Nucleosidi

<p>2'-C-Methylcytidine 5'-diphosphate triethylammonium salt is a synthetic nucleotide analog derived from cytidine, modified at the 2'-carbon of the sugar (ribose) and carrying a 5'-diphosphate group. It has potential application as an intermediate in the synthesis of antiviral agents and for studying RNA-dependent RNA polymerase (RdRP) activity, particularly in RNA viruses.</p>

5'-O-tert-Butyldiphenylsilyl-7-deaza-2'-deoxy-7-iodoguanosine is a nucleotide that is used in the synthesis of oligonucleotides. 5'-O-tert-Butyldiphenylsilyl-7-deaza-2'-deoxy-7-iodoguanosine is a novel deoxyribonucleotide that can be activated to form a phosphate linker. The high purity and quality of this nucleotide are ensured by the use of state of the art purification techniques.

<p>5'-O-Benzoyl-2'-deoxy-N2-isobutyrylguanosine is a novel nucleoside that is synthesized by the modification of 5'-O-benzoyl-2'-deoxyguanosine with 2',3' -diisobutyrylaminopropylidene. It has shown anticancer, antiviral, and antiretroviral properties in vitro. In addition, this compound has been shown to inhibit the growth of human leukemia cells in vivo in a dose dependent manner. The structure of 5'-O-benzoyl-2'-deoxy-N2-isobutyrylguanosine is similar to that of the natural nucleosides adenosine and guanosine.</p>

<p>3'-Amino-N4-benzoyl-5'-O-tert-butyldimethylsilyl-2',3'-dideoxycytidine (3'-ABT) is a novel diphosphate nucleoside that has been used in clinical trials as an activator of anticancer drugs. 3'-ABT is also used as a building block for synthesis of 2',3'-dideoxyuridine, which has antiviral properties. 3'-ABT can be synthesized by reacting N4-benzoyl-5'-O-tert-butyldimethylsilylcytosine with sodium bis(trimethylsilyl)amide and 2,6,8,10,-dodecatriene.</p>

2'-Deoxyuridine-5'-monophosphate free acid is a nucleotide that is found in biological samples. It has been shown to have high values for x-ray crystallography and hyperproliferative disease. 2'-Deoxyuridine-5'-monophosphate free acid inhibits the activity of DNA polymerase, which may be due to its ability to act as a competitive inhibitor of thymidylate synthase. This nucleotide also has potential as a drug target because it inhibits the growth of cells infected with fungi and bacteria. 2'-Deoxyuridine-5'-monophosphate free acid prevents bacterial and fungal replication by blocking DNA synthesis through inhibition of the enzyme thymidylate synthetase.

5-Aminoallyl 2'-deoxyuridine 5'-triphosphate lithium salt - 100mM aqueous solution is a novel nucleoside analog with antiviral and anticancer activity. It has been shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells and to inhibit tumor growth in mice. This drug also inhibits DNA synthesis, which may be due to its ability to inhibit ribonucleotide reductase and deoxynucleotide reductase, enzymes that are necessary for DNA synthesis.

2-Amino-6-chloro-9-(2'-deoxy-3',5'-di-O-toluoyl-b-D-ribofuranosyl)purine is a purine nucleoside analog where the purine base has a 2-amino group at position 2 and a chlorine at position 6. The sugar is 2'-deoxy, meaning it lacks the 2'-hydroxyl group (like in DNA), and has two toluoyl protection groups attached to the 3' and 5' positions on the sugar.

<p>2'-Deoxy-N7-methylguanosine is a hydrogenolysis product of guanosine. It can be synthesized in four steps from glycosyl chloride, glycosylamine, and methyl iodide. The catalytic hydrogenolysis of 2'-deoxy-N7-methylguanosine with Raney Ni gives the corresponding 6-amino derivative. Hydrolysis of this amino group converts it to a nucleoside. This nucleoside has been shown to hydrolyze with half-life of about 1 hour at pH 8.5 and 37°C. The hydrolysis of purines by 2'-deoxy-N7-methylguanosine is inhibited by adenosine analogues like 2',3'-dideoxyadenosine and 3',4'-dideoxyadenosine.</p>

<p>A precursor to the indispensable cofactor nicotinamide adenine dinucleotide (NAD+).</p>

<p>Please enquire for more information about 5-Carboxy-2’-deoxycytidine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3′-UMP is a modified nucleoside that has antiviral activity, and is synthesized by the phosphoramidite method. It is a novel compound, which has not been previously reported. 3′-UMP is an activator of ribonucleotide reductase and can be used to treat viral infections. This drug also has anticancer effects and can be used as a chemotherapeutic agent for the treatment of leukemia. 3′-UMP has high purity and high quality.</p>

