Carboidrati e Glicoconiugati

<p>4-Aminophenyl b-D-thiocellobiose is a modified sugar that has been synthesized and fluorinated. 4-Aminophenyl b-D-thiocellobiose is used in the synthesis of glycosylated bioactive molecules, including oligosaccharides and monosaccharides. The modification of this sugar is done by glycosylation, methylation, and conjugation. It can be used in the synthesis of complex carbohydrates as well as saccharides. This product's CAS No. is 68636-49-7.</p>

<p>Benzyl 4-O-(2,3,4,6-tetra-O-benzyl-a-D-galactopyranosyl)-2,3-di-O-benzylb -D-galactopyranoside is a Fluorination and Glycosylation product. It is a Custom Synthesis of Monosaccharide and Oligosaccharide. The CAS number for this product is 106835-99-8.</p>

<p>Hepta-O-acetyl-b-Lactosyl-N-Fmoc-L-threonine is a substance that can be used for the diagnosis of radiation exposure. It is a liquid that is injected into the body, where it accumulates in tissues such as bone marrow. The presence of Hepta-O-acetyl-b-Lactosyl-N-Fmoc-L-threonine in bone marrow cells can be detected using an imaging technique called balloon injury. This liquid also has synergistic effects with radiation and may be useful for the treatment of diseases such as thrombolysis.</p>

<p>Man-8 N-glycan is a modification of the carbohydrate Man-8. It is a complex carbohydrate that is synthesized from monosaccharides and polysaccharides. This product has been custom synthesized for high purity and high quality. It has been fluorinated to increase its stability, and it can be used in glycosylation reactions.</p>

<p>Difucosyllacto-N-neohexaose I is a fluorinated oligosaccharide that was synthesized by click chemistry. The synthesis of this compound involved the addition of a methyl group to the penultimate carbon on the reducing end of a disaccharide. Fluorination was then performed to introduce a trifluoromethyl group onto the sugar ring, which is an important step in obtaining a high level of purity. This compound has been shown to be effective in inhibiting bacterial growth and can be used as an antibacterial agent for prevention and treatment of various infections.</p>

<p>Hybrid N-glycans are glycan structures that contain both a high mannose and complex type oligosaccharide. Hybrid N-glycans are expressed on the surface of mammalian cells, and they can be found in human serum. Hybrid N-glycans have been shown to activate caspase 3 and induce apoptosis in some mouse models. They also have biological functions such as growth factor binding or antibody binding. Hybrid N-glycans may be involved in the activation of the immune system or in the development of cancerous tumors.</p>

<p>2,3,6,2',3',4',6'-Hepta-O-benzoyl-D-lactose is a custom synthesis that can be modified in a variety of ways. It has a high degree of fluorination and methylation to provide protection against degradation by enzymes. The monosaccharide units are synthesized and then assembled into oligosaccharides with glycosylations. Modifications can include glycosylation at any position on the molecule as well as the addition of complex carbohydrates.<br>2,3,6,2',3',4',6'-Hepta-O-benzoyl-D-lactose is an example of a polysaccharide consisting of glucose units with other hexoses such as galactose or mannose.</p>

<p>Ganglioside GM3 (ammonium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked a2,3 to the galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as, lung, brain and melanomas where it is over expressed. It is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganlioside is implicated in various other diseases involving chronic inflammation, such as, insulin resistance, leptin resistance, T-cell function and immune disorders (e.g. allergic asthma). GM3 ganglioside has also been shown to play an essential role in murine and human auditory systems, and a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).</p>

<p>A disaccharide</p>

<p>4-O-(2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-b-D-glucopyranosyl)-1,6-di-O-benzyl-2-deoxy--aDmuramic acid methyl ester is a synthetic carbohydrate. It is a modification of an oligosaccharide and can be used as a starting material in the synthesis of complex carbohydrates. 4ODBGMEM is synthesized by acetylation of 1,6 di O benzyl 2 deoxy a D muramic acid methyl ester with acetic anhydride and triethylamine. The compound has been shown to be effective in fluoroquinolone resistance and methicillin resistance.</p>

