Altri

<p>Applications Desmethyl 5-Methoxycarbonyl Nintedanib is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>

<p>Applications The trans-isomer used in the improved process for the production and purification of Bimatoprost (B386800).<br></p>

<p>Applications β-Hydroxyisobutanol is used as a reagent in the synthesis of pyrazolo[1,5-a]pyridinecarbonyl-substituted spirocyclic piperidine ketals as inhibitors of HCV protein NS4B and of hepatitis C viral replication and their lack of cytotoxicity in human cells.<br>References Tai, V.W.-F., et al.: Bioorg. Med. Chem. Lett., 24, 2288 (2014);<br></p>

<p>Applications A potent, selective and orally active cysteinyl leukotriene type 1 receptor antagonist. Used as an antiasthmatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matassa, V.G., et al.: J. Med. Chem., 33, 1781 (1990), Findlay, S.R., et al.: J. Allergy Clin. Immunol., 89, 1040 (1992), Krell, R.D., et al.: Am. Rev. Respir. Dis., 141, 978 (1990), Dunn, C.J., Drugs, 61, 285 (2001),<br></p>

<p>Applications Labelled Bimatoprost (B386800). Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004),<br></p>

<p>Applications 1,3-Dimethyl Barbituric Acid (Urapidil Impurity 4) is a derivative of Barbituric acid (B118650). All of the barbituric acid derivatives which have been reported to have pronounced hypnotic activity are disubstituted in the 5-position.<br>References Gupta, K., et al.: Eur. J. Med. Chem., 17, 448 (1982), Weber, L., et al.: Curr. Med. Chem., 9, 2085 (2002), Skiles, J., et al.: Curr. Med. Chem., 11, 2911 (2004),<br></p>

<p>Applications Hexamethyldisilazane is used in the preparation of 5-azacytidine, an antineoplastic drug. Also used in the preparation of β3-AR agonists used in anti-stress formulations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Vujjini, S. et al.: Org. Proc. Res. Dev., 17, 303 (2013); Xu, F. et al.: Org. Lett., 15, 1342 (2013);<br></p>

<p>Applications The main metabolite of Chlordiazepoxide (C327050).<br>References Barbone, F., et al.: Lancet, 352, 1331 (1998); Miki, A., et al.: J. Anal. Toxicol., 26, 87 (2002);<br></p>

<p>Applications (E)-4-Hydroxy Tamoxifen-d5 is an labelled metabolite of Tamoxifen (T006000). A hydroxylated analogue of Tamoxifen with anti-estrogenic properties.<br>References Muerdter, T.E., et al.: Clin. Pharmacol. Therapeut., 89, 708 (2011); Dorchies, O. M., et al.: Am. J. Pathol., 182, 485 (2013);<br></p>

<p>Impurity Fulvestrant EP Impurity A<br>Applications Fulvestrant (F862500) impurity A. The S-isomer of Fulvestrant.<br>References Sharman, G.J., et al.: Mag. Resonance Chem., 39, 549 (2001),<br></p>

<p>Applications N-Formyl Memantine is an impurity of Memantine (M218000). Memantine impurity E per USP.<br>References Gerzon, K., et al.: J. Med. Chem., 6, 760 (1963),<br></p>

<p>Applications (15R)-Bimatoprost Acid is an impurity of the antiglaucoma agent Bimatoprost (B386820). (15R)-Bimatoprost Acid is a metabolically stable analog of PGF2α (P838625) and is a potent agonist for the FP receptor.<br>References Balapure, A.K. et al.: Biochem. Pharmacol., 38, 2375 (1989); Hellberg, M.R. et al.: J. Ocular Pharmacol. Ther., 19, 97 (2003); Krishna, P.M. et al.: J. Pharm. res., 4, 2381 (2011); Resul, B., et al.: J. Med. Chem., 36, 243 (1993)<br></p>

<p>Impurity Atenolol EP Impurity E<br>Applications 4,4'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis-benzeneacetamide is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker. Atenolol EP Impurity E<br>References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984);<br></p>

<p>Impurity Atenolol USP Related Compound D; Atenolol EP Impurity F<br>Applications 4,4'-[[(1-methylethyl)imino]bis[(2-hydroxy-3,1-propanediyl)oxy]]bis-benzeneacetamide (Atenolol USP Related Compound D; Atenolol EP Impurity F) is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker.<br>References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984); Caplar, V., et al.: Acta. Pharma. Jugoslavica., 33, 71 (1983);<br></p>

<p>Applications 7-Ethyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine is known to show antihistiminic and anaphylactic compounds.<br>References Tozzi, S. et al.: J. Med. Chem., 18, 1 (1975);<br></p>

<p>Folinic acid (Leucovorin) is a biofolic acid that can be used in the treatment of methotrexate, often in combination with Methotrexate (MTX) to reduce MTX-</p>

<p>Applications α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.<br>References Eltze, M., et al.: Eur. J. Pharmacol., 59, 1 (1979), Barankay, A., et al.: Arzneim.-Forsch., 31, 849 (1981), Belz, G.G., et al.: Clin. Pharmacol. Ther., 37, 48 (1985),<br></p>