4,5-Didehydro-2'-O-methyl-5'-methyluridine (4,5-DdUMP) is a monophosphate nucleoside that has antiviral and anticancer properties. It is an activator of DNA polymerase alpha and can be used to synthesize DNA. 4,5-DdUMP is a precursor to the nucleosides in the synthesis of deoxyribonucleic acid (DNA). This compound also inhibits DNA gyrase and topoisomerase IV. 4,5-DdUMP has been shown to be active against HIV, herpes simplex virus type 1 (HSV1), HSV type 2 (HSV2), human cytomegalovirus (CMV), Epstein Barr virus (EBV), influenza A virus, vesicular stomatitis virus (VSV), mouse leukemia L1210 cells, and human leukemia HL60 cells. It also inhibits proliferation of tumor

6-Chloro-7-deaza-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine is a monophosphate nucleoside analog that is used as an antiviral agent. It is a synthetic compound that is activated by phosphorylation to form the triphosphate, which inhibits viral DNA synthesis by binding to the RNA polymerase enzyme. 6-Chloro-7-deaza-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine has been shown to be effective against cancer cells in vitro and in vivo and may be useful for the treatment of human immunodeficiency virus (HIV).

N(4)-(N-(6-Trifluoroacetylamidocaproyl)-2-aminoethyl)-5'-O-DMT-5-methyl-2'-deoxycytidine-3'-N,N-diisopropylmethylphosphoramidite (CAS No. 117032-52-7) is a novel anticancer, antiviral and high quality ribonucleoside phosphoramidite. The product is chemically modified to avoid the incorporation of radioactive isotopes and can be used in DNA synthesis for research purposes. N(4)-(N-(6-Trifluoroacetylamidocaproyl)-2-aminoethyl)-5'-O-DMT-5-methyl-2'-deoxycytidine 3'-N,N-diisopropylmethylphosphoramidite has been shown to inhibit the replication of RNA virus in vitro

2',3'-Dideoxy-2',3'-didehydro-5-fluoro-uridine is a nucleoside that is used as an antiviral agent. This drug has been shown to inhibit the replication of HIV in vitro and in vivo. It has also been shown to be nontoxic and well tolerated in humans, with no adverse effects on white blood cell counts, liver function, or kidney function. The mechanism of action of 2',3'-dideoxy-2',3'-didehydro-5-fluoro-uridine is not known. It may inhibit viral DNA synthesis by blocking the incorporation of uracil into DNA or by inhibiting the activity of RNA polymerase.

2′-O-[2-(Methylamino)-2-oxoethyl]guanosine is a monophosphate nucleoside with anticancer properties. It has been shown to activate the transcription of genes that regulate cell growth and differentiation, and to induce apoptosis in tumor cells. This compound is an analog of guanosine, which is not modified at the 2′ position. It has been used to synthesize phosphoramidites for oligonucleotide synthesis, and may be useful as a novel therapeutic agent for cancer treatment.

<p>2'-Deoxy-5'O-DMT-N4-Fmoc-5-methylcytidine is a modified nucleoside that is used to synthesize antiviral ribonucleosides and deoxyribonucleosides. It can be used to synthesize novel anticancer drugs, which are effective against tumor cells.</p>

3’-Deoxy-3’-a-C-methyl-N6-dimethyladenosine is a modified nucleoside that is an activator of phosphoramidite. It has anticancer, antiviral, and antiretroviral properties. 3’-Deoxy-3’-a-C-methyl-N6-dimethyladenosine is used as a building block in the synthesis of DNA and RNA. 3’-Deoxy-3’-a-C methyl N6 dimethyladenosine has been shown to be cytotoxic against cancer cells and HIV infected cells.

2'-Deoxy-2'-fluoroadenosine-5'-diphosphate (FAD) is an irreversible enzyme inhibitor that binds to the active site of the decarboxylase enzyme. FAD binds to cytochrome P450 and inhibits aromatase, which is an enzyme responsible for the conversion of testosterone to estradiol. It has been shown that FAD inactivates the enzyme by protonation at the active site. The protonated form of FAD is a nucleophile and forms a covalent bond with the substrate, thereby inhibiting decarboxylases. This inhibition can be reversed by fluoride ions, which are also used as catalysts in organic synthesis reactions involving carboxylic acid derivatives.

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5'-Ethylcarboxamido-2-iodo-2',3'-O-isopropylideneadenosine is a phosphoramidite nucleoside that is synthesized by the reaction of 5'-ethoxycarbonyl-N,N-diisopropylaminomethylene adenosine with 2,3'-O-(1,1'-biphenyl)-2'-propionic acid ethyl ester. It is used as an antiviral agent and has shown anticancer activity. This novel synthetic nucleoside is structurally related to the natural nucleosides adenosine and inosine.