<p>Desthiobiotin is a modified form of biotin that binds less tightly to biomolecules like proteins and carbohydrates than it does biotin, while still providing excellent specificity in affinity purification methods (Hirsch, 2002). The structure of GD2-oligosaccharide-desthiobiotin (sodium salt) comprises (GalNAcβ1,4Galβ1,4Glc) of its two sialic acids linked α2,3/α2,8 to the central galactose residue (Ledeen, 2009). The desthiobiotin is attached β to position 1 of the reducing glucose moiety. GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentration on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).</p>

<p>Heparin derived dp16 saccharide ammonium salt is a synthetic oligosaccharide with a molecular weight of approximately 16,000 Da. The compound is an amine-modified heparin sulfate fragment containing 16 saccharides linked in a linear fashion. It has been used for the click modification of proteins, and as a carbohydrate receptor in glycosylation studies. Heparin derived dp16 saccharide ammonium salt can also be custom synthesized to meet specific needs. Click modification and fluorination are two modifications that have been applied to the compound for various purposes.</p>

<p>5-O-(5-Amino-5-deoxy-b-D-ribofuranosyl)-1-N-[(S)-4-amino-2-hydroxybutanoyl]paromamine is a Glycosylation agent that is used in the synthesis of oligosaccharides and polysaccharides. It can be used for Click modification, fluorination, saccharide, modification, sugar, and oligosaccharide synthesis. This product is CAS No. 51417-97-9 and has purity &gt;99% (HPLC).</p>

<p>Lacto-N-fucopentaose II-BSA is a glycosylation agent that is derived from the natural substrate N-acetylgalactosamine. It is used in the synthesis of complex carbohydrates, such as glycoconjugates and polysaccharides. Lacto-N-fucopentaose II-BSA can be modified with methyl groups or fluorine atoms to generate derivatives, which are useful for studying glycosylation reactions. The CAS number for this product is 46645-96-8. This product is synthesized using custom methods and has been purified to high purity levels.</p>

<p>Drug carrier for cancer therapy &amp; imaging, biocompatible, soluble, biodegradable</p>

<p>3-O-(2-Acetamido-2-deoxy-b-D-glucopyranosyl)-D-galactose is a synthetic glycosylation of galactose and acetamide. This product is a high purity, custom synthesis with methylation, monosaccharide, and polysaccharide modifications. 3-O-(2-Acetamido-2-deoxy-b-D-glucopyranosyl)-D-galactose is available in bulk quantities.</p>

<p>The chemical compound 2-Acetamido-1,6-di-O-benzyl-3-O-(2,3,4-tri-O-benzyl-aL-fucopyranosyl)-4-O-[2-O-(2,3,4 -tri-O benzyl aL fucopyranosyl) 3,4,6 tri O benzyl bD galactopyranosyl]-2 deoxy D glucopyranoside has the CAS number 6092097. This is a synthetic monosaccharide that is not found in nature. It is an oligosaccharide and complex carbohydrate with glycosylation and polysaccharide modifications. The high purity of this compound makes it an excellent choice for use in research or as a precursor for other compounds.</p>

<p>3,4-Di-O-acetyl-2,6-di-O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl)-a-D-mannopyranosyl trichloroacetimidate is a modified sugar with the molecular formula of C54H79F14N5O26. It is a complex carbohydrate that can be synthesized and custom made. It has high purity and CAS No., and can be methylated, glycosylated, or polysaccarided. This product can also be fluorinated to produce a saccharide with the molecular formula of C54H79F14N5O26F3.</p>

<p>3,4,6-Tri-O-acetyl-2-O-(2,3,4-tri-O-benzoyl-a-L-fucopyranosyl)-D-galactopyranose (TFP) is a fluorinated carbohydrate synthesized by the reaction of 3,4,6 trihydroxyacetophenone with 2,3,4 trihydroxypentanediol and acetyl chloride. TFP is a complex carbohydrate that can be used to modify proteins and glycoproteins. The methylation of TFP has been shown to decrease the binding affinity between lectins and glycoproteins.</p>

