This drug also has novel properties such as an ability to inhibit the proliferation of cancer cells.</p>

<p>Polyoxin B is a natural product that is produced by the fungus Polyporus umbellatus. It is a synthetase inhibitor that specifically inhibits the enzyme malic acid synthetase in bacteria and fungi. Polyoxin B has been shown to have antifungal activity in vitro and to inhibit the growth of Cryptococcus neoformans, which may be due to its ability to inhibit terminal residues, such as acetate extract, bacterial strain, and synthase enzyme.</p>

2-Chloroinosine is an adenosine receptor agonist; metabolically stable analog of adenosine

<p>2-O-Ethylthymidine is a nucleoside that is used to study the structure and dynamics of DNA. It can be synthesized by reacting 1-β-D-arabinofuranosylbenzene with ethylmercury acetate. 2-O-Ethylthymidine can be used in kinetic studies as it is specific for dna. It has been shown to have a conformational change, which is stabilized by the presence of an aromatic ring such as phenanthrene. This compound was also found to inhibit neuroblastoma cell growth in vitro.</p>

<p>9-(β-D-Arabinofuranosyl)adenine 5'-monophosphate (Ara-AMP) is a prodrug that is converted to adenine arabinoside in vivo. It is used as an antiviral agent for the prevention of hepatitis B and C. Ara-AMP inhibits viral DNA synthesis by acting as a competitive inhibitor of adenosine triphosphate, which is required for viral DNA polymerase activity. Ara-AMP also has antiviral properties against some RNA viruses, such as HIV and influenza virus. Ara-AMP can be administered orally or by injection, making it suitable for use in children who are unable to take oral medication.</p>

<p>Adenosine 5'-monophosphate sodium is a nucleotide that is involved in the energy metabolism of cells. It has been shown to inhibit oxidative injury and to activate signal pathways in response to external stimuli, such as glucose deprivation. Adenosine 5'-monophosphate sodium can be synthesized from ATP by the enzyme adenosine kinase.</p>

<p>Thymidine-5'-triphosphate sodium salt is a modified nucleoside with anticancer properties. It is a high-quality, high-purity ribonucleoside that can be used as an activator for the synthesis of deoxyribonucleosides and phosphoramidites. Thymidine-5'-triphosphate sodium salt has antiviral activity, which is due to its ability to inhibit viral DNA replication and transcription. This compound also has the potential to be used in the treatment of cancer cells by inhibiting DNA synthesis and cell division.</p>

<p>4'-a-C-Methylcytidine is a nucleoside that is synthesized from 4'-a-C-methyluridine. It has antiviral and anticancer properties, and has been shown to be a potent activator of the immune system. The modified nucleosides in this compound are thought to be less toxic than other cytotoxic agents. 4'-a-C-Methylcytidine is also used as a building block for the synthesis of DNA, RNA and phosphoramidites.</p>

<p>2'-Deoxy-a-adenosine is a nucleoside that contains an adenine base. It has been studied for its biological properties, including its reaction with solution and its use as an antimicrobial agent. 2'-Deoxy-a-adenosine has been shown to inhibit the growth of bowel disease in mice by binding to the adenosine A3 receptor on the surface of cells. This nucleoside also binds to nuclear DNA and may be used as a pharmacological agent, but more research is needed to determine whether it would be effective against cancer cells. 2'-Deoxy-a-adenosine may also be useful as a potential drug target for the treatment of cancer due to its ability to bind with dna duplexes, which are found in all cancer cells.</p>

<p>2-Phenylaminoadenosine (2-PA) is a potent and selective inhibitor of the P2Y receptor. 2-PA has been shown to reduce myocardial infarct size in vivo in mice, which may be due to its ability to inhibit the release of dopamine from the brain. In addition, 2-PA binds to LPS receptors on endothelial cells, reducing the production of proinflammatory cytokines and preventing platelet aggregation. 2-PA also inhibits the activation of toll-like receptor 4 (TLR4) in human monocytes, leading to reduced expression of proinflammatory cytokines and increased expression of anti-inflammatory cytokines.<br>2-PA is an agonist that binds with high affinity to P2Y receptors on erythrocytes. This binding results in decreased adenosine triphosphate (ATP) production by adenosine deaminase, which leads to decreased intracellular calcium levels and inhibition of neutroph</p>

Thymidine-3',5'-diphosphate disodium salt is an antiviral and anticancer drug. It is a modified nucleoside which is synthesized from thymidine-3',5'-diphosphate and sodium bicarbonate (NaHCO3). This drug inhibits the synthesis of DNA and RNA, thereby inhibiting viral replication. Thymidine-3',5'-diphosphate disodium salt also has an antitumor effect by preventing the production of DNA in tumor cells.