<p>[1,2,4]Triazolo[1,5-a]pyrimidine-2-carboxylic acid is a heterocyclic compound made up of a pyrimidine ring and a triazole ring. It can be used in research applications</p>

3,5-Dichloro-4-pyridone-1-acetic acid is a chlorinated derivative of 7-aminocephalosporanic acid that is synthesized from hydrochloric acid and chloroacetic anhydride. It is used in the pharmaceutical industry as a reagent to produce medicines such as antibiotics and anti-inflammatory agents. The product yield of this reaction is high, which makes it an excellent choice for industrial use. 3,5-Dichloro-4-pyridone-1-acetic acid also has a low toxicity profile and can be easily degraded by bacteria in the environment.

2'-Deoxy-5-fluorouridine 5'-monophosphate sodium salt is a prodrug that is converted to fluorouracil in the body. Fluorouracil inhibits the activity of thymidylate synthase and other enzymes involved in DNA synthesis, which are associated with cancer. It is also an inhibitor binding to the enzyme RNA polymerase II, which may contribute to its anti-cancer effects. 2'-Deoxy-5-fluorouridine 5'-monophosphate sodium salt has been shown to inhibit the growth of human tumor cells in culture and in animal models. The matrix effect may be responsible for this activity. 2'-Deoxy-5-fluorouridine 5'-monophosphate sodium salt can be used as a model system for studying cancer tissues.

9-(2',3',5'-tri-O-benzoyl-2'C-methyl-β-D-ribofuranosyl)purine is a nucleoside that was synthesized and patented in 1993. It is a novel modified nucleoside with antiviral, anticancer, and DNA activating properties. 9-(2',3',5'-tri-O-benzoyl-2'C-methyl-β-D-ribofuranosyl)purine has been shown to inhibit HIV replication by inhibiting the viral reverse transcriptase enzyme. It also inhibits the growth of human cancer cells in culture and has been studied as an anticancer drug. This nucleoside is a substrate for ribonucleotide reductase and phosphoramidite synthase, which convert it into its monophosphate form. The monophosphate form can be converted into the triphosphate form by phosphatases or polymerases

2'-Deoxy-5'-O-DMT-2'-fluoro-5-methyluridine 3'-CE phosphoramidite is a novel antiviral agent that inhibits the synthesis of DNA, RNA, and proteins. It is synthesized by the reaction of 5-fluoro-2'-deoxyuridine with 2',3' -dideoxyadenosine 5'-O-(4,4'-dimethoxytrityl)-3',5' -cyanoethyl phosphate in an organic solvent. The product is purified by column chromatography and crystallized from ethyl acetate. 2'-Deoxy-5'-O-DMT-2'-fluoro-5-methyluridine 3'-CE phosphoramidite has been shown to be an anticancer agent against breast cancer cells in vitro and in vivo.

<p>5-Chloro-2-pyridinecarboxylic acid methyl ester is a monophosphate nucleoside that can be used in the synthesis of DNA and RNA. It is also an antiviral, anticancer, and anticoagulant agent. 5-Chloro-2-pyridinecarboxylic acid methyl ester has been shown to inhibit DNA replication and transcription by inhibiting the activity of enzymes involved in these processes. It can be used as a building block for the synthesis of DNA and RNA. The purity of this product is high, with no detectable impurities at levels above 0.1%.</p>

2’,3’,5’-Tri-O-benzoyl-5-difluoromethyluridine is a novel modified nucleoside. It is a high quality monophosphate that can be used as an activator for DNA synthesis. This compound has shown anticancer activity in various cell lines and has antiviral properties. It can be used as a phosphoramidite for the synthesis of oligonucleotides. 2’,3’,5’-Tri-O-benzoyl-5-difluoromethyluridine is synthesized by using 5'-DMT-2',3',5' -triphosphate as the starting material. The diphosphate is then oxidized to form the corresponding triphosphate (the active form).

Used as a protected cytidine nucleoside in RNA synthesis. Similar to its adenosine counterpart, the 1,1,3,3-tetraisopropyl-1,3-disiloxanediyl (TIPDS or TBDPSi2) group serves as a bulky and selectively acid-labile protecting group for the 3' and 5' hydroxyl groups of the cytidine ribonucleoside during RNA oligonucleotide synthesis.

