Nucleosidi

Gemcitabine 5'-elaidate is an analog of gemcitabine that has hydrophobic properties. It has been shown to be active against solid tumours, including lung cancer. In a study on murine xenografts, gemcitabine 5'-elaidate was found to have the same degree of efficacy as gemcitabine in reducing tumour growth and increasing survival time. Gemcitabine 5'-elaidate also has good antitumour activity against infectious diseases such as HIV and malaria, which may be due to its ability to bind to the epidermal growth factor receptor (EGFR) on the surface of cells. This binding prevents EGFR from initiating cellular signaling.

5'-O-DMT-inosine is a novel monophosphate nucleotide analogue. It is modified by the attachment of an aminooxy group to the 5' position of the pentose. This modification prevents ribonucleotide reductase from converting it into deoxyribonucleotides, which are then incorporated into DNA. 5'-O-DMT-inosine has been shown to be cytotoxic in human leukemia cells due to its ability to inhibit the synthesis of DNA and RNA.

2-(2-Cyclohexylethoxy)adenosine (CX-5461) is a new chemical entity that has been shown to have an incremental effect on muscle contraction. The mechanism of action of CX-5461 is not fully understood, but it has been shown to be nonselective and to bind to adenosine receptors. This binding produces a response in the cell similar to that of adenosine, which is a small molecule involved in the regulation of blood pressure and heart rate. CX-5461 also binds with platelet membranes at the site of inflammation and causes vasodilation. It has been shown to be effective in animal models of pertussis, where it reduces the severity of muscle spasms and increases the duration before death. These effects are due to CX-5461's ability to lower intracellular calcium concentrations by preventing calcium release from internal stores or from outside sources such as muscle cells or platelets.

7-Deaza-2'-deoxy-O6-methylguanosine is a novel nucleoside phosphoramidite that is the first of its kind to have been shown to be an antiviral agent. It is also anticancerous and stimulates diphosphate synthesis. 7-Deaza-2'-deoxy-O6-methylguanosine is a highly reactive nucleoside phosphoramidite that reacts with DNA in the same manner as deoxyribonucleotides. The monophosphate form of this compound has been shown to be anticancerous and stimulate diphosphate synthesis. This novel compound has been shown to inhibit replication of human immunodeficiency virus type 1 (HIV-1) in vitro.

2'-Deoxy-2'-fluoroadenosine-5'-triphosphate is an analog of adenosine triphosphate (ATP). It inhibits the synthesis of RNA by binding to the ribonucleotide reductase enzyme. This inhibition leads to the inhibition of DNA synthesis, which in turn prevents cell division and/or causes cell death. The inhibitory effect of 2'-deoxy-2'-fluoroadenosine-5'-triphosphate on protein and DNA synthesis has been shown in vivo and in vitro using cell culture techniques. This compound inhibits topoisomerase II, a key enzyme in DNA replication, at high concentrations.

L-Cystine dihydrochloride is a white crystalline powder that is used to treat acute radiation syndrome. It is an amino acid that contains two cysteine residues linked by a disulfide bond. Cysteine is necessary for the formation of proteins and peptides, which are important in antibody production. L-Cystine dihydrochloride has been shown to increase the uptake of radioactive substances in cells. This drug also increases the amount of bioactive molecules such as glutathione, which protects cells from oxidative damage caused by radiation. The effects of L-cystine dihydrochloride are dose dependent, with higher doses leading to greater cellular death.
The unpaired cysteines in L-cystine dihydrochloride can react with each other, forming a new molecule called S-thiolactone. This reaction is catalyzed by porcine pancreatic lipase (PPLL), a membrane protein found in pancreat

2'-Deoxy-5'-O-DMT-guanosine is a purine nucleoside that is converted to 2'-deoxy-5'-O-DMT-adenosine by the enzyme deoxyadenosyltransferase. This conversion is necessary for the synthesis of adenosylcobalamin, which is essential for the methylation of homocysteine to methionine. 2'-Deoxy-5'-O-DMT-guanosine has been shown to have cancer chemopreventive effects in vitro and in vivo. It also has been shown to enhance dna hybridization and hydrophobic interactions with cancerous cells, which may be due to its ability to inhibit gene expression.

