Carboidrati e Glicoconiugati

<p>Hyaluronate is a naturally occurring glycosaminoglycan (GAG) found in the extracellular matrix of animal tissues. It is a linear polymer composed of alternating units of N-acetylglucosamine and glucuronic acid. The molecular weight of hyaluronate ranges from 10,000 Da to 1,000,000 Da. Hyaluronate has been modified by fluorination, methylation, and click modification reactions. These modifications affect the physical properties of hyaluronate, including its reactivity with other molecules. Click modification reactions are often used to link two different molecules together. This may include linking an oligosaccharide or saccharide to the hydroxyl groups on the glucuronic acid residues in hyaluronate.</p>

3'-Sialyllacto-N-biose is a regiospecific, biochemically defined carbohydrate. It is a component of the glycan chains that are present on the surface of cell membranes. Lacto-n-biose has been shown to have inhibitory activity against the growth of Mycobacterium tuberculosis and Mycobacterium avium complex bacteria.

<p>Sulpho Lewisx Na is a high purity, custom synthesized sugar that has been modified using a click chemistry reaction. It has been fluorinated and glycosylated to produce a complex carbohydrate. Sulpho Lewisx Na is a synthetic oligosaccharide produced with the intention of mimicking the structure of Lewisx in order to study its properties. The CAS number for this compound is 2641-19-2 and it can be found under the name Oligosaccharide, Monosaccharide, saccharide, Carbohydrate on Pubchem CID 1039264.</p>

<p>2,3,4-Tri-O-acetyl-6-O-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl)-D-glucopyranose is a synthetic sugar. It is a monosaccharide that is synthesized from 2,3,4,6 tetraacetyl b D glucopyranosyl b D glucose and triethylene glycol. This compound can be used in the synthesis of polysaccharides or complex carbohydrates.</p>

The Lipid A moiety of lipopolysaccharide forms the outer monolayer of the outer membrane in most Gram-negative bacteria. Escherichia coli lipid A is synthesized on the cytoplasmic side of the inner membrane by a conserved pathway of nine constitutive enzymes. Following attachment of the core oligosaccharide, nascent core-lipid A is flipped to the outer surface of the inner membrane by the ABC transporter MsbA, where the O-antigen polymer is attached. These complex glycoforms protect bacteria from antibiotics and complement-mediated lysis. The core and O-antigen domains are required for virulence and consequently are present in most clinical and environmental isolates (Raetz, 2007).

<p>NGA4F N-Glycan is a modification of the N-glycan structure. It is an oligosaccharide composed of a single monosaccharide, methylated and glycosylated to form a polysaccharide with sugar groups on every other carbon. This product can be custom synthesized by our chemists at your request.</p>

<p>8-Ethoxycarbonylheptyl N,N'-di-O-acetyl-b-chitobioside is a custom synthesis of an oligosaccharide. It is a complex carbohydrate that is composed of saccharides and has a CAS number. 8-Ethoxycarbonylheptyl N,N'-di-O-acetyl-b-chitobioside is modified with methylation, glycosylation and click modification. This product is also fluorinated. 8-Ethoxycarbonylheptyl N,N'-di-O-acetyl-b-chitobioside has high purity and can be used as a sugar in the synthesis of other compounds.</p>

<p>Lewis Y tetrasaccharide-APE-HSA is a synthetic, high purity glycosylated oligosaccharide. It is composed of a Lewis Y tetrasaccharide linked to an APE peptide and HSA. The Lewis Y tetrasaccharide has been custom synthesized with click modification and fluorination. The APE peptide has been modified with glycosylation and methylation. The HSA has been modified with glycosylation, methylation, and acetylation. The oligosaccharide was synthesized using the solid phase method on a CEM Liberty Star Column. This glycoconjugate is CAS No., which can be found at Pubchem CID: 10609300.</p>

<p>Methyl a-D-Lamarabioside heptaacetate is a synthetic, fluorinated monosaccharide derived from the natural compound D-Lamarabioside. It is used as a building block for the synthesis of novel oligosaccharides and glycosylated proteins. This product also has applications in medical research and development, such as for the design of new drugs and vaccines, as well as in biotechnology and chemical engineering. Methyl a-D-laminarabioside heptaacetate is soluble in water with a melting point of 230°C. It can be used to modify proteins with high purity by introducing glycosylation sites. This product is also useful for click chemistry reactions.</p>

