Altri

Applications A potent, selective and orally active labelled cysteinyl leukotriene type 1 receptor antagonist. Used as an antiasthmatic.
References Matassa, V.G., et al.: J. Med. Chem., 33, 1781 (1990), Findlay, S.R., et al.: J. Allergy Clin. Immunol., 89, 1040 (1992), Krell, R.D., et al.: Am. Rev. Respir. Dis., 141, 978 (1990), Dunn, C.J., Drugs, 61, 285 (2001),

Stability Hygroscopic
Applications Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic.
References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),

Stability Hygroscopic
Applications Used as an antiparkinsonian and antispasmodic.
References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)

Applications Cyancobalamin-b-carboxylic Acid is a Vitamin B12 (V676005) derivative, which is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.
References Rickes, et al.: Science, 107, 396 (1948); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 10, 183 (1981); Grasbeck, R., et al.: Clin. Biochem., 17, 99 (1984)

Applications β-Hydroxyisobutanol is used as a reagent in the synthesis of pyrazolo[1,5-a]pyridinecarbonyl-substituted spirocyclic piperidine ketals as inhibitors of HCV protein NS4B and of hepatitis C viral replication and their lack of cytotoxicity in human cells.
References Tai, V.W.-F., et al.: Bioorg. Med. Chem. Lett., 24, 2288 (2014);

Impurity Lorazepam USP Related Compound C
Applications An impurity of the anxiolytic and anticonvulsant drug Lorazepam (L469850). Lorazepam USP Related Compound C.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, H. et al.: Yao. Fen. Zaz., 29, 1985 (2009); Dabas, P.C. et al.: Drug Dev. Ind. Pharm., 14, 133 (1988);

Applications Gentisuric Acid is a metabolite that was found in hen plasma, tissues, and eggs as a result of the consumption of naturally occurring salicylates.
References Protasiuk, E., & Olejnik, M.: Food Addit. Contam. Part A, 37, 946 (2020)

Applications 3-Methoxy-1,2-propanediol is used to prepare phosphorothioate analogs of sn-2 radyl lysophosphatidic acid as metabolically stabilized LPA receptor agonists. It is also used to synthesize diacylglycerol analogs as potential second-messenger antagonists.
References Jiang, G., et al.: Bioorg. Med. Chem. Lett., 23, 1865 (2013); Briggs, J., et al.: Bioorg. Med. Chem. Lett., 2, 127 (1992)

Applications 7-Ketoabiraterone Acetate is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)

Applications Methyl Ethanesulfonate is a sulfonic acid ester that is transparent at around 157 nm region, and is used in DFT calculations of vacuum-UV spectra in order to design the vinyl alkylsulfonate polymers for vacuum-UV photoresist applications.
References Fujigaya, T., et al.: J. Photopolym. Sci. Tec., 15, 643 (2002);

Applications Hexamethyldisilazane is used in the preparation of 5-azacytidine, an antineoplastic drug. Also used in the preparation of β3-AR agonists used in anti-stress formulations.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Vujjini, S. et al.: Org. Proc. Res. Dev., 17, 303 (2013); Xu, F. et al.: Org. Lett., 15, 1342 (2013);

Applications (E)-4-Hydroxy Tamoxifen-d5 is an labelled metabolite of Tamoxifen (T006000). A hydroxylated analogue of Tamoxifen with anti-estrogenic properties.
References Muerdter, T.E., et al.: Clin. Pharmacol. Therapeut., 89, 708 (2011); Dorchies, O. M., et al.: Am. J. Pathol., 182, 485 (2013);