5-Vinylcytidine is a nucleoside analog used in research to study DNA demethylation. It is an orthogonal molecule that can be used in assays to distinguish between different types of methylases. 5-Vinylcytidine is able to oxidize and formylate the N5 position of thymine, which leads to DNA demethylation. The mechanism of this process is not fully understood, but it may involve translocation or homologous recombination. 5-Vinylcytidine has been shown to react with alkyl groups, leading to its use as a probe for biochemical reactions involving methyltransferase enzymes.

N6-2-(4-Aminophenyl)ethyladenosine is a carbamazepine prodrug that is converted to the active form, carbamazepine, by esterases. It has been shown to inhibit the binding of adenosine to adenosine receptor subtypes and to have an antagonistic effect on the activity of endogenous adenosine at these receptors. N6-2-(4-Aminophenyl)ethyladenosine has also been shown to act as an antagonist at the A3 adenosine receptor. This drug has been shown to reduce bronchoconstrictor responses in animal models and may be used for treating asthma.
N6-2-(4-Aminophenyl)ethyladenosine has also been shown in vitro studies using human papillary muscle cells to enhance polymerase chain reactions (PCR).

(5'S)-2'-Deoxy-8,5'-cycloadenosine is a nucleoside analog that blocks the synthesis of DNA. It is a glycosylated nucleoside that contains an 8-carbon fatty acid chain linked to the 5’ carbon of the sugar ring. This compound is formed from the reaction of (5'S)-2'-deoxyadenosine and dicyclohexylcarbodiimide. The biological properties of this drug are not well understood, but it has been shown to be reactive with physiological levels and able to induce neuronal death in an experimental model. The mechanism for this effect is unknown, but may involve intramolecular hydrogen bonding or hydrolysis by esterases. A molecular docking analysis was performed to study the binding affinity between (5'S)-2'-deoxy-8,5'-cycloadenosine and human mda-mb-231 breast cancer cells. This analysis showed that wild

N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-5-methylcytosine-3'-O-succinate triethylammonium salt is a synthetic nucleoside. It is used for the treatment of HIV infection. N4-Benzoyl-1-(2'-deoxy-5'-O-DMT)-2'-fluoro -b -D -arabinofuranosyl) -5 methylcytosine (ADT) inhibits viral replication by inhibiting the activity of reverse transcriptase, which is an enzyme that synthesizes DNA from RNA. ADT is activated to its active form by phosphorylation with a kinase and then converted to diphosphate ADP by the enzyme pyrophosphatase. ADP then acts as a substrate for DNA polymerases, incorporating into newly synthesized DNA

Fluorescein-5(6)-carboxamidocaproyl-(5-[3-aminoallyl]uridine 5'-triphosphate) is a novel antiviral compound that is an activator of ribonucleoside and deoxyribonucleoside phosphorylation. It has been shown to selectively inhibit the proliferation of cancer cells, and to be cytotoxic to human leukemia cells in vitro. The compound is also able to inhibit HIV replication in vitro. Fluorescein-5(6)-carboxamidocaproyl-(5-[3-aminoallyl]uridine 5'-triphosphate) - 1 mM aqueous solution is a high purity product with CAS No. 134367-01-4 that can be used as a synthetically modified DNA or RNA building block for the production of phosphoramidites. This product has been shown to be cytotoxic against human leukemia cells in

2’-Deoxy-2-methyladenosine is a nucleoside that is chemically synthesized by the phosphorylation of 2,6-diaminopurine. It has been shown to be an effective activator of RNA polymerase and it also has anticancer properties. 2’-Deoxy-2-methyladenosine can be used as a substitute for thymidine in DNA synthesis. This nucleoside has also been shown to inhibit bacterial growth in culture by inhibiting DNA synthesis and protein synthesis. It is a modified nucleoside that can be used for the synthesis of DNA, RNA, or ribonucleic acids. The CAS number for this compound is 110952-90-4.