α-1,4-glucododecasaccharide derived from starch by hydrolysis and chromatography

<p>2-Acetamido-4-O-(2-acetamido-2-deoxy-a-D-glucopyranosyl)-2-deoxy-D-galactopyranose is a Custom synthesis of an oligosaccharide that is synthesized by the modification of natural sugars. This product has been fluorinated, methylated and modified with click chemistry. It is saccharide consisting of two monosaccharides, which are 2 acetamido 4 O-(2 acetamido 2 deoxy a D glucopyranosyl)-2 deoxy D galactopyranose and 2 deoxy D galactose. The molecular weight of this compound is 528.5 g/mol.</p>

<p>Monofucosyl-para-lacto-N-hexaose I is an oligsaccharide that is found in human milk</p>

<p>4-Deoxy-D-chitobiose heptaacetate is a synthetic compound that has been modified by the addition of a heptaacetate group. This modification provides an additional site for attachment to other molecules, such as nucleic acids or proteins. The fluorination of this saccharide provides further protection against degradation and increases its stability in aqueous solutions. 4-Deoxy-D-chitobiose heptaacetate is available in high purity and can be custom synthesized to meet your needs.</p>

<p>Man5GlcNAc is a glycoprotein that is expressed in the Golgi apparatus of mammalian cells. It is cleaved by alpha-mannosidase II and alpha-mannosidase I, which are enzymes located in the golgi apparatus. Man5GlcNAc has been shown to be an effective glp-1 analogue, which is a hormone that stimulates insulin secretion. This protein has also been shown to have structural similarities to high mannose type oligosaccharides, which are found on the surface of some bacteria. The protein may also act as a signal peptide for proteins that are exported from the golgi to the cell membrane.</p>

<p>Penta-guluronic acid sodium salt (1,4-linked α-L-sodium guluronopentaose) is one of a number of oligosaccharides obtained from alginate which is a polysaccharide in brown seaweeds containing: blocks of repeating mannuronic acid sequences (M-M-M-M etc), repeating guluronic acid sequences (G-G-G-G etc), and alternating M-G-M-G sequences. This oligosaccharide can be released by acid hydrolysis (Shimokawa, 1996) and a number of biological activities have been discussed in a recent review (Xing, 2020).</p>

<p>2-Acetamido-3-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-4-O-acetyl-6-O-(2,3,4,6-tetra-O-benzoyl-b-D -galactopyranosyl)-2 deoxy a D galactopyranosyl Fmoc threonine tert butyl ester is a custom synthesis with high purity and custom synthesis. This product is recommended for methylation and glycosylation reactions. It is a complex carbohydrate that has been modified by fluorination and saccharide.</p>

<p>Fluorogenic substrate is used for detection of hyaluronidase activity. Urinary hyaluronidase activity is elevated in patients with intermediate and high grade bladder cancer; the expression of hyaluronidase and hyaluronan synthase-1 mRNA in malignant tissue can predict bladder cancer metastasis and disease recurrence (Kramer, 2011). These findings underscore the potential utility of the hyaluronidases to serve as biomarkers for bladder cancer. A novel fluorescent substrate labelled with two dyes: fluorescein as a green donor fluorophore, and rhodamine B as a red acceptor fluorophore, was therefore developed to measure hyaluronidase enzyme kinetics (Zhang, 2008). It was then demonstrated that simultaneous measurements of green and red emission of HA–FRET could be used to measure hyaluronidase presence and activity (Fudala, 2011).</p>

<p>2, 3, 6, 2', 3', 4', 6'-Hepta-O-acetyl-D-maltose is a fluorinated monosaccharide that is used in the synthesis of glycosides. It has a CAS number of 56285-96-2 and can be custom synthesized. This product is an oligosaccharide that can be modified by glycosylation, methylation, or click modification. It is a complex carbohydrate with a high purity and can be used in the modification of sugars.</p>

<p>Man-2a N-glycan is a modification of the oligosaccharide mannose that is an important component of many glycoproteins. This product can be custom synthesized, and has been shown to have high purity. It is a carbohydrate that contains a monosaccharide and a polysaccharide. The glycan may also contain methylation, glycosylation, or fluorination. It has CAS No. 491845-49-9, which is the number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society to identify substances.</p>

<p>3'-Sulpho Lewisa-BSA is a custom synthesis of 3'-sulpho Lewis a-bovine serum albumin. It is an oligosaccharide that has been modified by saccharide methylation and glycosylation. 3'-Sulpho Lewisa-BSA has been modified with the click chemistry reaction and fluorinated with 18F. This complex carbohydrate is high purity, and is used for research purposes.</p>