Altri

<p>Applications Carfilzomib (2R,4S)-Diol is a derivative of Carflizomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.<br>References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);<br></p>

<p>Applications Silodosin is an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertrophy.<br>References (1) Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995) (2) Murata, S., et al.: J. Urol., 164, 578 (2000)<br></p>

<p>Applications (S)-2-((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic Acid is an intermediate for Carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.<br>References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);<br></p>

<p>Applications 15-Keto Bimatoprost is an impurity of Bimatoprost (B386800). Bimatoprost impurity III.<br>References Stjernschantz, J., et al.: Drugs Fut., 17, 691 (1992), Resul, B., et al.: J. Med. Chem., 36, 243 (1993),<br></p>

<p>Modified naphtol AS substrate used in histochemical and cytochemical staining</p>

<p>4-(Hydroxymethyl)phenyl-beta-D-glucopyranoside tetraacetate is a drug that has been shown to have antidiabetic effects in diabetic patients. It has been shown to inhibit tyrosinase activity and increase the production of gamma-aminobutyric acid (GABA) in brain cells. This compound also has a protective effect against glutamate toxicity, and is being studied as a potential treatment for epilepsy. 4-(Hydroxymethyl)phenyl-beta-D-glucopyranoside tetraacetate inhibits the production of tyrosinase, which is an enzyme responsible for the conversion of tyrosine to melanin. This process can be inhibited by inhibiting tyrosinase activity with 4-(hydroxymethyl)phenyl-beta-D-glucopyranoside tetraacetate.</p>

<p>2-Chloro-4-nitrophenyl 4-O-b-D-galactopyranosylmaltoside, also known as Gal-G2-CNP, is a high quality, water soluble, chromogenic substrate that is used as an enzyme substrate and can be used in bioluminescence and chemiluminescence assays. This product is designed for use in diagnostics, culture media, food testing, environmental testing, and other research applications. 2-Chloro-4-nitrophenyl 4-O-b-D-galactopyranosylmaltoside has been tested in chromogenic assays with alpha-amylases.</p>

<p>2-O-(4-Nitrophenyl)-a-D-N-glycolylneuraminic acid is commonly used to measure the activity of sialidase enzymes, specifically those that cleave glycoconjugates containing 2-O-(4-nitrophenyl)-alpha-D-N-glycolylneuraminic acid. The resulting product can be detected by measuring the absorbance at a specific wavelength using a spectrophotometer. This substrate offers a high degree of specificity for glycolylneuraminic acid-containing substrates and is useful for both research and diagnostic purposes.</p>

<p>4-Nitrophenyl beta-L-arabinopyranoside is a chromogenic substrate for beta-L-arabinosidase. Upon hydrolysis, para-nitrophenol is released yielding a yellowish colour. 4-Nitrophenyl beta-L-arabinopyranoside is used in different applications such as the Bacterial arabinan degradation assays, gut microbiome analysis</p>

<p>4-Nitrophenyl phosphate disodium salt hexahydrate is a substrate of the hydrolase alkaline phosphatase. The products of the enzymatic reaction are 4-nitrophenol and phosphate.</p>

<p>Chromogenic substrate for carboxylesterase yielding a salmon colored precipitate upon cleavage. Mainly used in histochemistry.</p>

<p>Chromogenic substrate for beta-glucanase</p>

<p>Chromogenic substrate for β-D-galactosidase, yielding a blue precipitate upon cleavage.</p>

<p>Naphthol AS-BI N-acetyl-beta-D-glucosaminide is a fluorogenic substrate for the pararosaniline-glyoxalase (PG) reaction. This substrate is used to study enzymatic activity in two human isoenzymes of PG, PG I and PG II. The conversion of this substrate by PG I or PG II results in a color change from yellow to red. Naphthol AS-BI N-acetyl-beta-D-glucosaminide may be used as an experimental tool to measure the activity of these enzymes and to study the effect of inhibitors on their activity. It can also be used as a marker for studying enzyme transfer between cells.</p>

<p>Chromogenic substrate yielding a soluble yellow chromophor for the colorimetric assay of phosphatases.</p>

<p>3-Indolyl 2-acetamido-2-deoxy-b-D-glucopyranoside is a substrate used for the detection of the enzyme N-acetylglucosaminidase (NAG). The enzyme hydrolyzes the NAG conjugate, releasing indole that can be detected through a colorimetric assay. This method is commonly used in clinical chemistry to evaluate kidney function, as NAG is excreted in urine and increased levels may indicate renal injury or disease. The indole NAG assay is also used in microbiology to detect the presence of NAG-producing bacteria.</p>

<p>Naphthol AS-D is a diagnostic chemical for phosphatase enzymes and is used to stain cells, tissues, and body fluids for diagnosis. The chemical reacts with the amino groups of proteins in cells and produces a brown color. Naphthol AS-D is not toxic to living cells in concentrations below 5%. It stains basophilic leukemia cells as well as brain cells. This chemical can be used to diagnose cutaneous lesions, such as psoriasis or melanoma, which are difficult to diagnose by standard methods.  present in these lesions and produce a brown color.</p>

<p>3-Indolyl 2-acetamido-2-deoxy-b-D-galactopyranoside is a fluorogenic substrate that reacts with the enzyme β-galactosidase to produce a blue product. This product can be used to diagnose the presence of β-galactosidase in culture media, as well as in food and environmental testing. 3IAG is also a chromogenic substrate that can be used for detection of β-galactosidase activity.</p>

<p>2-Chloro-4-nitrophenyl beta-D-maltotrioside, often abbreviated as CNP-G3, is a chromogenic substrate to detect and mesaure alpha-amylase activity. Evaluation and monitoring of alpha-amylase activity is important to help diagnose certain diseases such as pancreatitis.</p>

<p>6-Chloro-3-indoxyl caprylate is a high quality, enzyme substrate, chromogenic substrate, bioluminescence, chemiluminescence ligand, staining and diagnostics reagent. It has CAS No. 159954-35-5 and is used in food testing, culture media and environmental testing. 6-Chloro-3-indoxyl caprylate is also a fluorogenic substrate that is used for high purity applications such as conjugation with other molecules.</p>

<p>Chromogenic β-glucuronidase substrate yielding a yellow solution upon cleavage. Used to detect E. coli contamination in food and drinking water due to their β-glucuronidase activity.</p>

<p>Aldol® 458 beta-D-galactopyranoside is a chromogenic and fluorogenic enzyme substrate used for detection of ?-galactosidase activity. The colorless enzyme substrate is cleaved by lactose utilizing bacteria grown in liquid or solid media, yielding yellow coloration and green fluorescence. Aldol® 458 beta-D-galactopyranoside can also be used in ?-galactosidase gene reporter assays or immunoassay applications (ELISA). Aldol® 458 beta-D-galactopyranoside can be used under aerobic and anaerobic conditions.</p>

<p>5-Bromo-4-chloro-1H-indol-3-yl-b-D-cellotetraoside is a chromogenic substrate used to detect the specific enzymatic activity of cellulase. After cleavage, 5-bromo-4-chloro-indoxyl is released, resulting in a blue to blue-green color change in bacterial colonies or media. 5-Bromo-4-chloro-1H-indol-3-yl-b-D-cellotetraoside is used in bacterial cellulase detection and biomass conversion research.</p>