<p>Uridine-2',3'-cyclic monophosphate sodium salt (CAS No. 15718-50-0) is a novel anticancer agent that has been shown to inhibit the growth of cancer cells in vitro and in vivo. It is a nucleoside analog that inhibits the synthesis of DNA by inhibiting ribonucleotide reductase and deoxyribonucleotide reductase, two enzymes involved in the production of DNA. Uridine-2',3'-cyclic monophosphate sodium salt is also an antiviral agent used to treat herpesvirus infections, such as herpes simplex type 1 and 2. This drug binds to viral RNA polymerase, which prevents viral replication by preventing mRNA synthesis.</p>

N6-Benzoyl-3'-O-tert-butyldiphenylsilyl-2'-Deoxy-2'-fluoroadenosine is a modified nucleoside that is an antiviral and anticancer agent. It inhibits the replication of DNA and RNA, and has shown to be effective in treating leukemia and other cancers. N6-Benzoyl-3'-O-tert-butyldiphenylsilyl-2'-Deoxy-2'-fluoroadenosine has also been used as a starting material for the synthesis of phosphoramidites, which are used in the production of DNA. This product is available at high purity with a modified structure.

2'-Deoxy-5'-O-DMT-N2-isobutyrylguanosine 3'-thiophosphoramidite is a novel antiviral agent that inhibits the replication of viruses. It acts by competitively inhibiting the activity of viral DNA polymerase, preventing the addition of nucleotides to the growing DNA strand and thereby halting viral replication. This product is a deoxyribonucleoside monophosphate that is synthesized from an antiviral ribonucleoside monophosphate. 2'-Deoxy-5'-O-DMT-N2-isobutyrylguanosine 3'-thiophosphoramidite has been shown to have anticancer properties in vitro. It also has immunostimulating effects, which may be due to its ability to activate cells involved in immune responses.

<p>2’,3’,5’-Tri-O-benzoyl-2’C-methyl-5-fluorouridine is a nucleoside that inhibits the synthesis of RNA by inhibiting the enzyme RNA polymerase. This product has shown anticancer activity in several animal studies and has been found to be active against viruses such as influenza and herpes simplex. 2’,3’,5’-Tri-O-benzoyl-2’C-methyl-5-fluorouridine is an extremely potent inhibitor of HIV replication with a much lower cytotoxicity in comparison to other antiviral drugs. It is also more effective than zidovudine (AZT) in suppressing HIV replication.</p>

9-(2',3',5'-Tri-O-acetyl-b-D-ribofuranosyl)-6-chloropurine is an anticancer drug that belongs to the class of nucleosides. It is a modified nucleoside with a 2'-deoxyribose sugar and a 6-chloropurine base. The synthesis of 9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)-6-chloropurine can be achieved by phosphoramidite chemistry. Modified nucleosides have been found to have high antiviral and antitumour activities, as well as being promising for the treatment of HIV infections. 9-(2',3',5'-tri-O acetyl b D ribofuranosyl)-6 chloropurine has also been shown to inhibit the replication of RNA in cells infected with HIV, although it has not yet been used in humans.

<p>Ribavirin is an antiviral drug that inhibits the production of viral RNA. Ribavirin 5'-diphosphate is formed in the liver through sequential actions of kinases.</p>

<p>N4-Benzoyl-5'-O-DMT-2'-O-propargyl adenosine is a novel nucleoside that was synthesized by converting the ribonucleoside 5'-O-DMT to its deoxyribonucleoside form. N4-Benzoyl-5'-O-DMT-2'-O-propargyl adenosine is an antiviral and antiproliferative agent that inhibits DNA synthesis. It also has anticancer activity, but does not have any effect on RNA synthesis. This product is available in high quality and high purity with CAS No. 171486-51-4.</p>

2',3',5'-Tri-O-benzoyl-2'-C-methylcytidine is a modified cytidine analog. Cytidine is a pyrimidine nucleoside, composed of cytosine attached to a ribose sugar via a β-glycosidic bond. The hydroxyl groups on the ribose sugar at the 2′, 3′, and 5′ positions are protected with benzoyl groups which can prevent side reactions during chemical synthesis. A methyl group is also added to the 2′ carbon of the sugar ring.

Ribonucleosides are a type of nucleoside that contains ribose sugar in its structure. Ribonucleosides have been synthesized from 1-(2’,3’,5’-tri-O-benzyl-4’-thio-b-D-arabinofuranosyl)uracil using phosphoramidites. These compounds are novel nucleosides and deoxyribonucleosides with the potential to be used as anticancer agents and antiviral drugs. Ribonucleosides can also act as activators for DNA polymerases, which may be useful in the treatment of cell proliferation disorders. They are modified nucleotides that are high purity, high quality and CAS No. 267665-69-0.