<p>N-acetyllactosamine is a monosaccharide that belongs to the group of n-acetyllactosamine. It can be found in the form of an agglutinin, lactose, and lectin. The conformation of this molecule is an equilibrium between its alpha and beta forms. The pyridine can act as an acid catalyst for the alpha conformation. There are two forms of this molecule: one synthesized from D-glucose and one synthesized from D-galactose. 1,6-Anhydro-4-O-b-D-galactopyranosyl-b-D-glucopyranose is synthesized from D-glucose. Oligosaccharides containing this molecule have been expressed in Saccharomyces cerevisiae cells and purified by affinity chromatography on columns that contain immobilized antibody to human serum albumin. This molecule has been shown</p>

<p>Drug carrier for cancer therapy &amp; imaging, biocompatible, soluble, biodegradable</p>

<p>2-O-(3,4,6-Tri-O-acetyl-2-deoxy-2-N-phthalimido-b-D-glucopyranosyl)-3-O-benzyl-4,6-benzylidene -D -mannopyranose is a custom synthesis. It is a complex carbohydrate that has been modified with methylation and glycosylation. The saccharide in this compound is an oligosaccharide that has undergone fluorination and click chemistry. This product is of high purity and offers a range of useful applications.</p>

<p>8-Methoxycarbonyloctyl-3-O-benzyl-2,2'-dideoxy-2,2'-diphthalimido-3',4',6-tri-O-acetyl-b -cellobiose is a cellobiose with an 8 methoxycarbonyl group at the C8 position. It can be used in the synthesis of oligosaccharides and polysaccharides. The compound has been synthesized by methylation, click modification, and fluorination. The CAS number is 106445-30-1. 8MCOBBIOSE has a purity of &gt; 98% and may have a white to off white powder appearance.</p>

<p>An antioxidant used in food and feeds, produced from starch, using enzymes</p>

<p>Lacto-N-fucopentaose III-GEL is a synthetic monosaccharide that is used as a building block for the synthesis of complex carbohydrates. Lacto-N-fucopentaose III-GEL is synthesized from fructose, which is methylated with chloromethylated N,N'-diacetylchitobiose as the methylating agent and sodium methoxide as the catalyst. The resulting glycoconjugate is then treated with hydrofluoric acid to introduce fluorine atoms into the carbohydrate backbone.</p>

<p>3',4'-O-Carbonyl-6,6'-di-O-tert-butyldimethylsilyl lactal is a fluorinated carbohydrate that can be used as a building block for the synthesis of oligosaccharides. It is an important sugar in glycosylation, click chemistry and methylations. This compound has been shown to have high purity and is available for custom synthesis.</p>

<p>Oroxylum indicum is a plant that belongs to the family Bignoniaceae. It has been used in traditional medicine for the treatment of cancer and has been shown to possess anti-inflammatory properties. The sequenced genome of Oroxylum indicum has provided a model system for understanding the molecular mechanisms underlying tumorigenesis. This plant contains a number of monoclonal antibodies, including one that is active against mouse monoclonal antibodies and inhibits tumor xenografts. The extract of this plant also inhibits influenza virus and polymerase chain reactions, which are important steps in protein synthesis. Oroxylum indicum may have therapeutic potential as an anti-cancer drug because it can inhibit solid tumours by interfering with protein synthesis.</p>

<p>Gala1-3(Fuca1-2)Galb1-3GalNAc</p>

<p>6-O-(2,3,4,6-Tetra-O-acetyl-a-D-mannopyranosyl)-1,2,3,4-tetra-O-benzyl-a-D-mannopyranoside is an oligosaccharide with a complex carbohydrate structure. This chemical is a custom synthesis and it has high purity. 6-O-(2,3,4,6-Tetra-O-acetyl-a-D-mannopyranosyl)-1,2,3,4-- tetra--O--benzyl--A--mannopyranoside is used as an intermediate for the production of other compounds. The CAS number for this compound is</p>

<p>Methyl 3-O-(2-acetamido-2-deoxy-a-D-galactopyranosyl)-a-D-galactopyranoside is a synthetic carbohydrate. It is a biochemically active compound that can be used as an intermediate in the synthesis of oligosaccharides and monosaccharides, as well as other natural products. Methyl 3-O-(2-acetamido-2-deoxy-a-D-galactopyranosyl)-a-D-galactopyranoside has been studied for its potential use in cancer treatments, antiaging, and diabetes treatments.</p>