<p>ALS-8176 is a benzimidazole compound that has been shown to be effective against both wild-type and syncytial viruses. It is also active against the hepatitis B virus, which causes fulminant hepatitis in humans and death in 30% of cases. The antiviral activity of ALS-8176 was demonstrated by its ability to inhibit viral DNA synthesis and to prevent the release of new viral particles. ALS-8176 has also been shown to have a broad spectrum of activity against paramyxoviruses, including mumps, measles, and respiratory syncytial virus (RSV). This drug can be used for the treatment of influenza A and B when administered during the early stages of infection. ALS-8176 blocks the antibody response to influenza virus infection as well as monoclonal antibody binding sites on the hemagglutinin protein, preventing fusion between infected cells.</p>

Malonyl coenzyme A lithium salt - 90% is a fatty acid that is involved in the biosynthesis of fats. It is also involved in the synthesis of prostaglandins, which are hormone-like substances that have a wide variety of effects on many different tissues. Malonyl coenzyme A lithium salt - 90% may be useful for the treatment of insulin resistance and obesity due to its ability to stimulate glucose uptake by fat cells and increase insulin sensitivity. The following product details are for a supplement:

<p>5-Methyl-L-uridine is an antiviral drug which belongs to a class of compounds called nucleoside analogues. It is used in the treatment of chronic hepatitis B and C, as well as for prevention of hepatitis A and B. 5-Methyl-L-uridine inhibits the virus by turning off the production of viral DNA and RNA, through interactions with the virus's polymerase chain reaction process. This drug also prevents protein synthesis in cells infected with viruses such as HIV, herpes simplex virus type 1, and influenza A virus. 5-Methyl-L-uridine is a prodrug that is converted to its active form, uridine monophosphate, by enzymes in the liver. The cytotoxic effects of 5-methyluridine on cancer cells have been shown to be due to inhibition of cellular DNA synthesis and repair pathways.</p>

<p>8-Nitroguanosine is a nucleotide analogue that inhibits the activity of cyclic GMP in cells. It has been found to inhibit the growth of bacteria and cancer cells, as well as to stimulate the production of reactive oxygen species in brain cells. 8-Nitroguanosine has also been shown to inhibit the activity of cyclase enzymes in liver cells, which may be useful for treating liver disease. 8-Nitroguanosine is used as a chemical base for monoclonal antibodies that are used to study brain functions and pathogenic mechanisms.</p>

<p>2′,3′,5′-Tri-O-acetylinosine is a protected form of the nucleoside inosine, with potential for use in the preparation of modified nucleotides and nucleoside analogs.</p>

<p>2',3'-O-Isopropylideneinosineis a nucleoside for use in research applications</p>

Please enquire for more information about Caffeoyl-coenzym A including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Lamivudine-5'-triphosphate tetratriethylammonium salt - ca.15 mM Aqueous solution is an antiviral drug used to treat HIV/AIDS and hepatitis B infections. It is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) replication, acting by blocking the viral enzyme reverse transcriptase. Lamivudine-5'-triphosphate tetratriethylammonium salt - ca.15 mM Aqueous solution also inhibits cellular viral DNA synthesis and has been shown to exhibit anticancer activity in vitro and in vivo. This product is synthesized from raw materials through a novel process that involves modification of the phosphoramidite monophosphate with tetratriethylammonium salts.</p>

<p>Pyruvate kinase substrate</p>

<p>2'-Deoxyinosine-5'-triphosphate sodium (2'-dITP) is a modified nucleotide that has antiviral and anticancer properties. It has been shown to be an activator for ribonucleosides, deoxyribonucleosides, and DNA. 2'-DITP has also been shown to inhibit the growth of human breast cancer cells in vitro.</p>