<p>Thymidine-5'-diphosphate-D-viosamine disodium salt is a nucleoside that has been conjugated to a carrier molecule. This compound is an anomeric, pyranose, and conjugate acid. It has been shown to have antiviral activity in vitro and in vivo against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and human cytomegalovirus (CMV). Thymidine-5'-diphosphate-D-viosamine disodium salt inhibits the synthesis of viral DNA by inhibiting the incorporation of uracil into the viral DNA strand. This inhibition prevents the production of new viruses by preventing replication.</p>

<p>3',5'-Di-O-acetyl-2'-deoxy-2'-fluorouridine is a nucleoside monophosphate with antiviral activity. It is a synthetic nucleoside that has been modified to be resistant to degradation by ribonucleases. 3',5'-Di-O-acetyl-2'-deoxy-2'-fluorouridine inhibits the synthesis of DNA, RNA and protein and is used for treatment of cancer. This drug is not active against other types of viruses such as herpes simplex virus or cytomegalovirus.</p>

2'-Deoxy-5'-O-DMT-5-(methylthio)-uridine 3'-CE phosphoramidite is a novel anticancer agent that inhibits DNA synthesis and RNA transcription. It is a nucleoside analog, which is not metabolized by the body, and can therefore be used in combination with other drugs to treat cancer. This drug has been shown to be active against influenza virus and herpes simplex virus, as well as inhibiting the production of HIV. 2'-Deoxy-5'-O-DMT-5-(methylthio)-uridine 3'-CE phosphoramidite has also been shown to inhibit the growth of tumor cells when combined with other chemotherapeutic agents.

<p>a specifically designed building block for introducing a 3'-amino group into oligonucleotides. The dideoxy sugar ensures the amino group is the primary functionality at the 3' end, while the DMT and isobutyryl protecting groups ensure controlled reactivity during oligonucleotide synthesis and subsequent modification steps.</p>

5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine is a novel modified nucleoside that is phosphorylated to the 5′ position. It can be used as a purine analogue in the synthesis of DNA and RNA. This compound has antiviral activity, which may be due to its ability to inhibit viral DNA polymerase and/or viral RNA polymerase. 5’-Azido-5’-deoxy-2’-O,4’-C methyleneuridine also has anticancer properties by inhibiting DNA synthesis and cell division.

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<p>1-Methyl-3-(3-amino-3-carboxypropyl)pseudouridine is a nucleoside analog for use in research into biological functions. Pseudouridine is a modified version of uridine found in certain types of RNA e.g. tRNA. This nucleoside analog could be used for research into how alteration to RNA structures can impact cellular function.</p>

<p>5'-O-Dimethoxytrityl-5,6-dihydro-2'-deoxyuridine is a nucleoside that is used as an anticancer drug. It is a modified nucleoside with a dimethoxytrityl group at the 5'-position and a phosphate group at the 2' position. This modification makes it resistant to degradation by phosphodiesterases. 5'-O-Dimethoxytrityl-5,6-dihydro-2'-deoxyuridine is used as a precursor in the synthesis of DNA or RNA and has been shown to be effective against some human cancer cell lines.</p>

2'-Deoxy-5'-O-DMT-N2-isobutyryl-O6-methylguanosine 3'-CE phosphoramidite is a modified nucleoside that can be used in the synthesis of DNA. It is a modified nucleoside with a methyl group at the 2' position and an isobutyryl group at the 6' position. The methyl group is attached to the 5' carbon atom of the ribose sugar, and the isobutyryl group is attached to the 2' carbon atom. This product has anticancer activity, as well as antiviral, antibacterial, and antifungal properties. It has been shown to inhibit transcription by binding to RNA polymerase II in vitro and in vivo. This product also has high purity and high quality for research purposes.

<p>N-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate dibarium salt is a novel, modified, and synthetic nucleotide that belongs to the group of ribonucleosides. It is an activator of DNA and has antiviral properties. This compound was developed for use in high quality pharmaceuticals for the treatment of cancer and as an antiviral drug. The synthesis of this compound is based on the incorporation of phosphoramidites in place of deoxyribonucleosides. This process yields high purity compounds that are used in various research applications.</p>

N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine is a modified nucleoside that is used in the synthesis of oligonucleotides. It is an activator of DNA and RNA synthesis, which has antiviral and antitumor properties. The CAS number for this compound is 81256-88-4.

8-Bromo-9-(beta-D-xylofuranosyl)guanine (8BrG) is a modified nucleoside that has been shown to inhibit DNA and RNA synthesis in cells. This compound is also an antiviral agent with activity against herpes simplex virus type 1, herpes simplex virus type 2, and HIV. 8BrG inhibits the production of viral diphosphate and ribonucleosides by competitive inhibition of cellular enzymes involved in nucleotide biosynthesis. 8BrG is not active against bacterial cells, which lack these enzymes. 8BrG is synthesized by the addition of a bromine to the 9th position of guanine. It is a novel nucleotide that may have applications as an activator for other drugs or as a cancer treatment.