<p>Hyaluronate Rhodamine (HR) is a high purity, custom synthesis sugar that has been modified with Click chemistry. HR is a complex carbohydrate that consists of saccharides and oligosaccharides. HR has been synthesized using glycosylation and methylation reactions. Hyaluronate Rhodamine's CAS number is 1059-14-5.</p>

<p>GT1c oligosaccharide (free acid) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with three sialic acid residues (NeuAc) linked α2,8/α2,8/α2,3 to the inner galactose residue (Ledeen, 2009). A monoclonal antibody, established against the chick neural tube, was shown to recognize the trisialosyl residue, NeuAca2-8NeuAca2-8NeuAca2-3-R GT1c ganglioside in the cerebral cortex of fetal rats (Hirabayashi, 1989). This unusual multisialo ganglioside was recognised in chicken optic lobes and cerebrum, during embryonic development (Rosner, 1980) and in fish brains (Yu, 1980).</p>

<p>a1-3,a1-6-Mannotriose-BSA is a carbohydrate that is synthesized by the modification of maltotriose with a fluorinated alcohol. It is an oligosaccharide made up of three glucose units linked together in a 1,3 configuration and one glucose unit linked together in a 1,6 configuration. The molecular weight of this carbohydrate is 793 Daltons. This product has been shown to be high purity and custom synthesis for use in research.</p>

<p>NGA2 Glycan, 2-AB labelled is a complex carbohydrate that is custom synthesized for research purposes. It is a high purity, high quality product that has been fluorinated and glycosylated. NGA2 Glycan, 2-AB labelled is used in the synthesis of oligosaccharides and polysaccharides. This product can be used for glycosylation, methylation and click modification.</p>

<p>2-Acetamido-2-deoxy-6-a-O-sialyl-D-galactopyranose is a monosaccharide that is synthesized from D-galactose and acetamide. It has a molecular weight of 388.13 and an empirical formula of C8H14N2O4. This product can be custom synthesized to meet the needs of customers, with a purity level of 98%. 2-Acetamido-2-deoxy-6-a-O-sialyl--D--galactopyranose is used in glycosylation reactions, as well as in the synthesis of oligosaccharides, sugar and saccharide derivatives. This product can also be used for fluorination reactions, methylation reactions, and click modification reactions.</p>

<p>Hyaluronate is a naturally occurring glycosaminoglycan (GAG) found in the extracellular matrix of animal tissues. It is a linear polymer composed of alternating units of N-acetylglucosamine and glucuronic acid. The molecular weight of hyaluronate ranges from 10,000 Da to 1,000,000 Da. Hyaluronate has been modified by fluorination, methylation, and click modification reactions. These modifications affect the physical properties of hyaluronate, including its reactivity with other molecules. Click modification reactions are often used to link two different molecules together. This may include linking an oligosaccharide or saccharide to the hydroxyl groups on the glucuronic acid residues in hyaluronate.</p>

<p>Varenicline N-oxide is a synthetic drug product. It is the metabolite of varenicline, which is used as an aid to smoking cessation. Varenicline N-oxide has shown anti-inflammatory properties in vitro and in vivo, and may be useful for treating inflammatory diseases. Varenicline N-oxide also has been shown to inhibit the production of nitric oxide in macrophages and prevent the release of tumor necrosis factor alpha by macrophages.</p>

<p>3'-Sialyllacto-N-biose is a regiospecific, biochemically defined carbohydrate. It is a component of the glycan chains that are present on the surface of cell membranes. Lacto-n-biose has been shown to have inhibitory activity against the growth of Mycobacterium tuberculosis and Mycobacterium avium complex bacteria.</p>

<p>Sulpho Lewisx Na is a high purity, custom synthesized sugar that has been modified using a click chemistry reaction. It has been fluorinated and glycosylated to produce a complex carbohydrate. Sulpho Lewisx Na is a synthetic oligosaccharide produced with the intention of mimicking the structure of Lewisx in order to study its properties. The CAS number for this compound is 2641-19-2 and it can be found under the name Oligosaccharide, Monosaccharide, saccharide, Carbohydrate on Pubchem CID 1039264.</p>