Pyruvate kinase substrate

<p>Fludarabine phosphate is an antileukemic drug that inhibits DNA polymerase α and β, as well as other enzymes in the nucleotide synthesis pathway. It is used to treat patients with chronic myelogenous leukemia (CML) who have developed resistance to other treatments. Fludarabine phosphate has been shown to induce a cytotoxic effect against tumor cells by binding to ATP-binding cassette transporter proteins on the cell membrane and inhibiting intracellular targets such as DNA, RNA, and protein synthesis. Fludarabine phosphate has also been shown to inhibit the growth of tumor cells through synergistic interactions with other anticancer drugs such as hydroxyurea or busulfan, which may be due to its ability to inhibit enzyme activities such as erythrocyte alkaline phosphatase.</p>

<p>N2-Benzoylguanosine is a nucleotide derivative that is formed by the acetylation of guanosine. It has been shown to act as a buffer in alkaline solutions and isomerizes to its n-oxide form when heated. N2-Benzoylguanosine reacts with peroxides such as hydrogen peroxide, glyoxal, and organic peroxides, forming hydroperoxide intermediates that can be converted into other products. The acidic hydrolysis of N2-benzoylguanosine yields the corresponding 6-benzoyladenosines. It has been shown to enhance the activity of uridine in inhibiting bacterial growth, while also acting as an inhibitor of viral RNA synthesis. This compound also reacts with nitrous acid to form an n6-benzoyladenosine derivative that inhibits the formation of RNA chains during transcription.</p>

2'-Deoxy-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)uridine is a novel and synthetic nucleoside analog with antiviral activity. It inhibits the synthesis of DNA by binding to the enzyme ribonucleotide reductase. This compound has been shown to be an activator of PPARs in vitro.

5-Bromo-2'-deoxycytidine is a synthetic nucleoside analogue that is used to treat diabetic neuropathy. It is structurally similar to cytidine, and inhibits the enzyme DNA polymerase by intramolecular catalysis. This causes deamination of the 5-bromo group, which prevents further synthesis of DNA. 5-Bromo-2'-deoxycytidine has been shown to be effective in vivo in a mouse model for inflammatory bowel diseases, including colitis and eosinophilic enteritis. The drug was also found to inhibit the production of Eosinophil peroxidase from HL-60 cells in vitro.

<p>2-Fluoroadenosine is a nucleoside that has shown high resistance to the enzyme cyclase. This property may be due to its structural and conformational properties, which are different from those of adenosine. 2-Fluoroadenosine has been shown to inhibit the synthesis of ATP in ventricular myocardium and fat cells, as well as increase levels of adenylate kinase in blood. It has also been shown to have potential as a drug target for autoimmune diseases, such as multiple sclerosis. 2-Fluoroadenosine can be used for biochemical and pharmacokinetic studies because it is rapidly metabolized by the liver and excreted in urine.<br>2-Fluoroadenosine can also be used to measure changes in the ratio of adenylate kinase:adenylate kinase reductase (AKAR) in blood plasma.</p>

Universal sulfonate donor for in vivo sulfonation by sulfotransferases

<p>8-Aza-7-deaza-2'-deoxyguanosine is an alkynylated, cross-linked, single stranded nucleic acid. It has been shown to be effective at cross-linking and cross-linking nucleic acids. 8-Aza-7-deaza-2'-deoxyguanosine binds to the 7 deazapurine residues in DNA, forming a covalent bond between the two strands of the helix. This binding prevents the strand from unwinding and prevents the replication of DNA. The thermodynamic data for this compound shows that it is stable in both hot and cold water, which makes it a good candidate for use in research as well as in clinical settings.</p>

<p>2'-Deoxy-N2-methylguanosine is a nucleoside with anticancer properties. It is a phosphoramidite, which is an analog of the natural nucleotide guanosine, where the 2'-hydroxyl group has been replaced by a methylene group. This compound is used in DNA synthesis and RNA synthesis. It can be used as a monophosphate or diphosphate. It also has antiviral and anti-inflammatory activities, as well as N2-methylamino moiety that can be used for the treatment of cancer and inflammatory diseases such as arthritis.</p>