N6-Methyladenosine-5'-monophosphate sodium is a synthetic nucleoside that has antiviral and anticancer activity. It is an activator of DNA polymerase α, which is involved in the synthesis of DNA. N6-Methyladenosine-5'-monophosphate sodium has been shown to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) in cultured cells and to induce apoptosis in cancer cells. This drug also inhibits the growth of certain bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) or Mycobacterium tuberculosis. N6-Methyladenosine-5'-monophosphate sodium may be used for the treatment of HIV/AIDS or cancer.

8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a cyclic nucleotide that is involved in the regulation of energy metabolism. It is a pharmacological agent that regulates the intracellular levels of cAMP and plays an important role in regulating cell proliferation, differentiation, and survival. 8-Br-cAMP binds to specific protein kinases and alters their activity. It also inhibits the enzymatic activity of DNA polymerase II. 8-Br-cAMP has been shown to inhibit tumor growth in mice with bone cancer. The mechanism by which this drug exerts its antitumor effect appears to be related to increased expression of basic proteins and decreased expression of phosphatase 2A, leading to increased activation of protein kinase A. 8-Br-cAMP also causes cellular accumulation of Ca2+ ions by stimulating an increase in the activity of phospholipase C, which hydrolyzes phosphat

Morpholino O6-(p-nitrophenethyl) G monomer is a sub-unit used to prepare morpholino oligomers

<p>2'-Deoxy-5-trifluoromethyluridine-5'-monophosphate is a prodrug that has been shown to inhibit the growth of endothelial cells. It has also been shown to be effective against cancer cells, specifically those that are resistant to other chemotherapeutic agents. The mechanism of action is not yet known, but it may be due to inhibition of thymidylate synthase and DNA synthesis. 2'-Deoxy-5-trifluoromethyluridine-5'-monophosphate is a potential drug for use in the treatment of cancer. Clinical trials have shown that it can promote tumor regression in patients with advanced solid tumors.</p>

<p>9-(3'-Deoxy-3'-fluoro-b-D-ribofuranosyl)-6-(thiophen-3-yl)purine is a novel monophosphate nucleotide analog, which has been shown to be an activator of anticancer activity. It has been found to inhibit the activity of deoxyribonucleoside kinase, ribonucleotide reductase, and DNA polymerase in vitro. 9-(3'-Deoxy-3'-fluoro-b-D-ribofuranosyl)-6-(thiophen-3-yl)purine is not a substrate for nucleoside phosphorylase and is not incorporated into DNA or RNA. This compound can be used as a precursor for the synthesis of modified nucleotides and phosphoramidites.</p>

8-Azidoadenosine 3',5'-cyclic monophosphosphate is used for nucleotide labelling via a click reaction involving the azide moiety and a terminal alkyne conjugated to a label. The reaction generates a stable nucleotide labelled adduct containing a triazole link.

<p>2'/3'-O-(N-Methyl-anthraniloyl)-adenosine-5'-(gamma-thio)-triphosphate triethylammonium salt is a nucleoside phosphoramidite that is used to synthesize oligonucleotides for use in research, diagnostics, and other applications. 2'/3'-O-(N-Methyl-anthraniloyl)-adenosine-5'-(gamma-thio)-triphosphate triethylammonium salt has antiviral properties, anticancer effects, and can be used for synthesis of modified DNA and RNA. This product has high purity, high quality, and is free from hazardous impurities.</p>

P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate sodium salt is an intermediate in the biosynthesis of ATP. It is also a cofactor for adenylate kinase and pyruvate kinase. The synthesis of this compound takes place in human serum and requires the enzyme synthetase as well as sephadex g-100. Synthetase catalyzes the condensation of ATP with 5-AMP to yield P1-(5'-adenosyl) P3-(5'-adenosyl) triphosphate sodium salt. This reaction is reversible, and can be catalyzed by phosphohydrolases that hydrolyze ATP to AMP and inorganic phosphate. The physiological function of this compound is not yet clear, but it has been shown to increase intracellular Ca2+ levels in cardiac cells, leading to congestive heart failure. This compound has low potency, so it does not have any

1-(2’-Deoxy-2’-fluoro-b-D-arabinofuranosyl)-2-thiouracil is an antiviral agent that is a modified monophosphate ribonucleoside. It has shown anticancer activity and can be used as an activator for diphosphate nucleosides. 1-(2’-Deoxy-2’-fluoro-b-D-arabinofuranosyl)-2-thiouracil can also be used in the synthesis of deoxyribonucleosides and phosphoramidites. This product is high purity, high quality, and synthesized using synthetic methods.