<p>2,3,4-Tri-O-acetyl-6-O-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl)-D-glucopyranose is a synthetic sugar. It is a monosaccharide that is synthesized from 2,3,4,6 tetraacetyl b D glucopyranosyl b D glucose and triethylene glycol. This compound can be used in the synthesis of polysaccharides or complex carbohydrates.</p>

<p>The Lipid A moiety of lipopolysaccharide forms the outer monolayer of the outer membrane in most Gram-negative bacteria. Escherichia coli lipid A is synthesized on the cytoplasmic side of the inner membrane by a conserved pathway of nine constitutive enzymes. Following attachment of the core oligosaccharide, nascent core-lipid A is flipped to the outer surface of the inner membrane by the ABC transporter MsbA, where the O-antigen polymer is attached. These complex glycoforms protect bacteria from antibiotics and complement-mediated lysis. The core and O-antigen domains are required for virulence and consequently are present in most clinical and environmental isolates (Raetz, 2007).</p>

<p>NGA4F N-Glycan is a modification of the N-glycan structure. It is an oligosaccharide composed of a single monosaccharide, methylated and glycosylated to form a polysaccharide with sugar groups on every other carbon. This product can be custom synthesized by our chemists at your request.</p>

<p>Verbascotetraose is a disaccharide that is found in plants. Its chemical structure is composed of one glucose molecule and one fructose molecule. Verbascotetraose is produced by the plant tissue through a biosynthetic process, which involves the transfer reactions of phosphorylated hexoses. The resulting product is then converted to stachyose and oligosaccharides by dephosphorylation, glycan synthesis, and chromatographic method.<br>The production of verbascotetraose has been demonstrated in soybean products incubated with cellotriose and glycoside derivatives.</p>

<p>8-Ethoxycarbonylheptyl N,N'-di-O-acetyl-b-chitobioside is a custom synthesis of an oligosaccharide. It is a complex carbohydrate that is composed of saccharides and has a CAS number. 8-Ethoxycarbonylheptyl N,N'-di-O-acetyl-b-chitobioside is modified with methylation, glycosylation and click modification. This product is also fluorinated. 8-Ethoxycarbonylheptyl N,N'-di-O-acetyl-b-chitobioside has high purity and can be used as a sugar in the synthesis of other compounds.</p>

<p>Lewis Y tetrasaccharide-APE-HSA is a synthetic, high purity glycosylated oligosaccharide. It is composed of a Lewis Y tetrasaccharide linked to an APE peptide and HSA. The Lewis Y tetrasaccharide has been custom synthesized with click modification and fluorination. The APE peptide has been modified with glycosylation and methylation. The HSA has been modified with glycosylation, methylation, and acetylation. The oligosaccharide was synthesized using the solid phase method on a CEM Liberty Star Column. This glycoconjugate is CAS No., which can be found at Pubchem CID: 10609300.</p>

<p>Methyl a-D-Lamarabioside heptaacetate is a synthetic, fluorinated monosaccharide derived from the natural compound D-Lamarabioside. It is used as a building block for the synthesis of novel oligosaccharides and glycosylated proteins. This product also has applications in medical research and development, such as for the design of new drugs and vaccines, as well as in biotechnology and chemical engineering. Methyl a-D-laminarabioside heptaacetate is soluble in water with a melting point of 230°C. It can be used to modify proteins with high purity by introducing glycosylation sites. This product is also useful for click chemistry reactions.</p>

<p>α-1,4-glucododecasaccharide derived from starch by hydrolysis and chromatography</p>

<p>Oteracil is an antagonist of urate oxidase.</p>

<p>Remogliflozin is an effective sodium-glucose transporter 2 inhibitor (Kis = 12.4 and 26 nM for human and rat SGLT2, respectively).</p>

<p>Maxacalcitol (22-Oxacalcitriol) is a ligand of VDR-like receptors and a non-serum calcium vitamin D3 analogue.</p>