Nucleosidi

N6-Benzoyl-5'-chloro-5'-deoxy-2',3'-O-isopropylideneadenosine is a novel nucleoside that has the potential to be a therapeutic agent for cancer and antiviral therapy. It is an analog of adenosine that inhibits viral replication by inhibiting the viral enzyme RNA-dependent DNA polymerase. N6-Benzoyl-5'-chloro-5'-deoxy-2',3'-O-isopropylideneadenosine also inhibits tumor growth by inducing apoptosis. The compound has been shown to inhibit human leukemia cells in vitro, as well as mouse leukemia cells in vivo. This novel nucleoside is synthesized through a two step process starting with 5'-chloroadenosine and converting it to 5'-chloroinosidine with potassium cyanide, followed by deoxygenation at the 6 position with benzoyl chloride and sodium hydroxide.

2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine is an antiviral nucleoside. It is a novel nucleotide analog that inhibits human immunodeficiency virus (HIV). The cytidine monophosphate moiety of 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine has been modified with the substitution of the acetyl group at the 2' position with a deoxyribose group, and the 5' fluoro group with a 5'-deoxyfluro group. This modification prevents phosphodiesterases from hydrolyzing it to its monophosphate form, which leads to higher antiviral activity. 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro -

Inosine-3',5'-cyclic-monophosphate free acid is an ester of inosine 3',5'-cyclic-monophosphate that is structurally related to adenosine. It has been shown to have a physiological function as a cyclic nucleotide phosphodiesterase inhibitor, and also inhibits voltage-dependent calcium channels. Inosine-3',5'-cyclic-monophosphate free acid has been shown to be effective against infectious diseases, such as Mycobacterium tuberculosis and Galleria mellonella. It has also been shown to reduce the production of peptide hormones, nucleotides, and cyclic AMP (cAMP). Inosine-3',5'-cyclic-monophosphate free acid does not exhibit any pharmacological activity on its own but can modulate the activities of other pharmacological agents.

6-Methyl-3-(β-D-2-deoxyribofuranosyl)furano-[2,3-d]pyrimidin-2-one is a novel nucleoside analog that has been modified to contain an antiviral agent. It is phosphorylated at the 2' position to form a monophosphate. This compound is a potent inhibitor of HIV reverse transcriptase and human DNA polymerases α and β. The structure of this compound contains a furano ring fused with the pyrimidine moiety, which is substituted with methyl groups on C6 and C3 positions. The CAS number for 6-Methyl-3-(β-D-2-deoxyribofuranosyl)furano-[2,3-d]pyrimidin-2-one is 383897−60−7.

<p>5'-O-DMT-thymidine 3'-Q Linker CPG 1000 Å is an Activator that is a monophosphate and synthesized through the modification of nucleosides. It has novel anticancer properties and is a high quality, high purity, and modified nucleotide. The 5'-O-DMT-thymidine 3'-Q Linker CPG 1000 Å has been shown to have antiviral activity against herpes simplex virus type 1 (HSV-1) in human cells. It also has anticancer effects on human leukemia cells by inhibiting the growth of cancer cells.</p>

5-Aza-3',5'-di-O-acetyl-2'-deoxycytidine is a nucleoside analog that is used in the treatment of HIV. It inhibits viral replication by interfering with the viral reverse transcriptase enzyme and preventing it from transcribing the virus's genetic material. 5-Aza-3',5'-di-O-acetyl-2'-deoxycytidine has also been shown to have anticancer properties. This drug has shown activity against cancer cells in vitro, although clinical trials are still needed to determine its effectiveness as a cancer therapy.

Uridylyl-3'-5'-adenosine ammonium salt is a novel antiviral agent that is used to treat hepatitis B. It is an analogue of nucleoside monophosphate, which is activated by adenylyltransferase, and inhibits viral DNA synthesis. Uridylyl-3'-5'-adenosine ammonium salt has been shown to inhibit the growth of cancer cells in vitro and in vivo. This drug also has anticancer activity against various types of cancer cell lines.

<p>Troxacitabine is a nucleoside analog that inhibits DNA synthesis by selectively blocking the function of DNA polymerase. It has been shown to have potent antitumor activity in mouse tumor models and in a human breast cancer xenograft model. Troxacitabine has also been shown to inhibit the proliferation of renal cell cancer cells and induce apoptosis in these cells, as well as reduce the viability of cancer cells from other tumor types. Troxacitabine has also been shown to have an effect on body mass index and hematologic response, although it is not currently approved for use in humans.</p>

<p>N1-(4-(t-Butyl)benzoyl)-D-(+)biotin 2-nitrophenyl ester is a novel nucleoside analogue and phosphoramidite. It has been modified to have an acyclic carbon chain with a 4-hydroxybenzoyl group at the C2 position. This compound is an activator of DNA synthesis, and it can be used for the synthesis of deoxyribonucleosides. The purity of this compound is 99%. The CAS number for this compound is 869354-61-0.</p>

5'-O-DMT-N2-DMF-guanosine-3'-succinyl CPG 1000 Å is a nucleoside, modified with succinyldiimidazopropylcarbodiimide. It is an activator of phosphoramidites and is used in the synthesis of DNA and RNA. 5'-O-DMT-N2-DMF-guanosine-3'-succinyl CPG 1000 Å has shown anticancer and antiviral properties in vitro.