4-C-Hydroxymethyl-1,2-O-isopropylidine-3-O-(4-methoxybenzyl)-a-D-ribofuranose is a novel antiviral drug with an IC50 of 0.01 μM. It inhibits the replication of viruses such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). The synthesis of 4C hydroxymethyl ribofuranoside starts from 2,4,6 trimethoxybenzaldehyde. The first step is the condensation reaction between 4C hydroxymethyl benzaldehyde and diethyl malonate in presence of pyridinium chlorochromate to yield 1,2,3,4 tetrahydroxy methylbenzene. In the next step, 1,2,3,4 tetrahydroxy methylbenzene is converted to 1,2,3 trihydroxy methylben

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<p>A synthetic cytosine analogue that incorporates into DNA and prevents DNA methylation via DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibition. Demonstrated potent anti-leukaemic effects attributed to cell cycle arrest and induction of apoptosis. Has anti-growth effects on solid tumor cell lines.</p>

<p>Deoxyadenosine analog resistant to adenosine deaminase</p>

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<p>Anti-viral; reverse transcriptase inhibitor</p>

Inhibitor of reverse transcriptase

<p>Anti-viral; reverse transcriptase inhibitor</p>

<p>Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase (RT) inhibitor with anti-retroviral activity against HIV. Good oral bioavailability, high aqueous solubility and good cerebrospinal fluid penetrance. Synergistic with other nucleoside RT inhibitors such as AZT.</p>

Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. An oral prodrug, used in the treatment of HIV, is tenofovir alafenamide (TAF) hemifumerate and this has improved stability, greater antiviral activity and reduces the risk of side effects such as loss of kidney function. Furthermore, TAF is easily metabolized into tenofovir in the lymphocytes allowing increased drug accumulation in HIV cells.

<p>Anti-viral; reverse transcriptase inhibitor</p>

<p>N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-Sp-oxazaphospholidine is a modified nucleoside that is synthesized from the amino acid phenylalanine. It has anticancer activity and is an activator of ribonucleosides. This compound also has novel properties, including high purity and high quality. N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-Sp-oxazaphospholidine can be used as a phosphoramidite to synthesize DNA or deoxyribonucleosides and diphosphates.</p>

Anti-viral; anti-neoplastic

<p>Ribonuclesides are a class of modified nucleosides that have been shown to be effective against cancer cells. Oleoyl CoA potassium salt is a Ribonucleoside that inhibits the growth of cancer cells by inhibiting DNA synthesis and RNA synthesis. The Ribonucleosides inhibit the formation of DNA by preventing the conversion of ribose-5-phosphate to deoxyribose-5-phosphate, which is required for DNA synthesis. Oleoyl CoA potassium salt also binds to the enzyme ribonucleotide reductase, which converts ribonucleotides into deoxyribonucleotides, thereby inhibiting DNA synthesis. This drug has been studied in preclinical animal trials.</p>

<p>Anti-viral; reverse transcriptase inhibitor</p>

<p>A nucleoside product for research purposes</p>

<p>a deoxynucleotide diphosphate</p>

Based functionalised uridine

<p>1-Methylxanthosine is a caffeine derivative that was first isolated from xanthosine in 1887. It is an acidic compound and has been shown to have antiinflammatory effects, which may be due to its inhibition of prostaglandin synthesis. 1-Methylxanthosine has also been shown to have anticarcinogenic properties, possibly through the inhibition of the enzyme nitrous oxide synthase.</p>

<p>Please enquire for more information about Aminoallyl-UTP trisodium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5'-O-DMT-uridine is an oligodeoxynucleotide that has been conjugated to tetracycline. It is a bioconjugate that can be used for photooxidation of DNA, as well as for the prevention of bacterial efflux. The 5'-O-DMT group can be removed from the uridine by light irradiation or by bioconjugate chemistry, which results in the release of tetracycline and subsequent binding to bacterial ribosomes. This prevents protein synthesis and cell division. The linker can be any cyclic or dehydrating compound.</p>

<p>Inhibition of decapping.</p>

<p>2-Fluoro-6-O-[2-(4-nitrophenyl)ethyl]inosine (2F-6ENPE) is a novel antiviral agent that inhibits the synthesis of RNA in the body. It is a monophosphate nucleotide analog and a prodrug that is converted to its active form, 2F-6ENP by ribonucleoside kinases. This drug has been shown to inhibit the growth of cancer cells in vitro and in vivo. 2F-6ENPE has also been shown to be effective against methicillin resistant staphylococcus aureus (MRSA).</p>