7-Deaza-2',3'-dideoxy-7-iodoadenosine is a nucleoside analogue that is used as an antiviral, anticancer, and antifungal agent. It is a modified form of adenosine which inhibits viral replication by inhibiting the activity of reverse transcriptase. 7-Deaza-2',3'-dideoxy-7-iodoadenosine has also been shown to inhibit DNA synthesis in cells by blocking the incorporation of dCTP into DNA. This nucleoside analogue has shown potential for use as an activator in phosphoramidite chemistry and as a deoxyribonucleoside in oligonucleotide synthesis.

<p>N6-(6-Aminohexyl)-2'-deoxyadenosine is a novel nucleoside that is structurally related to the natural nucleosides, dATP and dGTP. It has been shown to be an activator of ribonucleosides and phosphoramidites, which are used in the synthesis of DNA and RNA. N6-(6-Aminohexyl)-2'-deoxyadenosine has also been shown to inhibit cancer cells as well as antiviral activity against HIV-1.</p>

<p>Stearoyl coenzyme A free acid hydrate is a natural, non-synthetic lipid molecule that belongs to the group of fatty acids. It is found in the form of a white crystalline powder and has a melting point at approximately 56°C. Stearoyl CoA free acid hydrate is an essential component of cellular metabolism, carrying out reactions such as desaturase, dextran sulfate, and other enzyme activities. Stearoyl CoA free acid hydrate may have therapeutic applications for metabolic disorders and obesity. The enzyme complex that catalyzes the synthesis of stearoyl CoA free acid hydrate in adipocytes is ATP-binding cassette transporter (ABC) A1 and ABCG1, which are members of the superfamily of ATP-binding cassette (ABC) transporters. It also plays a role in regulating immune responses via Toll-like receptor 4 (TLR4).</p>

<p>3′-Guanylic acid disodium is a nucleoside analog that inhibits viral replication and tumor growth. It is an antiviral agent that is active against herpes simplex virus type 1 and type 2, as well as cytomegalovirus. 3′-Guanylic acid disodium is also an anticancer agent that has shown promising results in animal models of glioma, lymphoma, lung cancer, and breast cancer. The molecule inhibits the synthesis of DNA by competitively inhibiting the action of ribonucleotide reductase. 3′-Guanylic acid disodium also inhibits protein synthesis by blocking the conversion of ribonucleotides to deoxyribonucleotides. This drug has been shown to have a high purity and quality with no detectable impurities or contaminants.</p>

5-Methoxyuridine-5'-triphosphate is a monophosphate nucleoside that serves as a precursor for the synthesis of 5-methoxyuridine (5MU) and other nucleosides. It has antiviral effects, and is used in the treatment of herpes zoster infection. 5-Methoxyuridine-5'-triphosphate is an analog of uridine and deoxyribonucleosides with antiviral activity, which can be used to treat herpes zoster infection. This drug also has anticancer properties, which may be due to its ability to inhibit DNA synthesis by inhibiting ribonucleotide reductase and DNA polymerase, leading to cell death.

<p>Uridine diphosphate choline (UDPC) sodium is a nucleotide that is used as a phosphoramidite for DNA synthesis. The chemical formula for UDPC is C8H14N4O8P. The activation of the molecule occurs in acidic conditions, which may be due to the formation of an amide bond between the terminal phosphate and the amino group on the phosphorylcholine. This same reaction can also occur in alkaline conditions. UDPC has been shown to inhibit viral replication, including HIV-1, by blocking reverse transcription of viral RNA into DNA. It also has anticancer effects, as it inhibits cell proliferation and induces apoptosis in cancer cells. UDPC does not have any known side effects or toxicity.</p>

<p>2',3',5'-Tri-O-acetyl-8-bromoguanosine is a synthetic nucleoside analog that inhibits the growth of tumor cells. It has been shown to inhibit the progression of prostate cancer and cervical cancer by binding to guanosine, preventing its conversion into ATP. This compound also prevents proliferation in hek293 and glioblastoma cells. The mechanism of action may be due to oxidative phosphite formation, which causes DNA damage and subsequent apoptosis.</p>