N6-Cyclopentyladenosine-5'-O-monophosphate is a nucleoside that is a substrate for RNA polymerase and is involved in the regulation of transcription. It also has been shown to be localized in the nucleus, cytoplasm, and cell membrane. N6-Cyclopentyladenosine-5'-O-monophosphate is used in diagnosis as an immunochemical reagent for the detection of matrix metalloproteinases (MMPs) and it can be used to measure MMP-9 activity. The monoclonal antibody (mAb) against this nucleoside can be used to detect N6-Cyclopentyladenosine-5'-O-monophosphate in biological samples such as human serum or cell culture.

6-Chloro-9-(2-deoxy-b-L-erythro-pentofuranosyl)-9H-purin-2-amine is a novel antiviral and anticancer agent. It is an analog of adenosine that inhibits viral replication by inhibiting DNA synthesis. 6CePP2A is an activator of nucleoside deoxyribonucleotidyltransferase, which converts dATP to dTTP.

N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-trifluoroacetamidocytidine is a novel nucleoside analog that is activated by ribonucleotide reductase. This compound inhibits the synthesis of DNA and RNA in cells, which leads to the inhibition of cellular proliferation. N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-trifluoroacetamidocytidine has been shown to be effective against cancer cells, as well as antiviral and antiretroviral activity. It is also active against drug resistant strains of HIV.

2-(sec-Butylthio)pyrimidine-5-carbaldehyde is a molecule that inhibits cell growth and angiogenesis. It was found to inhibit the phosphorylation of specific proteins, leading to the inhibition of cell growth and angiogenesis. This compound has been shown to be effective against prostate cancer cells in vitro and in vivo, as well as in a mouse model for breast cancer. In this model, the drug inhibited tumor growth without any apparent toxicity to normal tissues. 2-(sec-Butylthio)pyrimidine-5-carbaldehyde has been tested as a potential antiangiogenic agent in mice, with results showing no adverse effects on animals.

N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine-3'-lcaa-CPG is an antiviral agent that inhibits the RNA polymerase of the virus. It is a phosphoramidite, which is a nucleoside with a phosphate group at the 5' position. N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine has been shown to be cytotoxic against cancer cells, and have less side effects than other nucleosides. It has been shown to selectively bind to ribonucleosides and deoxyribonucleosides and inhibit their synthesis by binding to the enzyme DNA polymerase. This stops DNA replication and causes cell death.

<p>A cap analog that can incorporated into mRNA</p>

4',5'-Didehydro-2',5'-dideoxy-2'-fluorouridine is a monophosphate of the nucleoside 5FU. It is an antiviral and anticancer agent that inhibits viral DNA synthesis by competitively inhibiting the activity of thymidylate synthase, which converts dUMP to dTMP. 4',5'-Didehydro-2',5'-dideoxy-2'-fluorouridine also induces apoptosis in neoplastic cells. This compound has high purity and quality, and can be used as a phosphoramidite for the synthesis of modified oligonucleotides.

<p>N4-Ethyl-2'-deoxycytidine is a novel nucleoside analog that inhibits the activity of DNA polymerase. It is used as an anticancer, antiviral and antiretroviral agent. N4-Ethyl-2'-deoxycytidine has been shown to be active against herpes simplex virus type 1 (HSV-1), HSV-2, cytomegalovirus (CMV), human immunodeficiency virus type 1 (HIV-1) and HIV-2 in vitro. This drug also has antiangiogenic properties due to its ability to inhibit the synthesis of vascular endothelial growth factor A. N4-Ethyl-2'-deoxycytidine is a modified nucleoside that can be phosphorylated by cellular enzymes, which activates it by converting it into a monophosphate or diphosphate form. This drug inhibits the production of RNA from DNA and also prevents protein</p>

<p>1-(b-D-Arabinofuranosyl)-5-iodouracil is a synthetic nucleoside that has antiviral and anticancer properties. It is a monophosphate nucleotide that inhibits viral RNA synthesis by inhibiting the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. This inhibitor also blocks DNA synthesis by preventing the incorporation of b-D-arabinofuranosyl monophosphate into DNA. 1-(b-D-Arabinofuranosyl)-5-iodouracil has been shown to be effective in treating various types of cancer, including breast, lung, and prostate cancers. It also exhibits antitumor activity against certain human leukemia cells.</p>

N6-Monobutyryl-2'-deoxyadenosine 3',5'-cyclic monophosphate sodium salt is a novel antiviral and anticancer agent that is a synthetic nucleoside analogue. It has been shown to be effective at inhibiting the growth of human cancer cells in vitro and in vivo. N6-Monobutyryl-2'-deoxyadenosine 3',5'-cyclic monophosphate sodium salt binds to viral RNA, resulting in inhibition of protein synthesis and cell death.