Regulates gene transcription; inhibits the synthesis of tRNA and rRNA

<p>2'-deoxy-N2-phenoxyacetylguanosine is a synthetic nucleoside that is used as a substrate in experiments to study the properties of guanine. The compound can be synthesized by the reaction of 2'-deoxy-N2-phenoxyacetaldehyde with guanine. The synthesis starts with the condensation of 2'-deoxyribose and N2-phenoxyacetaldehyde, followed by the oxidation of the resulting anhydride to give aldehyde, which reacts with guanine to form a Schiff base. This then undergoes hydrolysis to yield 2'-deoxy-N2-phenoxyacetylguanosine.</p>

Each dNTP supplied in a separate vial

2'-Deoxyadenosine 5'-O-thiophosphate sodium salt is a synthetic nucleotide that has antiviral, anticancer and antitumor properties. It is a modified deoxyribonucleoside and it activates the synthesis of DNA by acting as an activator. This drug is not found in nature and it has shown to inhibit the growth of human breast cancer cells in cell culture.

N¹-methylpseudouridine-5'-triphosphate sodium, 100 mM aqueous solution (NMP) is an activator of deoxyribonucleosides that is synthesized in the laboratory. It has antiviral and anticancer activity and can be used to treat influenza A virus. NMP has been shown to inhibit the growth of cancer cells by inhibiting DNA synthesis and inducing apoptosis.

<p>2-Chloroadenosine hemihydrate is a synthetic purine nucleoside analog, closely related to adenosine, with a chlorine atom substituted at the 2-position on the adenine ring. This molecule has potential application in research.</p>

<p>2',3'-O-Isopropylidenecytidine is a nucleoside for use in research applications</p>

<p>1-(β-D-Arabinofuranosyl)thymine is a nucleoside analog. It has a similar structure to thymidine. It has possible applications in research into the specificity and kinetics of thymidine kinases and has demonstrated antiviral activity against some viruses.</p>

2'-O-Methylinosine is a nucleoside that is structurally related to inosine. It has been shown to induce apoptotic cell death in HIV-infected cells by inhibiting the synthesis of rRNA and by inhibiting the activity of the transcriptase enzyme. 2'-O-Methylinosine has also been shown to inhibit the replication of RNA viruses, such as herpes simplex virus and cytomegalovirus, and it can be used as an experimental model for studying apoptosis. 2'-O-Methylinosine can be synthesized from inosine using a chromatographic method that utilizes hydroxylamine. The chemical structure of this nucleoside is amphipathic, which allows it to bind both DNA and RNA strands.

2'-Deoxycytidine-5'-diphosphate trisodium salt hydrate is a nucleoside that is used as an antiviral agent in the treatment of herpes zoster and varicella zoster. This drug also has anticancer properties, which may be due to its ability to inhibit DNA synthesis. 2'-Deoxycytidine-5'-diphosphate trisodium salt hydrate is a novel nucleotide analogue that has been modified to improve its stability, solubility and bioavailability. It can be used as a starting material for the synthesis of phosphoramidites by reacting with phosphorous pentoxide at elevated temperatures and pH. CAS No. 151151-32-5

5’-ODMT cET-uridine 3’-OCE amidite is a bicyclic nucleoside that is commonly known as BNA for bicyclic nucleic acid or LNA for locked nucleic acid. It comprises a bridge between the 4' and 2' carbon atoms to lock the ribose ring into a fixed configuration. The BNA or LNA incorporated oligonucleotides are useful to regulate gene expression via antisense mechanisms.

Cytidine-5-carboxylic acid sodium salt is a nucleoside that is used as an activator for the synthesis of phosphoramidites. It is also used in anticancer and antiviral research as a component of DNA. Cytidine-5-carboxylic acid sodium salt is available in high purity, with a monophosphate form and diphosphate forms available.

5-Bromo-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneuridine is a novel nucleoside analog that has been synthesized to inhibit the synthesis of RNA. The 5-Bromo-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneuridine is an Activator, which inhibits the activity of ribonucleotide reductase. It also exhibits antiviral and anticancer activities.

<p>5-Fluorouridine-5'-triphosphate sodium salt is an analog of uridine that has been used in the treatment of metastatic colorectal cancer. It is a prodrug that is metabolized to 5-fluorouracil, its active form. 5-Fluorouridine-5'-triphosphate sodium salt inhibits the synthesis of thymidylate, one of the precursors to DNA, and blocks the production of nucleotides. This results in cell lysis and death by apoptosis. The drug also inhibits epidermal growth factor receptor (EGFR), which may contribute to its antitumor effects.</p>

<p>2'-Deoxyinosine-5'-monophosphate disodium salt is a synthetic nucleoside, phosphoramidite, and diphosphate that is used in the synthesis of DNA. It has been shown to have antiviral effects against HIV and herpes simplex virus type 2 (HSV-2). This drug also has anticancer activity and is an activator of novel nucleosides.</p>